Ha ho bonolo kamehla ho tseba mofuta oa lefu la tsoekere, hobane ho na le phapang ea lefu lena, eo matšoao a eona a ka tšoaeang mefuta ea pele le ea bobeli. Keketseho e tsitsitseng ea tsoekere e sa le monyane lilemong, joalo ka mofuta oa 1, e nang le mofuta o fokolang oa mofuta oa 2, e ne e bitsoa lefu la tsoekere la Modi.
MODI ke khutsufatso ea "tsoho ea peleho ea tsoekere ea ba banyenyane", e ka fetoleloang e le "lefu la tsoekere la batho ba baholo ho ba banyenyane." Lilemo tseo lefu lena le tsoang ho lona le sa feteng lilemo tse 25. Lefu la tsoekere la Mody le kopanya mefuta e mengata. Tse ling tsa tsona li na le matšoao a hlakileng a tsoekere e eketsehileng - lenyora le ho eketseha ha molumo oa moroto, empa boholo ba tsona ke asymptomatic mme li fumanoa feela nakong ea tlhatlhobo ea bongaka.
Phapang ea lefu la tsoekere la Modi ho mefuta e meng
Lefu la tsoekere la Mody ke lefu le fumanehang seoelo. Ho latela likhakanyo tse fapaneng, karolo ea bakuli e tsoa ho 2 ho isa ho 5% ea batho bohle ba lefu la tsoekere. Sesosa sa lefu lena ke phetoho ea liphatsa tsa lefutso, ka lebaka leo lihlekehleke tsa Langerhans li khaohileng. Tsena ke lihlopha tsa lisele tse khethehileng ka har'a manyeme, moo ho hlahisoang insulin.
Lefu la tsoekere le khatello e matla e tla ba ntho ea khale
- Ts'oarelo ea tsoekere -95%
- Ho felisoa ha vein thrombosis - 70%
- Ho felisa ho otla ha pelo e matla -90%
- Ho tlosa khatello e phahameng ea mali - 92%
- Keketseho ea matla mots'eare, ho ntlafatsa boroko bosiu -97%
Lefu la tsoekere la Mody le fetisoa ka tsela e atileng haholo ea moea. Haeba ngoana a amohela mofuta o le mong o nang le sekoli ho batsoali ba hae, bokuli ba hae bo tla qala ho 95% ea linyeoe. Monyetla oa phetiso ea liphatsa tsa lefutso ke 50%. Mokuli melokong e fetileng o tlameha ho ba le ba amanang ka kotloloho le lefu la tsoekere la Mody, lefu la bona le ka utloahala joaloka mofuta oa 1 kapa oa 2 oa lefu la tsoekere, haeba ho sa fumanoe tlhahlobo ea lefutso.
Lefu la tsoekere la Mody le ka belaelloa haeba glucose ea mali e nyoloha ka linako tse ling, keketseho ena e bolokoa maemong a lekanang nako e telele, ha e bake hyperglycemia le ketoacidosis e matla. Karolo e khethollang ke karabelo ea kalafo ea "insulin": kharebe ea kamora hore e qale ha e lule likhoeli tse 1-3, joalo ka lefu la tsoekere la mofuta oa 1, empa e le telele haholo. Litokisetso tsa "insulin", esita le lipalo tse nepahetseng tsa litekanyetso, kamehla li baka hypoglycemia e sa lebelloang.
Mekhoa ea ho khetholla ho khetholla lefu la tsoekere la Mody le mefuta e atileng ea lefu:
| Mofuta oa 1 | Modylefu la tsoekere |
| Monyetla oa lefa o tlaase, o sa feteng 5%. | Boemo ba ho ikoahlaela, menyetla e phahameng ea phetiso. |
| Ketoacidosis ke tšobotsi ea qalo. | Qalong ea lefu lena, ho lokolloa ha litopo tsa ketone ha ho etsahale. |
| Lithuto tsa laboratori li bonts'a boemo bo tlase ba C-peptide. | Palo e tloaelehileng ea C-peptide, e bonts'ang secretion ea insulin. |
| Qalong, li-antibodies li ikemiselitse. | Li-antibodies ha li eo. |
| Nako ea lechato ka mor'a ho qala kalafo ea insulin ha e ka tlase ho likhoeli tse tharo. | Glucose e tloaelehileng e ka nka lilemo tse 'maloa. |
| Litekanyetso tsa insulin li eketseha kamora hore lisele tsa beta li khaotse ho sebetsa. | Tlhokahalo ea insulin e nyane, hemoglobin e fokolang ha e holimo ho 8%. |
Lenane la 2
| Mofuta oa 2 | Lefu la tsoekere |
| E fumanoa e le motho e moholo, hangata kamora lilemo tse 50. | E qala bongoaneng kapa bohlankeng, hangata lilemong tse 9-13. |
| Maemong a mangata, botenya le takatso e matla ea lipompong li bonoa. | Bakuli ba phela bophelo bo tloaelehileng, ha ho boima bo feteletseng. |
Mefuta ea lefu la tsoekere la Mody
Boloetse bona bo aroloa ho latela mofuta oa 'mele o fetotsoeng. Ho na le liphetoho tse 13 tse ka eketsang tsoekere ea mali ho fihlela joale, palo e tšoanang ea mefuta ea lefu la tsoekere la Mody. Ha ba koahele linyeoe tsohle tsa lefu la tsoekere ka mokhoa o sa tloaelehang, ka hona, lithuto li lula li tsoela pele ho batla mefuta e mecha e nang le phoso. Butle-butle, palo ea mefuta ea lefu lena e tsebahala.
Tlanya lipalo-palo bakeng sa peiso ea Caucasus:
- Modi-3 - 52% ea linyeoe;
- Modi-2 - 32%;
- Modi-1 - 10%;
- Modi-5 - 5%.
Maemo a atamelaneng a Maasia:
- Modi-3 - 5% ea linyeoe;
- Modi-2 - 2,5%;
- Modi-5 - 2,5%.
Ke karolo ea 10 lekholong feela ea bakuli ba mofuta oa Mongoloid e seng e khona ho khetholla mofuta ona oa lefu la tsoekere, ka hona, lithuto tsa ho batla mefuta e mecha li etsoa sehlopheng sena sa baahi.
>> E Thusa: Ithute hore na lefu la tsoekere ke eng - //diabetiya.ru/pomosh/nesaharnyj-diabet.html
Litšobotsi tsa mefuta e atileng haholo:
| Mofuta | Mofuta o nang le phoso | Litšobotsi tsa ho baleha |
| Modi 1 | HNF4A, e laola ts'ebetso ea liphatsa tsa lefutso tse 'maloa tse ikarabellang bakeng sa metabolism ea lik'habohaedreite le phetisetso ea glucose ho tsoa maling ho ea lithong. | Ho thehoa ha insulin hoa eketseha, ha ho na tsoekere moriring, cholesterol ea mali le triglycerides hangata li tloaelehile. Ho noka tsoekere e kanna ea e-ba ntho e tloaelehileng kapa e phahameng hanyane, empa tlhahlobo ea mamello ea glucose e bonts'a phallo e kholo (e ka bang 5). Ho qala ha lefu lena ho bobebe, ha mathata a methapo a lefu la tsoekere a qala ho tsoela pele. |
| Modi 2 | GCK ke mofuta oa glucokinase o khothalletsang phetoho ea tsoekere e ngata ea mali ho glycogen, e laolang ho lokolloa ha insulin ho arabela keketseho ea tsoekere. | E bonolo ho feta mefuta e meng, hangata ha e hloke kalafo. Keketseho e nyane ea tsoekere e potlakileng e ka bonoa hantle ho tloha tsoalong, ka lilemo, lipalo tsa glycemic li eketseha hanyane. Matšoao ha a eo; mathata a tebileng ha a fumanehe. Glycated hemoglobin e moeling o kaholimo oa tse tloaelehileng, keketseho ea tsoekere nakong ea tlhahlobo ea mamello ea glucose e ka tlase ho likarolo tse 3,5. |
| Modi 3 | HNF1A phetoho e lebisa ho khathatsong e tsoelang pele ea lisele tsa beta. | Lefu la tsoekere hangata le qala kamora lilemo tse 25 (63% ea linyeoe), mohlomong hamorao, ho fihlela lilemo tse 55. Hyperglycemia e matla e ka etsahala qalong, kahoo Modi-3 hangata e ferekanngoa le lefu la tsoekere la mofuta oa 1. Ketoacidosis ha e eo, tlhahlobo ea mamello ea glucose e bonts'a kholo ea tsoekere ea likarolo tse fetang 5. Tšitiso ea renal e robehile, kahoo tsoekere ka har'a moroto e ka fumanoa esita le ka boemo bo tloaelehileng maling. Ha nako e ntse e tsamaea, bokuli bo tsoela pele, batho ba nang le lefu la tsoekere ba hloka taolo e matla ea glycemic. Ha e le sieo, mathata a tsoela pele kapele. |
| Modi 5 | TCF2 kapa HNF1B, e ama nts'etsopele ea lisele tsa beta nakong ea embryonic. | Ho na le nephropathy e tsoelang pele ea tlhaho e se nang lefu la tsoekere, atrophy ea pancreatic, lefu la setho sa botona le botšehali le ka tsoela pele ho ntlafatsoa. Ho ka fetoha ka mokhoa o ikemetseng, o senang lefa. Lefu la tsoekere le qala ho batho ba 50 ba nang le lefu lena. |
Matšoao a mang a ho belaela ke afe?
Ho thata haholo ho lemoha lefu la tsoekere la Mody-le qalong ea lefu lena, hobane hangata mafu a qala butle butle, 'me matšoao a hlakileng ha a eo ka botlalo. Bakeng sa lipontšo tse sa hlakang, mathata a pono a ka bonoa (lesira la nakoana ka pel'a mahlo, ho le thata ho tsepamisa mohopolo). Kotsi ea tšoaetso ea fungal e eketseha, basali ba tšoauoa ka ho pheta-pheta ha thrush.
Ha tsoekere ea mali e ntse e phahama, matšoao a tloaelehileng a lefu la tsoekere a qala:
- lenyora
- khafetsa ho ntša metsi khafetsa;
- takatso e matla ea lijo;
- fokolisa sesole;
- ho phekola hampe liso tsa letlalo;
- boima ba 'mele bo fetoha, ho latela mofuta oa lefu la tsoekere la Mody, mokuli a ka fokotsa boima ba' mele 'me a fola.
Ho bohlokoa ho hlahlojoa lefu la tsoekere la Modi haeba ngoana kapa motho e monyane a hlokometse glycemia makhetlo a 'maloa ho feta 5.6 mmol / l, empa ha ho na matšoao a lefu la tsoekere. Letšoao la temoso ke tsoekere e kholo ho feta 7.8 mmol / L qetellong ea tlhahlobo ea mamello ea glucose. Ho bana, ho ba sieo ha boima ba 'mele qalong ea lefu le tsoekere ha u qeta ho ja ho se na lipalo tse fetang 10 le tsona li supa lefu la tsoekere la Mody.
Bopaki ba laboratori ba lefu la tsoekere la Mody
Leha ho le thata le netefatso ea laboratori ea Mody-lefu la tsoekere, lithuto tsa liphatsa tsa lefutso li bohlokoa haholo, hobane li u lumella ho fumana malebela a nepahetseng a kalafo eseng feela ho mokuli, empa le ho beng ka eena ba baholo.
Tlhahlobo e felletseng e kenyelletsa:
- tsoekere ea mali
- tsoekere le protheine ka har'a moroto;
- C peptide;
- teko ea mamello ea glucose;
- li-antibodies tsa autoimmune ho insulin;
- glycated hemoglobin;
- lipids tsa mali;
- Ultrasound ea manyeme;
- amylase ea mali le moroto;
- fecal trypsin;
- lipatlisiso tsa liphatsa tsa lefutso.
Liteko tsa pele tsa 10 li ka nkuoa moo o lulang teng. Boithuto ba morao-rao bo u lumella ho bona hore na lefu la tsoekere la Mody, le se le etsoa. feela ho la Moscow le Novosibirsk. Boloetse bo ipapisitse le litsi tsa lipatlisiso tsa endocrinological. Bakeng sa lipatlisiso, mali a nkuoa, DNA e ntšoa ka seleng, e arotsoe likarolo 'me likarolo li hlahlojoa, likotsi tseo ho ka bang bonolo haholo ho tsona.
Phekolo
Lithethefatsi tse fanoang ke ngaka li itšetleha ka mofuta oa Modylefu la tsoekere:
| Mofuta | Phekolo |
| Modi 1 | Lits'oaetso tsa sulfanylureas - Glucobene, Glidanil, litokisetso tsa Glidiab li fana ka phello e ntle. Ba eketsa synthetic ea insulin mme ba u lumella ho boloka tsoekere e tloaelehileng ka nako e telele. Litokisetso tsa insulin li sebelisoa maemong a ikhethang. |
| Modi 2 | Ho phekola ka mokhoa o tloaelehileng ha ho na thuso, ka hona, ho etsa hore tsoekere e fokotsehe, ho hlokahala hore u latele lijo tse nang le lik'habohaedreite tse ngata 'me u lule u ikoetlisa kamehla. Ho thibela li-macrosomia tsa "fetal" (boholo bo boholo) nakong ea kemolo, mosali o fuoa ente ea insulin. |
| Modi 3 | Ha lefu la tsoekere la mofuta oa 3 Mody le etsa hore ho be bonolo ho lona, melemo ea sulfonylurea ke lithethefatsi tse ikhethileng, 'me lijo tse nang le carb e tlase le tsona lia sebetsa. Ha tsoelo-pele e etsoa, kalafo e joalo e nkeloa sebaka ke kalafo ea insulin. |
| Modi 5 | Insulin e fanoa hang hang ka mor'a ho fumanoa ha lefu lena. |
Phekolo e sebetsa haholoanyane ha ho se na boima bo feteletseng. Ka hona, bakuli ba nang le botenya ba fuoe lijo tse eketsehileng tse nang le likhalori tse fokolang.
Lingoloa tse sebetsang:
Mona re buile ka lefu la tsoekere la morao-rao
