Glycosylated hemoglobin ke palo ea mali a biochemical a bonts'ang ho bokellana ha tsoekere maling maling ka nako e telele. Glycohemoglobin e entsoe ka hemoglobin le glucose. Bophahamo ba hemoglobin ea glycosylated tlasa lipatlisiso e tsebisa ka palo ea hemoglobin maling, e hokahaneng le molek'hule ea glucose.
- Teko ea mali e lokela ho etsoa ho batho ba nang le lefu la tsoekere ho bona lefu la tsoekere kapele kamoo ho ka khonehang le ho thibela mathata a lefu lena. Sehlahlobisisi sa lisebelisoa tse khethehileng se thusa ho sena.
- Hape, boemo ba hemoglobin ea glycosylated bo fumanoa e le ho laola hore na kalafo ea lefu la tsoekere e sebetsa hakae. Mohlahlobisisi o bonts'a letšoao lena e le karolo ea halofo ea hemoglobin eohle.
- Ho bohlokoa ho batho ba lefu la tsoekere ho utloisisa hore na hemoglobin ea glycated ke eng. E thehoa ka ho kopanya tsoekere le amino acid eo li-enzyme li seng li le sieo. Ka lebaka leo, tsoekere le hemoglobin li theha mofuta oa hemoglobin oa glycosylated.
- Tekanyo ea ho thehoa le boholo ba glycogemoglobin ho latela hore na tsoekere e maling a mokuli e kae nakong ea bophelo ba lisele tse khubelu tsa mali. Ka lebaka leo, GH e ka ba le mefuta e fapaneng: HbA1a, HbAb, HbAc. Ka lebaka la hore tsoekere e phahame ho tsoekere ea lefu la tsoekere, karabelo ea lik'hemik'hale ha fusion ea hemoglobin e nang le tsoekere e feta kapele haholo, ka lebaka leo GH e eketsehang.
Nako ea bophelo ea lisele tse khubelu tsa mali ho hemoglobin ke matsatsi a 120. Ka hona, tlhahlobo e ka bontša hore na mokuli o na le glycemia halelele hakae.
Taba ke hore lisele tse khubelu tsa mali li boloka leseli ka palo ea limolek'hule tsa hemoglobin tse kopaneng le limolek'hule tsa glucose.
Ho sa le joalo, lisele tse khubelu tsa mali li ka ba tsa lilemo tse fapaneng, hobane, ha tlhahlobo ea mali, nako ea tšebetso ea tsona ea bohlokoa hangata e hakanyetsoa ho likhoeli tse peli ho isa ho tse tharo.
Ho hlokomela kalafo ea lefu la tsoekere
Batho bohle ba na le mofuta oa hemoglobin oa glycosylated, leha ho le joalo, ho diabetes, boemo ba ntho ena bo batla bo imenne habeli. Kamora hore maemo a tsoekere ea mali a fetoloe nakong ea kalafo, kamora libeke tse tšeletseng, mokuli hangata o ba le mofuta oa hemoglobin ea glycosylated.
Ha ho bapisoa le tlhahlobo e tloaelehileng ea tsoekere ea mali, tlhahlobo ea hemoglobin ea glycosylated e nkoa e nepahetse, kaha e thusa ho tseba boemo ba mokuli ka likhoeli tse 'maloa.
- Tlhahlobo e thusa ho tseba hore na kalafo ea lefu la tsoekere e sebetsa joang. E le molao, mohlahlobi o etsa tlhahlobo ea mali bakeng sa hemoglobin ea glycosylated e le ho lekola boleng ba kalafo likhoeling tse tharo tse fetileng. Haeba kamora liteko, ho fumaneha hore hemoglobin ea glycosylated e ntse e phahame, ho hlokahala hore ho hlahisoe liphetoho lithutong tsa lefu la tsoekere.
- Ho kenyelletsa hemoglobin ea glycosylated e lekantsoe e le ho fumana kotsi ea mathata a lefu la tsoekere. Haeba mokuli a e-na le hemoglobin e eketsehileng ea glycosylated, sena se bontša hore likhoeling tse tharo tse fetileng o bile le boemo bo eketsehileng ba glycemia. Sena le sona se baka mathata a lefu lena.
- Ho ea ka lingaka, haeba lefu la tsoekere le glycosylated hemoglobin ka nako e fokotsoe ke bonyane karolo ea 10, menyetla ea ho ba le lefu la tsoekere la retinopathy e fokotseha ka liperesente tse 45, tseo hangata li lebisang bofofu ba bakuli. Ka lebaka lena, ho hlokahala ho hlokomela boemo le ho etsa liteko tsa mali hangata kamoo ho ka khonehang. Litleliniking tsa boinotšing, hangata ba sebelisa sesebelisoa se ikhethang se bitsoang glycated hemoglobin analzer.
- Hape, tlhahlobo hangata e fuoa basali nakong ea kemolo ho bona lefu la tsoekere la morao. Leha ho le joalo, khafetsa liphetho tsa liteko ha li tšepahale ka lebaka la khaello ea phallo ea mali ho basali ba baimana, nako e khuts'oane ea bophelo ba lisele tse khubelu tsa mali, le ho fokotseha hoa maemo a tsoekere 'meleng oa mosali oa moimana.
Tekanyo ea Hemoglobin ea Glycosylated
Ho tseba hore na mokuli o na le tsoekere e kae ea mali, ho sebelisoa mekhoa e 'meli - ho lekanya tsoekere ea mali le ho etsa tlhahlobo ea mamello ea glucose.
Khabareng, ka lebaka la hore boemo ba tsoekere bo ka eketseha kapa ba fokotseha ka nako efe kapa efe, ho latela ts'ebeliso ea lijo le lintlha tse ling, ka linako tse ling lefu la tsoekere ha le na ho fumanoa. Ka lebaka lena, maemong a mang, ho etsoa tlhahlobo ea mali bakeng sa hemoglobin ea glycosylated, eo, har'a lintho tse ling, ho sebelisoang sesebelisoa sa ho hlahloba lintho.
Leha taba ea hore tlhahlobo ea hemoglobin ea glycosylated ke thuto e nepahetseng haholo, ke mokhoa o theko e boima, ka hona ha e etsoe likoranteng tsohle.
Bakeng sa tlhahlobo ea tsoekere ea mali, mokuli o nka 1 ml ea mali ho tsoa mothapong ho ea mpeng e se nang letho. Mofuta ona oa ho ithuta ha o khothalletsoe haeba mokuli a tšeloa mali ka mor'a ho buuoa, hobane litholoana li ka ba tse sa nepahalang.
Ntle le liteko tsa laboratori, tlhahlobo ea mali bakeng sa hemoglobin ea glycosylated e ka etsoa lapeng, haeba ho na le sesebelisoa se ikhethang sa ho hlahloba.
Lisebelisoa tse joalo hona joale li fumanoa ke litsebi tse ngata tsa poraefete le litleliniki tsa bongaka. Sehlahlobisisi se u lumella ho tseba karolo ea metsotso e 'maloa hemoglobin ka har'a sampole ea capillary le venous, mali a felletseng.
Glycated hemoglobin
Tekanyo ea hemoglobin ke karolo ea 4,5,5 ea kakaretso eohle ea hemoglobin. Ho diabetics, letšoao lena le atisa ho eketseha makhetlo a mabeli ho isa ho a mararo. Bakeng sa ho laola hemoglobin ea glycosylated, boiteko bo lokela ho etsoa pele ho theola tsoekere ea mali ea mokuli. Ke maemong ana feela, mokuli a tla ba le matšoao a tloaelehileng.
Ho fumana setšoantšo se felletseng, lits'ebetso hangata li etsoa ka mor'a libeke tse ling le tse ling tse tšeletseng. E le hore u se ke oa ea tleliniking, u ka sebelisa tlhahlobisiso ho tsamaisa thuto. Ha ho boloka mokhoa oa bophelo o phetseng hantle le kalafo e hlokahalang, sekhahla sa hemoglobin ea glycated se fihlella khoeli le halofo ka mor'a hore boemo ba tsoekere lithutong bo rarolloe.
Boithuto bo bontša hore haeba tekanyo ea hemoglobin e ithutoang e eketsoa ka bonyane karolo ea 1, tsoekere ea mali e eketseha ka 2 mmol / litha. Mohlala, moetlo oa liperesente tse 4,5-6,5 o bonts'a boleng ba tsoekere ea mali ea 2,6-6.3 mmol / litha.
Boemong ha lenane la hemoglobin ea glycosylated e nyoloheloa ho liperesente tse 8, tekanyo ea tsoekere ea mali e phahame ho feta se tloaelehileng mme ke 8.2-10.0 mmol / litha. Maemong ana, mokuli o hloka khalemelo e matlafatsang le bophelo bo botle.
Haeba letšoao le nyolohetse ho liperesente tse 14, ho bolelang hore boemo ba tsoekere ea mali bo phahame haholo ho feta tekano mme ke 13-21 mmol / litha, o lokela ho etela ngaka hang-hang. Boemo bona bo bohlokoa ho batho ba lefu la tsoekere mme bo ka baka mathata.
