Clopidogrel-Teva ke sethethefatsi se hatellang bongata ba liplatelese mme se hlapolla likepe tsa coronary. Sesebelisoa se sebelisoa bakeng sa kalafo le thibelo ea methapo ea pelo.
Lebitso la Machaba le sa Tšoanelehang
INN - Clopidogrel.
Clopidogrel-Teva ke sethethefatsi se hatellang bongata ba liplatelese mme se hlapolla likepe tsa coronary.
ATX
Khoutu ea ATX: B01AC04.
Lokolla liforomo le sebopeho
Motsoako o ka har'a matlapa a bolelele ba mmala o pinki o bobebe. Ntho e sebetsang ke Clopidogrel hydrosulfate (ka bongata ba 75 mg).
Baeti:
- lactose monohydrate;
- cellcose ea microcrystalline;
- hyprolosis;
- crospovidone;
- oli ea limela ea hydrogenated ea mofuta I;
- sodium lauryl sulfate.
Khetla ea filimi e na le likarolo tse latelang:
- lactose monohydrate;
- hypromellose 15 cP;
- tekanyetso ea titanium;
- macrogol;
- li-oxide tse khubelu le tse mosehla (dae ea tšepe);
- indigo carmine.
Setlhare se fumaneha ka mokhoa oa matlapa.
Ketso ea pharmacological
Ntho e sebetsang ea lithethefatsi e fokotsa ho kopana ha liplatelete. ADP nucleotides (adenosine diphosphates) e tloaetse ho kenya tšebetsong li-inhibitors tsa glycoprotein ebe e tlama ho liplatelete. Tlas'a tšusumetso ea Clopidogrel, lits'ebetso tsena lia senyeha ebe ka tsela eo mokokotlo oa mokokotlo oa batho oa fokotsoa. Ts'ebetso (PDE) ea phosphodiesterase ha e fetole ntho.
Phello ea antiplatelet ea lithethefatsi e lula ho pholletsa le potoloho ea bophelo ea liplatelete (matsatsi a ka bang 7).
Mofumahali
Ha ho nooa ka molomo, matlapa a kenngoa ka potlako pampiring ea tšilo ea lijo. Clopidogrel e na le bioavailability e phahameng, empa e sa fetoheng ha e na thuso (sena ke sethethefatsi). E maling mading ka nako e khuts'oane 'me e kenngoa ka sekhahla ka har'a sebete ho thehoa metabolites e sebetsang le e sa sebetseng. Ebe Clopidogrel le metabolite e sebetsang e tlama hoo e batlang e le liprotheine tsohle tsa mali.
Hora e le 'ngoe ka mor'a ho sebelisa moriana o maling, ho bonoa palo e phahameng ea metabolite e sa sebetseng ka plasma, e tsoang ho carboxylic acid.
Setlhare sena se qheletsoe ka har'a moroto le makhopho ka nako ea matsatsi a 5. Metabolite e sebetsang e qhaloa nakong ea lihora tse 16.
Matšoao a ho sebelisoa
Moriana o laetsoe ho thibela mathata a pelo maemong a latelang:
- Myocardial infarction.
- Ischemic stroke.
- Acute coronary syndrome ntle le keketseho ea karolo ea ST.
- Thrombosis (e sebelisitsoe hammoho le acetylsalicylic acid).
- Thromboembolism.
- Fibrillation ea methapo.
- Boteng ba li-contraindication bakeng sa ts'ebeliso ea li-anticoagulants tsa ketso e sa tobang.
Contraindication
Letlapa ha lea lumelloa ho nka ho bakuli ba nang le ho se sebetse ha sebete (nete e matla), hypersensitivity ho lithethefatsi kapa ho tsoa mali haholo.
Contraindication hape ke ho ima, ho anyesa le bana ba ka tlase ho lilemo tse 18.
Ka tlhokomelo
Ka hlokolosi, sethethefatsi se laeloa bakeng sa ts'ebetso ea ho senyeha ha renal (ho se lekane ka tumello ea creatinine ea 5-15 ml / min), ho tsoa mali ho eketsehileng (hematuria, menorrhagia), le kamora ts'ebetso ea ts'ebetso ea opereishene, likotsi le liphoso tsamaisong ea heestatic.
Molemong oa bakuli ba nang le mafu a sebete, coagulogram e etsoa khafetsa mme ts'ebetso ea sebete e hlahlojoa.
Ka hlokolosi, moriana o laeloa hore o sebetse hantle renal.
U ka nka Clopidogrel-teva joang?
Bakuli ba kileng ba ba le myocardial infarction ba fuoa 75 mg ea moriana (1 letlapa) ka letsatsi ka matsatsi a 7-35. Kamora ho otloa, moriana o nooa ka tekanyetso e le 'ngoe, empa kalafo e ka nka likhoeli tse tšeletseng.
Bakuli ba nang le asiti e matla ea k'holeseterole ntle le keketseho ea karolo ea ST ba khothaletsoa ho nka 300 mg ka letsatsi e le lethal dose la pele. Ebe mori o fokotseha ho 75 mg ka letsatsi, empa motsoako oa antiplatelet o nang le acetylsalicylic acid o kopantsoe. Therapy e etsoa selemo se le seng.
Le lefu la tsoekere
Ho bakuli ba nang le lefu la tsoekere mellitus, ho eketseha hoa liplatelete hangata ho bonoa. Bakeng sa thibelo ea lefu la coronary le lefu la coronary, 75 mg ea clopidogrel-Teva e laetsoe ka letsatsi.
Nako ea tsamaiso le tekanyo ea insulin e lokela ho khethoa ke ngaka, ho latela boemo ba mokuli.
Litla-morao tsa clopidogrel-Teva
Karolong ea litho tsa pono
Ka morao ho nka moriana, ho ka hlaha li-hemular hemorrhages (retinal le conjunctival).
Ho tsoa ho lisele tsa musculoskeletal le tse sebetsang
Kameho e mpe tsamaisong ea musculoskeletal ha e fumanehe. Ramatiki, arthralgia le myalgia lia khonahala.
Setlhare se ka lebisa ho kholo ea colitis.
Phekolo ea ka mpeng
Tšusumetso ea tšilo ea lijo e bontšoa ka tsela e latelang.
- bohloko ba ka mpeng;
- ho tsoa mali ka mpeng;
- ho nyekeloa le pelo le ho hlatsa
- lets'ollo
- lcerative ulcerative;
- gastritis;
- prick;
- hepatitis;
- pancreatitis
- stomatitis
- ho hloleha ha sebete.
Hematopoietic litho tsa ka hare
Ho tloha lehlakoreng la sistimi ena ho bonoe:
- thrombocytopenia;
- leukocytopenia;
- eosinophilia.
Tsamaiso ea methapo e bohareng
Moriba ha o ame ts'ebetso ea methapo. Maemong a sa tloaelehang, hlooho ea hlooho, ho tsekela le pherekano li etsahala.
Ho tsoa ts'ebetsong ea moroto
Litla-morao tse tsoang lipelong tsa ka moroto:
- hematuria;
- glomerulonephritis;
- eketseha ka tlhahiso ea kaine maling.
Ho tsoa tsamaisong ea phefumoloho
Litlamorao tsamaisong ea phefumoloho:
- nosebleeds;
- hemorrhage ea pulmonary;
- bronchospasm;
- interstitial pneumonitis.
Ho tsoa ts'ebetsong ea genitourinary
Litla-morao ha li hlahisoe.
Ho tsoa ho tsamaiso ea methapo ea pelo
Ho tsoa ho ts'ebetso ea pelo le pelo li bonoa:
- ho tsoa mali
- arterial hypotension;
- vasculitis.
Allergie
Maikutlo a latelang a ho kula a ka hlaha:
- Edema ea Quincke;
- bokuli ba serum;
- urticaria;
- ho hlohlona
Khahlano le semelo sa ho sebelisa meriana ena, e ka ba le karabelo e itseng.
Tšusumetso ho bokhoni ba taolo ea methapo
Bakuli ba bang ba tšoaroa ke hlooho le ho tsekela ha ba nka Clopidogrel-Teva. Ho lokela ho ba hlokolosi ha ho laoloa mochini kapa ho etsa mosebetsi o hlokang tlhokomelo e phahameng.
Litaelo tse khethehileng
Pele o buuoa, moriana o tlameha ho khaotsa (matsatsi a 5-7 pele ho ts'ebetso ea bongaka) ka lebaka la kotsi e kholo ea ho tsoa mali.
Sebelisa botsofaling
Setlhare sena se sebelisetsoa ho phekola bakuli ba tsofetseng. Empa boemong bona, kalafo e etsoa ntle le lethal dose ea ho laolla (lethal dose le le leng le lekanang le 300 mg) qalong ea kalafo.
Ho laela Clopidogrel-Teva ea bana
Moriana ona o thibetsoe bana ba ka tlase ho lilemo tse 18.
Sebelisa nakong ea bokhachane le pelehi
Boimana le ho anyesa matsoele ke li-contraindication ts'ebelisong ea lithethefatsi.
U ke ke ua sebelisa lithethefatsi nakong ea kemolo.
Sebelisa bakeng sa ts'ebetso ea sebete e sa sebetseng
Bakuli ba nang le methapo ea sebete (cirrhosis, ho hloleha ha sebete) ba fuoa moriana ka hloko. Bakeng sa ho qoba ho tsoa mali, kalafo e lokela ho tsamaea le ho lekola ts'ebetso ea sebete.
Clopidogrel-Teva E Feteletseng
Ka tsamaiso e le 'ngoe ea molomo ea litekanyetso tse kholo tsa lithethefatsi (ho fihlela 1050 mg), ho ne ho se na litlamorao tse mpe bakeng sa mmele.
Ho sebelisoa ha nako e telele ho tekanyetso e kholo ho ka lebisa ho tsoa mali.
Ho sebelisana le lithethefatsi tse ling
Ka lebaka la kotsi ea ho tsoa mali, ho thibetsoe ho nka moriana ona hammoho le lithethefatsi tse kang:
- Li-Anticoagulants.
- Glycoprotein IIa / IIIb inhibitors.
- NSAIDs.
Litlhokomelo li lokela ho kopanngoa le heparin.
Litlhokomelo li lokela ho kopantsoe le thrombolytics le heparin. Ka tšebeliso e tšoanang le omeprazole, esomeprazole le li-inhibitors tse ling tsa proton, ho fokotseha hoa matla a antiplatelet ho etsahala.
Tekanyo ea joala
Setlhare ha se khothalletsoe ho kopantsoe le ts'ebeliso ea lino tse tahang. Ho tahoa hoa 'mele ho ka bonoang ke ho hlatsa, lets'ollo, ho tsitsipana, feberu, ho hloleha ho phefumoloha le ho holofala.
Li-analog
Lithethefatsi tse tummeng tse nang le phello e tšoanang ke:
- Lopirel.
- Plavix.
- Sylt.
- Tlhaselo.
- Aggregal.
- Egithromb.
Ntho e sebetsang ea li-analogues tsena ke clopidogrel.
Lipehelo tsa khefu ea khemisi
A na nka reka ntle le lengolo la ngaka?
Ho latela litaelo, moriana o ka fuoa taelo ke ngaka.
Clopidogrel-Teva Theko
Litšenyehelo tsa sephutheloana sa litafole tse 14 li tsoa ho li-ruble tse 290 ho isa ho 340, matlapa a 28 - li-ruble tse 600-700.
Maemo a polokelo ea moriana
Ho boloka ho lokela ho etsoa sebakeng se lefifi ka mocheso o sa feteng + 25 ° C.
Letsatsi la ho felloa ke nako
Sethethefatsi se loketse lilemo tse 2.
Moqapi
Moqapi - Teva (Isiraele).
Setlhare se fanoa ka taelo ea ngaka.
Tlhahlobo ea clopidogrel-Teva
Irina, ea lilemo li 42, Moscow.
Ha ke etsa tlhahlobo ea mali, ke ile ka fumana liplatelete tse eketsehileng. Ngaka e ile ea beha Clopidogrel. Ke nkile moriana ona libeke tse 3, 'me palo ea liplatelete maling e ile ea khutla e tloaelehileng.
Alexander, ea lilemo li 56, Izhevsk.
Ke ile ka qala ho sebelisa moriana ona ka khothatso ea ngaka ka mor'a ho otloa ke stroke. Ke e nkile ka likhoeli tse peli 'me ha ke belaele ka bophelo bo botle ba ka. Ha ho litla-morao tse etsahetseng. Setlhare se na le chelete.
Leonid, ea lilemo tse 63, Volgograd.
Ke sebelisitse lipilisi tsena ho thibela mathata ka mor'a ho buuoa ka lesapo la mokokotlo. Nakong ea ts'ebetso, moriana o thusitse ho thibela mali. Ke mamelletse ho amoheloa ha hae hantle; ha kea ka ka ba le liketso tse mpe.
