Saroten Retard ke oa sehlopha sa li-antidepressants tsa li-tricyclic. Setlhare se sebelisoa ts'ebetsong ea bongaka ho felisa ho tšoenyeha le ho tšoenyeha ho bakoang ke boemo bo sithabetsang. Litsebi li ka fana ka litlhare bakeng sa mofuta o sa feleng oa bothata ba bohloko le nts'etsopele ea khatello ea maikutlo le schizophrenia. Li-capsule ha lia etsetsoa ho sebelisoa bongoaneng ebile ha li laetsoe basali baimana.
Lebitso la Machaba le sa Tšoanelehang
Amitriptyline.
ATX
N06AA09.
Saroten Retard ke oa sehlopha sa li-antidepressants tsa li-tricyclic.
Lokolla liforomo le sebopeho
Setlhare se etsoa ka mokhoa oa li-capsules ka phello e telele. Amitriptyline hydrochloride 50 mg e sebelisoa e le ntho e sebetsang lihlopheng tsa li-antidepressant. Litaba tsa likotlo li tlatselletsoa ke likhomphutha tse thusang:
- likarolo tsa tsoekere;
- povidone;
- stearic acid;
- shellac.
Khetla e kantle e na le gelatin le titanium dioxide. Tint e 'mala o bofubelu ho liphekolo e fana ka boteng ba dae e thehiloeng ho oxide ea iron.
Ketso ea pharmacological
Lithethefatsi ke tsa antidepressants tse nang le tšusumetso ea nako e telele tsamaisong ea methapo ea kutlo. Ntho e sebetsang ea amitriptyline ka nako e ts'oanang e thibela ho ts'oaroa ha norepinephrine le serotonin pele e kenella ka har'a phallo. Sehlahisoa se ka sehloohong sa amitriptyline metabolism (nortriptyline) se na le phello e matla ea kalafo. Ka lebaka la ketso ea sethethefatsi, ts'ebetso ea li-receptor tsa H1-histamine le li-receptor tsa M-cholinergic lia fokotseha. Mokuli o tsoa khatello ea maikutlo, matšoenyeho le matšoenyeho lia nyamela.
Ka lebaka la matla a ho susumetsa, lithethefatsi li thibela karolo ea boroko ea REM, ka ho etsa joalo e eketsa nako ea karolo ea eona e tebileng ea butle.
Mofumahali
Kamora ho tsamaisoa ka molomo, khetla ea gelatin e qhibiliha ka mpeng, amitriptyline e tsoa mme e kenella ka 60% ea microvilli e ka mpeng ea mala. Ho tloha leboteng la setho, ntho e sebetsang e kenella phallo ea mali, moo mahloriso a plasma a fihlella boleng ba eona bo phahameng ka nako ea lihora tse 4-10. Amitriptyline e tlama liprotheine tsa plasma ka 95%.
Metabolism ea motsoako o sebetsang e feta ka har'a sebete ka hydroxylation ka ho thehoa ha nortriptyline. Bophelo ba halofo ea lithethefatsi ke lihora tse 25-27. Lintho tse sebelisang litlhare li siea 'mele ka mantle le ka har'a' mele.
Matšoao a ho sebelisoa
Moriana o laetsoe boteng ba boemo bo sithabetsang ba maikutlo le neurosis, haholoholo maemong ao tlolo ea molao e tsamaeang le khatello ea maikutlo, pherekano ea boroko, ho ferekana. Li-antidepressants li ka kenyelletsoa ho phekolo ea motsoako oa schizophrenia.
Contraindication
Antidepressant e thibetsoe ka tieo hore e ka sebelisoa ha ho e-na le karabelo ho lintho tse etsang mofuta oa litekanyetso. Setlhare ha se fuoe batho ba nang le mofuta oa lefutso la fructose, malabsorption ea glucose le galactose, le khaello ea isomaltase.
Ka tlhokomelo
Tlhokomelo e tlameha ho nkuoa ha u nka Saroten maemong a latelang:
- mathata a ho ferekanya kelello
- tšenyo e matla sebeteng le tsamaisong ea methapo ea pelo;
- ho eketsa secretion ea hormonal ea tšoelesa ea qoqotho;
- asthma ea bronchial;
- bone marrow hematopoiesis disc;
- khatello e eketsehileng ea intraocular;
- ho tlohela joala syndrome
Ka lebaka la monyetla o ka bang teng oa ho holofala ha mesifa e boreleli ea tšilo ea lijo, moriana ona ha o khothaletsoe bakeng sa peristalsis e holofetseng.
Mokhoa oa ho nka Saroten Retard?
Li-capsule kapa lintho tse kahare (li-pellets) li khothalletsoa ho noa metsi a mangata ntle le ho hlafuna. Bakeng sa khatello ea maikutlo, ho kenyelletsa boemo bo sa tsotelleng bo khahlano le semelo sa schizophrenia, ho hlokahala hore ho nkoe 1 capsule ka letsatsi bakeng sa lihora tse 3-4 pele ho robala, ka keketseho e latelang ea litekanyetso beke le beke ho ea 100-150 mg. Ha phello e tsitsitseng ea kalafo e fumanoa, tekanyetso ea letsatsi le letsatsi e fokotseha ho ba bonyane ba 50-100 mg.
Matla a ho thibela khatello ea kelello a phahame ka mor'a libeke tse 2 ho isa ho tse peli. Phekolo ea lithethefatsi e tlameha ho tsoelapele, hobane kalafo e bontša ka nako e behiloeng ke ngaka e eang. Ho thibela ho oela hape, ho khothalletsoa ho tsoela pele kalafo bakeng sa likhoeli tse 6. Ka khatello ea maikutlo a le mong, li-antidepressant li nkuoa lilemo tse ngata e le pheko ea tlhokomelo ho thibela ho khutla.
Le lefu la tsoekere
Batho ba nang le lefu la tsoekere ba lokela ho nka lipilisi ka hloko, hobane amitriptyline e ka fetola ts'ebetso ea insulin ho ea plasma ea tsoekere maling. Ka phetoho ea tsoekere, hoa hlokahala ho fetola litekanyetso tsa li-insulin le li-hypoglycemic agents.
Litla-morao tsa Saroten Retard
Maemong a mang, litla-morao tse tloaelehileng (ho tsekela kamehla, ho fokotseha ha moea, ho thothomela, metabolism e liehang, ho opisa hlooho) e ka ba matšoao a khatello ea maikutlo.
Phekolo ea ka mpeng
Takatso ea lijo ea fokotseha kapa ea eketseha, maikutlo a ho nyekeloa le ho omella ka hanong ea molomo oa hlaha, boholo ba litšoelesa tsa mongobo lia eketseha, mosebetsi oa hepatocytic transaminases oa eketseha.
Tsamaiso ea methapo e bohareng
Litlamorao tse mpe tsa khatello ea maikutlo ea CNS li bontšoa e le:
- ho otsela
- ho thothomela ha maoto le matsoho;
- ho senyeha ha tatso, li-tactile le li-oloticory receptors;
- ho hloka boroko
- pherekano, matšoenyeho le litoro tse tšosang;
- ho tsekela le ho ferekanya kelello;
- khatello ea kelello;
- menahano ea ho ipolaea;
- boits'oaro ba manic;
- hallucinations khahlano le semelo sa khatello ea maikutlo ea schizophrenic.
Phetoho ea tatso ke e 'ngoe ea litlamorao tsa moriana.
Ho bakuli ba nang le lefu la ho akheha, ho tsubella ho atisa khafetsa.
Ho tsoa ts'ebetsong ea moroto
Ho boloka urinary ho ka etsahala.
Karolong ea letlalo
Ka tlolo ea tekanyo ea-electrolyte ea metsi ka lebaka la ho nka Saroten, nts'etsopele ea letlalo la letlalo, alopecia e ka etsahala.
Ho tsoa ts'ebetsong ea genitourinary
Ho sitisoa ha mokhoa oa ho ikatisa ho bonoa feela ho banna, ho bonahatsoa ka mokhoa oa ho se sebetse ka botlalo le ho ruruha ha litšoelesa tsa mammary.
Ho tsoa ho tsamaiso ea methapo ea pelo
Ka nts'etsopele ea karabelo e mpe, mokuli a ka ikutloa a otla pelo, khatello ea fokotseha, tachycardia e hlaha. Kotsi ea atrioventricular blockade, likhathatso tsa conduction ka bongata ba likhahla tsa Hae. Ka ho thibela ts'ebetso ea hematopoietic, agranulocytosis le leukopenia li nts'etsapele.
Allergie
Ho bakuli ba reriloeng esale pele, ho fetoha ha letlalo, urticaria, ho hlohlona, erythema li ka hlaha. Maemong a sa tloaelehang, Quincke edema le kutloisiso ea khanya ea nts'etsopele ea leseli.
Tšusumetso ho bokhoni ba taolo ea methapo
Haeba e sa sebelisoe ka nepo, lithethefatsi li ka baka ho otsela le khatello ea maikutlo tsamaisong ea methapo, ka hona nakong ea kalafo e nang le antidepressant ho khothalletsoa hore u se ke oa khanna koloi, u sebetse ka lisebelisoa tse rarahaneng 'me u kenelle mesebetsing e meng e hlokang lebelo le phahameng la maikutlo le khatello ea maikutlo.
Litaelo tse khethehileng
Mokuli o lokela ho tsebisoa hore ho na le monyetla oa litla-morao tse mpe tse tsoang tsamaisong ea pelo le pelo.
Ho sithabela maikutlo ho thusa ho holisa tloaelo ea ho batla ho ipolaea. Menahano ea ho ipolaea e ka tsoela pele ho fihlela bophelo bo botle bo ntlafala, kahoo ho hlokomela mokuli ea noang meriana ka hloko hoa hlokahala nakong ea kalafo. Sena sea hlokahala mohatong oa pele oa kalafo, ha boemo bo tebileng ba boemo bo ka etsahala, le nts'etsopele ea litšekamelo tsa ho ipolaea khahlanong le eona. Boemong bo joalo, hoa hlokahala ho fokotsa ts'ebeliso ea moriana.
Ha boitšoaro ba manic bo hlaha, kalafo ea emisoa.
Setlhare se emisoa pele ho ts'ebetso e reriloeng ea ho buuoa. Haeba ho hlokahala hore ho etsoe opereishene ka potlako, ngaka e thibelang lefutso e hloka ho lemosoa mabapi le ho nka khatello ea meriana. Makhopho a sefahleho a ka baka hypotension.
Ka ho khaotsa ho teba ha ho nka Saroten khahlanong le semelo sa kalafo ea nako e telele, maemong a mang, ho ba le lefu la ho khaotsa. Ho fokotsa kotsi ea karabelo, ho hlokahala hore butle-butle u fokotse litekanyetso tsa moriana ho feta libeke tse 4-5.
Moriana ona o thibetsoe ho sebelisoa ho bana ba ka tlase ho lilemo tse 18.
Sebelisa botsofaling
Batho ba kaholimo ho lilemo tse 65 ba lokela ho nka karolo e le 'ngoe ea 50 mg ka shoalane.
Khetho ea Sarotin Retard ho bana
Moriana ona o thibetsoe ho sebelisoa ho bana ba ka tlase ho lilemo tse 18.
Sebelisa nakong ea bokhachane le pelehi
Li-antidepressants li thibetsoe ho basali nakong ea kemolo, hobane amitriptyline e ka sitisa ho beoa ha litho tsa mantlha le lits'ebetso nakong ea kholo ea embryonic, haholoholo ho trimester ea boraro.
Ha o sebelisa li-antidepressants, lactation ha e hlakoloe haeba ho hlokahala ka tleliniki. Nakong ea kalafo, ho hlokomela boemo ba ngoana ea sa tsoa hlaha ka khoeli ea pele ea bophelo ba hae hoa hlokahala.
Sebelisa bakeng sa ts'ebetso ea sebete e sa sebetseng
Bakuli ba nang le ts'ebetso ea sebete e sa sebetseng ba lokela ho ba hlokolosi 'me, haeba ho khoneha, ba laole ho hlaseloa ha amitriptyline serum.
Ha o sebelisa li-antidepressants, lactation ha e hlakoloe haeba ho hlokahala ka tleliniki.
Tekanyetso e feteletseng ea Saroten Retard
Ka tekanyetso e le 'ngoe ea tekanyetso e phahameng ea moriana bakeng sa hora, o ka ba le:
- ho otsela
- hallucinations;
- tsosa
- ho ruruha ha setho;
- molomo o omileng
- ho tsitsipana le khatello ea maikutlo ea methapo ea methapo;
- naha e ntle, pherekano, komisi;
- metabolic acidosis, phokotso ea potasiamo e fokotsehile;
- pelo lippitations;
- matšoao a lefu la pelo: ho theoha ha khatello ea mali, ho thothomela hoa pelo, ho nyekeloa ke pelo.
Motho ea hlokahalitsoeng o hloka ho kena sepetlele ka potlako. Maemong a ho ema, ho hlokahala hore u hlatsoe ka mpeng 'me u fane ka adsorbent ho thibela ho tlosoa ha moriana hape.
Phekolo e reretsoe ho khutlisa mosebetsi oa ho hema le oa pelo, ho feliseng matšoao a boloi bo bongata. Tlhahlobo ea ts'ebetso ea pelo e hlokahala matsatsing a 3-5.
Ho sebelisana le lithethefatsi tse ling
Tšebeliso e tšoanang ea amitriptyline le meriana e meng e fana ka tšebelisano e latelang:
- Hammoho le monoamine oxidase inhibitors, ho hlaha lefu la serotonin, le khetholloang ka pherekano, myoclonus, feberu, ho thothomela ha liphello. Ho fokotsa monyetla oa tšebeliso e mpe ea lithethefatsi, Saroten o laeloa feela kamora libeke tse peli ho tloha pheletsong ea kalafo ka li-inhibitors tsa MAO tse sa fetoheng kapa lihora tse 24 kamora ts'ebeliso ea li-blocker ea monoamine oxidase blocker.
- Phello ea kalafo ea li-barbiturates e ea matlafatsoa.
- Ho eketsa menyetla ea ho kenella ka mpeng ka lebaka la thibelo ea mesifa ea mala ea boreleli ha u nka li-antipsychotic kapa anticholinergics. Ka hyperthermia, ho se sebetse hantle ha bowel ho tsamaisana le hyperpyrexia. Ha o nka li-antipsychotic, monyetla oa ho ikemisetsa ho ts'oaroa oa fokotseha.
- Amitriptyline e ntlafatsa cardiotoxicity ea anesthetics, li-decongestants, ephedrine le phenylpropanolamine. Ka lebaka la ts'enyehelo e ka bang teng tsamaisong ea pelo le methapo, lithethefatsi tse joalo ha li fuoe litlhare tse kopanyang.
- Ntho e sebetsang ea Saroten e fokotsa phello ea hypotensive ea Methyldopa, Guanethidine, Reserpine le lithethefatsi tse ling tsa antihypertensive. Ka tsamaiso e tšoanang ea amitriptyline, o hloka ho fetola litekanyetso tsa lithethefatsi tse fokotsang khatello ea mali.
- Lipilisi tsa thibelo ea bokhachane le lithethefatsi tse nang le lihormone tsa basali tsa botona li eketsa bioavailability ea amitriptyline, e hlokang ho fokotsoa litekanyetso tsa lithethefatsi tsena ka bobeli. Haeba ho hlokahala, ho tlosoa ha Saroten ho ka hlokahala.
Hammoho le acetaldehydrogenase inhibitors, menyetla ea ho ba le maemo a psychotic, pherekano le tahlehelo ea kelello li eketseha.
Nakong ea phekolo ea lithethefatsi, ho hlokahala ho khaotsa ho sebelisa lino tse tahang.
Tekanyo ea joala
Nakong ea phekolo ea lithethefatsi, ho hlokahala ho khaotsa ho sebelisa lino tse tahang. Joala ba ethyl bo ka fokotsa phello ea litlhare tsa khatello ea maikutlo, ea matlafatsa kapa ea eketsa menyetla ea ho etsa lintho tse bohloko. Haholo-holo mabapi le ts'ebetso ea methapo, hobane ethanol e na le phello e sithabetsang tsamaisong ea methapo e bohareng.
Li-analog
Methati ea Saroten e kenyelletsa li-agents tse phetelang sebopeho sa lik'hemik'hale tsa antidepressant le thepa ea pharmacological:
- Amitriptyline;
- Clofranil;
- Doxepin;
- Khothatiso.
Ho khutlisoa ha moriana ho etsoa feela ha ho se na phello e ntle, kamora ho buisana le ngaka.
Lipehelo tsa khefu ea khemisi
Lipilisi li rekisoa ka taelo ea ngaka.
Clofranil ke analogue ea Saroten.
A na nka reka ntle le lengolo la ngaka?
Boholo ba litlhare ba karolo ea lithethefatsi tsa psychotropic, ka hona, haeba li sebelisoa hampe, li ka baka khatello ea maikutlo. Ka lebaka lena, thekiso ea mahala e lekantsoe.
Theko ea Sarotin Retard
Litsenyehelo tse tloaelehileng tsa li-capsules ke li-ruble tse 590. Belarus - li-ruble tse 18.
Maemo a polokelo ea moriana
Li-capsule li tlameha ho bolokoa sebakeng se nang le mongobo o tlase, se sirelelitsoeng ke khanya ea letsatsi, ka mocheso o sa feteng 25 + C.
Letsatsi la ho felloa ke nako
Lilemo tse 3
Moqapi
H. Lundbeck AO, Denmark.
Litlhahlobo tsa Saroten Retard
Taras Evdokimov, ea lilemo li 39, Saransk.
O tobana le khatello ea maikutlo ea nako e telele. Ke ne ke sitoa ho tsoa seterekeng sena ke le mong, ka hona ke ile ka leba ho ngaka ea mafu a kelello bakeng sa thuso. Ngaka e laetse Saroten. Ke nka moriana o sebetsa, o sebetsana hantle le maikutlo a ho tšoenyeha mme o thusa ho felisa ho hloka boroko. Li-capsule li lokela ho nooa motšeareng ka litekanyetso tsa 50 mg le ka nako ea ho robala, 100 mg. Kamora beke, ho ne ho ka sebelisoa tekanyetso ea bosiu feela. Ha ke a hlokomela litla-morao leha e le life, haeba e se ho otsela. Empa o oa hlokahala ho sebetsana le ho hloka boroko.
Angelica Nikiforova, ea lilemo li 41, St. Petersburg.
Setsebi sa kelello se laetse li-capsot tsa Saroten mabapi le maemo a ho tšoenyeha. Ha e sebelisoa hantle, ka tieo ho latela litaelo, e na le phello e matla. Ke nkhothaletsa ho nka pilisi ea ho qetela ho fihlela 20:00. Haeba sena se sa etsoa, ka nna, ho ipeha hoa ts'ebetso ea methapo le ho hloka boroko ho qalile. Haeba tachycardia e hlahile, ea khanna ho robala, joale fokotsa litekanyetso, matšoao a ile a nyamela.Re amohetse phello e tsitsitseng ha u nka 50 mg makhetlo a 2 ka letsatsi le e eketsehileng ea 50 mg bosiu. Ho bohlokoa ho khetha litekanyetso tse nepahetseng ka ho buisana le ngaka ea hau.
