Sesebelisoa se etselitsoe kalafo ea lefu la tsoekere la mofuta oa 2. Ntho e sebetsang e matlafatsa lisele tsa pancreatic ho hlahisa insulin e ngata ho theola tsoekere ea mali.
Lebitso la Machaba le sa Tšoanelehang
Gliclazide.
Diabeteson MV e etselitsoe phekolo ea lefu la tsoekere la mofuta oa 2.
ATX
A10BB09.
Lokolla liforomo le sebopeho
E fumaneha ka foromo ea letlapa:
- Li-pcs tse 15., E behiloe ka har'a lithutsoana tse 2 kapa 4 likhomphutha. ka litaelo tsa ts'ebeliso e kentsoeng lebokoseng la karete;
- Li-pcs tse 30., Liphutheloana tse ts'oanang tsa lithutsoana tse 1 kapa tse peli ka pakete e le 'ngoe.
Letlapa le le leng le na le 60 mg ea ntho e sebetsang - gliclazide.
Likarolo tse thusang:
- hypromellose 100 cP;
- anhydrous colloidal silicon dioxide;
- maltodextrin;
- magnesium stearate;
- lactose monohydrate.
Diabeteson MV e fumaneha ka foromo ea letlapa.
Ketso ea pharmacological
Moemeli oa Hypoglycemic.
Ntho e sebetsang ke sulfonylurea derivative. Ha e bapisoa le li-analog, e na le naetrojene e nang le endocyclic bond ka reng ea heterocyclic. Ka lebaka la ketso ea gliclazide maling, karoloana ea "glucose" e fokotsehile, 'me secretion ea insulin ke lisele tsa beta tsa lihlekehleke tsa Langerhans li hlohlelletsoa.
Keketseho e eketsehileng ea C-peptide le insulin ea postprandial e phehella lilemo tse 2 kamora kalafo.
Ho ja tsoekere ka lefu la tsoekere la mofuta oa 2, ha u sebelisa moriana, ho thusa ho khutlisa tlhoro ea pele ea "insulin" le ho matlafatsa karolo ea eona ea bobeli. Secretion e eketseha haholo ka tekanyo ea tsoekere.
Keketseho e eketsehileng ea C-peptide le insulin ea postprandial e phehella lilemo tse 2 kamora kalafo.
E na le phello ea hemovascular. Ntho e sebetsang e ama lits'ebetso tse tlatselletsang ntlafatsong ea mathata a lefu la tsoekere, joalo ka:
- ho fokotseha ha khatello ea methapo ea tlhaho ea thromboxane B2 le beta-thromboglobulin;
- thibelo e sa felletseng ea ho khomarela le ho kopanya lintho tsena tse bopehileng.
E khothaletsa ts'ebetso e eketsehileng ea activator ea tisy ea plasminogen le ho khutlisetsa tšebetso ea fibrinolytic ea vascular endothelium.
Mofumahali
Ho monya ntho ka botlalo hoa ntho e sebetsang ho etsahala kamora ho ts'oaroa hoa moriana, ho sa tsotelehe ho ja lijo. Ho na le keketseho ea butle-butle ea khatello ea plasma lihoreng tse 6 tse qalang. Tlhokomelo ea boemo ba sehlaba ke lihora tse 6-12. Ho hloka mamello ho tlase.
Ho fihla ho 95% ea ntho e sebetsang e tlama liprotheine tsa plasma. Bophahamo ba kabo ea thepa ke lilithara tse 30. Ho nka Letlapa le le leng ka letsatsi le boloka motsoako o hlokahalang oa gliclazide maling ho feta letsatsi.
Metabolism e etsahala haholo-holo ka har'a sebete.
Metabolism e etsahala haholo-holo ka har'a sebete. Ha ho na metabolites e sebetsang ho plasma. Metabolites e hloekisoa haholo ke liphio, ka tlase ho 1% - e sa fetoheng. Ho felisoa ha halofo ea bophelo ke lihora tse 12-20.
Matšoao a ho sebelisoa
Moriba o laeloa ho tsamaisoa ka molomo maemong a latelang:
- boteng ba mofuta oa lefu la tsoekere la mofuta oa 2 le nang le matla a fokolang a ho ja, ho ikoetlisa le ho theola boima ba 'mele;
- bakeng sa thibelo ea mathata: ho hlahloba maemo a glycemic ka matla ho bakuli ho fokotsa kotsi ea litla-morao tsa "retinopathy, nephropathy" le litla-morao tsa methapo ea methapo.
Diabeteson MV e laetsoe boteng ba mofuta oa 2 mellitus oa tsoekere ka katleho e tlase ea lijo tse sebelisitsoeng, ho ikoetlisa le ho theola boima ba 'mele.
Contraindication
Lithethefatsi ha li fanoe maemong a latelang:
- hypersensitivity ho gliclazide le likarolo tse ling tsa lithethefatsi, ho kenyeletsoa ho sulfonamides;
- mofuta oa 1 lefu la tsoekere;
- ho nka miconazole;
- ho ima le ho nyekeloa ke mpa;
- lefu la tsoekere le letlalong;
- ho hlohlona ho matla ha hepatic kapa renal;
- lefu la tsoekere la ketoacidosis.
Setlhare sena se kopantsoe le ho bana.
Ha e khothalletsoe tšebeliso ea bakuli ba nang le glucose-galactose malabsorption, galactosemia, ts'oarellano ea lactose.
Ka tlhokomelo
Tlhokomelo moriana o sebelisetsoa:
- bokhoba ba joala;
- pituitary kapa adrenal, renal kapa ho hloleha ha sebete;
- ho haella ha glucose-6-phosphate dehydrogenase;
- matla methapo ea pelo le methapo;
- tšebeliso ea nako e telele ea li-glucocorticosteroids;
- lijo tse se nang litekanyetso kapa tse sa tloaelehang;
- botsofe.
Mokhoa oa ho nka Diabeteson MV?
Sekhahla sa letsatsi le letsatsi ke matlapa a 0,5-2 a 1 ka letsatsi. Matlapa a metsitsoe hohle ntle le ho choachoasela le ho hlafuna.
Matlapa a metsitsoe hohle ntle le ho choachoasela le ho hlafuna.
Likamohelo tse lahlehileng ha li pusetse tekanyo e ntseng e eketseha ea litekanyetso tse amohelang tse latelang.
Tekanyetso e khethoa ke ngaka ho latela boemo ba HbA1c le tsoekere ea mali.
Phekolo le thibelo ea lefu la tsoekere
Qala kalafo ka pilisi ea.. Haeba taolo e lekane e etsoa, joale tekanyetso ena e lekane bakeng sa kalafo ea tlhokomelo. Haeba taolo ea glycemic e sa lekana, tekanyetso e eketsoa ka 30 mg ka mor'a bonyane khoeli e le 'ngoe ea ho sebelisa moriana ka tekanyetso e boletsoeng esale pele, ntle le bakuli bao maemo a bona a glucose a sa fokotsehang kamora thupelo ea libeke tse peli. Bakeng sa ena, lethal dose le eketseha matsatsi a 14 kamora ho qala ts'ebetso.
Sekhahla se phahameng sa letsatsi ke 120 mg.
Qala kalafo ka pilisi ea..
Bakeng sa bakuli ba kotsing ea ho ba le hypoglycemia, ho fanoa ka lethal dose e nyane (matlapa a 0.5).
Bakeng sa thibelo ea mathata a lefu la tsoekere, tekanyetso ea lithethefatsi e eketseha butle butle ho isa ho 120 mg / ka letsatsi. Ho nka meriana ho tsamaea le ho ikoetlisa le ho ja ho fihlela boemo ba HbA1c bo fihlella. Nakong ea kalafo, lithethefatsi tse ling tsa hypoglycemic li ka sebelisoa:
- Insulin
- alpha glucosidase inhibitor;
- li-thiazolidinedione derivative;
- Metformin.
Ho nka meriana ho tsamaea le lijo.
Kopo ea ho aha
Sehahi sa 'mele se hloka thupelo ea insulin bakeng sa boima bo potlakileng. Papaling ena, e tsebahala ka lebaka la hore:
- rekisoa ka bolokolohi likhoebong;
- ha e behe bophelo bo botle kotsi;
- e na le phello e bobebe mmeleng.
Tšebeliso ea lithethefatsi e lokela ho kopanngoa le phepo e nepahetseng ea moatlelete. Ho molemo ho baka kapa mohloa. Moriana o nooa ka mpeng e se nang letho halofo ea hora pele ho lijo. Se ke oa ja lijo nakong ea koetliso le ± hora ea 1 pele le kamora eona.
Moriana ona o nooa makhetlo a 3 ka letsatsi. Tekanyo e khethoa ke bongata ba semathi. Ho eketseha ho lebisa ho ho ja ho feta tekano, tk. Ho fokotseha ha tsoekere ho hloka puseletso ka mokhoa oa lijo tse nang le khalori e phahameng.
Sehahi sa 'mele se hloka thupelo ea insulin bakeng sa boima bo potlakileng.
Litlamorao
Ha o sebelisa gliclazide, joalo ka meriana e meng ea sulfonylurea, sethethefatsi se ka baka hypoglycemia ha se tlohella lijo kapa mekhoa e seng metle. Matšoao a latelang a bonoa:
- bradycardia;
- phefumoloho e sa tebang;
- maikutlo a ho hloka thuso;
- ho lahleheloa ke kelello ka nts'etsopele e ka bang teng ea ho soahlamanya ka kotsi ea lefu;
- Ho tsekela
- cramps
- mokhathala;
- bofokoli
- paresis;
- thothomela
- tahlehelo ea boitšoaro
- pono le puo e sa sebetseng;
- aphasia;
- Ho sithabela maikutlo
- fokotsa nako ea tlhokomelo;
- pherekano ea letsoalo;
- tsosa
- ho se khonehe;
- ho nyekeloa le pelo le ho hlatsa
- khathatso ea boroko;
- maikutlo a eketsehileng a tlala;
- hlooho e bohloko.
Karabelo ea Adrenergic e boetse e boletsoe:
- angina pectoris;
- arrhythmia;
- Matšoenyeho
- tachycardia;
- palpitations
- khatello ea mali e phahameng;
- letlalo le boreleli;
- hyperhidrosis.
Liteko tsa laboratori li thehile hore tlolo ea ts'ebetso ea sebete le nts'etsopele ea cholestasis e ka etsahala.
Matšoao a lefu lena a emisa ho ja lik'habohaedreite. Ho nka li-sweeteners ha ho na thuso. Ha ho kgothaletswe ho nka tse ling tse tsoang ho sulfonylurea.
Phekolo ea ka mpeng
Ho fokotsa litla-morao tsena, o hloka ho sebelisa moriana o ntse o ja lijo tsa hoseng. Tsena li kenyeletsa:
- ho nyekeloa le pelo le ho hlatsa
- ho sokela
- lets'ollo
- bohloko ba ka mpeng.
Hematopoietic litho tsa ka hare
Ha e bonoe hangata:
- granulocytopenia;
- leukopenia;
- thrombocytopenia
- phokolo ea mali
Haholo-holo e feto-fetoha ha ho felisoa moriana.
Diabeteson MB e ka baka bohloko ba ka mpeng.
Tsamaiso ea methapo e bohareng
Ho boletsoe tse latelang:
- pono e senyehileng ea tikoloho;
- ho sotleha haholo.
Ho tsoa ts'ebetsong ea moroto
Ha e khetholloe.
Karolong ea litho tsa pono
Ho ferekana ho bonahalang ho ka etsahala ka liphetoho tsa tsoekere ea mali. Tšoaetso e atileng haholo ea nako ea pele ea kalafo.
Haeba u fetola tsoekere ea mali a hau ha u ntse u sebelisa moriana o mong, mahlo a hao a ka 'na a fifala.
Karolong ea letlalo
E shebiloe:
- Lefu la Stevens-Johnson;
- erythema;
- Edema ea Quincke;
- ho hlohlona
- chefo e hlahisoang ke chefo e ka fokotsang;
- lekhopho, incl. maculopapullous;
- urticaria.
Karolong ea sebete le tsamaiso ea biliary
Ho boletsoe tse latelang:
- hepatitis maemong a ikhethileng;
- ts'ebetso e eketsehileng ea li-enzyme tsa sebete (alkaline phosphatase. AST, ALT).
Kalafo ea emisa ha jaundice ea cholestatic e etsahala.
Maemong a sa tloaelehang, lefu la sebete le ka hlaha nakong ea kalafo le Diabeteson MV.
Litaelo tse khethehileng
Setlhare sena se laeloa bakuli ba jang lijo tse nang le lik'habohaedreite kamehla le lijo tsa hoseng. Ponahalo ea hypoglycemia e tsamaisoa ke:
- ho ikoetlisa nako e telele
- ho sebelisa lithethefatsi tse 'maloa tsa hypoglycemic ka nako e le' ngoe;
- lijo tse nang le khalori e tlase;
- joala.
Matšoao a emisang ha a lumelle ho khutlela morao. Ka matšoao a matla, mokuli o tlameha ho kena sepetlele.
Kotsi ea hypoglycemia e eketseha ka:
- overdose;
- ho hlaphoheloa ha sebete le sebete haholo;
- ho haella ha adrenal le pituitary;
- lefu la qoqotho;
- ho se leka-lekane pakeng tsa palo ea lik'habohaedreite tse nkiloeng le tšebetso ea 'mele;
- taolo e tšoanang ka nako e tšoanang ea lithethefatsi tse 'maloa tse kenang;
- ho se khonehe ha mokuli ho laola boemo ba hae;
- Phetoho mokhoeng oa ho ja, ho ja lijo tse phahameng, ho itima lijo, ho se lekane le khaello ea phepo e nepahetseng.
Kotsi ea hypoglycemia e eketseha le lefu la qoqotho.
Tekanyo ea joala
Ha joala bo fanoa ka hloko. Ho nwa joala ho ka baka glycemia.
Tšusumetso ho bokhoni ba taolo ea methapo
Bakuli ba tsebisoa ka matšoao a hypoglycemia. Ba lokela ho ba hlokolosi ha ba nka mehato e hlokang ho tsepamisa maikutlo le lebelo le leholo la karabelo ea psychomotor, haholo maemong a pele a kalafo.
Sebelisa nakong ea bokhachane le pelehi
Tlhahisoleseling mabapi le ts'ebeliso ea ntho e sebetsang nakong ea kemolo ha e fumanehe. Litekong tsa liphoofolo, ha ho na phello ea teratogenic e fumanoeng.
Ka moimana o reriloeng le ho qala ha nako ea phekolo, ho kgothaletswa ho nkela baemeli ba hypoglycemic molomo ka kalafo ea insulin.
Ka lebaka la khaello ea tlhaiso-leseling mabapi le ho kenella ha ntho e sebetsang lebeseng la matsoele, ho sebelisa sethethefatsi sena nakong ea matsoele ho hlakotsoe.
Tlhahisoleseling mabapi le ts'ebeliso ea ntho e sebetsang nakong ea kemolo ha e fumanehe.
Ho fana ka taelo ea lefu la tsoekere ho bana
Ha ho na datha ka phello ea lithethefatsi ho bana ba banyenyane.
Sebelisa botsofaling
Matla a bohlokoa a likarolo tsa pharmacokinetic ho batho ba tsofetseng ha a bonoe.
Kopo ea ts'ebetso ea renal e senyehileng
Ka ho hloleha ho matla ha renal, insulin e khothalletsoa. Ka mekhahlelo e bonolo le e leka-lekaneng ea pathology ena, lethal dose ha le fetoloe.
Sebelisa bakeng sa ts'ebetso ea sebete e sa sebetseng
E kopantsoe le ho hloleha ho matla ha sebete.
Ka ho hloleha ho matla ha renal, insulin e khothalletsoa.
Bongata
Haeba tekanyetso e fetisitsoe, hypoglycemia e ka hlaha. Haeba matšoao a loketseng a lefu lena a hlaha ntle le matšoao a ho ruruha le ho ferekana kelellong, eketsa palo ea lijo tse nang le lik'habohaedreite phepong, fetola lijo le / kapa fokotsa tekanyetso.
Mefuta e matla ea maemo a hypoclycemic, a khetholloang ke mafu a fapaneng a methapo, ho kenyeletsa ho tsitsipana le komello, tse hlokang ho kena sepetlele hanghang.
Haeba ho kula ho belaetsa ka ho ferekanya kelello kapa ho qaleha ha eona ho belaela, tharollo ea glucose ea 20-30% ka molumo oa 50 ml e fanoa ho mokuli kahare. Ho boloka maemo a tsoekere ea mali ka holimo ho 1 g / l, ho sebelisoa tharollo ea 10% dextrose. Ka lihora tse 48, boemo ba mokuli bo hlahlojoa, ka mor'a moo ngaka e etsa qeto ea tlhoko ea tlhahlobo e ngoe hape.
Dialysis ha e na thuso, hobane ntho e sebetsang e amahanngoa le liprotheine tsa plasma.
Haeba tekanyetso e fetisitsoe, hypoglycemia e ka hlaha.
Ho sebelisana le lithethefatsi tse ling
Hoa hlokahala ho ela hloko motsoako oa lithethefatsi le li-anticoagulants, hobane ha li nkuoa hammoho, ho ka etsahala ho eketsa phello ea tsona.
Motsoako o kopantsoeng
Miconazole e ka baka komello ea hypoglycemic ha o sebelisa li-gel ho mucosa ea molomo le tsamaiso ea methapo.
Ha e khothalletsoe motsoako
Tsena li kenyeletsa:
- Phenylbutazone e nang le tsamaiso ea methapo ka lebaka la phello e matla ea hypoglycemic. Ho molemo ho sebelisa lithethefatsi tse ling khahlano le ho ruruha.
- Ethanol, e matlafatsang hypoglycemia hofihlella kholo ea komello. Ho hana ha ho hlokahale feela ka joala, empa le meriana e nang le ntho ena.
- Danazole - e thusa ho eketsa bongata ba tsoekere maling.
Danazole - e thusa ho eketsa bongata ba tsoekere maling.
Mekhaako e hlokang ho ba hlokolosi
Sena se kenyelletsa motsoako oa sethethefatsi le meriana e itseng. Eketsa kotsi ea hypoglycemia:
- beta-blockers;
- li-agents tse ling tsa hypoglycemic: Insulin, Acarbose, agPists ea GLP-1, thiazolidinidione, Metformin, dipeptidyl peptidase-4 inhibitors;
- Fluconazole;
- MAO le ACE inhibitors;
- histamine H2 li-receptor blockers;
- sulfonamides;
- NSAIDs
- Clarithromycin
Eketsa tsoekere ea mali:
- Chlorpromazine e tekanyetso e phahameng;
- glucocorticosteroids;
- Terbutaline, Salbutamol, Ritodrin ka tsamaiso ea methapo.
Maninil ke analogue ea lithethefatsi Diabeteson MV.
Analogs of Diabeteson MV
Tsena li kenyeletsa:
- Maninil;
- Gliclazide MV;
- Glidiab;
- Glucophage;
- Diabefarm MV.
Litlatsi tse tlase li sebelisoa kamora ho buisana le ngaka.
Ke eng e betere: Diabetes kapa Diabeteson MV?
Diabeteson MV e fapana le Diabeteson maemong a ho lokolloa ha ntho e sebetsang. "MV" ke tokollo e fetotsoeng.
Nako ea ho kenngoa ha glycoside ho Diabeteson ha e sa feta lihora tse 2-3. Motsoako - 80 mg.
CF e nkuoa nako e le 'ngoe ka letsatsi, e sebetsa ka mokhoa o bobebe, kotsi ea hypoglycemia e nyane.
Diabeteson MV e fapana le Diabeteson maemong a ho lokolloa ha ntho e sebetsang.
Lipehelo tsa khefu ea khemisi
Lithethefatsi (Diabeteson MR ka Latin) ke lengolo la ngaka.
Theko ea Diabeteson MV
Litsenyehelo tse tloaelehileng ke li-ruble tse 350.
Maemo a polokelo ea moriana
Sebakeng se sa fumaneheng ho bana, ka mocheso o sa feteng 25 + C.
Letsatsi la ho felloa ke nako
Lilemo tse 2
Moqapi
- "Indasteri ea Basebeletsi ba Lihokelo tsa Basebetsi", Fora.
- Serdix LLC, Russia.
Litlhahlobo mabapi le Diabeteson MV
Lingaka
Shishkina E.I., Moscow
Ho sebetsa hantle ho phahame. Litlamorao ha li bonoe. E qala ho nka khato ka potlako. Setlhare se setle sa lefu la tsoekere.
Litsebi tsa lefu la tsoekere
Diana, ea lilemo li 55, Samara
Ngaka e laetse 60 ml / ka letsatsi, empa hoseng khatello ea glucose e ne e le 10-13. Ka keketseho ea litekanyetso ho matlapa a 1.5, boemo ba hoseng bo fokotsehile ho isa ho 6 mm. Ho ikoetlisa hanyane le ho ja ho boetse hoa thusa.
