Haeba tekanyo ea cholesterol e phahameng e fumanoe nakong ea tlhahlobo ea mali, ngaka e lokela ho fana ka lipilisi tse khethehileng ho thibela mafu a pelo le a methapo. Lithethefatsi tsena ke tsa sehlopha sa li-statins.
Mokuli o lokela ho tseba hore o lokela ho nka pilisi nako eohle. Lipalo, joalo ka litlhare tse ling li na le litla-morao tse ling, 'me ngaka e lokela ho bolella mokuli ka tsona.
Motho e mong le e mong ea anngoeng ke bothata ba k'holeseterole e phahameng oa ipotsa: na ho na le meriana ea ho tloaela boemo ba motsoako ona le hore na o a li noe.
Meriana ea Cholesterol e arotsoe ka lihlopha tse peli tse kholo:
- Maemo
- Fibrate
Joaloka li-adjuvants, lipoic acid le mafura a omega-3 acid le tsona li ka jeoa.
Statins - cholesterol e theolelang lithethefatsi
Statins ke metsoako ea lik'hemik'hale e etsang hore 'mele o fokotse tlhahiso ea li-enzyme tse hlokahalang bakeng sa ho theha cholesterol maling. Haeba u bala litaelo tsa meriana ena, ke mohato o latelang o laetsoeng moo:
- Statins e fokotsa cholesterol ea mali ka lebaka la phello e thibelang ho fokotsoa ha HMG-CoA le khatello ea mantlha sebeteng.
- Statins e thusa ho theola cholesterol e phahameng ho batho ba nang le homozygous hypercholesterolemia, e ke keng ea phekoloa le lithethefatsi tse ling ho theola cholesterol.
- Statins e fokotsa cholesterol e felletseng ka 30-45%, le seo ho thoeng ke "mpe" cholesterol - ka 45-60%.
- Ho eketseha ha cholesterol e ntle (lipalo tse phahameng tsa methapo) le apolipoprotein A ea eketseha.
- Lipalo-palo ka 15% li fokotsa kotsi ea ho ba le li-ischemic pathologies, ho kenyelletsa infraction ea myocardial, le monyetla oa ho nts'etsapele angina ka lipontšo tsa ischemia ea myocardial ka 25%.
- Ha li na kankere hammoho le mutagenic.
Litla-morao tsa li-statins
Meriana ea sehlopha sena e na le litla-morao tse ngata. Har'a tsona ke:
- - Hangata ho tšoaroa ke hlooho le bohloko ba ka mpeng, ho hlobaela, ho nyekeloa, lefu la asthenic, lets'ollo kapa ho qhekella, lefufuru, bohloko ba mesifa;
- - ho tsoa ho ts'ebetso ea methapo ho na le paresthesia, kizungu le malaise, hypesthesia, amnesia, peripheral neuropathy;
- - ho tsoa ho tšilo ea lijo - hepatitis, lets'ollo, ho ipolaisa tlala, ho hlatsa, pancreatitis, cholestatic jaundice;
- - ho tloha tsamaisong ea musculoskeletal - bohloko ba mokokotlo le mesifa, mokokotlo, ramatiki ea manonyeletso, myopathy;
- - lipontšo tsa ho kulisa - urticaria, lekhopho la letlalo, ho hlohlona, erythema e ruruhileng, lefu la Lyell, ho ts'oaroa hoa anaphylactic;
- - thrombocytopenia;
- - mathata a metabolic - hypoglycemia (ho theola tsoekere ea mali) kapa lefu la tsoekere;
- - boima ba 'mele, botenya, ho hloka matla, edema ea ho potoloha.
Ke mang ea hlokang ho nka li-statins
Papatso ea meriana e re ho hlokahala hore ho fokotsoe k'holeseterole, 'me li-statins li tla thusa ho sena, li tla ntlafatsa boleng ba bophelo, li fokotse kotsi ea ho ba le stroke le lefu la pelo.
Liphuputso tse ngata li bontšitse hore lithethefatsi ke mokhoa o sebetsang haholo oa ho thibela likotsi tsa methapo le ho baka litlamorao tse 'maloa. Empa o hloka ho ba hlokolosi ka lipolelo tse kang "mang kapa mang ea noang li-statins o na le k'holeseterole e mpe le cholesterol e ntle." Ntle le netefatso, mantsoe a joalo ha aa lokela ho tšeptjoa.
Ebile, ho ntse ho na le ngangisano ka tlhoko ea ho sebelisa li-statin botsofaling. Hajoale, ha ho na maikutlo a sa lekanyetsoang ho sehlopha sena sa lithethefatsi. Boithuto bo bong bo paka hore ha cholesterol e le ngata haholo, ho kenella ha bona hoa hlokahala ho fokotsa kotsi ea lefu la pelo le methapo.
Bo-rasaense ba bang ba lumela hore meriana e ka ba kotsi haholo ho bophelo ba batho ba baholo mme e baka litlamorao tse mpe, mme melemo ea bona khahlano le semelo sena ha e kholo haholo.
Litekanyetso tsa Khetho ea Statin
Motho e mong le e mong, ho latela litlhahiso tsa ngaka, o lokela ho iketsetsa qeto ea hore na o tla nka li-statins. Haeba ho etsoa qeto e ntle, joale matlapa a khethehileng a k'holeseterole a lokela ho beoa ke ngaka, a nahanela mafu a tsamaeang le ona.
U ke ke ua sebelisa meriana ho theola cholesterol ka boeona. Haeba ho na le liphetoho kapa ho ferekanngoa ha metabolism ea lipid ka har'a lipatlisiso, u lokela ho ikopanya le ngaka ea pelo le ngaka ea mafu. Ke setsebi feela se ka hlahlobang ka nepo kotsi ea ho nka li-statin bakeng sa motho ka mong, ho nahanela:
- lilemo, bong le boima;
- ho ba teng ha mekhoa e mebe;
- mafu a khahlano le a pelo le methapo ea mali le li-pathologies tse fapaneng, haholo-holo lefu la tsoekere.
Haeba statin e laetsoe, joale u lokela ho e nka ka tieo ho tekanyetso e boletsoeng ke ngaka. Tabeng ena, tlhahlobo ea mali a biochemical e lokela ho nkuoa nako le nako. Tabeng ea theko e phahameng haholo ea moriana o khothalelitsoeng, ho hlokahala hore ho buisanoe ka ho nkeloa sebaka ke mofuta o theko e phahameng haholo.
Leha ho le molemo ho sebelisa lithethefatsi tsa pele, hobane li-genetic, haholo-holo tse tsoang Russia, li mpe haholo ho feta lithethefatsi tsa pele, kapa le lithethefatsi tse tsoang kantle ho naha.
Fibrate
Ena ke sehlopha se seng sa lipilisi tsa ho theola cholesterol ea mali. Ke lintho tse tsoang ho fibroic acid, 'me li ka tlama ho bile acid, ka tsela eo, li fokotsa ho sebetsa ha k'holeseterole e leng ka har'a sebete. Li-fenofibrate li fokotsa khatello ea cholesterol e phahameng ka lebaka la hore li theola palo eohle ea lipids 'meleng.
Boithuto ba kliniki bo bontšitse hore ts'ebeliso ea fenofibrate e lebisa taba ea hore cholesterol e felletseng e theoha ka 25%, triglycerides ka 40-50%, mme cholesterol e ntle e eketseha ka 10-30%.
Litaelong tsa fenofibrate le ciprofibrate ho ngoliloe hore ts'ebeliso ea bona e lebisa ho fokotseha hoa li-deposits tse eketsehileng (tendon xanthomas), mme sekhahla sa triglycerides le cholesterol ho bakuli ba nang le hypercholesterolemia le sona sea fokotseha.
Ho lokela ho hopoloa hore lithethefatsi tsena, joalo ka tse ling tse ngata, li baka karohano e fapaneng. Pele ho tsohle, sena se ama mathata a amanang le tšilo ea lijo, 'me ha ho kgothaletswe ho thunya cholesterol nakong ea kemolo.
Litlamorao tsa fenofibrate:
- Sistimi ea lijo tsa ka mpeng - bohloko ba ka mpeng, lefu la sebete, lefu la gallstone, pancreatitis, ho nyekeloa le pelo le ho hlatsa, lets'ollo, lefufuru.
- Sistimi ea musculoskeletal - e senya myalgia, bofokoli ba mesifa, rhabdomyolysis, mesifa ea mokokotlo, myositis.
- Ts'ebetso ea pelo - pulmonary embolism kapa venous thromboembolism.
- Mokhoa oa tsamaiso ea methapo - tlolo ea tšebetso ea thobalano, hlooho e bohloko.
- Liponahatso tsa maemo a mang le a mang - makhopho a letlalo, ho hlohlona, hives, hypersensitivity ho bobebe.
Ts'ebeliso e kopaneng ea li-statins le li-fibrate ka linako tse ling e laeloa ho fokotsa litekanyetso tsa li-statins, hape. ka hona, litlamorao tsa bona.
Mekhoa e meng
Keletso ea ngaka, u ka sebelisa litlatsetso tsa ho ja, ka mohlala, Tykveol, oli e lohiloeng, Omega 3, lipoic acid, eo hammoho le kalafo e ka sehloohong e tlatsetsang ho fokotseheng ha cholesterol.
Omega 3
Litsebi tsa pelo tsa Amerika li eletsa ka matla bakuli bohle ba nang le cholesterol e phahameng ea mali hore ba noe matlapa a oli ea tlhapi (Omega 3) e le hore ba ka itšireletsa mafu a pelo le ho thibela khatello ea maikutlo le ramatiki.
Empa oli ea litlhapi e tlameha ho nkuoa ka hloko, kaha e ka baka nts'etsopele ea pancreatitis e sa foleng, mme mona lipilisi tsa cholesterol li ke ke tsa thusa.
Tykveol
Sena ke lithethefatsi tse entsoeng ka oli ea peo ea mokopu. E fuoe batho ba nang le atherosulinosis ea likepe tsa mokelikeli, cholecystitis, hepatitis.
Phytopreparation ena e na le litlamorao tse khahlanong le ho ruruha, hepatoprotective, choleretic le antioxidant.
Lipoic acid
E sebelisoa e le moemeli oa kalafo le prophylactic bakeng sa coronary atherosulinosis, joalo ka ha e amana le li-antioxidants tsa endo native.
E na le phello e ntle ho metabolism ea lik'habohaedreite, e eketsa tlhahiso ea glycogen sebeteng, e ntlafatsa phepo e nepahetseng ea li-neuron, mme pokello ea sebete e ka nkuoa ka kopanelo, litlhahlobo tsa tsona li ntle haholo.
Pheko ea Vitamin
Li boetse li thusa ho boloka cholesterol e tloaelehileng. Li-vithamine B6 le B12, folic acid, vithamine B3 (acid e nicotinic) li bohlokoa haholo.
Empa ho bohlokoa haholo hore livithamini ke tsa tlhaho ebile ha li entsoe, ka hona, phepo e lokela ho ba le lijo tse matlafalitsoeng.
SizingPren
Ena ke tlatsetso ea lijo tse nang le fir maoto a nkoang. E na le beta-sitosterol le polyprenols. E sebelisoa bakeng sa khatello ea mali, atherosclerosis, cholesterol e phahameng ea mali le triglycerides.
Re lokela ho hopola hore litlatsetso tsa ho ja ha se meriana, ka hona, ho ea ka pono ea bongaka, li fokola haholo ho feta li-statin li thibela ho shoa ha pele ho nako le likotsi tsa methapo.
Hona joale ho boetse ho na le moriana o mocha oa ho theola cholesterol ea mali - ezetemib. Ketso ea eona e thehiloe ho fokotsa ho monya k'holeseterole ka mpeng. Tekanyetso ea letsatsi le letsatsi ea lithethefatsi ke 10 mg.
