Bafuputsi ba Marussia ba qapile lintho tse ka hlahisoang ho tsona ho khutlisetsa le ho boloka bophelo bo botle ba pancreatic ka mofuta oa 1 lefu la tsoekere.
Li-pancreas, ho na le libaka tse ikhethang tse bitsoang Lihlekehleke tsa Langerhans - ke tsona tse hokahanyang insulin 'meleng. Hormone ena e thusa lisele ho monya tsoekere e tsoang maling, 'me ho haella ha eona - karolo e itseng kapa e felletseng - ho baka kholo ea tsoekere, e lebisang ho lefu la tsoekere.
Tsoekere e ngata e mpefatsa tekano ea biochemical 'meleng, khatello ea oxidative ea hlaha, le mefuta e mengata ea mahala ea methapo liseleng, e sitisang bots'epehi ba lisele tsena, e baka tšenyo le lefu.
Hape, glycation e etsahala 'meleng, moo tsoekere e kopanang le liprotheine. Bathong ba phetseng hantle, ts'ebetso ena e ntse e tsoela pele, empa butle butle, 'me ho tsoekere e potlakisa le ho senya lisele.
Lesakana le nang le likotsi tse mpe le bonoa ho batho ba nang le lefu la tsoekere la mofuta oa 1. Ka eona, lisele tsa Langerhans Islets li qala ho shoa (lingaka li lumela hore sena se bakoa ke tlhaselo ea autoimmune ea 'mele), mme leha ba ka arohana, ba ke ke ba khutlisa chelete ea bona ea mantlha, ka lebaka la khatello ea kelello le khatello ea moea tse bakoang ke glucose e feteletseng. shoa ka lebelo haholo.
Ka letsatsi le leng, makasine oa Biomedicine & Pharmacotherapy o phatlalalitse sengoloa ka liphetho tsa boithuto bo bocha ke bo-rasaense ba tsoang Univesithing ea Ural Federal (Univesithi ea Ural ea Federale) le Setsi sa thuto ea thuto ea mafu a bakuli (IIF UB RAS). Litsebi li fumane hore lintho tse hlahisitsoeng motheong oa 1,3,4-thiadiazine li hatella karabelo ea autoimmune e boletsoeng ka holimo ka mokhoa oa ts'oaetso, e senyang lisele tsa insulin, mme, ka nako e ts'oanang, e felise litlamorao tsa khatello ea glycation le oxidative.
Ho litoeba tse nang le lefu la tsoekere la mofuta oa 1, tse lekang litekanyetso tsa 1,3,4-thiadiazine, liprotheine tsa "immune protein" li ile tsa fokotsoa haholo 'me hemoglobin ea glycated ea nyamela. Empa ntho ea bohlokoa ka ho fetisisa ke hore, liphoofolong palo ea lisele tse kopanyang insulin makhophong e eketsehile makhetlo a mararo 'me boemo ba insulin ka boeona bo ile ba eketseha, bo fokotsang khatello ea tsoekere maling.
Mohlomong lithethefatsi tse ncha tse thehiloeng motheong oa lintho tse boletsoeng kaholimo li tla ntlafatsa kalafo ea lefu la tsoekere la mofuta oa 1 'me li fe bakuli ba limilione menyetla e matlafatsang ea bokamoso.
