Nakong ea theknoloji ea tlhahisoleseling le meloko e mecha ea lithethefatsi tsa antidiabetic, lithethefatsi tsa khale tse lekiloeng li lula li hlokahala. Tse tummeng ka ho fetisisa ke tse susumetsang manyeme ho hlahisa insulin e eketsehileng. Re bua ka tse tsoang ho letoto la li-sulfonylurea le li-siriagogue tsa sulfonylurea - letsopa.
Repaglinide le eona ke ea sehlopha sa ho qetela. Phapang ea eona e ka sehloohong ke phello karolong ea pele ea ho lokolloa ha hormone maling, ha kamora ho ja maling ho na le ho tlola ho matla ha tsoekere maling, 'me' mele oa motho ea nang le lefu la tsoekere (o nang le lefu la 2) o sitoa ho sebetsana le ona.
Kamora ho bala litaelo, ho hlahloba melemo le mathata ohle, o ka buisana le ngaka ea hau ka mofuta oa hau oa kalafo ea lefu la tsoekere.
Sebopeho le litlhaloso tsa moriana
Letlapa le leng le le leng le na le 0.5 kapa 1 mg ea motsoako o sebetsang oa micagized repaglinide e tlatselletsoang ka lisebelisoa tse thusang: calcium hydrogen phosphate anhydrous, colloidal silicon dioxide, cellcosestalline cellulose, croscarmellose sodium, hydroxypropyl cellulose, meglumine, magnesium stearate, le dyes.
Matlapa a biconvex a chitja a ka bonoa ka ho ngola linomoro tse bonts'ang litekanyetso. Ka letšoao la 0.5, li tšoeu, li na le 1 mg - lavender kapa 'mala o mosehla. Ka morao u ka bona khutsufatso RP, J le ba bang. Matlapa a 10 a pakiloe ka marang-rang. Ho tla ba le lipolanete tse joalo ka lebokoseng la karete.
Moriana oa ngaka o fumanehang. Theko ea Repaglinide ke tekanyetso e phethahetseng: matlapa a 30 a 2 mg ho la Moscow a ka rekoa li-ruble tse 200-220. Ba lokolla bongaka naheng ea Denmark, Israel, India le linaheng tse ling, ho kenyeletsoa le libakeng tsa post-Soviet.
Bophelo ba lishelefo tsa moriana, bo phatlalalitsoeng ke moetsi, ke ka lilemo tse 3. Moriana ha o hloke maemo a khethehileng bakeng sa polokelo. Kamora nako e boletsoeng, matlapa a tlameha ho lahloa.
Litšobotsi tsa Pharmacological
Phello e ka sehloohong ea lithethefatsi ke hypoglycemic. Lithethefatsi li thibela lits'ebetso tse itšetlehileng ka potoloho ea potasiamo tsa ATP tse kahara membrane ea b-cell, li kenya letsoho ho depolarization ea tsona le tokollong ea liketane tsa calcium. Kahoo, sephiri se etsa hore ho ratoe lihormone.
Boithuto ba tsa bongaka ha bo fumane mutagenic, teratogenic, carcinogenic litlamorao ho liphoofolo le tsoalo e sa sebetseng.
Repaglinide e kenella ka potlako le ka botlalo ho tsoa mohloling oa tšilo ea lijo, ho fihlela e fihla maling a eona ka hora.
Haeba e nooa le lijo, Cmax e fokotseha ka 20%. Khokahano ea lithethefatsi e theoha ka potlako mme kamora lihora tse 4 e fihla letšoao le tlase. Litlhare li tlama ho liprotheine tsa plasma hoo e batlang e le ka botlalo (ho tloha ho 98%) ka bioavailability ea 56%. Biotransformation le ho thehoa ha li-metabolite tsa inert e hlaha ka har'a sebete.
Setlhare se felisoa ka lihora tse 4-6 ka halofo ea bophelo ba hora ea 1. Ho 90% e feta ka har'a li-ducts tsa bile, hoo e ka bang 8% e hloekisoa ke liphio.
Repaglinide e etselitsoe mang?
Moriana o etselitsoe ho laola lefu la tsoekere la mofuta oa 2 haeba mefuta ea mekhoa ea ho ja (lijo tse bobebe tsa carb, mojaro o lekaneng oa mesifa, taolo ea maikutlo) e sa fane ka taolo e felletseng ea glycemic.
Hoa khoneha ho sebelisa glinide kalafo e rarahaneng le metformin le thiazolidinediones, haeba monotherapy, phepo e nepahetseng ea phepo le ts'ebetso ea 'mele ha e fane ka sephetho se lakatsehang.
Ho Repaglinide ho ngolisitsoe mang
Ntle le lithibelo tsa moetlo (ho se mamelle motho ka mong, boimana, bana, matsoele), lithethefatsi li tlatsitsoe:
- Litsebi tsa lefu la tsoekere le lefu la 1;
- Le lefu la tsoekere la tsoekere;
- Boemong ba ho akheha le ho hlaka;
- Haeba mokuli a e-na le mathata a ka mpeng le a sebete;
- Maemong a hlokang phetoho ea nakoana ea insulin (ts'oaetso, ho sithabela maikutlo, ho buoa).
Ho lokela ho lebisoa tlhokomelo e khethehileng ho hlahiseng lingoloa tsa bokhoba ba joala, batho ba nang le lefu le sa foleng la liphio le feberu.. Ho na le lithibelo tsa lilemo: u se ke ua fana ka litlhare ho lingaka tsa tsoekere pele ho lilemo tse 18 le kamora lilemo tse 75 ka lebaka la tlhaiso ea bopaki bakeng sa mekhahlelo ena.
Mokhoa oa kopo
Bakeng sa repaglinnid, litaelo tsa tšebeliso li khothaletsa ho nka pilisi pele ho lijo. Ngaka e tla khetha tekanyetso e hlokahalang bakeng sa taolo e nepahetseng ea glycemic ho latela liphetho, litekanyetso tsa lefu lena, li-pathologies tsa lilemo, lilemo, karabelo ea 'mele oa motho ka mong ka letsopa.
Ho hlakisa tekanyetso ea bonyane ba kalafo, hoa hlokahala ho laola tsoekere e lapileng le ea ka morao lapeng le ka laboratoring. Ha u lokisa mekhoa ea lithethefatsi, li boetse li tataisoa ke matšoao a hemoglobin ea glycated.
Ho beha leihlo hoa hlokahala ho khetholla ho hloleha ha mantlha le bobeli, ha boemo ba glycemia bo oela ka tlase ho tloaelehileng qalong ea thupelo kapa kamora nako ea kalafo ea pele.
Nako ea ho nka repaglinide ha e thata: metsotso e 15-30 pele ho lijo kapa hang ha motho a qala lijo. Haeba ho kenyelletsoa seneke e le 'ngoe (kapa ho tlotsoa), pilisi e' ngoe e eketsoe (kapa e tlotsoe).
Haeba motho ea nang le lefu la tsoekere ha a e-so fumane lithethefatsi tse fokotsang tsoekere, tekanyetso ea letsopa e lokela ho ba e fokolang - 0.5 mg pele ho lijo tse ling. Haeba a fetohela ho iphekola ka moriana o mong oa antidiabetes, o ka qala ka 1 mg pele ho lijo tse ling.
Ka kalafo ea tlhokomelo, moriana o khothalletsoang ha o fetele 4 mg pele ho lijo tse kholo. Kakaretso ea letsopa ea letsatsi le letsatsi ha ea lokela ho feta 16 mg.
Ka kalafo e rarahaneng, tekanyo ea repaglinide ha e fetohe, 'me litekanyetso tsa lithethefatsi tse ling li khethoa ho latela' malo oa glucometer le mofuta oa kalafo oa kalafo o fetileng.
Liphetho tse sa rateheng
Har'a lintho tse mpe tse atileng tse hlahisoang ke glinids, hypoglycemia e kotsi haholo. Ha u fana ka litlhare, ngaka e lokela ho tsebisa bakuli matšoao a eona le mekhoa ea eona ea pele le ho itlhokomela.
Har'a liketsahalo tse ling tse sa lebelloang:
- Mathata a amanang le dyspeptic;
- Tlokotsi ea morethetho oa metsamao ea maoto;
- Makhopho a letlalo le allergic;
- Ho senyeha ha sebete ka tsela ea keketseho ea transistor mesebetsing ea transaminase;
- Ho senyeha ho bonahalang ka lebaka la phapang e teng maemong a glycemic.
Liphetoho tsa ho sebelisana le lithethefatsi
Ka tšebeliso e tšoanang ea repaglinide le li-β-blockers, li-inhibitors tsa ACE, chloramphenicol, lino tse tahang, li-inhibitors tsa MAO, li-anticoagulants tse sa tobang tsa NSAIDs, probenecid, salicylates, sulfonamides, anabolic steroid, katleho ea letsopa e eketseha.
Tsamaiso e ts'oanang ea li-repaglinide le calcium block blockers, corticosteroids, thiazide diuretics, isoniazid, nicotinic acid ka tekanyetso e sa tloaelehang, estrogen (e fumanehang ho lithibela-pelehi), psychathomimetics, phenothiazines, phenytoin, lihormone tsa qoqotho li fokotsa menyetla ea glinides.
Thuso ka overdose
Boemo bona bo ka bonoa ke:
- Takatso e sa laoleheng;
- Mokhathala;
- Pherekano e phahameng;
- Ho eketsa matšoenyeho;
- Mathata a ho robala;
- Phetoho mokhoeng oa boitšoaro (boemo bo ts'oanang le botahoa);
- Phokotso ya puo le pono;
- Ho hloka tšebelisano-hloko le tlhokomelo;
- Ho ferekana kelellong;
- Letlalo le boreleli;
- Tachycardia;
- Li-spasms tsa mesifa;
- Mofufutso o feteletseng;
- Ho faola, komisi.
Thuso ho motho ea hlasetsoeng ke matšoao ebile ea tšehetsang. Haeba lefu la tsoekere le tseba, o hloka ho fuoa lik'habohaedreite tse tsoekere (tsoekere, pipi), kamora nakoana, 'mele o tletse ka tsoekere e lokela ho phetoa, kaha ho na le monyetla oa ho khutla.
Haeba mokuli a se na matšoao a letsoalo, tharollo ea glucose (50%) e tsamaisoa ka matla, ho boloka boemo ba glycemic bo kaholimo ho 5.5 mmol / l, lerotholi le kentsoe ka tharollo ea glucose ea 10%. Maemong a boima, ho hlokahala sepetlele ka potlako.
Litlhahiso tse ling
Tlhokomelo e khethehileng (taolo ea ho itima lijo le tsoekere ea ka morao ho mmele, ts'ebetso ea litho tse fumanehang) ha ho laeloa letsopa ho hlokahala ke batho ba lefu la tsoekere ba nang le lefu la tsoekere le la hepatic. Ba lokela ho tseba hore maemong a tlolo ea litekanyetso le litekanyetso tsa moriana, tšebeliso ea lino tse tahang, lijo tse nang le khalori e fokolang, ho imeloa ke mesifa, khatello ea maikutlo, ho hlokahala hore o fetole tekanyetso ea repaglinide, hobane maemo a joalo a ka baka hypoglycemia.
Mabapi le litlamorao tse mpe, ho tlameha ho ba hlokolosi ha u khanna makoloi le mochini o rarahaneng, o kotsi, ha o sebetsa libakeng tse phahameng, jj.
Ho thibela hypoglycemia, batho ba nang le lefu la tsoekere ba nang le matšoao a fokolang a baetapele, hammoho le ba nang le maemo a joalo ha ba tloaele, ho lokela ho nkuoe mehato ea ho ba hlokolosi, ho lekola kotsi e ka bang teng le ts'ebetso ea eona.
Repaglinide - analogues
Repaglinide e lokolloa tlasa mabitso a fapaneng a khoebo: NovoNorm, Diclinid, Iglinid, Repodiab.
Ho latela khoutu ea ATX ea boemo ba 4, li-antidiabetesic agents tsa Bayeta injekeng ea entenatide e sebetsang le Viktoza le motsoako o sebetsang oa liraglitide o tsamaellana le eona.
Batho ba bang ba lefu la tsoekere ba nka lefu la bona e le ho se utloisisane ka bomalimabe, ba sa lemohe hore lefu lena le bolotsana le ka romella lefats'e le leng ka nako efe kapa efe.
Repaglinide ke moemeli ea matla oa hypoglycemic, ho leka ho itlhalosa le ho e beha sebakeng se seng ho kotsi ho bophelo bo botle, kaha setlhare se sebetsa kapele, ka lenane le tebileng la li-contraindication le litlamorao. Haeba ho fumaneha hore o na le lefu la tsoekere, o hloka ho phekoloa ka ho teba, ntle le ho phomola ho fihlela hamorao.
Likhethong tsa bongaka tsa kalafo ea lefu la tsoekere la mofuta oa 2 u ka fumanoa video.
