Captopril-FPO ke sethethefatsi se felisang matla ka lebaka la bokhopo ba vasodilating. Phello ea kalafo e bakoa ke ho thibeloa ha ACE le thibelo e sa tobang ea ho phatloha ha bradykinin. Lithethefatsi li thibela ho etsoa ha li-angiotensin 2. Ka lebaka la keketseho ea methapo e meholo le e pallang, ho potoloha ha mali sebakeng sa ischemia ho matlafatsoa, boemo ba mokuli bo ntlafala molemong oa methapo ea methapo ea methapo ea methapo ea methapo. Moriana o lokela ho nooa ka tieo ho latela litaelo tsa ngaka e eang.
Lebitso la Machaba le sa Tšoanelehang
Captopril.
![](http://img.diabetesentity.com/img/sayd-2020/1144/rezultati-primeneniya-kaptopril-fpo-pri-diabete.jpg)
Captopril-FPO ke sethethefatsi se felisang matla ka lebaka la bokhopo ba vasodilating.
ATX
C09AA01.
Lokolla liforomo le sebopeho
Moriana o fumaneha ka mokhoa oa matlapa a masoeu a nang le tranelate e bolila, e nang le 25 kapa 50 mg ea ntho e sebetsang - Captopril. Ho eketsa ho monya le ho baoaoa ka nako ea ts'ebetso ea tlhahiso, metsoako e thusang e eketsoa karolong e sebetsang:
- cellcose ea microcrystalline;
- starch ea poone;
- tsoekere ea lebese;
- magnesium stearate;
- aerosil.
Litsi tsa kalafo li ka ba le monko o ikhethang. Matlapa a kenngoe ka har'a mekotla ea blister ea likotoana tsa 5-10.
Ketso ea pharmacological
Setlhare ke sa sehlopha sa lithethefatsi tse antihypertensive, mochini oa eona o thehiloeng ho blockade ea angiotensin e fetolang enzyme (ACE). Ka lebaka la phello ea kalafo, phetoho ea angiotensin I ea Fomu II ea fokotseha, e lebisang ho vasoconstriction - spasm ea vascular endothelium. Ka ho fokotseha ha lumen ea sejana khahlanong le semelo sa phallo e tloaelehileng ea mali, khatello ea mali e phahama. Moriba o thibela spasm, ka tsela ena o emisa ho phatloha ha bradykinin, enzyme e hlapollang methapo ea mali.
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Captopril FPO e liehisa kholo ea kholo ea pelo.
Ka lebaka leo, likepe li atoloha le khatello ea methapo e ea tloaelehileng, ha feela boholo ba phepelo ea mali bo lekane ho tlatsa bethe ea khale. ACE inhibitor ka lebaka la khatello ea methapo e na le liketso tse latelang:
- e fokotsa ho hanyetsa ka har'a lijana tsa pulmonary le peripheral;
- e eketsa khatello ea methapo ho mojaro, e fokotsa kotsi ea ho phatloha ha leballo la phallo ea mali;
- e thibela tlolo ea ts'ebetso ea ventricle e ka lehlakoreng le letšehali, e bakoang ke khatello e phahameng ea mali (BP);
- e liehisa kholo ea ho hloleha ha pelo;
- e fokotsa ho bokellana ha sodium ho plasma ea mali khahlanong le semelo sa lefu le sa foleng la pelo;
- e ntlafatsa ts'ebetso ea methapo ea methapo ea methapo ea methapo le kutloisiso ea li-microcirc libakeng tsa ischemic.
Moriana ona o thibela ho khomarela liplatelete.
Mofumahali
Kamora ho tsamaisoa ka molomo, Captopril e kenella ka 75% leboteng la jejunum. Ka sejo se tšoanang, ho monya ho fokotsoa ka 35-40%. Karolo e sebetsang e fihlela boleng bo phahameng ba serum ka nako ea metsotso e 30-90. Tekanyo ea "binding" ho plasma albin ha e kenella maling a mali e tlaase - 25-30%. Ka mokhoa oa ho rarahana ho joalo, sethethefatsi se tšeloa metsoako ea hepatocytes ka ho etsoa ha lihlahisoa tsa biotransfform tse se nang litlamorao tsa lithethefatsi.
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Ho feta 95% ea Captopril e tlohela 'mele ka thuso ea liphio, ha 50% e pepesoa ka sebopeho sa eona sa pele.
Bophelo ba halofo e ka tlase ho lihora tse tharo. Nako e eketseha khahlano le nalane ea ho se sebetse hantle ha molapo ka lihora tse 1-29, ho latela botebo ba lefu lena. Ho feta 95% ea Captopril e tlohela 'mele ka thuso ea liphio, ha 50% e pepesoa ka sebopeho sa eona sa pele.
Ho thusang
Motsoako o sebelisoa ho tsa bongaka bakeng sa kalafo le thibelo ea mekhoa e latelang ea methapo ea methapo.
- khatello e phahameng ea mali, ho kenyelletsa le khatello ea methapo ea kutlo;
- e le karolo ea kalafo e pharalletseng ho felisa ho se sebetse hantle hoa pelo;
- tšitiso ea ts'ebetso ea ts'ebetso ea "ventricle" ea ts'ebetso kamora ho hlaseloa ke pelo, ha feela mokuli a sa tsitsa
- tšenyo ea lisebelisoa tsa glomerular le renal parenchyma ea mofuta oa 1 lefu la tsoekere.
Contraindication
Setlhare sena se thibetsoe hore se sebelisoe ke batho ba nang le mamello e le 'ngoe ea ho khetha bongaka le lintho tse ling tse etsang sehlahisoa seo. Ka lebaka la boteng ba lactose monohydrate, Captopril ha e khothalletsoe hore e sebelisoe bathong ba nang le bothata bo bobe ba monosaccharide malabsorption, ho hloka mamello kapa ho haelloa ke lactase.
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Tekanyetso
Litekanyetso li thehoa ka kotloloho ke ngaka ea lefu la pelo, e itšetlehileng ka matšoao a laboratori le ho teba ha methapo ea methapo ea mafu. Setlhare sena se etselitsoe bakuli ba baholo ba lilemo tse fetang 18. Motsoako oa ho qala o khothalelitsoeng ke 12,5 mg makhetlo a 2 ka letsatsi.
Le lefu la tsoekere
Bakeng sa thibelo le kalafo ea nephropathy khahlanong le semelo sa lefu la tsoekere le itšetlehileng ka insulin, ho hlokahala hore o nwe ho tloha ho 75 ho isa ho 100 mg ea moriana ka letsatsi.
Ha pelo e sa sebetse hantle
Ho haelloa ke pelo ha nako e telele ho hloka hore motho a sebelise makhetlo a 25 mg makhetlo a 3 ka letsatsi mohato oa pele oa kalafo. Ka khatello e tloaelehileng kapa e tlase ea mali, hammoho le bakuli ba nang le hypovolemia le sodium e tlase maling, ho khothalletsoa ho fokotsa litekanyetso ho isa ho 6.25-12.5 mg ka tsamaiso ea makhetlo a mangata ho isa ho makhetlo a 3 ka letsatsi. E le pheko ea tlhokomelo, makhetlo a 3 ka letsatsi a lokela ho nkuoa 12,5 kapa 25 mg, ho latela boemo ba mamello ho moriana.
Tlas'a khatello
Ho tsitsisa khatello ea mali ea boima bo bobebe kapa bo itekanetseng qalong ea kalafo, 25 mg e lokela ho nkuoa makhetlo a 2-3 ka letsatsi. Ka karabelo e tlase ea kalafo, moriana o le mong o lokela ho eketsoa ho 50 mg feela ha e mamelletsoe hantle. Sekhahla se lekaneng se amohelehang ka letsatsi ke 150 mg.
Haeba matšoao a khatello ea mali a lakatsehang a sa ka a fella ka matsatsi a 14-21 a kalafo, diuretics tsa thiazide li eketsoa ho feta pilopril-FPO monotherapy. Boitšoaro ba 'mele bo bonoa libeke tse 1-2. Ho felisa ts'ebetso e matla ea pathological, o ka eketsa tekanyetso e le 'ngoe ho ea 100-150 mg ka khafetsa ea tsamaiso ho fihlela makhetlo a 2-3 ka letsatsi.
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Ho felisa koluoa ea khatello ea mali, ho hlokahala hore o behe moriana o ka tlase ho leleme ka tekanyo ea 6.25-50 mg.
Ho felisa koluoa ea khatello ea mali, ho hlokahala hore o behe moriana o ka tlase ho leleme ka tekanyo ea 6.25-50 mg. Phello ea kalafo e bonoa kamora metsotso e 15-30.
Ka infarction ea myocardial
Lithethefatsi li laetsoe matsatsi a 3 kamora lefu la myocardial. Tekanyetso qalong ea kalafo ea lithethefatsi ke 6.25 mg ka letsatsi. Ka karabelo e ntle ea 'mele ho moriana, keketseho ea tloaelo ea letsatsi le letsatsi ho isa ho 12,5 mg ka tsamaiso ea linako ho fihlela makhetlo a 3 ka letsatsi e lumelloa. Ka mor'a libeke tse 'maloa, litekanyetso li ntse li eketseha ho fihlela li emeletsoe ka bongata.
Mokhoa oa ho nka Captopril-FPO
Matlapa a nooa ka mpeng e se nang letho metsotso e 60 pele ho lijo, hobane lijo li fokotseha kapa li kena-kenana le mokhoa o tloaelehileng oa ho monya lithethefatsi.
Tlas'a leleme kapa lino
Sublingual Captopril e sebelisoa feela ho potlakisa phello ea kalafo. Ho fokotseha ka sekhahla ha khatello ea mali hoa hlokahala ha ho na le koluoa ea khatello ea mali.
Ho nka nako e kae
Ka tsamaiso e poteletseng, phello ea hypotensive e bonoa metsotso e 15-30 ka mor'a hore pente e qhaloe ka tlas'a leleme. Ha e kenelle, phello e matla ea kalafo e fihlella ka nako ea lihora tse 3-6, ea pele - kamora lihora tse 1-2.
Ke nooa hangata hakae
Ho sebelisoa hangata - makhetlo a 2-3 ka letsatsi.
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Litlamorao
Litlamorao tse mpe li hlaha ka lebaka la mofuta o fosahetseng oa litekanyetso. Ha li hlaha, ho khothalletsoa ho fokotsa tekanyetso.
Phekolo ea ka mpeng
Litla-morao tse hlahang ka har'a tšilo ea lijo li bonahala e le:
- ho nyekeloa
- takatso e fokotsehileng;
- ho hloka tatso;
- bohloko ba ka mpeng;
- eketsa mosebetsi oa enzymatic oa hepatic transaminases;
- hyperbilirubinemia;
- lets'ollo, ho sokela;
- nts'etsopele ea mafura a mafura a sebete.
Maemong a sa tloaelehang, stagnation ea bile e ka etsahala. Ho bile le liketsahalo tse ikhethileng tsa ho ruruha makhopho a makhopho.
Hematopoietic litho tsa ka hare
Litlokotsi tsa hematopoiesis ea masapo ha li tlalehiloeng ka seoelo:
- phokolo ea mali
- fokotseha palong ea li-neutrophils;
- fokotseha ha sebopeho sa lisekelete.
Ho bakuli ba nang le mafu a autoimmune, agranulocytosis e ka hlaha.
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Tsamaiso ea methapo e bohareng
Ka tšenyo ea tsamaiso ea methapo, ho na le kotsi ea ho ba le letsoele, ho tšoaroa ke hlooho, mokhathala o sa foleng, paresthesias. Ts'ebetso ea kelello e ka sitisoa.
Ho tsoa ts'ebetsong ea moroto
Maemong a mang, protheine e ka pepesoa ka har'a moroto, litaba tsa uric acid le creatinine maling a mali li eketseha.
Ho tsoa tsamaisong ea phefumoloho
Ponahalo ea khohlela e omileng ea khonahala.
Karolong ea letlalo
Boitšoaro ba letlalo bo bonahala e le lekhopho la maculopapular kapa ho hlohlona. Ho bakuli ba reriloeng hore ba ka ba le bothata ba ho se sebetse hantle, ho ka hlaha Tsamaiso ea Johnsons, Johnson, kapa dermatitis.
Ho tsoa ts'ebetsong ea genitourinary
Ho banna, ho eketsoa ha sefuba kapa nts'etsopele ea ho senyeha ha erectile hoa khoneha.
Allergie
Allergy e bonahala ka mokhoa oa ho saroloha ha letlalo, bronchospasm e nang le litšitiso tsa moea, Quincke's edema, ho makala ha anaphylactic, bokuli ba serum, le boteng ba li-antibodies tsa mali maling.
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Tšusumetso ho bokhoni ba taolo ea methapo
Setlhare ha se ame mosebetsi oa litsebo tse ntle tsa makoloi, boemo ba kelello le ba 'mele ba mokuli. Ka hona, nakong ea phekolo le Captopril, ha ho na tlhoko ea ho fokotsa nako ea ho khanna koloi kapa ho sebetsa ka mekhoa e rarahaneng.
Litaelo tse khethehileng
Tlhokomeliso e ea eletsoa ha u nka maemo a latelang:
- stenosis ea methapo ea methapo;
- lefu la pelo;
- kotsi ea methapo ea methapo;
- a phatlalatsa mafu a autoimmune;
- khatello ea khatello ea mali;
- lefu la tsoekere;
- nako ea ho hlaphoheloa kamora ho fetisoa ha meno;
- aortic stenosis;
- lijo tse nang le sodium e fokolang
- botsofali;
- molumo o fokolang oa mali o potoloha, ho omella.
Nakong ea phekolo ea lithethefatsi, ho hlokahala hore ho lemose basebetsi ba laboratori mabapi le ho hlaha hoa litholoana tse ntle tsa leshano ha ho hlahlojoa urine bakeng sa ho ba teng ha acetone.
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Sebelisa nakong ea bokhachane le pelehi
Ts'ebeliso ea lithethefatsi ho li-trimesters tsa II le III tsa nts'etsopele ea embryonic e bonts'a fetotoxity, ka lebaka leo ho beoa litho tsa kahare ho "fetus" ho ka sitisang. Monyetla oa tsoalo pele ho nako e eketsoa. Basali ba baimana ba thibetsoe ka thata ho sebelisa moriana.
Captopril e hloekisoa hammoho le lebese la matsoele, ka hona, nakong ea lebone, hoa hlokahala ho emisa ho lactation.
Tekanyo ea joala
Setlhare ha se lumelletsoe ho se sebelisa hammoho le lino tse tahang, ka hona, nakong ea kalafo ea lithethefatsi, ha ua lokela ho noa joala kapa ho nka lihlahisoa tse nang le ethanol. Joala ba ethyl bo fokotsa matla a antihypertensive, bo eketsa kotsi ea ho chekoa ke mali ka lebaka la ho kopana ha liplatele mme ho eketsa monyetla oa ho putlama.
Bongata
Maemong a lithethefatsi tse ngata, ho theoha haholo ha khatello ea mali hoa khoneha. Ka lebaka la khatello ea kelello, motho a ka lahleheloa ke letsoalo, a oa kapa a akheha, 'me ho ts'oaroa ha pelo ho ka etsahala. Ka ho sebelisa lithethefatsi hampe, hlooho e qala ho bilika, thempereichara likoeng le ea fokotseha.
Ho fokotsa khatello ea mali, ho hlokahala hore ho qobelle motho ea hlasetsoeng hore a robala mokokotlong oa hae mme a phahamise maoto. Maemong a ho ema, ho alafshoa kalafo ea matšoao.
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Ho sebelisana le lithethefatsi tse ling
Ts'ebeliso e tšoanang ea li-Captopril le lithethefatsi tse ling e bonts'oa liketsong tse latelang:
- Lithethefatsi tsa Cytostatic le immunosuppressive, azathioprine e eketsa monyetla oa ho nts'etsapele leukopenia. Azathioprine e baka ho fokotseha hoa moko oa masapo a hematopoiesis.
- Li-diuretics tsa potassium-sparing le lithethefatsi tse seng khahlanong le ho ruruha li ka baka hyperkalemia. ACE inhibitor e fokotsa mokokotlo oa aldosterone, ka lebaka leo ho nang le ho lieha ha ion ea potasiamo.
- Ka tšebeliso e le 'ngoe le lithethefatsi tsa diuretic, phello e matla ea hypotensive e bonoa. Ka lebaka leo, ho khoneha nts'etsopele ea khatello ea methapo e matla ea methapo, hyperkalemia le ho se sebetse hantle ha renal. Hape, ho theoha ho matla ha khatello ea mali ho bonoa ka ho hlahisoa hoa lichelete bakeng sa ho opa hlooho ka kakaretso.
- Allopurinol e eketsa menyetla ea ho ba le litla-morao le mafu a hematological.
- Acetylsalicylic acid, ibuprofen le indomethacin li fokotsa phello ea kalafo ea Captopril.
- Captopril e eketsa khatello ea plasma ea digoxin.
Lithibela-mafu tsa cyclosporin li ka baka nts'etsopele ea oliguria le ho fokolisa mosebetsi oa liphio.
Li-analog
Matlapa a Captopril-FPO ha ho se na sesosa se hlokahalang sa antihypertensive a ka nkeloa sebaka ke meriana e latelang:
- Kapoten;
- Blockordil;
- Captopril Sandoz;
- Angiopril;
- Rilcapton;
- Captopril-STI;
- Captopril-Akos.
Captopril-FPO e fapane joang le ea Captopril
Generic, ho fapana le sethethefatsi sa pele, e na le phello e telele e matlafatsang 'me e na le phello e ntlafalitsoeng ea kalafo.
Maemo a phomolo bakeng sa Captopril-FPO ho tsoa pharmacy
E lumelloa ho reka ka mabaka a tobileng a bongaka.
A na nka reka ntle le lengolo la ngaka?
Ka lebaka la tšebeliso e fosahetseng, nts'etsopele ea methapo ea kutlo e ka etsahala, ka hona, ho reka Captopril ntle le lengolo la ngaka ho thibetsoe.
Theko ea Captopril-FPO
Theko e tloaelehileng literekeng tsa litlhare ke li-ruble tse 128.
Maemo a polokelo ea moriana
Ho khothalletsoa ho boloka moriana o le sebakeng se arohaneng le khanya ea letsatsi, ka mocheso o sa feteng 25 + C
Letsatsi la ho felloa ke nako
Lilemo tse 3
Moqapi oa Captopril-FPO
CJSC FP Obolenskoye, Russia.
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Tlhahlobo ea lingaka le bakuli ka Captopril-FPO
Olga Kabanova, ngaka ea methapo ea maikutlo, Moscow
Ke hlokometse hore Captopril le li-generator tsa eona ha li sebetse ho bakuli bohle. Nka khothaletsa sethethefatsi ho fokotsa khatello ea mali maemong a tšohanyetso. O ka nwa moriana ona ho fihlela makhetlo a 3 ka letsatsi. Maemong a mang, bakuli ba tletleba ka ho khohlela ho matla. Sebelisa ka hlokolosi ha o ka hloleha ho phekola a lereo.
Ulyana Solovyova, ea lilemo tse 39, Vladivostok
Ke siea tlhahlobo e ntle. Letlapa le lenyenyane le lesoeu le arotsoe habonolo likarolo tse 4 ka lebaka la lintlha tse khethehileng. Ka nna, ngaka e khothalelitse ho beha lithethefatsi ka tlasa leleme hore li sebetse kapele. E etselitsoe phokotso ea tšohanyetso ea khatello ea mali. Ketso e bonoa metsotso e 5. Ha kea fumana letho, ntle le ka tatso e bohloko. Ha ke ikemiselitse ho nkela moriana sebaka. Ha ho litla-morao.