Lithethefatsi Rosuvastin le Atorvastatin ke lihokela tsa hypolipidemic. Ntle le bokhoni ba ho fokotsa cholesterol ea mali, li na le thepa ea antioxidant hape li thibela kholo le karohano ea lisele tsa tumor. E hlahisoa ke lik'hamphani tse fapaneng tsa meriana tsa Russia ebile ke tse ling tsa litlhare tse fanoang ke lingaka.
Litšobotsi tsa rosuvastatin
Lithethefatsi ke letlapa le biconvex le tšoeu le tšetseng ntho e sebetsang ea rosuvastatin, lintlheng tse latelang:
- 5 mg;
- 10 mg;
- 20 mg;
- 40 mg
Lithethefatsi Rosuvastin le Atorvastatin cholesterol e tlase ea mali, li na le thepa ea antioxidant hape li thibela kholo ea lisele tsa tumor.
Matlapa a rekisoa mabokoseng. Palo e fokolang ka har'a sephutheloana ke li-pcs tse 7., Bophahamo ke li-pcs tse 300.
The bioavailability ea moriana o ka bang 20%. Tsitsipano e phahameng maling e fihlella lihora tse 5 kamora ts'ebetso. Ho felisoa ha halofo ea bophelo ke lihora tse 19.
Tekanyetso e khothalletsoang ea lithethefatsi ke 10 mg (bakeng sa bakuli ba morabe oa Mongoloid - 5 mg), e nooang hang ka letsatsi. Haeba ho hlokahala, e ka eketsoa ho 20 mg hang ka letsatsi, empa eseng pejana ho feta kamora khoeli ea tsamaiso. Ts'ebeliso ea litekanyetso tsa 40 mg e ka etsahala feela ka mefuta e matla ea lefu lena le ka tlasa taolo ea ngaka.
Sebopeho sa Atorvastatin
Karolo e sebetsang ea lithethefatsi ke eona ntho e le 'ngoe e sebetsang, e ka kenngoang letlapeng mehatong e latelang:
- 10 mg;
- 20 mg;
- 40 mg;
- 80 mg
Ho latela moqapi, matlapa a ka ba a chitja kapa a oval, a ba le mongolo ho e 'ngoe ea mahlakore. Setlhare se rekisoa ka mabokoseng a karete. Palo e tlase ea likhabana ka har'a sephutheloana ke likotoana tse 10, boholo ke likotoana tse 300.
Atorvastatin e tlameha ho nkuoa ka mpeng e se nang letho, hobane ho kopana le lijo ho sitisa ho monya ntho e sebetsang.
Setlhare se tsebahala ka bioavailability e tlase (12%). Ts'oarello e kholo e fihlella ka mor'a lihora tse 1-2 ka mor'a tsamaiso. Bophelo ba halofo ke lihora tse 13.
Litekanyetso tsa lithethefatsi li itšetlehile ka khatello ea pele ea cholesterol mme li lokela ho khethoa ka bomong bakeng sa mokuli ka mong. Motsoako oa pele o khothalelitsoeng ke 10 mg hang ka letsatsi. Tekanyo e kholo e lumelletsoeng ka letsatsi ke 80 mg. Moriana o lokela ho nooa ka mpeng e se nang letho. Ho kopana le lijo ho sitisa ho monya ntho e sebetsang.
Papiso ea lithethefatsi
Lithethefatsi tsena ka bobeli li hlahlojoa li karolo ea sehlopha sa li-statin tsa maiketsetso. Ha ho bapisoa le lintho tse ling tsa sehlopha sena, li tšoantšoa le ho fokotseha ho boletsoeng boemong ba TG. Leha ho le joalo, metsoako ea bona e sebetsang ha e tšoane.
E tšoanang
Lithethefatsi tsena li na le sepheo se tšoanang sa ho nka - ho theola cholesterol. Phello ea bona ea pharmacological e fokotseha ho thibela ts'ebetso ea HMG-CoA reductase. Liphetho tsa liphetoho tsena ke ho fokotseha ha cholesterol liseleng le ts'ebetsong ea cholesterol ea LDL. Tekanyo ea hore na mahloriso a eona o fokotseha hakae ho latela tekanyo ea moriana.
Liphetho tse ling tse ntle tsa ho nka Rosuvastatin kapa Atorvastatin e tla ba:
- ntlafatso ea endothelium ka ho se sebetse hantle ha eona;
- normalization ea rheological thepa ea mali;
- ntlafatso ea boemo ba methapo ea methapo le atheroma.
Matšoao a ts'ebeliso ea ona ke maloetse a latelang:
- hypercholesterolemia ea limelo tse fapaneng, ho kenyelletsa hypercholesterolemia ea homozygous
- mofuta oa hyperlipidemia IIa le IIb;
- Mofuta oa III oa dysbetalipoproteinemia;
- endo native hypertriglyceridemia (mofuta IV).
Ntle le moo, lithethefatsi tse joalo li sebelisoa bakeng sa prophylaxis ke bakuli ba nang le lintlha tse 'maloa bakeng sa nts'etsopele ea lefu la pelo le coronary, joalo ka:
- lilemo tse ka holimo ho lilemo tse 55;
- ho tsuba
- lefu la tsoekere;
- khatello ea mali
- cholesterol e tlase (HDL) maling;
- tlhekefetso ea lefutso.
E boetse e fuoa batho bao ba seng ba fumanoe ba na le ischemia, molemong oa ho fokotsa menyetla ea ho ba le angina pectoris, lefu la pelo kapa stroke.
Meriana e na le likhohlano tse tšoanang. Rosuvastatin kapa Atorvastatin ha e fuoe:
- le mafu a sebete karolong e sebetsang;
- nakong ea bokhachane le pelehi;
- bana le bacha.
Ka hlokolosi, lithethefatsi li lokela ho sebelisoa le:
- bokhoba ba joala;
- preisposition to myopathy;
- ho hloleha ho matla ha renal.
Lipontšo tsa karabelo e mpe ea 'mele ea ho phekola ka meriana ena li tšoana. Ha li nkuoa, nts'etsopele ea litla-morao tse kang:
- ho hloka boroko le ho tsekela, hammoho le lintho tse ling tse tsoang ho tsamaiso ea methapo e bohareng;
- dysfunctions tsa maikutlo, joalo ka tahlehelo ea tatso kapa tinnitus;
- bohloko ba sefuba, arrhythmia, angina pectoris;
- khaello ea mali, khaello ea mali;
- bronchitis, pneumonia, asthma ea bronchial, nosebleeds;
- ho nyekeloa ke pelo le lintho tse ling tse amanang le tšilo;
- ramatiki, ho mpefala ha gout;
- ho ruruha
- nts'etsopele ea tšoaetso ea urogenital;
- karabelo ea methapo;
- phetoho lipalo tsa mali tsa laboratori;
- boima ba mmele;
- kholo ea sefuba;
- liponahatso tsa meroalo.
Phello e phahameng ea kalafo e fumanoa kamora libeke tse 4 tsa kalafo ka meriana ena.
Ha u sebelisa meriana ena, basali ba lilemo tsa ho ba le bana ba tlameha ho sebelisa mekhoa e tšepahalang ea thibelo ea bokhachane.
Phapang ke efe?
Leha ho na le ho tšoana, lithethefatsi tsena ke tsa meloko e fapaneng ea li-statin. Rosuvastatin ke ntšetso-pele e ncha e u lumellang ho fokotsa litekanyetso le litekanyetso tse phahameng tsa ntho e sebetsang ka lebaka la ts'ebetso e kholo.
Lithethefatsi tse boletsoeng li na le mekhoa e fapaneng ea ho li felisa:
- atorvastatin e epolloa ho tsoa 'meleng ka bile ka mokhoa oa metabolites moo e fetoleloang ke li-enzyme tsa sebete;
- rosuvastatin - e sa fetoheng le mantle.
Rosuvastatin ke ntho e fanang ka hydrophilic, mme Atorvastatin e qhibilihisoa mafura.
Ho mofuta oa 2 mellitus oa lefu la tsoekere, ho molemo ho khetha rosuvastatin, kaha e na le phello e fokolang ho metabolism ea lik'habohaedreite.
E leng sireletsehileng
Boithuto bo bonts'a hore ts'oaetso ea maikutlo a mabe le eona e tšoanang ho lithethefatsi tsena ka bobeli.
Ho ile ha hlokomeloa hore ka lefu la tsoekere la mofuta oa 2, ho molemo ho khetha li-acid tsa hydrophilic, tse kenyeletsang Rosuvastatin, hobane lintho tse joalo li na le phello e fokolang ho metabolism ea lik'habohaedreite.
E leng theko e tlase
Theko ea Rosuvastatin le Atorvastatin ho latela lintlha tse 'maloa:
- palo ea litafole ka pakete e ngoe le e ngoe;
- moetsi oa lithethefatsi;
- pholisi ea litheko
- tikoloho ea ho reka lithethefatsi.
K'hemistri e tsebahalang ea inthaneteng e tšepisa ho reka Rosuvastatin ka litheko tse latelang:
- Matlapa a 30 a 10 mg a hlahisitsoeng ke Izvarino Pharma - li-ruble tse 545.7;
- Matlapa a 30 a 10 mg a entsoeng ke Vertex - 349.3 li-ruble;
- Matlapa a 60 a 20 mg, a entsoe ke Canonpharm Production LLC, - li-ruble tse 830.5 .;
- Matlapa a 90 a 20 mg a hlahisitsoeng ke k'hamphani "North Star" - li-ruble tse 1010.8.
Atorvastatin e ka rekoa ka litšenyehelo tse latelang:
- Matlapa a 30 a 10 mg a hlahisoang ke k'hamphani ea North Star - 138 li-ruble;
- Matlapa a 30 a 10 mg a entsoeng ke Ozone LLC - li-ruble tse 65,4;
- Matlapa a 60 a 40 mg a hlahisoang ke k'hamphani ea North Star - li-ruble tse 361.4;
- Matlapa a 90 a 20 mg ea brand ea Vertex - li-ruble tse 799.
Ho tsoa litheko tse qotsitsoeng, ho hlakile hore Atorvastatin ke lithethefatsi tse theko e tlaase ho feta Rosuvastatin.
Ke efe e betere - rosuvastatin kapa atorvastatin?
Lintlha tse teng mabapi le ho bapisa katleho ea meriana ena li bonts'a hore kalafo ea rosuvastatin e na le phello e boletsoeng haholoanyane ea ho theola khatello ea cholesterol. Ntle le moo, setlhare sena ke sa "statins" ea meloko e mene, 'me se fana ka maikutlo a ho sebetsa hantle joaloka prophylactic bakeng sa lefu la methapo ea methapo.
Leha ho le joalo, khetho ea lithethefatsi e lokela ho etsoa ke ngaka e eang ho mokuli e mong le e mong, ho nahanela litšobotsi tsa hae, mafu a kopaneng le bokhoni ba lichelete.
Na rosuvastatin e ka nkeloa sebaka ke atorvastatin?
Leha taba ea ho bapisoa ha lipina e bonts'a hore ntho e sebetsang ea Rosuvastatin le Atorvastatin ha se ntho e le 'ngoe, li tšoana ebile lia fetoha. Leha ho le joalo, pele o tloha ho sethethefatsi se seng o ea ho se seng, o lokela ho buisana le ngaka kamehla, hobane li-pharmacokinetics tsa lithethefatsi li fapane, ka lebaka leo lithethefatsi tsena li amang lisele tsa sebete le boko ka mekhoa e fapaneng, hape li na le mekhoa e fapaneng ea li-excretion.
Tlhahlobo ea lingaka
Grigory, ea lilemo li 46, Moscow: "Ntho ea mantlha eo mokuli a hlokang ho e tseba ha a sebelisa meriana e joalo ke hore sepheo sa bona ha se felise tlhoko ea ho latela lijo tse behiloeng. Pele ho tsohle, kamehla ke khothaletsa Rosuvastatin, kaha ts'ebeliso ea eona e ntle e netefalitsoe ka mokhoa oa bongaka. .
Valentina ea lilemo li 34, e leng Novosibirsk: "Ke nka ho nka lithethefatsi tsena e le tšireletso e ntle ea mafu a pelo le methapo ea methapo. Ke li fa bakuli bohle ba nang le cholesterol e phahameng."
Tlhahlobo ea Mamello bakeng sa Rosuvastatin le Atorvastatin
Nikolai: ea lilemo li 52, Kazan: "Monyetla o le mong oa Atorvastatin ke litšenyehelo tsa hae tse tlase. Ho nna, tsamaiso ea bona e ne e tsamaea le maikutlo a mangata a fapaneng: ho nyekeloa ke pelo le hlooho li ne li tšoenyeha khafetsa. Ka nako e ts'oanang, boemo ba cholesterol ea mali bo ile ba lula bo phahamisitsoe."
Svetlana ea lilemo li 45, Murmansk o re: "Keletso ea ngaka, ke tlohetse ho nka Atorvastatin ke e isa Rosuvastatin, ka lebaka la kalafo ea khafetsa ea ho nyekeloa ke pelo. Ke ka re moriana o mocha ha o bake karabelo e joalo, empa e ama le cholesterol."
