Amitriptyline Nycomed ke setho sa sehlopha sa li-antidepressant tse tharo. Moriana ke karolo ea theko e tlase, e bohlokoa, hobane khafetsa nako ea kalafo e nka libeke tse 'maloa kapa likhoeli.
Lebitso la Machaba le sa Tšoanelehang
Amitriptyline.
Amitriptyline Nycomed ke setho sa sehlopha sa li-antidepressant tse tharo.
ATX
N06AA09.
Lokolla liforomo le sebopeho
Sehlahisoa se ka tsela ea matlapa. Ena ke tokiso ea karolo e le 'ngoe, e nang le 1 e sebetsang - amitriptyline. Matlapa a na le khetla, ka lebaka leo boemo ba phello e matla ea lithethefatsi li ka mucous membrous ea tšilo ea lijo li fokotsoang. Khatello ea ntho e sebetsang: 10 kapa 25 mg (ho 1 pilisi). Antidepressant e na le likarolo tse 'maloa tse sa sebetseng tse sebelisetsoang ho fumana tšebeliso ea lithethefatsi eo u e batlang:
- magnesium stearate;
- cellcose ea microcrystalline;
- silika;
- talc;
- lactose monohydrate.
- starch.
Amitriptyline e hlahisoa ka mokhoa oa matlapa a koahetsoeng, ka lebaka leo boemo ba phello e matla ea lithethefatsi ho li-membrane tsa mucous tsa mpa ea mpa li fokotsoang.
Khetla ea sehlahisoa le eona e sebetsa ka bongata:
- macrogol;
- dimethicone;
- propylene glycol;
- tekanyetso ea titanium;
- hypromellose;
- talcum phofo.
Matlapa a na le botlolo e nang le li-pcs tse 50.
Ketso ea pharmacological
Molao-motheo oa ts'ebetso oa li-antidepressants tsa tricyclic o thehiloe ho thibelo ea ho tšoaroa ha li-monoamine, tse emeloang ke norepinephrine, dopamine le serotonin. Lintho tsena li ikarabella bakeng sa maikutlo a thabo.
Setlhare, joalo ka mekhoa e meng ea sehlopha sa li-antidepressant sa tricyclic, se na le "backback "e mengata e mpe e hlahang nakong ea kalafo. Sena se bakoa ke molao-motheo oa ketso o seng khetho. Ka lebaka leo, lithethefatsi ha li ame feela ho ts'oaroa ha li-monoamine, empa li thibela le maikutlo a mang a biochemical.
Amitriptyline ka nako e ts'oanang e etsa mesebetsi e mengata. Thepa ea eona ea mantlha ke e loantšang likhathatso. Ntle le moo, sethethefatsi se fana ka tšusumetso, khatello ea kelello, hypnotic. Sena se bolela hore nakong ea kalafo ha se maemo a kelello a mokuli feela a tloaelehileng, empa hape le boroko boa khutlisoa, matšoenyeho a nyamela.
Amitriptyline e fana ka tšusumetso e matla ea hypnotic, ka lebaka leo mokuli a tsosang boroko.
Ka lebaka la bokhoni ba ho thibela ho phetoa hape ha li-monoamine, ho lemohuoa keketseho ea khatello ea bona mokhoeng oa synaptic oa system ea methapo e bohareng. Ho feta moo, karolo e sebetsang ea Amitriptyline Nycomed e thibela li-M1- le M2-muscarinic cholinergic receptors, li-receptor tsa histamine, le ka nako e ts'oanang alpha1-adrenergic receptors. Kameho e ntle ea kalafo le antidepressant ena e bonoa ka lebaka la khokahano e teng lipakeng tsa li-neurotransmitters tse fumanehang ka har'a methapo ea kelello le boemo ba maikutlo.
Karolo e 'ngoe ea lithethefatsi ke phello e liehang ho tsamaea. Tšusumetso e ntle ha e fihlelle hang-hang, empa kamora ho hlaseloa ha ntho e sebetsang ka plasma ea mali ho fihlela moeli oa tekano. Ntle le moo, ha e fihla boemong bo itseng (e fapana ho latela tekanyetso), phello e matlafatsang kelello le eona ea bonahala. Leha ho le joalo, sephetho se lula se netefatsoa khahlano le sekhahla sa keketseho ea khatello ea metabolite ea mantlha ea amitriptyline - nortriptyline.
Ka keketseho le phokotso ea litekanyetso, litheko tsa moriana li fetoha hanyane. Kahoo, ha ho fihla tekanyo e itseng, ts'ebetso ea nortriptyline e fokotseha, ts'ebetso ea amitriptyline ea eketseha. Leha ho le joalo, ho fokotseha ha litlamorao tsa li-antidepressant ka linako tse ling ho hlokomeloa. Ka lebaka lena, u ke ke ua inkela moriana u le mong, hobane ho bohlokoa ho khetha mofuta o nepahetseng oa kalafo o nahanela litšobotsi tsa 'mele. Re lokela ho hopola hore ho nka tekanyetso e nyane ha ho na ho fana ka sephetho se lakatsehang.
Ka amitriptyline, o ka laola lebelo la pelo ea hau. Sena se bakoa ke phello ea litlhare tsa lithethefatsi.
Sesebelisoa seo ho buuoang ka sona se sebetsa le ho tlola mosebetsi oa CCC. Mohlala, e ka sebelisoa ho laola sekhahla sa pelo. Sena se bakoa ke phello ea litlhare tsa lithethefatsi. Ha ho fana ka moriana ho litekanyetso tsa kalafo, ho fokotseha ho teba ha ts'ebetso ea ventricular conduction.
Mofumahali
Amitriptyline e tšoauoa ka ho monya kapele. Kamora lihora tse 2-6, tlhoro ea ts'ebetso ea ntho ena e fihletsoe. E khetholloa ke sekhahla sa kakaretso sa bioavailability (50%). Empa ho tlamahana le liprotheine tsa serum ho phahame - 95%. Ka lebaka la hore moriana o fana ka sephetho se lakatsehang kamora ho fihlela motsoako o lekanang oa karolo e sebetsang 'meleng, phello e ntle ha ea lokela ho lebelloa pejana ho beke 1 hamorao. Sena se bakoa ke taba ea hore nako e joalo ea nako e hlokahala ho phethahatsa boemo ba mantlha boo matšoao a lefu la tsoekere a qalang ho nyamela.
Motsoako o sebetsang o tšeloa ka har'a sebete. Taba ea mantlha, e ea pele, nortriptyline, e ea lokolloa. Ebe, ka bobeli amitriptyline le metabolite ea eona e sebetsang ke hydroxylated, ebe e lateloa ke ho lokolloa ha lintho tse se nang matla. Bophelo ba halofo ea lithethefatsi bo fapana ho tloha lihora tse 9 ho isa ho tse 46, tse anngoeng ke boemo ba 'mele, ho ba teng ha li-pathologies tse ling.
Se laetsoeng
Ho eletsoa ho sebelisa lithethefatsi bakeng sa mathata a mangata a kelello, haholoholo:
- mefuta e fapaneng ea khatello ea maikutlo, e tsamaeang le ho tšoenyeha ha boroko, matšoenyeho, ha sethethefatsi seo ho buuoang ka sona se sebelisoa e le mohato o ka sehloohong oa phekolo;
- e le karolo ea kalafo e rarahaneng, antidepressant e fanoa maemong a 'maloa: boits'oaro, phobic, khatello ea maikutlo, ho se sebetse hantle ha lesapo (enuresis le lipontšo bosiu), anorexia, bulimia.
Contraindication
Ho na le lithibelo tse ngata mabapi le ts'ebeliso ea lithethefatsi tsena:
- karabelo e le 'ngoe e mpe ea motho e mong le e mong ea ka karolo (e sebetsang le e sa sebetseng);
- myocardial infarction, ho kenyelletsa le nalane ea;
- chefo ea ethanol e kotsi;
- maemo a amanang le lefu la kelello
- chefo ka lithethefatsi (li-antidepressants, psychotropic kapa hypnotics);
- arrhythmia;
- glaucoma ea angle-koaloa;
- tlolo ea intraventricular, atrioventricular conduction;
- tlhekefetso ea liphatsa tsa lefutso e amanang le khaello ea lactase, ho se mamellane ha lactose, lefu la glucose-galactose malabsorption;
- mefuta e mengata ea lisele liseleng tsa tšoelesa ea senya, e lebisang ho fokotseng matla ha leseli la urethra;
- ho sithabela ha mala;
- litekanyetso tsa potasiamo tse fokotsehileng;
- bradycardia.
Ka tlhokomelo
Lits'ebetso tse amanang:
- khatello ea mali e phahameng;
- maemo a amanang le phetoho e tsamaeang le phetoho sebopeho le thepa ea mali;
- khatello e eketsehileng ea methapo le mafu a mang a litho tsa pono;
- mofuta ofe kapa ofe oa lefu la methapo o tsamaeang le ho bolokoa ha moroto;
- cramps
- schizophrenia
- lefu la sethoathoa
- lefu la ho ferekana kelellong;
- tlolo ea tšoelesa ea qoqotho (hypothyroidism).
Mokhoa oa ho nka Amitriptyline Nycomed
Khetho ea mofuta oa kalafo e etsoa ho latela mofuta oa lefu lena. Nahana ka lilemo, tekanyo ea nts'etsopele ea pathology, ho ba teng ha lithibelo ts'ebelisong ea Amitriptyline Nycomed. Matlapa ha a lokela ho hlafuneloa. Fana ka litlhare ka mor'a ho ja.
Lenaneo la ho theola batho ba baholo
Phekolo e lokela ho qala ka tekanyetso ea 50-75 mg. Ebe e eketsoa, haeba ho hlokahala, ka 25-50 mg. Chelete ena e nkuoa hang pele a robala kapa e arotsoe ka litekanyetso tse peli. Leha ho le joalo, u ke ke ua feta tekanyetso ea letsatsi le letsatsi ea 200 mg. Nako ea thuto - likhoeli tse 6.
Amitriptyline Nycomed lethathamo la litekanyetso bakeng sa bana
Abelana le enuresis: 25 mg hang ho bakuli ho tloha ho lilemo tse 7 ho isa ho 12, tse fetang lilemo tse 12 - 50 mg. Ho khothalletsoa ho nka chelete pele u robala.
Ho nka moriana oa lefu la tsoekere
Setlhare se ho buuoang ka sona se ama phello e hlahisoang ke insulin, hape se ka baka phetoho khorong ea glucose. Ka lebaka lena, maemong a mangata, ho hlokahala hore ho fetotsoe tekanyetso ea lethal dose. Palo ea lithethefatsi e fanoe ka bonngoe.
Ke bokae ha e sebetsa
Sesebelisoa se fana ka phello libekeng tse 'maloa. E qala ho sebetsa nakong ea lihora tsa pele kamora ho qala kalafo. Phello e bakoang e lula matsatsi a 1-2.
Mokhoa oa ho hlakola Amitriptyline Nycomed ka nepo
Ho qoba ho ntša maikutlo, ho khothaletsoa ho fokotsa tekanyetso butle-butle.
Litlamorao
Re lokela ho hopola hore moriana o boletsoeng o kenya letsoho pontšong ea maikutlo a mangata a fosahetseng.
Phekolo ea ka mpeng
Ho nyekeloa ke pelo, li-membrane tsa mucous tse omileng, liphetoho sebopeho sa setuloana sa mmele (ho sokela). Ho tsoa ho sesebelisoa sa tšilo ea lijo, matšoao a latelang a hlaha hangata: ho se khotsofale ka hanong, ho ruruha, li-caries. Hangata, lets'ollo, ho hlatsa, ho ruruha ha leleme, hepatitis, jaundice, le mala.
Hematopoietic litho tsa ka hare
Ts'ebetso ea masapo a senyehileng, maemo a 'maloa a methapo eo ho eona ho nang le phetoho sebopeho le thepa ea mali.
Tsamaiso ea methapo e bohareng
Bofokoli bo akaretsang, ho otsela, ho thothomela ka maoto le hlooho, ho opeloa ke hlooho, ho akheha, ho bua, tatso.
Ho tloha ka lehlakoreng la metabolism
Fetola takatso ea lijo: eketsa, fokotseha. Ka lebaka leo, boima ba 'mele boa eketseha kapa boa fokotseha.
Allergie
Vasculitis, urticaria, e bonahatsoang ke ho hlohlona, lekhopho.
Tšusumetso ho bokhoni ba taolo ea methapo
Nakong ea kalafo, o lokela ho hana ho khanna likoloi, hobane setlhare se kenya letsoho ho hlokeng ts'ebetso ea methapo, se ama litho tsa pono le kutlo, 'me se baka likotsi tsa kelello.
Litaelo tse khethehileng
Phekolo e qala ka taolo ea khatello ea mali.
Ha o fetola boemo ba 'mele, tlhokomelo e lokela ho nkuoa; metsamao e bohale e ke ke ea etsoa.
Bakuli ba lilemo tse ka holimo ho 50 ba na le menyetla e eketsehileng ea ho robeha masapo.
Ka linako tse ling ho ka hlokahala ho laola lipalo tsa mali.
Liketsahalo tsa ho ipolaea li tsoela pele ho fihlela ha karolo e sebetsang e thusa ho fokotsa matšoao a bokuli ba kelello.
Bacha (ho fihlela lilemo tse 24), menyetla ea ho ipolaea ka kalafo le Amitriptyline Nycomed e eketseha.
Pele o etsa ts'ebetso e pharaletseng, lits'ebetso tsa meno, o lokela ho khaotsa ho sebelisa lithethefatsi.
Sebelisa nakong ea bokhachane le pelehi
Ha ea abeloa.
Sebelisa botsofaling
Hoa amoheleha ho sebelisa antidepressant ka potso, empa u lokela ho ba hlokolosi. U hloka ho qala mokhoa oa kalafo ka 25-30 mg (hang ka letsatsi). Eketsa palo ea lithethefatsi e lokela ho ba nako e le ngoe ka matsatsi a mabeli. Tekanyo e phahameng ea letsatsi le letsatsi ke 100 mg.
Kopo ea ts'ebetso ea renal e senyehileng
Ho bakuli ba nang le mafu a setho sena, tlhahiso ea metabolite ea Amitriptyline Nycomed e tsoang 'meleng e ea fokotseha. Ha ho na lithibelo tse thata tsa ho sebelisa sethethefatsi sena.
Sebelisa bakeng sa ts'ebetso ea sebete e sa sebetseng
E lumelletsoe ho sebelisa ka hloko. Ka ts'ebetso e sa lekaneng ea sebete, lethalinyana le fokotsehile.
Bongata
Li-amitriptyline tse ngata li ka baka blockade e matla ea intraventricular. Litlamorao tse ling lia holisoa. Phekolo: mpa e ea hlatsuoa ho fokotsa sekhahla sa lithethefatsi, ho fanoa ka litlolo tsa matsoele, haeba ho hlokahala, li-inhibitors tsa choline lia tsamaisoa, khatello ea maemo e ea hlokahala, 'me ho lekantsoe botsitso ba motlakase.
Ho sebelisana le lithethefatsi tse ling
Thibelo ea ts'ebetso ea methapo e bohareng e ntlafatsoa ka ho kopantsoe le lithethefatsi tse ho buisanoang ka tsona le li-antipsychotic, sedative, hypnotics, anesthetics, narcotic analgesics.
Hammoho le Amitriptyline, li-inhibitors tsa MAO ha li sebelisoe. Ha ho ratehe ho e kopanya le Adrenaline, Ephedrine, Dopamine, Noradrenaline, Phenylephedrine.
Tekanyo ea joala
Lino tse nooang tse tahang ka joala le meriana e hatellang ha e kopane.
Li-analog
Lithethefatsi tse sebetsang tse sebelisitsoeng sebakeng sa Amitriptyline Nycomed:
- Anafranil;
- Melipramine;
- Ladisan;
- Doxepin le ba bang
Phapang ke efe pakeng tsa Amitriptyline le Amitriptyline Nycomed
Lithethefatsi tse nang le lebitso la lebitso Nycomed ka lebitso ha li etsoe ka tsela ea tharollo. E ka rekoa feela matlapeng. Amitriptyline e fumaneha ka mefuta e fapaneng: solid, fluid (ente). Litokisetso tsa lihlopha tsena li sehlopheng se tšoanang sa theko. E ka fapana ka tekanyo ea motsoako o sebetsang.
Maemo a matsatsi a phomolo Amitriptyline Nycomed ho tsoa pharmacy
Setlhare ke ngaka.
A na nka reka ntle le lengolo la ngaka?
Che.
Theko ea Amitriptyline Nycomed
Litsenyehelo tse tloaelehileng ke li-ruble tse 60.
Maemo a polokelo ea moriana
Bana ba tlameha ho koala sehlahisoa. Maemo a polokelo a khothalletsoang: + 15 ... + 25 ° С.
Letsatsi la ho felloa ke nako
Setlhare se boloka thepa ea sona ka lilemo tse 5 ho tloha ka letsatsi la ho lokolloa.
Moetsi Amitriptyline Nycomed
Takeda Pharma A / S, Denmark.
Litlhahlobo mabapi le Amitriptyline Nycomed
Litsebi tsa kelello
Chukhrov V.V., ngaka ea mafu a kelello, ea lilemo li 49, Chelyabinsk
Setlhare se seng se felile, li-analogue tse ncha hona joale li hlahile tse bonts'ang karabelo tse fokolang tse mpe tsa kalafo.
Kochev V.O., Psychiatrist, ea lilemo li 34, Stavropol
Motsoako o sebetsang oa litlatsetso, ka ho eketsehileng o tlosa hlooho ea hlooho ka psychosomatics. E kanna ea etsa hore o liehe ho tsoa mosebetsing.
Bakuli
Larisa, ea lilemo li 34, Barnaul
Ke nkile matlapa a 10 mg. Phello ea kalafo e etsahetse kamora libeke tse 3, e leng nako e telele. Empa, qetellong, khatello ea maikutlo e ile ea hlola.
Marina, ea lilemo li 41, Moscow
A nka sethethefatsi sena. Ke feela ka nako e telele ke sa kang ka khona ho mamella. Taba ea mantlha ke hore ngaka e hlokomelisitse hore ho na le sephetho se iphumatsang khoeling ea pele kamora ho qala thupelo. Taba ea bobeli, litla-morao tsa tharollo ena ha lia ka tsa lumella kalafo e eketsehileng.
