Liteko tsa laboratori bakeng sa tlhahlobo ea mali, ho kenyeletsoa lefu la tsoekere, li bapala karolo ea bohlokoa. Ha se kamehla matšoao a lefu lena le boemo ba glycemia ea mali bo bonts'a ts'ebetso ea 'mele ea sebele ea' mele, e lebisang liphosong tsa ho lemoha mofuta oa lefu la tsoekere.
Proinsulin ke mofuta o sa sebetseng oa molek'hule ea "protheine" ea "insulin" e entsoeng ke li-islets ka har'a li-pancreas ho batho. Kamora ho hlaka ho tsoa ho proinsulin, sebaka sa protheine (seo hape se tsejoang e le C-peptide), ho fumanoa molek'hule ea "insulin" e laolang metabolism eohle 'meleng oa motho, haholo-holo katamelo ea tsoekere le tsoekere e meng.
Ntho ena e bolokoa liseleng tsa lihlekehleke tsa Langerhans, moo e fetoleloang ho ba insulin e sebetsang ea lihormone. Leha ho le joalo, hoo e ka bang 15% ea ntho e ntse e kenella maling a sa fetoheng. Ka ho lekanya palo ena, molemong oa C-peptide, motho a ka khetholla ts'ebetso ea lisele tsa β le bokhoni ba tsona ba ho hlahisa insulin. Proinsulin e na le ts'ebetso e fokolang ea catabolic mme e telele ho 'mele oa motho ho feta insulin. Empa, leha hole le sena, tekanyetso e phahameng ea proinsulin (e bonoang nakong ea ts'ebetso ea oncological ka har'a manyeme (insulinoma, jj) e ka tsosa hypoglycemia ho batho.
Ho itokisetsa tlhahlobo ea proinsulin
Ho khetholla boemo ba proinsulin ho batho, mali a venous a bokelloa. Pejana, mokuli o hloka ho latela likeletso tse 'maloa tse sa rarahaneng, tseo ka kakaretso li tšoanang le litokisetso tsa tlhahlobo ea biochemical ho tseba boemo ba tsoekere.
- Monehelo oa mali o etsoa hoseng pele ho lijo tsa motšeare, ka mpa e se nang letho. E lumelloa ho nka metsi a fokolang a balehang, ntle le lisebelisoa tse eketsang.
- Letsatsi pele ho thuto, ho hlokahala hore ho behelle kantle ho joala, ho tsuba, ho ikoetlisa ka ho feteletseng le taolo ea lithethefatsi, haeba ho khonahala, haholo-holo lithethefatsi tse theolelang tsoekere (glibenclamide, lefu la tsoekere, amaryl, jj.).
Matšoao a tlhahlobo ea laboratori
Ho hlahlojoa ha proinsulin ho etsoa ho latela lipontšo tsa bongaka, e le ho hlakisa lintlha tse joalo:
- Ho hlakisoa ha lisosa tsa maemo a hypoglycemic a tšohanyetso.
- Boitsebiso ba insulinomas.
- Ho fumana tekanyo ea tšebetso e sebetsang ea li-pancreatic β-cell.
- Boikemisetso ba mofuta oa kliniki ea lefu la tsoekere mellitus (mofuta oa 1 kapa 2).
Mofetoleli oa sephetho sa proinsulin assay
Ka tloaelo, ka mpeng e se nang letho, boemo bo tloaelehileng ba proinsulin ho motho ha bo felle ho 7 pmol / L (ho kheloha hanyane hoa litholoana hoa khoneha, li-laboratories tse fapaneng tsa tlhahlobo kahare ho 0.5-1 pmol / L, tse hlalosoang ke phoso ea lisebelisoa tsa tlhahlobo).
Ho fokotseha ho hoholo ha index ea methapo ea mali ho bonahala feela maemong a mofuta oa 1 lefu la tsoekere. Keketseho e holim 'a monyako o tloaelehileng e tloaetse mofuta oa lefu la tsoekere la mofuta oa 2, "pancreatic oncology", "endocrine" pathology ea "gland" ea senya, le liphio.
