Bakuli ba nang le mathata a lipid metabolism hangata ba na le khetho, e leng betere - Atorvastatin kapa Rosuvastatin? Le ha Rosuvastatin e sebelisitsoe haholo haufinyane, ha ho khonehe ho fana ka karabo e tobileng potsong ena, hobane moriana ka mong o na le melemo le likotsi.
Lithethefatsi ka bobeli li lokela ho nooa bakeng sa pathologies joalo ka motsoako kapa homozygous hypercholesterolemia (eketseha LDL), hypertriglyceridemia (triglycerol e feteletseng) le atherosulinosis (e fokotsang lumen ea methapo ea mali ka lebaka la subsidence ea cholesterol plaques). Li boetse li sebelisetsoa ho thibela mathata a atherosulinosis - khatello ea mali, lefu la pelo le ho otloa ke lefu la pelo.
Kaha ho na le phapang lipakeng tsa li-contraindication, liphetoho tse fapaneng, li-pharmacokinetics le pharmacodynamics, hoa hlokahala ho fumana hore na ke lithethefatsi life tse sebetsang le tse sireletsehileng haholoanyane.
Li-statins ke eng?
Statins e kenyelletsa sehlopha se seholo sa lithethefatsi se sebelisetsoang ho theola khatello ea mali ea LDL le VLDL maling.
Ts'ebetsong ea morao-rao ea bongaka, li-statin li ke ke tsa abjoa bakeng sa thibelo le kalafo ea atherosclerosis, hypercholisterinemia (e tsoakiloeng kapa homozygous), hammoho le mafu a pelo.
Ka kakaretso, lithethefatsi tsa sehlopha sena li na le phello e tšoanang ea kalafo, i.e. maemo a tlase a LDL le VLDL. Leha ho le joalo, ka lebaka la likarolo tse fapaneng tsa tšebetso le tse thusang, ho na le liphapang tse tlamehang ho elloa hloko ho qoba ho hlaha hampe.
Statins hangata e arotsoe ka I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) le IV moloko (Pitavastatin, Rosuvastatin).
Statins e ka ba tsa tlhaho le tsa maiketsetso. Ho setsebi, ho khethoa ha lithethefatsi tse tlase kapa tse tlase ho bohlokoa ho mokuli.
Rosuvastatin le Atorvastatin hangata li sebelisoa ho theola cholesterol. E 'ngoe le e' ngoe ea lithethefatsi e na le likarolo:
Rosuvastatin e bua ka li-statins tsa moloko oa bone. Moemeli ea fokotsang lipid o entsoe ka botlalo ka litekanyetso tse tloaelehileng tsa motsoako o sebetsang. E hlahisoa tlas'a matšoao a fapaneng a khoebo, ka mohlala, Krestor, Mertenil, Rosucard, Rosart, jj.
Atorvastatin e bua ka li-statins tsa moloko oa boraro. Joalo ka analogue ea eona, e na le tšimoloho ea maiketsetso, empa e na le tekanyetso e phahameng ea ntho e sebetsang.
Ho na le liemahale tse tšoanang le lithethefatsi tse kang Atoris, Liprimar, Toovacard, Vazator, jj.
Sebopeho sa lik'hemik'hale tsa lithethefatsi
Lithethefatsi ka bobeli lia fumaneha ka sebopeho sa letlapa. Rosuvastatin e hlahisoa ka litekanyetso tse 'maloa - 5, 10 le 20 mg ea karolo e le' ngoe e sebetsang. Atorvastatin e lokolloa ka tekanyetso ea 10,20,40 le 80 mg ea motsoako o sebetsang. Ka tlase ke tafole e bapisang likarolo tse thusang tsa baemeli ba babeli ba tsebahalang ba li-statin.
| Rosuvastatin | Atorvastatin (Atorvastatin) |
| Hypromellose, starch, titanium dioxide, crospovidone, cellcose ea microcrystalline, triacetin, magnesium stearate, silicon dioxide, daemane ea titanium, dae ea carmine. | Lactose monohydrate, sodium croscarmellose, titanium diode, hypromellose 2910, hypromellose 2910, talc, calcium stearate, polysorbate 80, cellulose ea microcrystalline, |
Phapang e kholo pakeng tsa Rosuvastatin le Atorvastatin ke thepa ea bona ea fisiks. Monyetla oa rosuvastatin ke hore e robeha habonolo plasma ea mali le maro a mang, i.e. ke hydrophilic. Atorvastatin e na le tšobotsi e 'ngoe: e qhibilihisoa ka mafura, i.e. ke lipophilic.
Ho ipapisitsoe le likarolo tsena, phello ea Rosuvastatin e lebisoa haholo ho lisele tsa "parenchyma" ea sebete, le Atorvastatin - ho sebopeho sa boko.
Pharmacokinetics le pharmacodynamics - phapang
Hona joale sethaleng sa ho nka litafole, ho na le phapang ea ho monya ha tsona. Kahoo, ts'ebeliso ea Rosuvastatin ha e ea itšetleha ka nako ea letsatsi kapa ea lijo. Atorvastatin ha ea lokela ho jelloa ka nako e le 'ngoe le lijo, joalo ka sena se ama hampe ho amoheloa ha karolo e sebetsang. Litaba tse kaholimo ho Atorvastatin li fumaneha kamora lihora tse 1-2, le Rosuvastatin - kamora lihora tse 5.
Phapang e 'ngoe lipakeng tsa li-statins ke metabolism ea tsona. 'Meleng oa motho, Atorvastatin e fetoloa sebopeho se sa sebetseng se sebelisa li-enzyme tsa sebete. Kahoo, ts'ebetso ea moriana e amana ka kotloloho le ts'ebetso ea sebete.
E boetse e angoa ke lithethefatsi tse sebelisoang ka nako e le 'ngoe le atorvastatin. Analogue ea eona, ka lehlakoreng le leng, ka lebaka la tekanyetso e tlase, ha e sebetse ka litlhare tse ling. Le ha hona ha ho mo pholohe ho ba teng ho karabelo e mpe.
Atorvastatin e pepesitsoe haholo ke bile.
Ho fapana le li-statins tse ngata, Rosuvastatin e batla e sa sebelisoe ka har'a sebete: ho feta 90% ea ntho e tlosoang e sa fetoloe ka mala mme ke 5-10% feela ke liphio.
Contraindication le liphetoho tse fapaneng
Ho ba teng ha li-contraindication le liketso tse mpe ke lintlha tsa bohlokoa ha u khetha moriana o nepahetseng ka ho fetisisa. Tse latelang ke maloetse a mantlha le moo ts'ebeliso ea lithethefatsi li thibetsoeng, hammoho le litlamorao tse ka khonehang.
| Contraindication | |
| Rosuvastatin | Atorvastatin |
| Boikutlo ba motho ka mong. Bokhachane le pelehi. Tšenyo ea hepatocytes le li-enzyme tse phahameng tsa sebete. Bana le bacha ba ka tlase ho lilemo tse 18. Myopathy kapa ho e rera esale pele. Phekolo e phethahetseng le cyclosporine le fibrate. Ho se sebetse hantle. Bokhoba ba tahi bo sa feleng Myotooticity ha u ntse u nka li-inhibitors tse ling tsa HMG-CoA inhibitors. Ts'ebeliso ea li-blocker tsa li-protein tsa HIV. Baemeli ba lebelo la Mongoloid (ke litekanyetso tse fokolang feela tse lumelloang). | Hypersensitivity ho likarolo. Keketseho ea tšebetso ea li-enzyme tsa sebete. Ho ba le ngoana le nako ea ho anyesa. Bana le bacha ba ka tlase ho lilemo tse 18, ntle le kalafo bakeng sa heterozygous hereditary hypercholesterolemia. Ho hloka thibelo ea bokhachane bo lekaneng. Ts'ebeliso ea li-blocker tsa li-protein tsa HIV. Lefu le sebetsang la sebete. |
| Lintho tse fapaneng tse tla etsahala | |
| Ho opeloa ke hlooho, mathata a khokahano, malaise ka kakaretso. Ntshetsopele ea proteinuria le hematuria. Letlalo la letlalo, likhahla, ho hlohlona. Mathata a tsamaiso ea masculoskeletal. Dyspepsia, mokokotlo o holofetseng, ho ruruha ha manyeme (pancreatitis). Mellitus e sa itšetleheng ka insulin. Khōlo ea sefuba ho banna. Ho ba teng ha khohlela e omileng, ho hema hanyane. Stevens-Johnson Syndrome. | Ntshetsopele ea nasopharyngitis, ts'oaetso ea ts'oaetso ea mofets'e. Ketsahalo ea thrombocytopenia. Hypo- le hyperglycemia, anorexia. Ho opeloa ke hlooho, paresthesia, nts'etsopele ea peripheral neuropathy, hypesthesia, amnesia, kizunguzungu, dysgeusia. Ho utloa ho senyeha, tinnitus, ho senyeha ha pono. 'Mala o bohloko, nosebleeds. Dyspeptic disorder, belching, bohloko ba epigastric, nts'etsopele ea pancreatitis. Urticaria, makhopho a letlalo, edema ea Quincke. Ponahalo ea gynecomastia. Maloetse a sa tšoaneng a tsamaiso ea musculoskeletal. Hepatitis, ho hloleha ha sebete, cholestasis. Hyperthermia, asthenia, malaise. Keketseho ea tšebetso ea li-enzyme tsa sebete, QC le tlhahlobo e nepahetseng ea leukocytes ka moroto. |
Ts'ebetso le Khopolo ea Moreki
Mosebetsi o ka sehloohong oa lithethefatsi tsa statin ke ho fokotsa khatello ea LDL maling le ho eketsa boemo ba HDL.
Ka hona, ho khetha pakeng tsa Atorvastatin le Rosuvastatin, re tlameha ho bapisa hore na ba fokotsa cholesterol hantle hakae.
Patlisiso ea saense ea morao tjena e pakile hore rosuvastatin ke sethethefatsi se sebetsang haholoanyane.
Liphetho tsa tleliniking li hlahisoa ka tlase:
- Ka litekanyetso tse lekanang tsa lithethefatsi, Rosuvastatin e fokotsa cholesterol ea LDL ka 10% ka katleho ho feta analogue ea eona. Monyetla ona o lumella tšebeliso ea moriana ona ho bakuli ba nang le hypercholesterolemia e matla.
- Khafetsa ea nts'etsopele ea mathata a pelo le ho qala ha sephetho se bolaeang e phahame Atorvastatin.
- Kotsi ea karabelo e mpe e tšoanang ho lithethefatsi tsena ka bobeli.
Ho bapisoa le katleho ea ho fokotsa khatello ea "cholesterol" e mpe "ho paka 'nete ea hore Rosuvastatin ke lithethefatsi tse sebetsang haholoanyane. Leha ho le joalo, motho ha aa lokela ho lebala ka lintho tse kang ho ba teng ha li-contraindication, litla-morao le theko. Ho bapisoa litheko tsa lithethefatsi tsena tse peli ho hlahisoa ka har'a tafole.
| Tekanyetso, palo ea matlapa | Rosuvastatin | Atorvastatin |
| 5mg No. 30 | 335 rub | - |
| 10mg No. 30 | Li-ruble tse 360 | 125 rub |
| 20mg No. 30 | 485 RUB | 150 rub |
| 40mg No. 30 | - | 245 RUB |
| 80mg No. 30 | - | 490 rub |
Kahoo, atorvastatin ke analog ea theko e tlaase eo batho ba lefuoang ka tlase ba ka e khonang.
Ke seo bakuli ba nahanang ka lithethefatsi - Rosuvastatin e mamelloa hantle ebile ha e na mathata. Ha e nkoa, k'holeseterole e mpe e ea fokotseha
Papiso ea lithethefatsi e thusa ho fihlela qeto ea hore joale boemong ba nts'etsopele ea bongaka, maemo a pele har'a matlapa a cholesterol a matle a lula ho li-statins tsa moloko oa bone. Rosuvastatin.
Mabapi le lithethefatsi Rosuvastatin le analogues ea eona li hlalositsoe videong ena.
