Li-antibodies tsa insulin ke eng? Tsena ke li-autoantibodies tseo 'mele oa motho o li hlahisang khahlanong le insulin ea eona. AT ho insulin ke letšoao le ikhethang ka ho fetisisa la lefu la tsoekere la mofuta oa 1 (lefu la tsoekere la mofuta oa pele), 'me ho ntse ho khethoa lithuto bakeng sa ho khetholla lefu lena ka bolona.
Mofuta oa 1 oa lefu la tsoekere le itšetlehileng ka insulin o hlaha ka lebaka la tšenyo ea autoimmune lihlekehlekeng tsa tšoelesa ea Langerhans. Psychology ena e tla lebisa ho haelloang ka botlalo ha insulin 'meleng oa motho.
Sena ke sona mofuta oa 1 lefu la tsoekere o hanyetsanang le lefu la tsoekere la mofuta oa 2, le sa amaneng le mathata a mangata haholo a amanang le phekolo ea meriana. Ho khetholla phapang ea mefuta ea lefu la tsoekere ho bohlokoa haholo ho tsoelopele le mahlale a kalafo e sebetsang.
Mokhoa oa ho khetholla lefu la tsoekere
Bakeng sa boikhethollo bo fapaneng ba mofuta oa lefu la tsoekere, likotsi tsa lefutso tse lebisitsoeng khahlanong le lisele tsa islet beta lia hlahlojoa.
'Mele oa batho ba lefu la tsoekere ba mofuta o le mong o hlahisa li-antibodies ho likarolo tsa manyeme ea bona. Bakeng sa batho ba nang le lefu la tsoekere la mofuta oa 2, li-autoantibodies tse tšoanang ha li senyehe.
Mofuteng oa 1 oa lefu la tsoekere, insulin e sebetsa e le autoantigen. Insulin ke autoantigen e ikhethang e ikhethang.
Hormone ena e fapana le li-autoantigener tse ling tse fumanehang ho lefu lena (mefuta eohle ea liprotheine tsa lihlekehleke tsa Langerhans le glutamate decarboxylase).
Ka hona, lets'oao le ikhethang la autoimmune pathology ea makhopho a lefu la tsoekere la 1 e nkuoa e le teko e ntle ea li-antibodies ho insulin ea lihormone.
Li-autoantibodies ho insulin li fumanoa maling a halofo ea batho ba nang le lefu la tsoekere.
Mofuteng oa 1 oa lefu la tsoekere, li-antibodies tse ling le tsona li fumanoa maling a fetiselitsoeng ho lisele tsa beta tsa manyeme, mohlala, li-antibodies ho glutamate decarboxylase le tse ling.
Hona joale nakong eo lefu lena le hlahang:
- 70% ea bakuli ba na le mefuta e meraro kapa ho feta ea li-antibodies.
- Mofuta o le mong o bonoa ka tlase ho 10%.
- Ha ho na li-autoantibodies tse khethehileng ho 2-4% ea bakuli.
Le ha ho le joalo, li-antibodies ho li-hormone tsa lefu la tsoekere ha se sesosa sa kholo ea lefu lena. Li bontša feela timetso ea sebopeho sa sele ea pancreatic. Li-antibodies ho insulin ea bana ho bana ba nang le lefu la tsoekere la 1 ba ka shebeloa hangata ho feta ho batho ba baholo.
Ela hloko! Ka tloaelo, ho bana ba nang le lefu la tsoekere la mofuta oa 1, li-antibodies tsa insulin li hlaha pele ebile li le maemong a phahameng haholo. Mokhoa o tšoanang o boleloa ho bana ba ka tlase ho lilemo tse tharo.
Ho nka likarolo tsena, tlhahlobo ea AT kajeno e nkuoa e le tlhahlobo e ntle ka ho fetisisa ea laboratori ho theha tlhahlobo ea lefu la tsoekere la mofuta oa 1 ho bana.
Ho fumana leseli le felletseng ho fumaneng lefu la tsoekere, ha ho hlalosoe feela tlhahlobo ea lithibela-mafu, empa hape le boteng ba autoantibodies mofuta o mong oa lefu la tsoekere.
Haeba ngoana ea se nang hyperglycemia a e-na le letšoao la lesapo la autoimmune la langerhans islet, sena ha se bolele hore lefu la tsoekere le teng ka mofuta oa bana ba 1. Ha lefu la tsoekere le ntse le tsoela pele, boemo ba li-autoantibodies bo ea fokotseha 'me bo ka bonahala hantle.
Kotsi ea ho fetisoa ha lefu la tsoekere la mofuta oa 1 ka lefa
Leha taba ea hore li-antibodies ho Hormone li amoheloa e le letšoao le hlahelletseng la lefu la tsoekere la 1, ho na le maemo ha ho ne ho fumanoa li-antibodies tsena mofuteng oa 2 oa lefu la tsoekere.
Bohlokoa! Mofuta oa 1 oa lefu la tsoekere o futsoa haholo. Batho ba bangata ba nang le lefu la tsoekere ke bajari ba mefuta e itseng ea mofuta o tšoanang oa HLA-DR4 le HLA-DR3. Haeba motho a e-na le baena ba nang le lefu la tsoekere la mofuta oa 1, menyetla ea hore o tla kula e eketseha ka makhetlo a 15. Karolelano ea likotsi ke 1:20.
Hangata, li-pathologies tsa immunological ka mokhoa oa letšoao la tšenyo ea autoimmune liseleng tsa li-islets tsa Langerhans li fumanoa nako e telele pele mofuta oa lefu la tsoekere la 1 le hlaha. Sena se bakoa ke taba ea hore sebopeho se felletseng sa matšoao a lefu la tsoekere se hloka ho senngoa ha sebopeho sa lisele tsa 80-90% ea lisele tsa beta.
Ka hona, tlhahlobo ea autoantibody e ka sebelisoa ho supa kotsi ea kholo ea tsoekere ea mofuta oa 1 ho batho ba nang le nalane ea lefutso e boima. Ho ba teng hoa letšoao la autoimmune lesion ea li-islet tsa Largenhans ho bakuli bana ho supa kotsi e eketsehang ea 20% ea ho ba le lefu la tsoekere lilemong tse 10 tse tlang tsa bophelo ba bona.
Haeba li-antibodies tsa 2 kapa ho feta tsa mofuta oa tsoekere ea mofuta oa 1 li fumanoa maling, menyetla ea ho hlaha ha lefu lena lilemong tse 10 tse tlang ho bakuli bana e eketseha ka 90%.
Leha taba ea hore thuto e mabapi le autoantibodies ha e khothalletsoe e le tlhahlobo ea lefu la tsoekere la mofuta oa 1 (sena se sebetsa le ho litekanyetso tse ling tsa laboratori), tlhahlobo ena e ka ba molemo ho hlahloba bana ba nang le lefutso le boima ho latela mofuta oa lefu la tsoekere.
Hammoho le tlhahlobo ea mamello ea glucose, e tla u lumella ho khetholla lefu la tsoekere la 1 pele ho hlaha lipontšo tsa kliniki, ho kenyeletsa lefu la tsoekere. Tloaelo ea C-peptide ka nako ea tlhahlobo le eona e tlōtsoe. Taba ena e bonts'a litekanyetso tse ntle tsa tšebetso e setseng ea beta-cell.
Ke habohlokoa ho hlokomela hore kotsi ea ho ba le lefu ho motho ea nang le teko e nepahetseng ea li-antibodies ho insulin le ho ba sieo ha nalane e futsanehileng ea lefutso mabapi le lefu la tsoekere la 1 ha e tšoane le kotsi ea lefu lena ho baahi.
'Mele oa bakuli ba bangata o amohela liente tsa insulin (recombinant, exo native insulin), kamora nakoana o qala ho hlahisa li-antibodies ho ea ho hormone.
Liphetho tsa lithuto ho bakuli bana li tla ba ntle. Ho feta moo, ha lia itšetleha ka hore na nts'etsopele ea li-antibodies ho insulin ke ntho ea khale kapa che.
Ka lebaka lena, tlhahlobo ha e lokele tlhahlobo e fapaneng ea lefu la tsoekere la 1 ho batho ba seng ba sebelisitse litokisetso tsa insulin. Boemo bo tšoanang bo etsahala ha lefu la tsoekere le belaela ho motho ea fumanoeng a na le lefu la tsoekere la 2 ka phoso, mme a amohela kalafo ea insulin ea 'mele ho lokisa hyperglycemia.
Maloetse a amanang le ona
Bakuli ba bangata ba nang le lefu la tsoekere la mofuta oa 1 ba na le lefu le le leng kapa a 'maloa a autoimmune. Hangata ho ka etsahala ho tseba:
- autoimmune thyroid mafu a (lefu la Graves, Hashimoto's thyroiditis);
- Lefu la Addison (bothata ba ho hloleha ha adrenal);
- lefu la celiac (celiac Enteropathy) le khaello ea mali e matla.
Ka hona, haeba tšoaetso ea autoimmune pathology ea lisele tsa beta e fumanoe mme lefu la tsoekere la 1 le tiisitsoe, liteko tse ling li lokela ho fuoa. Li hlokahala e le hore li ka kenyeletsa mafu ana.
Hobaneng patlisiso e hlokahala
- Ho qolla mofuta oa 1 le mofuta oa lefu la tsoekere ho mokuli.
- Ho bolela esale pele kholo ea lefu lena ho bakuli ba nang le nalane e futsitsoeng ea lefutso, haholoholo baneng.
Nako ea ho beha Tlhatlhobo
Tlhahlobo e fanoa ha mokuli a senola matšoao a kliniki a hyperglycemia:
- Ho eketsa molumo oa moroto.
- Nyoriloe.
- Ho fokotsa boima ba 'mele bo sa hlalosoang.
- Ho eketsa takatso ea lijo.
- Phokotso ea kutlo ea lipheletso tse tlase.
- Ho sitisoa ha pono.
- Li-uloph tsa letheka maotong.
- Maqeba a nako e telele a pholiso.
Joalokaha ho pakoa ke liphetho
Tloaelehileng: 0 - 10 Units / ml.
Pontšo e ntle:
- mofuta oa 1 lefu la tsoekere;
- Lefu la Hirat (AT insulin syndrome);
- polyendocrine autoimmune syndrome;
- boteng ba li-antibodies ho litokisetso tsa insulin tsa kantle le tse ling hape.
Sephetho se mpe:
- tloaelehileng;
- boteng ba matšoao a hyperglycemia ho supa monyetla o moholo oa lefu la tsoekere la mofuta oa 2.
