Gliclazide MB ke tlhoekiso ea molomo ea hypoglycemic e amanang le litokollo tsa molumo oa 2 oa sulfonylurea. Moriana:
- e susumetsa tlhahiso ea "insulin" ea hormone;
- e ntlafatsa phello ea sephiri sa "insulin";
- e fokotsa tsoekere ea mali;
- e phahamisa kutloisiso ea insulin ho lisele tsa thipa .;
- normalizing boemo ba ho itima lijo glycemia;
- e fokotsa tlhahiso ea tsoekere ka sebete;
- ntle le ho ama metabolism ea carbohydrate, moriana o ntlafatsa microcirculation.
Glyclazide e fokotsa menyetla ea ho bolaoa ha mali ka har'a methapo e menyenyane, e ama ka nako e ts'oanang mekhoa e 'meli e amehang ho hlahiseng mathata a lefu la tsoekere:
- inhibition e sa lekanyetsoang ea ho khomarela liplatelete le ho ikopanya;
- bakeng sa ho hlaphoheloa;
- ho fokotsa lintlha tsa ts'ebetso ea platelet (thromboxane B2, beta-thromboglobulin).
Litaelo tsa tšebeliso le lipontšo
Gliclazide hammoho le kalafo ea ho ja e laeloa lefu la tsoekere la mofuta oa 2, haeba lijo le boikoetliso li sa hlahisa litholoana tse ntle.
Contraindication
- mofuta oa 1 lefu la tsoekere;
- sensitivity e phahameng ho Glyclazide kapa likarolo tsa moriana (ho sulfonamides, ho sulfonylurea derivatives);
- ho ima le ho nyekeloa ke mpa;
- a hlobaetsang haholo hepatic kapa renal;
- ho nka miconazole;
- lefu la tsoekere;
- lefu la tsoekere;
- lefu la tsoekere la ketoacidosis;
- lilemo ho isa ho lilemo tse 18;
- khaello ea lactase;
- congenital lactose tsietsing;
- glucose-galactose malabsorption .. Lingaka ha li khothaletse tšebeliso ea lithethefatsi ka nako e tšoanang hammoho le danazol kapa phenylbutazone.
Nako e lokelang ho nkuoa ka hloko
Gliclazide e ke ke ea sebelisoa ntle le lengolo la ngaka, hobane setlhare ha se na motho e mong le e mong. Mona ke lenane la maemo ao ho ona a lokelang ho sebelisoa ka hloko:
- phepo e sa leka-lekanang kapa e sa sebetseng hantle;
- botsofali;
- hypothyroidism;
- pituitary kapa adrenal ho haella;
- mafu a matla a tsamaiso ea methapo ea pelo (atherosclerosis, lefu la pelo);
- hypopituitarism;
- kalafo ea nako e telele ea glucocorticosteroid;
- ho se sebetse hantle ha sebete kapa liphio;
- tsoekere ea glucose-6-phosphate dehydrogenase;
- bokhoba ba joala.
Ela hloko! Setlhare se laeloa feela batho ba baholo!
U ka nka joang nakong ea kemaro le kanyeso
Ha ho na datha mabapi le ts'ebeliso ea moriana nakong ea kemaro. Tlhahisoleseling mabapi le ts'ebeliso ea tse ling tse fumanoeng sulfonylurea nakong ea kemolo e lekanyelitsoe.
Lithutong tsa laboratori mabapi le liphoofolo, litlamorao tsa lithethefatsi ha lia ka tsa fumanoa. Ho fokotsa kotsi ea bofokoli ba tlhaho ea ho tsoala, o hloka taolo e hlakileng ea lefu la tsoekere mellitus (kalafo e nepahetseng).
Bohlokoa! Litlhare tsa Hypoglycemic tsa molomo nakong ea kemolo ha li laeloe. Bakeng sa kalafo ea lefu la tsoekere nakong ea kemolo, insulin ea lithethefatsi e khethoa. Ho amoheloa meriana ea hypoglycemic ho khothalletsoa hore e nkeloe sebaka ke kalafo ea insulin.
Ho feta moo, molao ona o sebetsa maemong a ha moimana a bile teng ka nako ea ho sebelisa moriana, mme haeba ho ima ho kenyeletsoa merero ea mosali feela.
Ka lebaka la taba ea hore ha ho na data ea ho ja lijo tsa lithethefatsi ka lebese la matsoele, menyetla ea ho hlaha ea "fetal hypoglycemia" ha e khetholloe. Ka hona, ts'ebeliso ea Gliclazide nakong ea matsoele e hlakotsoe.
Litaelo le litekanyetso
Matlapa a lokolotsoeng a 30 mg a lokela ho nooa nako e le ngoe ka lijo tsa hoseng. Haeba mokuli a fumana kalafo ena ka lekhetlo la pele, tekanyetso ea pele e lokela ho ba 30 mg, sena se sebetsa le ho batho ba lilemo tse fetang 65. Butle-butle fetola tekanyetso ho fihlela phello e hlokahalang ea kalafo e etsahala.
Khetho ea tekanyetso e khothalletsoa ho latela boemo ba tsoekere maling le kamora ho qala kalafo. Phetoho efe kapa efe ea kamora e latelang e ka etsoa feela kamora libeke tse peli.
Glyclazide MB e ka nkeloa sebaka ke matlapa a Glyclazide ka tokollo e tloaelehileng (80 mg) ka lethal dose ea letsatsi le letsatsi ea likotoana tsa 1-4. Haeba ka lebaka le itseng mokuli a hloloehile moriana, lethal dose le latelang ha lea lokela ho ba holimo.
Haeba matlapa a Glyclazide MB 30 mg a sebelisoa ho nkela sethethefatsi se seng sa hypoglycemic, nako ea phetoho ha e hlokehe ho sena. Hoa hlokahala feela ho phethela ho lekana letsatsi le leng le le leng la lithethefatsi tse fetileng mme feela ka letsatsi le hlahlamang ho nka Gliclazide MB.
Bohlokoa! Haeba mokuli a kile a phekoloa ka sulfonylureas ka nako e telele ea halofo ea bophelo, ho shebella ka hloko tsoekere ea mali maling ho hlokahala bakeng sa libeke tse peli.
Sena sea hlokahala e le ho qoba nts'etsopele ea hypoglycemia, e ka 'nang ea hlaha khahlano le semelo sa lits'oaetso tsa kalafo e fetileng.
Moriana o ka kopantsoe le alpha-glucosidase inhibitors, biguanides kapa insulin. Bakuli ba nang le bothata ba ho hlaphoheloa ha reisal ka bonolo kapa ka tsela e itekanetseng, Gliclazide MB e fanoa ka tekanyetso e lekanang le ea bakuli ba sebetsang hantle ba renal. Setlhare se kopantsoe le ho hloleha ho matla ha a liphio.
Bakuli ba kotsing ea ho ba le hypoglycemia
Bakuli ba kotsing ea ho ba le hypoglycemia:
- ka ho se leka-lekane kapa khaello ea phepo e nepahetseng;
- ka mathata a fokolang kapa a fokolang a endocrine (hypothyroidism, adrenal le pituitary insuffence);
- ka ho felisoa ha li-hypoglycemic agents ka mor'a ts'ebeliso ea bona ea nako e telele;
- le mefuta e kotsi ea methapo ea pelo (lefu la atherosclerosis, carotid arteriosclerosis, lefu la pelo la pelo);
Bakeng sa bakuli ba joalo, Glyclazide MB ea lithethefatsi e fanoe ka tekanyetso e fokolang (30 mg).
Litlamorao
Lithethefatsi li ka baka glycemia, e bonahatsoang ke matšoao a latelang:
- maikutlo a tlala;
- mokhathala, bofokoli bo matla;
- hlooho e opang, ho tsekela;
- ho fufuleloa ho eketsehileng, ho thothomela, paresis;
- arrhythmia, palpitations, bradycardia;
- ho eketseha ha khatello ea mali;
- ho hloka boroko, ho otsela;
- ho hloka botsitso, ho tšoenyeha, ho ba mabifi, khatello ea maikutlo;
- moferefere;
- ho tsepamisa maikutlo mohopolo;
- ho arabela butle le ho se khone ho tsepamisa mohopolo;
- litšitiso tsa maikutlo;
- ho senyeha ha pono;
- aphasia;
- tahlehelo ea boitšoaro
- maikutlo a ho hloka thuso;
- phefumoloho e sa tebang;
- cramps
- delirium;
- ho lahleheloa ke kelello, komisi.
Litla-morao:
- erythema;
- lekhopho la letlalo;
- urticaria;
- ho hlohlona ha letlalo.
Ho na le litla-morao tse tsoang ho tšilo ea lijo:
- bohloko ba ka mpeng;
- ho ruruha;
- ho nyekeloa ke pelo, ho hlatsa
- hangata "cholestatic jaundice hepatitis", empa ba hloka ho tlosoa ha moriana hanghang.
Ho sebelisa tekanyetso e phahameng le tšebelisano
Ha u na le litekanyetso tse sa lekaneng, monyetla oa ho ba le boemo bo matla ba hypoglycemic, o ka tsamaeang le mathata a methapo ea kutlo, ho akheha, ho ferekana. Ponong ea pele ea lipontšo tsena, mokuli o hloka ho kena sepetlele ka potlako.
Haeba ho kula ho belaelloa ka ho ferekanya kelello ka hypoglycemic coma kapa ho fumanoe tharollo ea 40-50% dextrose e fanoa kahare ho mokuli. Kamora moo, ba beha lerotholi le nang le tharollo ea 5% ea dextrose, e hlokahalang ho boloka phallo e tloaelehileng ea tsoekere maling.
Kamora hore mokuli a hlaphoheloe kelellong hape, e le hore a qobe ho pheta-pheta hypoglycemia, o lokela ho fuoa lijo tse nang le lik'habohaedreite tse bonolo tse jang lijo. Sena se lateloa ke ho lekola ka hloko maemo a tsoekere ea mali le ho lekola mokuli lihora tse 48 tse latelang.
Ketso tse ling, ho latela boemo ba mokuli, li khethoa ke ngaka e eang. Ka lebaka la litlama tse boletsoeng tse tlamang liprotheine tsa plasma, dialysis ha e na thuso.
Glyclazide e ntlafatsa ts'ebetso ea li-anticoagulants (warfarin), boemo feela ke hore u ka hloka ho ntlafatsa tekanyetso ea anticoagulant.
Danazole hammoho le Gliclazide ke phello ea lefu la tsoekere. Ka bobeli nakong ea tšebeliso ea danazol le ka mor'a ho khaotsa ha eona, taolo ea tsoekere le phetoho ea litekanyetso tsa glycazide lia hlokahala.
Tsamaiso ea systemic ea phenylbutazone e ntlafatsa phello ea hypoglycemic ea Gliclazide (e liehisa ho chesoa hoa 'mele, e tlosa thepa lipuisanong tsa liprotheine tsa mali. Ho hlahlojoa letheba la Glyclazide le ho lekola tsoekere ea mali hoa hlokahala. Ka bobeli ka nako ea ho nka phenylbutazone, le kamora ho e tlosa.
Ka tsamaiso ea ts'ebetso ea Miconazole le ha o sebelisa mokokotlo molomong oa molomo, e ntlafatsa phello ea hypoglycemic ea lithethefatsi, ho fihlela nts'etsopele ea komello.
Ethanol le lintho tse tsoang ho eona li ntlafatsa hypoglycemia, li ka lebisa ho nts'etsopele ea hypoglycemic coma.
Ha e sebelisoa hammoho le lithethefatsi tse ling tsa hypoglycemic (biguanides, acarbose, insulin), fluconazole, beta-blockers, H2-histamine receptor blockers (cimetidine), angiotensin-converting enzyme inhibitors (enalapril, Captoprilamide antioxidants, non-steroidal sulfide inhibitors hypoglycemic effect, ka ho latellana, kotsi ea hypoglycemia.
Chlorpromazine ka litekanyetso tse kholo (tse fetang 100 mg / ka letsatsi) e eketsa tsoekere e maling, e thibelang sephiri sa insulin. Ka bobeli nakong ea ts'ebeliso ea chlorpromazine, mme kamora ho itokolla, taolo ea tsoekere le phetoho ea tekanyetso ea Glyclazide lia hlokahala.
GCS (rectal, ntle, intraarticular, systemic) e eketsa tsoekere ea mali ka nts'etsopele ea ketoacidosis. Ka bobeli nakong ea ts'ebeliso ea GCS le kamora ho tlohela, taolo ea tsoekere le phetoho ea tekanyetso ea Gliclazide lia hlokahala.
Terbutaline salbutamol, ritodrin kahare - eketsa tsoekere ea mali. Ho laoloa ha tsoekere maling ho hlokahala 'me ha ho hlokahala, phetoho ea kalafo ea "insulin".
Litlhahiso tse khethehileng le foromo ea tokollo
Motsoako oa Gliclazide MB o sebetsa hantle feela ha o kopana le lijo tse nang le khalori e fokolang, e nang le lik'habohaedreite tse nyane. Ho lekola khafetsa khatello ea tsoekere, ka mpeng e se nang letho le ka mor'a lijo, hoa hlokahala. Sena se bohlokoa haholo sethaleng sa kalafo.
Nakong ea kalafo le sethethefatsi, e le ho qoba likotsi le likotsi tseleng, ho khothalletsoa ho qoba ho khanna likoloi le ho sebetsa ka mekhoa e kotsi e hlokang tlhokomelo e phahameng le lebelo la karabelo.
Matlapa a 30 mg, a pakiloe ka marang-rang a likotoana tse 10.
Bophelo ba sehatsetsing ba Gliclazide ke lilemo tse 3, kamora moo bo ke keng ba sebelisoa. Setlhare se lokela ho bolokoa sebakeng se omileng, se lefifi le se phodileng, se sa fumaneheng ho bana.
Libakeng tse fapaneng tsa naha, theko ea lithethefatsi e fapana ho tloha ho li-ruble tse 120 ho isa ho tse 150. Re bua ka lipakete tse nang le matlapa a 60. Ho na le ho paka ka har'a makotikoti a polymer. Pitsa e le 'ngoe kapa marang-rang a le 1 ho isa ho a tšeletseng e kentsoe lebokose la karete.
Phapang ea theko e latela lintlha tse fapaneng: moetsi, sebaka, boemo ba k'hemisi.
