Litaelo tsa ho sebelisoa Glidiab MV

Phekolo ea lefu la tsoekere ha se phetoho ea lijo feela, empa le ts'ebeliso ea meriana e khethehileng.

Ka lefu la mofuta oa 2, hangata batho ba fuoa litlhare ho fihlela litekanyetso tse tloaelehileng tsa glycemia. Motsoako o mong o joalo ke Glidiab MV.

Tlhahisoleseling ka kakaretso, sebopeho le mofuta oa tokollo

Lithethefatsi Glidiab MV ke e 'ngoe ea litokollo tsa sulfonylurea (meloko e 2), ka hona e reretsoe ho susumetsa lisele tsa beta tse fumanehang manyeme.

Lithethefatsi li hlahisoa tikolohong ea Moscow ke k'hamphani ea meriana Akrikhin mme e nkuoa e le analogue ea matlapa a hypoglycemic Diabeteson MV, e entsoeng Fora. Moemeli o na le foromo ea tekanyetso e khetholloang ka tokollo e fetotsoeng.

Setlhare se fumaneha ka mokhoa oa matlapa a nang le whitish tint. Li tšoana le ponahalo ea meqomo ea litebele. Setlhare sena se fumaneha ka mekotla ea matlapa a 30 kapa 60.

Ha e bapisoa le Diabeteson MV, e nang le litekanyetso tsa 0,06 g, Glidiab MV e na le halofo ea karolo e sebetsang (0,03 g).

Moetso:

• Gliclazide ke eona ntho ea mantlha;
• selulose (microcrystalline);
• hydroxypropyl methylcellulose;
• magnesium stearate;
• Aerosil;

Bakuli ba bangata ba fuoe Glidiab 80, e nang le ntho e sebetsang, eseng 30 mg, empa 80 mg ka ho e 'ngoe.

Ketso ea pharmacological

Likarolo tsa Glidiab MV li ama 'mele ka tsela e latelang:

• potlakisa secretion ea insulin e hlahisoang ka har'a manyeme;
• eketsa kutloisiso ea lithane ho qoqotho e hlahisitsoeng;
• fokotsa sekhahla ho tloha motsotso oa lijo tseo motho a li jang ho fihlela a tsoa insulin;
• tlasa tšusumetso ea lithethefatsi tsena, secretion ea insulin e khutlisetsoa methating ea pele ho bapisoa le sulfonylureas e ngoe;
• ntlafatsa li-microcirculation ka lebaka la ho ts'oaroa ha lisele tsa liplatelete, ho khutlisetsoa hoa boteng ba methapo ea methapo le kotsi e tlase ea micothrombosis;
• fokotsa glycemia;
• kenya letsoho ho feliseng protenuria;
• liehisa nts'etsopele ea retinopathy;
• kenya letsoho ho fokotsa boima ba 'mele, ho latela lijo tse tlamang.

Mofumahali

Ts'ebetso ea ho monya, ho ajoa hoa 'mele, metabolism le phello ea likarolo li etsahala ka tsela e latelang:

1. Suction. Setlhare se batla se anngoe ka ho felletseng ka tšilo ea lijo (gastrointestinal tract). Ts'oarello ea eona e eketseha ka plasma hanyane ka hanyane, e fihla hofihlella ho tloha motsotso oa tsamaiso kamora lihora tse 6 kapa tse 12. Lits'ila ha li ame sekhahla sa ho amoheloa. Moriana o sebetsa lihora tse 24.
2. Tsamaiso. Puisano le liprotheine tsa plasma le likarolo tsa lithethefatsi li behiloe ho 95%.
3. Metabolism. Ts'ebetso ena e etsahala sebeteng, e khetholloang ka ho thehoa ha li-metabolites tse lumellanang.
4. Ho tsala. Excretion e etsahala ka liphieng ka sebopeho sa metabolites, ke 1% feela ea moriana o tsoang ka moroto. Ho felisoa ha halofo ea bophelo ba lithethefatsi ho etsahala ka lihora tse 16.

Mekhoa ea drugacokinetic ea lithethefatsi ho bakuli ba tsofetseng ha e fetohe.

Matšoao le contraindication

Matlapa a Glidiab MV ke lithethefatsi tsa hypoglycemic, ka hona, li sebelisoa kalafong ea lefu la tsoekere la mofuta oa 2, ha mekhoa e meng ea ho fokotsa tsoekere e sa khutlisetse letšoao ho tloaelehileng.

Lintho tse amanang le tšebeliso ea lithethefatsi ke tsena:

• ketoacidosis;
• ts'ebetso ea menoana e sa sebetseng;
• Mofuta oa 1 lefu la tsoekere;
• coma (lefu la tsoekere kapa hyperosmolar);
• ts'ebetso;
• likotsi
• makhopho a sitisang;
• boimana
• maemo a bakang hypoglycemia (mohlala, mafu a mofuta o sa foleng);
• leukopenia;
• ho chesa ho hoholo;
• hypersensitivity ea lintho tse sebopeho sa sehlahisoa;
• sefuba.

Litaelo tsa tšebeliso le litaelo tse ikhethang

Tekanyetso ea moriana e ipapisitse le litšobotsi tsa mofuta oa lefu la tsoekere le lipontšo tsa lona, ​​ka hona le khethoa ke ngaka ka bonngoe ho mokuli ka mong.

Qalong ea ho sebelisa moriana o nooa moriana oa 30 mg kapa 1 pilisi. Ho latela boemo ba mokuli nakong ea phekolo, palo ea lintho tse sebetsang ka letsatsi e ka nyoloheloa ho 120 mg (lethal dose le phahameng).

Matlapa a nooa ka molomo nakong ea lijo tsa hoseng (hang ka letsatsi). Ho senyeha ha renal (e nang le creatinine ho tloha ho 15 ho isa ho 80 ml / min) ha ho hloke tokiso ea tekanyetso.

Qalong ea kalafo ea lithethefatsi le ho fihlela lethalamo le hlokahalang le khethoa, hangata bakuli ba nang le hypoglycemia ha baa lokela ho etsa mosebetsi o hlokang karabelo e potlakileng kapa tlhokomelo e eketsehileng.

Basali ha ba khone ho sebelisa lithethefatsi nakong ea ho beleha ngoana, hammoho le matsoele.

Tekanyo e mpe ea liphio kapa sebete e thibela ts'ebeliso ea moriana esita le litekanyetso tse fokolang.

Melao ea kopo:

1. Ntho ea bohlokoa e hlokahalang bakeng sa ho fihlela katleho ea kopo ke ho latela mokhoa oa ho ja le ho ikoetlisa ka tsela e itekanetseng. Lijong tsa letsatsi le letsatsi, lik'habohaedreite li lokela ho ba teng ka tekanyo e fokolang.
2. Ho bohlokoa hore glycemia e hlahlojoe pele le ka mor'a lijo, e le hore litekanyetso li ka fetoloa ho latela sephetho sa litekanyo.
3. Bakeng sa ho buuoa kapa lefu la tsoekere le bolileng, moriana o lokela ho nkeloa sebaka ka ente ea insulin.
4. Bakeng sa ho qoba ho hlaha ha hypoglycemia, hammoho le karabelo e kang ea discriram, u se ke ua noella joala.
5. Ho thibetsoe ho tlola lijo, ho qoba ho ja lijo tse bobebe ka nako ea tlala.
6. Pele ho mosebetsi o boima oa 'mele, tekanyetso e lokela ho fokotsoa.

Lithethefatsi tse amehang ka ho fetisisa ho li-hypoglycemic ke:

• batho ba botsofaling;
• bakuli ba sa tsebeng ho ja ka mokhoa o leka-lekaneng;
• batho ba nang le mmele o fokolang;
• bakuli ba nang le lefu le kang pituitary-adrenal insufficiency.

Litla-morao le ho sebelisa overdose haholo

Ho nka litafole ho ka baka karabelo e latelang ho motho:

• mabapi le ts'ebetso ea endocrine - hypoglycemia e nang le maikutlo a hlooho ea hlooho, ho fufuleloa, bofokoli, khatello ea maikutlo, ho thothomela, ho ferekana ha kelello, pono e sa sebetseng le tšebelisano ea motsamao;
• ho tloha ka lehlakoreng la ho cheka - dyspepsia, anorexia, ho ferekana sebeteng;
• leukopenia, thrombocytopenia, anemia;
• lipontšo tsa lintho tse kulang (ho hlohlona, ​​lekhopho, kapa urticaria).

Ka moriana o feteletseng oa lithethefatsi, hypoglycemia e etsahala. Ho felisa matšoao a eona, ho lekane ho nka lik'habohaedreite tse ngata, ha feela motho a tseba. Maemong moo mokuli a ke keng a hlola a ja lijo a le mong, o lokela ho fuoa tharollo ea glucose e kenang (40%) le ente ea ente ea glucagon. Kamora ho khutlela ho motho ea nang le lefu la tsoekere, o hloka setlamo se seng hape ho qoba ho theoha ha tsoekere e ngata khafetsa.

Tšebelisano le meriana e meng le li-analogues

Ts'ebeliso ea lithethefatsi tse ling hammoho le Glidiab MV e ka ntlafatsa kapa ea fokotsa sephetho sa hypoglycemic.

Phekolo e kopaneng le lithethefatsi tse kang:

• Li-inhibitors tsa ACE;
• li-antifungal agents (fluconazole);
• Li-NSAID;
• antihistamines;
• Fibrate;
• lithethefatsi tse khahlanong le lefuba;
• Salicylates;
• Pentoxifylline;
• Ethanol;
• lithethefatsi tse thibelang secretion ea tubular.

Phello ea hypoglycemic e hatelloa ha e kopantsoe le litlhare tse latelang:

• barbiturates;
• li-thiazide diuretics;
• Furosemide;
• lihormone ho boloka tšebetso ea qoqotho;
• Litokisetso tsa lithium;
• estrogens;
• mekhoa ea ho thibela pelehi ka molomo.

Har'a litlhare tse nang le litlamorao tse tšoanang le tsa Letlapa la Glidiab MV, ho latela hangata ho fanoa ka tse latelang:

• Meglimide;
• Aletare
• Glibetic;
• Clay;
• Glimepiride;
• Eglim;
• Glairie
• Glibenclamide;
• Glurenorm.