Thioctic acid ke ntho e kang vithamine, antioxidant ea endo native. Foromo ea litekanyetso ke lithethefatsi tsa khetho ho phekolo ea ho hlohlona ha mmele (endothelioneural dysfunction) (ho senyeha hoa tšilafalo le boemo ba methapo ea methapo ka lebaka la phokotso ea phepelo ea mali ka lebaka la methapo ea methapo ea methapo le khatello ea methapo.
Lebitso
Lipoic acid, alpha lipoic acid, thioctacid ke lipapatso tsa thioctic acid.
Ka Senyesemane, ntho ena e bitsoa Thioctic acid. Ka Latin - Acidum thiocticum (genus Acidi thioctici). Lebitso la khoebo le ka fapana (Oktolipen, Berlition 600, jj.).
Thioctic acid ke ntho e kang vithamine, antioxidant ea endo native.
ATX
Khoutu ea ATX ke A16AX01.
Lokolla liforomo le sebopeho
E fumaneha joalo ka:
- lipilisi
- tharollo ea ente, 1 ml e na le 25 mg ea α-lipoic acid;
- tsepamisa maikutlo bakeng sa tharollo ea infusion.
Thioctacid e fumaneha ka mokhoa oa matlapa a koahetsoeng.
Lipilisi
Thioctacid e fumaneha ka mokhoa oa matlapa a koahetsoeng ka tekanyetso ea 200 le 600 mg ea ntho e sebetsang.
Phofo
Ka mokhoa oa phofo, ntho ea kalafo ha e sebelisoe, hobane qhibilihang feela ka har'a ethanol.
Ketso ea pharmacological
Ho ba antioxidant ea tlhaho, thioctacid e thibela ts'ebetso ea ntho ea nyutlelie kappa-bi ka lebaka la radicals ea mahala. Ho tlola molao oa eona ho baka mafu a autoimmune, ho potoloha ha lisele le apoptosis (lefu) la lisele.
Kameho ea nalological e bakoa ke thepa ea eona:
- ho nka karolo karabong ea decarboxylation ea alpha-keto acid - ho netefatsa phapanyetsano ea matla le ho thibela DKA;
- bokhoni ba ho theola boemo ba mafura acid, cholesterol;
- antioxidant - ho tlangoa ha li-radicals tse mpe, 'mala o phefumolohang, tsosoloso ea glutathione;
- khatello ea mofuta oa nitric oxide ka lisele tsa sebete - thibelo le khutso ea phlebopathy;
- radioprotective.
Ka ho sebetsa ka endothelium ea methapo ea mali, acid ea lipoic (thioctic) e fokotsa tšenyo ea karolo e kahare ea eona, e fokotsa lumen, fragility le kotsi ea ho bolaoa ha mali.
Ka lebaka la thepa ena ea thioctacide, lithethefatsi li na le tšusumetso e ngata 'meleng:
- e tsamaee phallo ea mali a neural;
- e thibela ho hatelloa ha NO synthetase, e thibelang tšenyo ea ischemic ho lithane tsa tsamaiso ea methapo;
- e potlakisa boits'oaro ba methapo ea kutlo;
- e tsamaisa mosebetsi oa glutathione;
- e thibela tšenyo ea ho senya lisele.
Sephetho sa tšebetso ea moemeli ke:
- normalization ea k'holeseterole;
- fokotseha ho hanyetsa insulin;
- taolo e eketsehileng ea glycemic;
- tšireletso ea "isanc" ea pancreatic e hlahisang insulin;
- ho fokotseha ha maemo a lipid, a hlalosang phello e ntle ea kalafo ea botenya;
- thibelo ea edema ea sele ka lebaka la ho bokellana ha sorbitol ho tsona;
- ntlafatso ea thepa ea maemo a phahameng le ho thothomela ha methapo ea mali;
- phokotso ea lintho tse khahlanong le ho ruruha ka plasma ea mali;
- ho ntlafatsa ts'ebetso ea detoxification ea sebete, tlhahiso ea li-acid acid le ho sireletsa sebopeho sa sele ea setho hore e se ke ea senyeha.
Ho sebetsa ka endothelium ea methapo ea mali, acid ea lipoic (thioctic) e fokotsa tšenyo ea karolo e kahare ea eona, e fokotsa lumen, brittleness le kotsi ea ho soetseha ha mali, lits'ebetso tsa ho ruruha.
Asiti e hlola habonolo litšitiso tsa mali le bokong, tse etsang hore e sebetse hantle kalafong ea encephalopathy le lefu la methapo ea methapo: Alzheimer's and Parkinson's.
Mofumahali
Ha ho nooa ka molomo, moriana o se o kenelle ka botlalo mokhoeng oa ho silila. Ts'ebetso ea kopanelo ea sethethefatsi ka lijo e fokotsa matla a eona a lijo. Ts'ebetso ea Peak (Cmax) ea moriana e bonoa kotara ea hora kapa hora kamora ts'ebetso. Sebeteng, biotransformation ea alpha lipoic acid e etsahala nakong ea karolo ea pele ka marako a mala, sebete, matšoafo, e leng ho eketsang bioavailability ea ntho ho fihlela 30-60%.
Ha ho nooa ka molomo, moriana o se o kenelle ka botlalo mokhoeng oa ho silila.
Vp ea eona (bophahamo ba modumo) e batla e le 450 ml / kg, e bonts'a phokotso e pharalletseng ea lithethefatsi liseleng tsa 'mele. Nako ea halofo ea bophelo (T1 / 2), kapa nako ea ho lahleheloa ke ts'ebetso ea 50%, ea lipoic acid ke metsotso e 20-50, eo ka lebaka la ho felisoa ha lihlahisoa tsa phetoho ea ntho e etsahalang sebeteng ka liphio. Sekhahla sa tlhoekiso ea plasma ea mali (Cl plasma) ho tsoa ho sethethefatsi ke 10-15 ml / min.
Se hlokahalang bakeng sa
Thioctacid e sebelisoa kalafo ea maloetse a bakoang ke khatello ea oxidative, hyperinsulinemia, ho hanyetsa insulin, ho hloka taolo ea endothelial. E sebelisoa kalafo ea:
- Bakuli ba nang le lefu la tsoekere le mathata a lona, a kang:
- lefu la tsoekere la polyneuropathy;
- lefu la tsoekere le amanang le lefu la tsoekere;
- lefu la sebete la mafura ho bakuli ba hanyetsang insulin;
- lefu la tsoekere la retinopathy;
- cardiovascular autonomic neuropathy;
- botenya
- Polycystic ovary syndrome ho basali.
- Maloetse a sebete a bakoang ke ho taoa ke joala, tšepe e boima, chefo ea tlhaho; kenyelletso ea moemeli oa vaerase (hepatitis C, B) e sa foleng.
- Alcoholic pancreatitis.
- Rheumatoid Arthritis.
Ntho, e nang le bokhoni ba ho tsamaisa lik'habohaedreite le metabolism ea mafura, e sebelisoa e le karolo ea lijo ho fokotsa boima le ho phekola botena.
Ho cosmetology, asene e sebelisoa bakeng sa:
- felisa ho ruruha;
- ts'ireletso litlamorao tsa lintho tse mpe tse kantle tse bakang makhopho, ho fifala ha letlalo;
- ho hlakisoa, ts'ireletso ea UV;
- nchafatso ea mesifa;
- glycation inhibition - ketso ea "gluing" likhoele tsa "collagen" tse nang le tsoekere;
- ntlafatso.
Ntho ena e ntlafatsa phello letlalong le 'meleng oa vithamine D, ascorbic acid le tocopherol.
Lihlahisoa tsa litlolo ha li na 10% lipoic acid ho latela Molao oa EU. Ts'ebeliso ea bona e bonts'oa basali ba nang le letlalo la botsofe, khatello ea maikutlo, tloaelo ea ho ruruha, ho teneha. Hape, litlolo tse nang le thioctacid li sebelisoa haeba letlalo le na le oli, le pores e holisitsoeng le makhopho.
Contraindication
Kaha lipoleic acid ka bongata bo hlokahalang e ka etsoa ka mokhoa o tsoileng 'meleng oa motho, ha e na tšebeliso ea letho. The contraindication e ka sehloohong ke hypersensitivity ho ntho. Sebelisa lithethefatsi ka hloko le:
- ho ima le ho nyekeloa ke mpa;
- lilemo tsa mokuli li ka fihla ho lilemo tse 6.
The contraindication e ka sehloohong ke hypersensitivity ho ntho.
Meeli e bakoa ke khaello ea boiphihlelo ba ho sebelisa lithethefatsi ho bakuli ba lihlopha tsena le ho se be le liphetho tse lekaneng tsa polokeho.
Ka kalafo ea pilisi, boteng ba lactose e le filler bo lokela ho tsotelloa. Morero oa lintho tse joalo o tšoaetsanoa ho bakuli ba nang le malabsorption - lefutso la lefutso la lefutso.
Mokhoa oa ho nka acid ea thioctic
Phekolo e qala ka ts'ebeliso ea thioctic acid ka tsamaiso ea methapo kapa ea infusion. Ha boemo bo tsitsa, ho fanoa ka phekolo ea ho hlokomela matlapa ka matlapa.
Ha ho etsoa tharollo ea infusion e tsoang ka har'a li-ampoules, lintho tse kahare tsa eona li hlapolotsoe ka tharollo ea letsoai - NaCl tharollo.
Bakeng sa tsamaiso ea metheo (ka molomo), ho latela likeletso tse latelang:
- ho ja pele ho lijo hang ka letsatsi;
- u se ke oa qhekella, ua metsa, u noe metsi a mangata;
- kamora halofo ea hora o hloka lijo tsa hoseng;
- tekanyetso e phahameng ea letsatsi le letsatsi hangata ha e felle ho 600 mg ea thioctacide;
- Nako ea kalafo ke likhoeli tse 3 ho latela lipontšo, nako ea kalafo e ka eketsoa.
Phekolo e qala ka ts'ebeliso ea thioctic acid ke tsamaiso ea methapo ea moemeli.
Phekolo ka matlapa a fanoa kamora ho ea thupelong ea libeke tse 2 ea 4 ea tsamaiso ea moriana kapa infusion.
Kahare, moriana o fanoa butle ho qoba litla-morao. Lerotholi le laoloa ho kenyelletso ea butle-butle. Bophahamo ke 300-600 mg.
Thioctic acid e boetse e sebelisoa bakeng sa tsamaiso ea methapo. Ho qoba karabelo e mpe, ha ho khothalletsoe ho enta tharollo e fetang 2 ml sebakeng se le seng.
Thioctic acid e hahang mmele
Ka ho haha 'mele, koetliso ea matla le lipapali tsa setsebi, thioctacid e sebelisoa ho fokotsa khatello ea maikutlo ka mor'a ho ikoetlisa haholo. Bokhoni ba ho fokotsa ts'ebetso ea tsoekere le ho bo fetisetsa ho lisebelisoa tse nang le matla a mangata le bona bo na le karolo ea bohlokoa: thepa ena ea meriana e thusa ho fana ka matla ho mesifa ea marapo le ho fumana sephetho se phahameng ho tloha thupelong. Ntle le moo, asiti e ntlafatsa thermogenesis, e thusa ho tlosa litšenyehelo tsa mafura libakeng tsa mathata, ka hona ha e fuoe feela lipapaling, empa le bakeng sa ho fokotsa boima ba 'mele.
Ka ho haha 'mele, koetliso ea matla le lipapali tsa setsebi, thioctacid e sebelisoa ho fokotsa khatello ea maikutlo ka mor'a ho ikoetlisa haholo.
Baatlelete ba baholo ba bontšoa tekanyetso ea 50 mg makhetlo a 3-4 ka letsatsi halofo ea hora ka mor'a lijo. Ka boikoetliso bo matla, palo ea meriana e eketsoa ho 300-600 mg ka letsatsi.
Ho nka moriana oa lefu la tsoekere
Ho lefu la tsoekere mellitus, lithethefatsi li qala ho sebelisoa ka mokhoa oa botsoali (ka ho tšela mala). Ho tsepamisa mohopolo ho kenngoa ka 100-250 mg ea 0,9% ea sodium chloride mme ka bongata ba 600 mg e tsamaisoa ka mokhoa o thellang ka matsatsi a 15. Moriana o fanoa ka potoloho ea matsatsi a 5 le matsatsi a mabeli pakeng tsa 'ona. Ka kakaretso, ho sebelisoa li-ampoules tse 15 bakeng sa kalafo.
Kamora ho phethoa ha kalafo ea ente, mokuli o fetisetsoa matlapeng a thioctacid, 1 pc. letsatsi pele ho lijo tsa hoseng.
Ho lefu la tsoekere mellitus, lithethefatsi li qala ho sebelisoa ka mokhoa oa botsoali (ka ho tšela mala).
Ho fokotsa tsoekere le ho etsa hore tlhahiso ea hau e sebetse hantle ho ka hloka tokiso ea litheko tsa litlhare tse theolelang tsoekere. Mathateng a tebileng, kalafo e ka ba likhoeli tse 3-5.
Litlamorao
Litlamorao tse mpe li bonoa nyeoeng e le 'ngoe ho bakuli ba 10,000. E bonts'itsoe ka mokhoa oa:
- allerg ea letlalo;
- hypoglycemia;
- ka ts'ebeliso ea molomo, mathata a dyspeptic, ho otla ha pelo, bohloko ba epigastric lia khoneha;
- ka iv, ho tsitsipana, ho phahama ha khatello ea mali le khatello ea methapo, pono e habeli, ho koaleha moea, ho ruruha, le ho ruruha ho ka hlaha.
Lipontšo li nyamela ha tekanyetso e fokotsehile kapa kamora hore tsamaiso ea ntho e emisoe.
Litaelo tse khethehileng
Bakuli ba nang le lefu la tsoekere ba lokela ho lekola maemo a tsoekere kamehla. Litharollo tse lokiselitsoeng li na le tšusumetso e matla haholo, ka hona li sebelisoa hang kamora ho tlosoa kapa ho sireletsoa ka skrini se senang khanya.
Tekanyo ea joala
Moriana ona ha o lumellane le joala, hobane ethanol e fokotsa katleho ea ho pepeseha.
Tšusumetso ho bokhoni ba taolo ea methapo
Ha e ame ka kotloloho boemo ba methapo ea methapo, empa lipontšo tse mpe tse ka bang teng li hloka tlhokomeliso nakong ea kalafo.
Sebelisa nakong ea bokhachane le pelehi
Hoa amoheleha ho fana ka moriana nakong ea boitšisinyo haeba molemo oa kalafo o feta likotsi tse ka bang teng. Maemong ha ho hlokahala kalafo ha ho anyesa, ho hlokahala hore o fetisetse lesea ho fepa ka maiketsetso.
Hoa amoheleha ho fana ka moriana nakong ea boitšisinyo haeba molemo oa kalafo o feta likotsi tse ka bang teng.
Ho laela bana ba thioctic acid
Litaelo tsa tšebeliso ea lithethefatsi ha li khothaletse tšebeliso ea tsona ho bana bao lilemo tsa bona li ka tlase ho lilemo tse 6. Leha ho le joalo, ho latela lipontšo, sethethefatsi se ka laeloa ka palo ea:
- 0.012 g makhetlo a 2-3 ka letsatsi ho bana ba ka tlase ho lilemo tse 7;
- 0.012-0.024 g makhetlo a 2-3 ka letsatsi bakeng sa bana ba ka holimo ho lilemo tse 7.
Bongata
Monyetla oa tšebeliso e ngata ea bongoana e nyane, empa ha motho a e-na le boits'oaro kapa a tlola melaoana ea tsamaiso, ho ka etsahala tse latelang:
- hlooho e bohloko
- ho nyekeloa le pelo le ho hlatsa.
Tabeng ea botahoa, kalafo e etsoa ka sepheo sa ho emisa matšoao.
Ka moriana o feteletseng oa lithethefatsi, hlooho ea hlooho e hlaha.
Ho sebelisana le lithethefatsi tse ling
Acid ha e tsamaisane le:
- Tharollo ea Ringer le li-ejenti tse ling tse nang le calcium le magnesium;
- litokisetso tsa tšepe;
- ethanol.
Moriana o ntlafatsa phello ea li-insulin le li-agents tsa hypoglycemic tsa molomo.
Li-analog
Li-analogue tsa Acidum thiocticum ke meriana:
- Alpha lipon;
- Berlition;
- Thioctacid;
- Thiogamma;
- Oktolipen;
- Lipoic acid, lebitso le tloaelehileng ke vithamini N;
- Lipothioxone;
- Neuroleipone;
- Sepolotiki.
Lipehelo tsa khefu ea Pharmacy
Ka lengolo la ngaka.
A na nka reka ntle le lengolo la ngaka?
Che.
Theko ea thioctic acid
Ho latela moetsi le mofuta oa tokollo, theko ea moriana e fapana ho tloha ho 40 (matlapa a 50) ho isa ho li-ruble tse 2976 (100). Thioctacid 600 ho ampoules e bitsa li-ruble tse 1,539. bakeng sa ho paka. Ukraine, theko e tsoa ho 92 ho isa ho 292 UAH.
Maemo a polokelo
Lenane la B - Boloka sebakeng se pholileng, se lefifi.
Setlhare se lokolloa feela ha mokuli a e-na le lengolo la ngaka.
Letsatsi la ho felloa ke nako
Lilemo tse 3
Thioctic Acid Litlhahlobo
Ke khale lithethefatsi li sa baketse ngangisano har'a basebelisi le litsebi. Mme ponahalo ea mefuta ea sejoale-joale e nang le litlamorao tse fokolang e lebisa ho litlhahlobo tse ntle.
Lingaka
Elena Sergeevna, setsebi sa bongaka, Kiev: "Ke lefu la tsoekere 'me ke bone tšebetso ea thioctic acid, ka hona, ka letsoalo le hlakileng, ke beha Thioctacid BV ho bakuli."
Inga Olegovna, setsebi sa endocrinologist, Kostroma: "Ts'ebetsong ea ngaka, ho bohlokoa ho ba le bonnete ba ts'ebetso le polokeho ea moriana. Ke lula ke kholoa hore na litholoana tsa kalafo ka lithethefatsi tsa Thioctacid BV li phatlalalitsoe joang."
Bakuli
Mirra ea lilemo li 45, Krivoy Rog o re: "Likhoeling tse tšeletseng tse fetileng, ke ile ka qala ho ikutloa ke ts'oeroe ke menoana le matsoho. Ngaka e ile ea re sesosa ke lefu la tsoekere, 'me ka re ke ngole halofo ea matlapa a Thioctacid BV. Ke noele halofo feela,' me bophelo ba ka bo ntlafala haholo."
Oksana, ea lilemo li 31, Odessa: "Litaelo li bontša hore ho kulisoa hoa khoneha, empa meriana ha e-so ka ea baka matšoao a bobebe, leha ke le motho ea kulang le ea nang le boiphihlelo."
Anna, ea lilemo li 40, Kazan: "Ntle le lefu la tsoekere, ho na le mathata a maholo a mokokotlo. Ke ntse ke e-noa moriana o fetang likhoeli tse 3. Le ha ke e-noa meriana e meng e mengata ntle le eena, ho ne ho se na litla-morao, esita le boima bo ile ba fokotseha hanyane ntle le lijo tse itseng. "
