Tricyclic antidepressant e nang le antihistamine, ketso ea anticholinergic. E sebelisoa ho phekola maemo a sithabetsang feela, empa le somatoform neuroses e nang le tšenyo ea mokhoeng oa ka mpeng, tsamaiso ea bronchopulmonary le litho tse ling.
Lebitso
Lebitso la machabeng: Amitriptyline.
ATX
Li-antidepressants, N06A A09.
Lokolla liforomo le sebopeho
Lipilisi
25 mg ea ntho e sebetsang ka har'a letlapa le le leng e fumaneha lipaketeng tsa 20, 50, 100 likhomphutha.
Amitriptyline e sebelisetsoa ho phekola maemo a sithabetsang feela, empa le somatoform neuroses.
Liforomo tse seng teng tsa tokollo
Tharollo ea 10 mg / ml 10 ampoules ea 2 ml ea liente tsa intramuscular. Dragees bakeng sa bana ba 10 le 25 mg, sephutheloana sa li-pcs tse 50.
Mokhoa oa ketso
Tricyclic e kopaneng. Phello ea eona e lemohuoa ka lebaka la ho thibela ho khutlisoa hape ha li-neurotransmitters - adrenaline, norepinephrine, serotonin, dopamine. Ka lebaka leo, lintho tse thathamisitsoeng li ka har'a selekane sa synaptic nako e telele 'me lia bokellana. Mocheso oa ntlafala, tšebetso ea boko ea mpefala.
E na le anticholinergic, antihistamine athari, ka lebaka eo e sebelisoa e le pilisi e loantšang khatello, e khahlanong le ho tšoenyeha le ho robala. Ke tatelano ea nako, e lokisa boemo bo sithabetsang bo nang le boikemelo le lithibelo tsohle. Liphetho tse susumetsang le tse thibelang ts'ebetsong ea methapo ea methapo li itšetlehile ka tekanyetso.
Mofumahali
E qotsitsoe pampiring ea tšilo ea lijo. Ts'oarello e kholo e fihlella lihora tse 2-12 kamora hore li tsamaisoe. Lijo ha li ame ho amoheloa ha moriana. Boholo ba eona - 92-95% e hokahana le liprotheine tsa plasma.
E kenella ka har'a mali le bokong ba hematoplacental, hape le ka lebese la matsoele.
Metabolism e etsahala ka har'a sebete, e pepesitsoeng ke liphio. Ho felisoa ha halofo ea bophelo ke lihora tse 40-75.
Se hlokahalang bakeng sa
E bua ka psychoanaleptics. E sebelisoa kalafo ea khatello ea maikutlo ea etiology efe kapa efe, haholo-holo ea ka morao, eo ho leka-lekana li-neurotransmitters. E sebelisoa bakeng sa asthenovegetative syndrome, schizophrenic psychosis, mathata a kelello, a tsamaeang le matšoenyeho, ho hloka boroko.
Amitriptyline e sebelisetsoa mafu a kelello a tsamaeang le matšoenyeho.
Joaloka sesebelisoa se nang le ts'ebetso ea anticholinergic, e thusa ho imolla mats'oafo ka ho teneha 'mala, "hyperactive neurogenic senya". E na le phello ea anti-inflammatory ka lebaka la phello ea antihistamine.
Fokotsa acidity ea ka mpeng, e bonts'a phello ea thibelo ea M-anticholinergic le H1-histamine, e e lumellang hore e sebelisoe bakeng sa liso tsa ka mpeng le liso tsa duodenal (joalo ka lipontšo tsa somatoform neurosis).
E sebelisoa bakeng sa asthma ea bronchial - e na le phello ea antigergic mme e atolosa bronchi, e fokotsa secretion ea bona ea mucus.
Phello ea eona ea analgesic e boetse e hlahisoa bakeng sa fibromyalgia, hlooho ea hlooho (migraines). E felisa ho ferekana kelellong, ho tšoenyeha, ho hloka boroko. Thepa ea antidepressant ho fokotsa tlhahiso ea lihormone tsa khatello ea kelello - cortisol - e se e thehiloe, e sirelletsa lisele tsa boko ho tloha lefung.
E sebelisoa e le motsoako oa mafu a amanang le ho ja - anorexia, bulimia, hammoho le li-dystonia tsa neurocirculatory.
Ka lebaka la tekano lipakeng tsa litlamorao tse susumetsang le tse susumetsang, Amitriptyline ha e bake matšoao a hlahisang - hallucinations, thetso, mania, hypomania - ho fapana le Imipramine.
Amitriptyline e thusa ho felisa ho hloka boroko.
Contraindication
Setlhare sena se kopantsoe ha ho na le hypersensitivity ho sona, lefu le matla la pelo, ho nyekeloa ke pelo, ho senyeha haholo hoa pelo (ho kenyeletsa le porphyria), psychoses ea manic, kalafo ka monoamine oxidase inhibitors (nakong ea libeke tse peli kamora ho khaotsa ts'ebeliso).
U ke ke ua isa meriana ena ho basali baimana le bana ba ka tlase ho lilemo tse 16.
U ka e nka joang
Mokhoa oa litekanyetso li beoa ho latela hore na bakuli ba na le lilemo life le hore na ba hokae.
Mokhoa oa litekanyetso tsa batho ba baholo
Ho phekola khatello ea maikutlo, lethalamo la 25 mg le sebelisoa, matsatsing a latelang a 5-6 le eketsoa ho fihlela phello ea kalafo e fihlelleha.
Ka kalafo ea lapeng, tekanyo e phahameng ke 200 mg.
Kamora ho ntlafala, butle-butle tekanyetso e fokotsoa hore e sebetse bonyane, hangata 50-100 mg ka letsatsi. Khafetsa ea tsamaiso ke makhetlo a 2-3 ka letsatsi kapa hang bosiu, hobane ho na le pilisi ea ho robala.
Ho ata ha moriana ho joalo ka makhetlo a 2-3 ka letsatsi kapa hanngoe bosiu.
Haeba letsatsi la kamohelo le lahliloe, kamohelo e latelang e etsoa e sa fetohe. Nako ea kalafo ke likhoeli tse 3-6. Ho batho ba baholo, kalafo e qala ka tekanyetso ea 25 mg, e eketsehe butle butle, hobane mojaro ho tsamaiso ea pelo le methapo e ka khona.
Rejista regimen bakeng sa bana
Bana ba lilemo li 6-12 lilemo tse 10-30 mg ka letsatsi kapa ba nahanela boima ba 1-5 mg / kg ka letsatsi.
Ho nka moriana oa lefu la tsoekere
Ka lebaka la ts'ebetso e eketsehang ea adrenaline, antidepressant e eketsa boemo ba tsoekere maling, ka hona, ho lefu la tsoekere mellitus, lethal dose le eketseha ka hloko, ho laola letšoao lena.
Ke bokae ha e sebetsa
E bolokiloe 'meleng bakeng sa lihora tse 80-150. Kamora nako ena, e se e bontšitsoe.
Mokhoa oa ho hlakola amitriptyline
Cancellation syndrome e bontšoa ke ho teneha, ho hloka boroko, hlooho e bohloko le asthenia. Ka hona, ho tlosoa ha moriana ho lokela ho etsahala butle - tekanyetso e fokotseha butle butle.
Lefu la ho khaola le bonahala ka hlooho.
Litlamorao
Ka litho tse fapaneng, litla-morao li iponahatsa ka litsela tse fapaneng.
Phekolo ea ka mpeng
Matla a anticholinergic a tsamaisana le ho fokotseha ha mokoka, ho omella molomo, ho fokotseha ha acidity ea mokokotlo, ho nyekeloa ke pelo, ho hlatsa, ho fokotsa ts'ebetso ea makoloi le ho otla ha pelo. Mohlomong nts'etsopele ea leus e holofetseng, ho sokela, lets'ollo.
Hematopoietic litho tsa ka hare
Fokotseha ka palo ea leukocytes le liplatelete, eosinophilia.
Ho tloha ka lehlakoreng la metabolism
Ho phahamisa boima ba 'mele, ho ruruha ka leoto, gynecomastia le likhathatso tse ling tsa endocrine, tsoekere e eketsehileng ea mali.
Tsamaiso ea methapo e bohareng
Ho tsekela, ho fokola, ho oela hoa orthostatic, tinnitus, litoro tsa bosiu. Bakeng sa mathata a nang le tšoelesa ea qoqotho (hypothyroidism), ho sebelisa lithethefatsi ho baka boemo ba manong kapa hypomania. Mohlomong ho eketseha ha khatello ea maikutlo le tšekamelo ea ho ipolaea. Ka lefu la sethoathoa, le ka baka ho eketseha ha lefu la sethoathoa.
Bakeng sa mathata a nang le tšoelesa ea qoqotho (hypothyroidism), ho sebelisa lithethefatsi ho baka boemo ba manon.
Allergie
Ka matla a eketsehileng a kutlo, e baka lekhopho la letlalo, ho hlohlona, ka linako tse ling edema ea Quincke, karabelo ea anaphylactoid, ho hema hanyane.
Litaelo tse khethehileng
Ho nka moriana o maemong a fapaneng ho hloka tlhokomeliso.
Sebelisa nakong ea bokhachane le pelehi
E ke ke ea sebelisoa nakong ea bokhachane le pelehi. Lits'oants'o tse ka bang le litlamorao tse chefo bokong ba lesea le sa tsoa tsoaloa.
Sebelisa botsofaling
Li sebelisoa ka hlokolosi, hobane botsofaling ho na le kotsi ea ho ba le khatello ea mali le tlhaselo ea infyo ea myocardial.
Ka ho se sebetse hantle ha sebete
Phekolo e etsoa tlasa taolo ea ACT, ALT, bilirubin e tobileng, phofo ea alkaline, litlutaminase. Haeba ho hlokahala, ho sebelisoa hepatoprotectors.
Tabeng ea ts'ebetso ea ho senyeha ha sebete, kalafo le Amitriptyline e etsoa tlasa taolo ea boemo ba AcT, Alt.
Ka mosebetsi o sa sebetseng oa renal
Creatinine le urea maling li hlahlojoa.
Tšusumetso ho bokhoni ba taolo ea methapo
Phello ea Hypnotic e fokotsa khatello ea maikutlo.
Tekanyo ea joala
E ntlafatsa ho ata ha ethanol. E hanana le joala.
Bongata
E iponahatsa e le hallucinations, ho lahleheloa ke kelello, nts'etsopele ea sethoathoa sa sethoathoa, ho tsitsipana, ho fokotse mocheso oa 'mele, palpitations.
Bakeng sa chefo, komisi kapa lefu li ka etsahala.
Ho hlokahala sefuba sa ka mpeng, ho qobelloa ha diureis, hemodialysis.
Ho sebelisana le lithethefatsi tse ling
Ho thibetsoe ho sebelisa antidepressant e nang le li-inhibitors tsa MAO (Furazolidone, wort ea St. John, joalo-joalo), li-antidepressants tsa li-tricyclic (Clomipramine, Imipramine), sympatholytics - Reserpine, SSRIs (Clozapine, jj.) - serotonin syndrome e ka khonahala.
Ts'ebeliso ea antidepressant e nang le li-inhibitors tsa MAO, li-antidepressants tsa troteclic, li-sympatholytics li thibetsoe.
E ntlafatsa phello ea inhibitory tsamaisong e bohareng ea methapo ea joala, li-antipsychotic (Atarax, Triftazin), li-barbiturates, lithethefatsi tsa lefu la Parkinson. Fokotsa botebo ba phello ea antihypertensive ea beta-blockers le lithethefatsi tse ling bakeng sa khatello ea mali. Fokotsa tšebetso ea li-anticonvulsants.
Li-Barbiturates le carbamazepine li fokotsa khatello ea lithethefatsi, li potlakisa ho pepeseha ha eona, cimetidine, ho fapana le moo, e thusa ho boloka ha eona maling. Ts'ebeliso e kopanetsoeng le Sucralfate e fokotsa ho monya.
Ha e kopantsoe le lihormone tsa qoqotho, keketseho ea ho ruruha le ho ferekana kelellong, ho pepeseha morethetho oa pelo le tachycardia.
Ho tsamaisana le Grandaxin e sebelisetsoa ho phekola ho hloka boroko, ho otsela ho eketsehileng. Le li-blockers tsa anticholinergic - nts'etsopele ea ho sitisoa ha mala.
Li-analog tsa amitriptyline
Ntho e sebetsang e hlahisoa ke lik'hamphani tse 'maloa (Nycomed, Grindeks, Ozone, Zentiva) e le karolo ea litokisetso tsa analog tsa Anafranil, Saroten, Doxepin, Clofranil, jj.
Lipehelo tsa khefu ea khemisi
E fanoe ke lengolo la ngaka.
A na nka reka ntle le lengolo la ngaka?
Lifekthering tse ling, sethethefatsi sena se rekisoa ka bongata.
Theko
Litsenyehelo tsa ho jara matlapa a 50 ke li-ruble tse 21-30. Li-ampoule tse 10 tsa 2 ml, 10 mg / ml li theko ea li-ruble tse 52.
Lipehelo le lipehelo tsa polokelo ea lithethefatsi Amitriptyline
Boloka sebakeng se omileng se nang le mocheso o sa feteng 25 ° C. Qoba hole le bana. Bophelo ba Shelf ke lilemo tse 3.
Litlhahlobo mabapi le amitriptyline
Litlhahlobo tsa lingaka le bakuli ba tsona ka lithethefatsi li ntle haholo.
Litsebi tsa kelello
Vlasov V.A.
Setlhare ha se theko e tlaase ebile sea sebetsa. Litlamorao tse ngata li ne li ka se qojoe leha e le ka lebaka la lipatlisiso tsa mashome a lilemo. E netefalitsoe ke nako le tloaelo. Leha ho le joalo, ha e ea lokela bakuli bohle, ba bang ba ka baka takatso ea ho ipolaea, ka hona ho bohlokoa ho tsamaisa kalafo ka nako.
Andreev A.L.
O bontšitse ts'ebetso ea hae eseng feela maemong a sithabetsang, empa hape le ho psychosomatic pathology - bakuli ba nang le liso tsa ka mpeng, asthma, lefu la masapo a halefang ha a hlaphoheloa. Leha ho le joalo, ho lemalla lithethefatsi ho ka etsahala.
Bakuli
Michael K.
Mohatelli enoa oa khatello o ile a thusa ka bohloko. Ke tšoeroe ke lefu la masapo le bohloko. Setlhare sena se boetse se ntlafatsa mohopolo.
Dmitry Sh.
Ho ne ho e-na le leqeba la ka mpeng, khatello ea maikutlo mosebetsing e ile ea tsosa ponahalo ea eona. Setsebi sa gastroenterologist se laetse sethethefatsi sena. Ho tloha litla-morao, ke hlokometse ho otsela le ho fokotseha hanyane hoa libido le potency.
