Tekanyo ea li-peptide ho lefu la tsoekere mellitus e bontša kamoo lisele tsa pancreatic beta li sebetsang li etsang mosebetsi oa tsona oa insulin.
Tlhahlobo e thusa ho tseba lisosa tsa ho fokotseha kapa keketseho ea litaba tsa C peptides.
Ntle le moo, ke thuto ena e khethang mofuta oa lefu la tsoekere. Ka hona, motho ka mong, haholo-holo ea kotsing, o hloka ho tseba hore na tlhahlobo ea li-peptide tsa C ke eng, le hore na motho ea phetseng hantle o lokela ho ba le mekhoa efe le hore na o khelohile joang.
Phapang lipakeng tsa Mofuta oa 1 le Lefu la tsoekere la Mofuta oa 2
"Lefu le monate" ke lefu la endocrine. Mofuteng oa 1 oa lefu la tsoekere, litonki tsa pancreatic li senngoe, e leng tšobotsi ea autoimmune. Ts'ebetso ea ts'oaetso ea lisele e kenyelletsa ho fokotseha hoa khatello ea C peptide le insulin. Psychology ena e bitsoa ea bocha, hobane e hola ho batho ba ka tlase ho lilemo tse 30 le bana ba banyenyane. Maemong ana, ho hlahlojoa ha peptide ea C ke eona feela mokhoa o ka khethollang boteng ba lefu lena le ho u lumella ho qala kalafo kapele.
Mofuta oa 2 oa lefu la tsoekere o tšoauoa ka maikutlo a senyehileng a lisele tsa pherekano ho insulin e patiloeng. Hangata e ba teng ho batho ba nang le boima bo fetang tekano le lefutso ka mor'a lilemo tse 40. Tabeng ena, peptide ea C e ka eketseha, empa litaba tsa eona li ntse li tla tlase ho boemo ba tsoekere ea mali.
Pele, matšoao a hlakileng a kang lenyora le ho ea ntlung ea ka tlung a ka se hlahe. Motho a ka utloa ho fokotseha ka kakaretso, ho otsela, ho teneha, ka hona, hlooho ha e ele hloko matšoao a 'mele.
Empa ho lokela ho hopoloa hore tsoelo-pele ea lefu la tsoekere e lebisa litlamorao tse mpe - infraction ea myocardial, ho se sebetse hantle lipelong, pono e sa sebetseng hantle, koluoa ea khatello ea mali le mathata a mang a mangata.
Mabaka a ho fetisa tlhahlobo
Ngaka e ka laela tlhahlobo bakeng sa palo ea li-peptide tse tsoekere. Kahoo, mesebetsi e latelang e tla thusa ho utloisisa mofuta oa lefu leo mokuli a nang le lona le likarolo tsa kholo ea hae. Ho etsa sena, etsa mesebetsi e latelang:
- Hlwaya sesosa se bakang hypoglycemia ho mofuta oa 1 kapa lefu la tsoekere la 2.
- Lekola boemo ba insulin ka mokhoa o sa tobang, haeba boleng ba eona bo sa nyenyefatsoe kapa bo eketsehile.
- Fumana mosebetsi oa li-antibodies ho insulin, haeba litekanyetso li sa lateloe.
- Tseba ho ba teng ha makhopho a emeng hantle kamora ho buuoa.
- Lekola ts'ebetso ea sele ea beta ho bakuli ba nang le mofuta oa 1 le lefu la tsoekere la 2.
Ho tlameha ho tsebahatsa li-peptide tsa C ho tseba:
- mofuta oa lefu la tsoekere;
- Mokhoa oa phekolo ea pathology;
- hypoglycemia, hammoho le ho belaella ho fokotseha ho khethehileng ha maemo a glucose;
- boemo ba manyeme, haeba ho hlokahala, emisa kalafo ea insulin;
- boemo ba bophelo bo botle ba bacha ba boima bo feteletseng;
- tlhahiso ea insulin ho mafu a sebete;
- boemo ba bakuli ba nang le manyeme a tlositsoeng;
Ntle le moo, tlhahlobo ke mohato o tlamehang ho khetholla boemo ba bophelo bo botle ba mosali ea nang le lefu la ovary polycystic.
C peptide assay process
Ho hlokahala thuto ho netefatsa mosebetsi oa makhopho.
Pele ho tlhahlobo, o tlameha ho hlokomela phepo e nepahetseng.
Ntle le moo, ho itokisetsa tšebetso ho kenyelletsa lintho tse latelang:
- ho ithiba ho ja bonyane lihora tse robeli;
- metsi a nooang a lumelloa feela ntle le tsoekere;
- ho ila lino tse tahang;
- ho qheleloa ka thoko lithethefatsi;
- ho tlohela ho tsuba bonyane lihora tse tharo pele ho tlhahlobo;
- ho kenyelletsoa ha khatello ea maikutlo le 'mele.
Teko ea mali e etsoa ka mpeng e se nang letho. Kaha ha u khone ho ja bonyane lihora tse robeli pele ho sena, nako e nepahetseng ea ho nka mali ke hoseng. Ho hlahloba li-peptide tsa C, ho nkoa mali a venous.
Ebe biomaterial e hlahisang e feta ka har'a centrifuge ho arola serame, ebe ea tsofala. Ho feta moo, ka laboratoring ka thuso ea li-reagents tsa lik'hemik'hale, tlhahlobo ea mali e etsoa tlasa microscope. Maemong moo letšoao la peptide C le tloaelehileng kapa le lekana le moeli oa lona o tlase, tlhahlobo ea tlhahlobo e etsoa ho sebelisoa tlhahlobo e susumetsoang. Ka lehlakoreng le leng, e hlahisoa ka litsela tse peli:
- ho sebelisa ente ea glucagon (e thibetsoe ho bakuli ba nang le khatello ea mali ea methapo);
- lijo tsa hoseng pele ho hlahlojoa bocha (tšebeliso ea lik'habohaedreite tse sa feteng 3 "likarolo tsa bohobe").
Liphetho tsa bohlahlobo hangata li ka fumaneha lihora tse tharo kamora ho nka biomaterial. Ntle le moo, haeba ho sa khonehe ho hana tšebeliso ea meriana pele ho thuto, ho bohlokoa ho lemosa ngaka ka ntlha ena.
Likahare tse phahameng tsa peptide
Boemo bo tloaelehileng ba peptide pele ho lijo bo fapana ho tloha ho 0,26-0.63 mmol / l (boleng bo bongata 0.78-1.89 μg / l). Ho fumana tlhahiso e ntseng e eketseha ea hormone ea pancreatic ho tsoa ka ente ka ente, karo-karolelano ea insulin ho ea peptide e ikemiselitse.
Boleng ba letšoao bo lokela ho ba kahare ho yuniti. Haeba e fetoha tlase ho bonngoe, joale sena se bontša tlhahiso e eketsehileng ea insulin. Haeba boleng bo feta bonngoe, motho o hloka ho hlahisoa ka insulin ho tsoa kantle.
Haeba boemo bo phahameng ba peptide bo fumanoe maling, sena se ka supa maemo a joalo:
- nts'etsopele ea insulinomas;
- phetisetso ea manyeme kapa lisele tsa eona tsa beta;
- tsamaiso ea kahare ea lithethefatsi tsa hypoglycemic;
- ho hloleha ha rems;
- mokuli ea boima bo feteletseng;
- tšebeliso ea nako e telele ea li-glucocorticoids;
- tšebeliso ea nako e telele ea estrogen ho basali;
- nts'etsopele ea lefu la tsoekere la mofuta oa 2.
Boleng bo tloaelehileng ba peptide bo bontša tlhahiso ea hormone. Ha e hlahisoa ke manyeme haholoanyane, e sebetsa hantle le ho feta. Leha ho le joalo, ha boemo ba peptide maling bo nyoloha, sena se ka supa hyperinsulinemia, e hlahang mehatong ea pele ea lefu la tsoekere la mofuta oa 2.
Haeba protheine e eketseha, empa boemo ba tsoekere ha bo joalo, sena se bontša ho hanyetsa insulin kapa foromo e bohareng (prediabetes). Maemong a joalo, mokuli a ka etsa ntle le meriana, a latela lijo tse nang le carb e tlaase le ho ikoetlisa.
Haeba insulin e nang le peptide e phahamisa, mofuta oa 2 pathology oa nts'etsopele. Maemong ana, mokuli o lokela ho latela litlhahiso tsohle tsa ngaka ho thibela ts'ebetso e joalo ka kalafo ea insulin nakong e tlang.
Likahare tse tlaase tsa peptide
Haeba sephetho sa tlhahlobo se bonts'a peptide e fokotsehileng, sena se ka supa maemo le li-pathologies:
hypoglycemia ea maiketsetso (ka lebaka la ente e nang le hormone), opereishene ea pancreatic, nts'etsopele ea lefu la tsoekere la mofuta oa 1.
Ha C peptide e theoleloa maling le tsoekere ea glucose e eketseha, ho bolela hore mokuli o tsoetse pele lefu la tsoekere la 2 kapa lefu la tsoekere le itšetlehileng ka insulin. Ka hona, mokuli o hloka liente tsa hormone ena.
Hape ho lokela ho hopoloa hore boemo ba peptide bo ka fokotseha tlasa ts'usumetso ea lintlha tse joalo ka joala bo tahang le khatello e matla ea maikutlo.
Ha ho na le "peptide" e nang le "peptide" e tlase le "glucose" e ngata maling, ho na le menyetla e mengata ea "lefu lena le monate" le ke keng la fetoloa.
- lefu la tsoekere la lefu la tsoekere - tšitiso ea likepe tse nyane tse fumanehang kahara litšupa tsa mahlo;
- tlolo ea tšebetso ea methapo ea methapo le methapo ea maoto, e kenyang nts'etsopele ea makhopho, ebe o khaola likarolo tse tlase;
- pathology ea liphio le sebete (nephropathy, cirrhosis, hepatitis le maloetse a mang);
- liso tse fapaneng tsa letlalo (acantokeratoderma, dermopathy, sclerodactyly le ba bang).
Kahoo, ha mokuli a buisana le ngaka ka litletlebo tsa lenyora, molomo o ommeng le ho opa khafetsa, ho ka etsahala hore a be le lefu la tsoekere. Tlhahlobo ea li-peptide tsa C e tla thusa ho fumana mofuta oa pathology. Bafuputsi ba bangata ba re nakong e tlang, lefu la tsoekere le tla kenngoa ka bobeli ka insulin le C peptide. Ba pheha khang ea hore tšebeliso ea lihormone le protheine ka tsela e akaretsang e tla thusa ho thibela nts'etsopele ea litlamorao tse mpe ho batho ba nang le lefu la tsoekere.
Lithuto tsa C peptide li lula li tšepisa, hobane ke protheine ea bohlokoa e khethollang katleho ea manyeme le menyetla ea lefu la tsoekere. Video e sehloohong sena e ka khetha hore na ho etsoe liteko life bakeng sa lefu la tsoekere.
