Maninil ke setlhare se sebelisetsoang ho phekola lefu la tsoekere la mofuta oa 2. Sesebelisoa se sebetsang ke glibenclamide. E fumaneha ka botlolo ea matlapa a 120 bakeng sa tsamaiso ea molomo. Li-glibenclamide tsa 5 mg li ka har'a letlapa le le leng.
Liphello tsa tšebeliso
Manin e fokotsa bongata ba tsoekere maling, ke ea sehlopha sa lintho tse tsoang ho sulfonylurea.
Maninil ea lefu la tsoekere:
- E fokotsa postprandial (kamora ho ja) hyperglycemia.
- Ha e na phello e kholo mokhoeng oa ho itima lijo oa tsoekere.
- E kenya tšebetsong mofuta oa li-b-cell tsa manyeme a insulin ea eona.
- Phokotso ea insulin ea bofokoli.
- E eketsa monyetla oa ho amohela li-receptor tse ikhethang le linama tse itseng ho insulin.
- Ha e ame haholo ho hanyetsa insulin.
- E hatella ho phatloha ha glycogen le mofuta oa tsoekere bokong.
- E na le phello ea antiarrhythmic, e fokotsang sebopeho sa litheko tsa mali.
- E fokotsa menyetla ea ho ba le mathata a latelang a lefu la tsoekere: angiopathy (vascular lesion); lefu la pelo (lefu la pelo); nephropathy (renal pathology); retinopathy (pathology ea retina).
Litlamorao kamora ho nka mannyl li phehella lihora tse fetang 12.
Phekolo ea lefu la tsoekere ha ea lokela ho ba e akaretsang eseng feela kalafo ea lithethefatsi, empa le lijo
Matšoao
Maninil o khothalletsoa hore a khethoe mofuta oa mofuta oa tsoekere ea mofuta oa 2 lefu la tsoekere (mofuta o sa itšetleheng ka insulin) ka litholoana tse sa khotsofatseng ho tsoa litlhare tse sa sebeliseng lithethefatsi (lijo, boikoetliso bo itekanetseng).
Contraindication
Setlhare ha se sebelisoe ka lefu la tsoekere la mofuta oa 1 (mofuta o itšetlehileng ka insulin), le litekanyetso tsa tsoekere ea mali ka tlase ho lipalo tse tloaelehileng, ponahalo ea li-acetone tse tsoang moroto, mali, kapa nts'etsopele ea lefu la tsoekere. Maninil ha ea lokela ho nkuoa nakong ea ho emara le ho nyekeloa. E boetse e hanyetsanoa ho bakuli ba nang le mefuta e fokolisitsoeng ea mafu a sebete le a liphio, ka ho se mamellane ha lithethefatsi.
Tekanyetso le tsamaiso
Litekanyetso tsa lithethefatsi le nako ea kalafo li fanoa ke endocrinologist ho latela boemo ba puseletso bakeng sa lefu lena. E le molao, matlapa a nooa makhetlo a 2 ka letsatsi, halofo ea hora pele ho lijo. Nakong ea kalafo, litekanyetso tsa moriana li fetoloa ho fihlela phello ea kalafo e lakatsehang e fihlelleha. Tekanyetso e nyane ea kalafo ea lithethefatsi ke matlapa a 0.5, tekanyetso e kholo ea letsatsi le letsatsi e fumanehang ke matlapa a 3-4.
Maninil o na le litekanyetso tse bonolo, tse u lumellang hore u khethe mofuta o le mong oa kalafo ho mokuli e mong le e mong
Litlamorao
Litlamorao tse latelang li ka hlaha nakong ea kalafo ka maninil:
- hypoglycemia;
- boima ba mmele;
- makhopho a letlalo;
- ho hlohlona
- mathata a ho ja
- bohloko bo kopaneng
- mathata a sebopeho sa mali;
- hyponatremia (ho fokotseha hoa boemo ba sodium maling);
- hepatotoxicity;
- ponahalo ea protheine ka har'a moroto.
Ka ho teba ha litlamorao, lithethefatsi li felisitsoe 'me ho fanoa ka phekolo e' ngoe.
Litaelo tse ikhethang
Sebelisa ka hloko ha u nka clonidine, b-blockers, guanethidine, reserpine ka lebaka la ho thatafalloa ke ho bona matšoao a hypoglycemia. Nakong ea kalafo ka mannil, ho ja le ho lekola tsoekere ea mali hoa hlokahala.
Maninil e tlameha ho bolokoa sebakeng se lefifi.
Ka kakaretso, sethethefatsi se sebelitse hantle ka bobeli ho monotherapy ea mofuta oa 2 lefu la tsoekere, le hammoho le lithethefatsi tse ling tse theolelang tsoekere.
