1 ampoule (12 ml) ea Berlition 300 e na le motsoako o sebetsang: letsoai la ethylenediamine la acid ea α-lipoic (thioctic) acid 0,388 g (ho latela α-lipoic (thioctic) acid - 0,300 g le lintho tse thusang: metsi bakeng sa ente, propylene glycol, ethylene diamine.
Matlapa a koahetsoeng, e 'ngoe le e' ngoe ea eona e na le asiti e sebetsang ea α-lipoic (thioctic) - 300 mg kapa 600 mg;
Ntle le moo, ho na le lintho tse thusang:
- magnesium stearate;
- lactose monohydrate;
- crodarmellose sodium;
- cellcose ea microcrystalline;
- colloidal anhydrous silica;
- povidone (boleng K = 30);
Opadry OY-S-22898 "mosehla" ka hara khetla, e na le:
- hypromellose,
- sodium dodecyl sulfate,
- titanium dioxide (E 171),
- Dae e putsoa ea 'mala oa lamunu (E 110),
- Quinoline e dae (E 104),
- parafini ea metsi.
Melemo ea pharmacological
Mofumahali Sesebelisoa sa mantlha sa motsoako ke antioxidant ea tlhaho e kopanyang li-radicals tsa mahala. Acid e hlahisoa ke 'mele ka lebaka la litla-morao tsa oxidative ho li-acid tsa α-keto.
Ela hloko! Litlhahlobo tsa lingaka li bonts'a hore moriana o na le phello e molemo ho fokotseheng tsoekere ea mali, ho eketsa maemo a glycogen a sebete le ho hlola khanyetso ea insulin.
Ka thepa ea bona ea biochemical, matlapa a Berlition 300 le 600 a haufi le livithamini tsa B.
- Nka karolo ho tloaelehileng ha carbohydrate le lipid metabolism.
- Ntlafatsa ts'ebetso ea sebete, hlohlelletsa metabolism ea cholesterol.
- Ba na le hypoglycemic, hepatoprotective, hypocholesterolemic, hypolipidemic effect.
Tšebeliso ea Berlition 300 le 600 ho infusions bakeng sa ente e kenang ea methapo e ka fokotsa botebo ba karabelo e bohloko.
Mofumahali Matlapa a Berlition 300 le 600, ka nepo, lintho tsa ona tse sebetsang, a na le bokhoni ba "ho fetela" pele ho sebete. Thioctic acid le likarolo tsa eona li batla li lekantsoe ka botlalo (80-90%) ke liphio.
Tharollo ea ente Berlition. Nako ea ho fihlela khatello e phahameng 'meleng ka tsamaiso ea methapo e 10 ke metsotso e 10-11. Sebaka se tlas'a curveutical curve (nako ea mahloriso) ke 5 μg h / ml. Khatello e kholo ke 25-38 mcg / ml.
Matlapa a Berlition bakeng sa tsamaiso ea molomo a kenella ka potlako 'me a kenella ka botlalo mokhoeng oa ho silila. Ha e nkoa ka lijo, adsorption ea fokotseha. Khatello e phahameng ea lithethefatsi e fihlella ka mor'a metsotso e 40-60. Bioavailability ke 30%.
Bophelo ba halofo ke metsotso e 20-50. Tlhahiso ea plasma ka botlalo ke 10-15 ml / min.
Matšoao a ts'ebeliso ea lithethefatsi
Lefu la tsoekere la polyneuropathy le bakoang ke lefu la tsoekere kapa bokhoba ba tahi. tharollo ea ente e sebelisoa hape. Tekanyetso ea letsatsi le letsatsi ea lithethefatsi ke 300 kapa 600 mg. 1 ampoule e na le 300 mg.
Berlition e kenelletsoa ka tharollo ea 0,9% ea sodium chloride mme e fuoa mokuli ka ho tsubella methapo. Nako ea kenyelletso e ka ba metsotso e 30.
Qalong ea kalafo, Berlition e laeloa libeke tse 2-4. Kamora moo, o ka ntšetsa pele tsamaiso ea molomo ea matlapa a Berlition ka tekanyetso ea 300-600 mg ka letsatsi.
Matlapa a Berlition a bontšoa hore a ka sebelisoa ho 600 mg hang ka letsatsi. Tsena ke matlapa a mabeli. Moriana o lokela ho nooa ka mpeng e se nang letho, e ka bang halofo ea hora pele ho lijo.
Matlapa a tlameha ho metsoa a felletse ntle le ho hlafuna. Noa metsi a mangata. Ke ngaka feela e etsang qeto ea hore na nako ea kalafo e tla tšoareloa neng.
Likarolo tse ling tsa lithethefatsi
Litlhahlobo tsa lingaka le bakuli ka Berlition li ntle haholo, empa joalo ka lithethefatsi tse ling, e na le litšobotsi tsa eona. Nakong ea kalafo, bakuli ba lokela ho hana ho itlopa joala.
Litsebi tsa lefu la tsoekere li hloka ho hlahlojoa khafetsa maemong a tsoekere ea plasma. Sena ke sa bohlokoa haholo qalong ea kalafo. Ka linako tse ling ho ka hlokahala ho fokotsa tekanyetso ea lithethefatsi tsa insulin kapa hypoglycemic tse nkuoang ke bakuli ka hare. Kahoo, kotsi ea hypoglycemia e thibetsoe.
Tharollo ea ente ea Berlition 300 kapa 600 e lokela ho sireletsoa ho mahlaseli a UV. Sena se etsoa ka ho phuthela botlolo ka foil ea aluminium. Tharollo e sirelelitsoeng ka tsela ena e ka bolokoa lihora tse 7.
Litlamorao
Hangata, ha li etsahale, empa maemong a sa tloaelehang, ka mor'a ho thella ka tharollo, ho tsitsipana, hemorrhages e nyane ho li-membrane tsa mucous le letlalo, hemorrhagic rash, thrombocytosis lia etsahala. Ka tsamaiso e potlakileng haholo, ho na le monyetla oa khatello ea maikutlo le ho hema ka thata.
Litlhahlobo tse tsoang ho bakuli le lingaka li re matšoao ana kaofela a tsamaea ntle le ts'ebetso.
Ho na le karabelo ea lehae e hlahang sebakeng sa ente. E ka ba pontšo ea urticaria kapa phello e 'ngoe ea ho kula, ho fihlela mokokotlong oa anaphylactic. Nts'etsopele ea hypoglycemia, e ka hlahisoang ke ntlafatso ea ho monya tsoekere, ha e qheleloe ka thoko.
Matlapa a Berlition hangata a mamelloa ntle le litlamorao tse mpe. Empa ka linako tse ling mathata a latelang a ka etsahala:
- ho hloleha ho phefumoloha;
- pelo e bohloko;
- ho nyekeloa
- ho hlatsa
- hypoglycemia nakong ea kemaro;
- urticaria.
Ho sebelisana le meriana e meng
Berlition "in vitro" e kopana le metsoako ea tšepe ea ionic. Mohlala, cisplatin e ka nahanoa. Ka hona, ho sebelisoa ka nako e le 'ngoe le cisplatin ho fokotsa phello ea eona.
Empa phello ea lithethefatsi tsa hypoglycemic tsa molomo le insulin, Berlition 300 kapa 600, ho fapana le hoo, ea matlafala. Ethanol, e fumanoang lino tse tahang, e fokotsa matla a kalafo a lithethefatsi (bala litlhahlobo).
Motsoako o sebetsang oa Berlition, ha o sebetsana le tsoekere, o etsa metsoako e ke keng ea qhibiliha. Ho latela sena hore tharollo ea thioctic acid e ka se kopane le infusion ea dextrose, Ringer le tharollo tse ling tse tšoanang.
Haeba Berlition 300, matlapa a 600 a ne a nkuoe hoseng, o ka sebelisa lihlahisoa tsa lebese, magnesium le litokisetso tsa tšepe feela ka mor'a lijo tsa motšeare kapa ka shoalane. Mabapi le lihlahisoa tsa lebese, sena se bakoa ke taba ea hore li na le calcium e ngata.
Ho na le litlolo tse teng
- Nako ea kemaro le kanyeso. Le ha litlamorao tse mpe tsa moriana li sa netefatsoa, kaha ha ho na litlhahlobo le lithuto tsa Morero o joalo.
- Kutloisiso e phahameng ho likarolo tsa Berlition.
- Moriana ha o ngoletsoe bana (ha ho na litlhahlobo mabapi le polokeho le katleho).
Matšoao a Ho feta a Borokho bo feteletseng
- ho nyekeloa
- ho hlatsa
- hlooho e bohloko.
Ha ho na antidote, ke matšoao a phekoloang.
Ho boloka, phomolo, ho paka
Setlhare ke sa lethathamo la B. E lokela ho bolokwa ka mocheso o sa feteng 25 ° C, sebakeng se lefifi se sa fumaneheng ho bana.
Nako ea ts'ebeliso e latela mofuta oa tokollo:
- tharollo ea ente - lilemo tse 3;
- lipilisi - lilemo tse 2.
Berlition e lokolloa feela ka lengolo la ngaka. Tharollo ea ente e fumaneha ka ampoules e lefifi ea 25 mg / ml. Mabokose a likarete tsa (likarete) a na le li-ampoules tse 5. Litaelo tsa tšebeliso ke tsena.
Matlapa a Berlition a koahetsoe 'me a kenngoe ka likotoana tse 10 ka marang-rang a entsoe ka thepa ea PVC ea opaque kapa foil ea aluminium. Phutheloana ea karete e na le lithupa tse 3 tse joalo le litaelo tsa ho li sebelisa.
