Glimepiride (Glimepiride) - litokisetso tsa sejoale-joale tsa sulfonylurea. Ka lefu la tsoekere, e eketsa ho tsoa ha insulin maling, e fokotsa glycemia. Ka lekhetlo la pele, ntho ena e sebetsang e sebelisitsoe ke Sanofi matlapeng a Amaryl. Hona joale lithethefatsi tse nang le motsoako ona li hlahisoa lefatšeng ka bophara.
Glimepiride ea Russia le eona e mamelloa hantle, e fokotsa tsoekere hantle, e baka litlamorao tse fokolang, joalo ka matlapa a pele. Litlhahlobo li bontša boleng bo holimo le theko e tlase ea meriana ea lapeng, ka hona ha ho makatse hore batho ba nang le lefu la tsoekere hangata Glimepiride ba rata Amaril ea mantlha.
Ke mang ea bonts'itsoeng glimepiride
Setlhare se khothalletsoa hore se tloaelehe glycemia feela mofuteng oa 2 oa lefu la tsoekere. Taelo ea tšebeliso ha e hlalose ha kalafo le Glimepiride e loketse, kaha khetho ea moriana o itseng le litekanyetso tsa lona ke bokhoni ba ngaka e eang. A re lekeng ho fumana hore na ke mang ea bontsitsoeng lithethefatsi Glimepiride.
Tsoekere ea lefu la tsoekere e nyoloha ka mabaka a mabeli: ka lebaka la ho hanyetsa insulin le ho fokotseha ha tokollo ea insulin liseleng tsa beta tse fumanehang manyeme. Khanyetso ea insulin e hlaha esita le pele ho lefu la tsoekere, e ka fumanoa ho bakuli ba nang le botenya le prediabetes. Lebaka ke khaello ea phepo e nepahetseng, ho se ikoetlise, ho nonofa haholo. Boemo bona bo tsamaisana le tlhahiso e eketsehileng ea insulin, ka tsela ena 'mele o leka ho hlola khanyetso ea lisele le ho hloekisa mali a tsoekere e ngata. Ka nako ena, kalafo e nang le kelello ke ho fetola mokhoa o phetseng hantle le ho fana ka metformin, sethethefatsi se fokotsang ho hanyetsa insulin.
Ha glycemia ea mokuli e le holimo, mellitus e eketseha haholoanyane. Mathata a mantlha a amana le ho fokotseha ha secretion ea insulin, mme hyperglycemia e boetse e hlaha ho mokuli. Ho ea ka lingaka, tlhahlobisong ea lefu la tsoekere, khaello ea insulin e fumanoa hoo e ka bang halofo ea bakuli. Mothating ona oa lefu lena, ntle le insulin, ho lokela ho fanoe ka meriana e khothalletsang ts'ebetso ea lisele tsa beta. Tse sebetsang ka ho fetisisa le tse theko e tlase ho tsona ke li-sulfonylurea derivatives, tse khutsufalitsoeng tsa PSM.
Lefu la tsoekere le khatello e matla e tla ba ntho ea khale
- Ts'oarelo ea tsoekere -95%
- Ho felisoa ha vein thrombosis - 70%
- Ho felisa ho otla ha pelo e matla -90%
- Ho tlosa khatello e phahameng ea mali - 92%
- Keketseho ea matla mots'eare, ho ntlafatsa boroko bosiu -97%
Ho ipapisitse le se boletsoeng ka holimo, re tla totobatsa matšoao a ho khethoa ha sethethefatsi Glimepiride:
- Ho haella ha katleho ea phepo, boikoetliso le metformin.
- Ho netefalitsoe ke tlhahlobo ea tlhaiso ea insulin ea bona.
Taeo e lumella ts'ebeliso ea lithethefatsi Glimepiride e nang le insulin le metformin. Ho latela litlhahlobo, sethethefatsi sena se boetse se tsamaea hantle le li-glitazones, gliptins, incretin mimetics, acarbose.
Mokhoa oa ts'ebetso ea moriana
Ho lokolloa ha insulin ho tsoa makhophong ho tsoa maling ho ka etsahala ka lebaka la liteishene tse khethehileng tsa KATP. Li teng seleng e 'ngoe le e' ngoe e phelang 'me li fana ka phallo ea potasiamo ka membrane ea eona. Ha tsoekere ea glucose ka har'a likepe e le ka har'a meeli e tloaelehileng, lisele tsena tsa lisele tsa beta li bulehile. Ka kholo ea glycemia, ea koala, e bakang calcium e ngata mme ka mor'a moo ho lokolloe insulin.
Lithethefatsi Glimepiride le liteishene tsohle tse haufi tsa potasiamo tsa PSM, ka hona li eketsa tlhahiso ea insulin le secretion. Tekanyo ea lihormone tse tsoang maling e itšetleha feela ka litekanyetso tsa glimepiride, eseng ho boemo ba tsoekere.
Lilemong tse mashome a seng makae tse fetileng, meloko e 3, kapa ho nchafatsoa, ha PSM e qapiloe le ho lekoa. Ketsahalo ea lithethefatsi tsa moloko oa 1st, chlorpropamide le tolbutamide, e ile ea susumetsoa ka matla ke lipilisi tse ling tsa lefu la tsoekere, tseo hangata li ileng tsa lebisa ho hypoglycemia e matla e sa lebelloang. Ka ho hlaha ha moloko oa PSM 2, glibenclamide, glyclazide le glipizide, bothata bona bo rarollotsoe. Ba ikopanya le lintho tse ling tse fokolang haholo ho feta PSM ea pele. Empa lithethefatsi tsena li boetse li na le mefokolo e mengata: maemong a tlhekefetso ea lijo le mojaro, li baka hypoglycemia, li lebisa ho phaello e nyane ea boima ba 'mele, ka hona, keketseho ea ho hanyetsa insulin. Ho latela liphuputso tse ling, meloko ea PSM 2 e ka ama ts'ebetso ea pelo hampe.
Ha ho thehoa lithethefatsi Glimepiride, litlamorao tse ka holimo li ile tsa nkuoa. Ba khonne ho ba nyenyefatsa tokisetsong e ncha.
Molemo oa Glimepiride ho feta PSM ea meloko e fetileng:
- Kotsi ea hypoglycemia ha e nkoa e tlase. Khokahano ea moriana le li-receptor ha e tsitsitse ho feta ea sehlopha sa eona, ho feta moo, 'mele o boloka likarolo tsa thibelo ea insulin le tsoekere e tlase. Ha u bapala lipapali, ho haella ha lik'habohaedreite lijong, glimepiride e baka hypoglycemia e bonolo ho feta PSM e ngoe. Ho shebiloe ho bontša hore tsoekere ha u nka matlapa a glimepiride a theoha ka tlase ho tloaelehileng ho 0,3% ea batho ba nang le lefu la tsoekere.
- Ha ho na phello ho boima. Ho fumana insulin e ngata maling ho thibela ho fokotseha ha mafura, hangata hypoglycemia e thusa ho eketsa takatso ea lijo le takatso ea lijo tse matla tsa caloric ka kakaretso. Glimepiride e bolokehile ntlheng ena. Ho latela bakuli, ha e bake boima ba 'mele,' me ka botenya bo boetse bo thusa ho fokotsa boima ba 'mele.
- Kotsi e tlase ea lefu la pelo le pelo. PSM e khona ho sebelisana le liteishene tsa KATP tse fumanehang eseng feela ka har'a manyeme, empa le maboteng a methapo ea mali, e eketsa kotsi ea ts'ebetso ea bona ea methapo. Glimepiride ea lithethefatsi e sebetsa feela makhophong, ka hona e lumelloa bakeng sa lefu la tsoekere le angiopathy le lefu la pelo.
- Litaelo li bonts'a bokhoni ba Glimepiride ho fokotsa ho hanyetsa insulin, ho eketsa synthes ea glycogen, le ho thibela tlhahiso ea tsoekere. Ketso ena e fokola haholo ho feta metformin, empa e betere ho feta PSM kaofela.
- Setlhare se sebetsa ka potlako ho feta li-analogues, khetho ea lethal dose le katleho ea matšeliso bakeng sa lefu la tsoekere ha le nke nako e nyane.
- Matlapa a Glimepiride a hlohlelletsa mekhahlelo e meng le e meng ea insulin secretion, ka hona, ba fokotsa glycemia kapele ka mor'a ho ja. Lithethefatsi tsa khale li sebetsa haholo-holo mohato oa 2.
Tekanyetso
Tekanyetso e amoheloang ka kakaretso ea glimepiride, eo baetsi ba e latelang, ke 1, 2, 3, 4 mg ea ntho e sebetsang letlapeng. U ka khetha tekanyo e nepahetseng ea lithethefatsi ka nepo e phahameng, haeba ho hlokahala, ho bonolo ho fetola tekanyetso. Ha e le molao, letlapa le na le kotsi, eu lumellang hore u e arole ka halofo.
Phello e fokotsang tsoekere ea lithethefatsi e eketseha ka nako e ts'oanang le keketseho ea lethal dose ho tloha ho 1 ho isa ho 8 mg. Ho ea ka lefu la tsoekere, batho ba bangata ba hloka feela 4 mg kapa ka tlase ho glimepiride ho lefella lefu la tsoekere. Litekanyetso tse kholo li ka khonahala ho bakuli ba nang le tsoekere e bolileng le ho hanyetsa ka matla insulin. Li lokela ho fokotseha hanyane ka hanyane ha mmuso o tsitsa - ho ntlafatsa kutloisiso ea insulin, ho theola boima ba 'mele le mokhoa o fetolang oa bophelo.
Ho theoha ho lebeletsoeng ho glycemia (lipalo tse tloaelehileng ho latela thuto):
| Dose mg | Ts'ebetso e fokotsehile | ||
| Tsoekere e potlakileng, mmol / l | Glucose ea postprandial, mmol / l | Glycated hemoglobin,% | |
| 1 | 2,4 | 3,5 | 1,2 |
| 4 | 3,8 | 5,1 | 1,8 |
| 8 | 4,1 | 5,0 | 1,9 |
Tlhahisoleseling e tsoang ho litaelo tse mabapi le ho khetha lethal dose eo u e batlang:
- Litekanyetso li qala ka 1 mg. Hangata ho lekane ho batho ba nang le lefu la tsoekere ba nang le tsoekere e nyane hanyane, hammoho le ho bakuli ba nang le bothata ba ho phekoloa ka methapo. Maloetse a sebete ha a ame boholo ba lethal dose.
- Palo ea litafole e eketseha ho fihlela lipheo tsa tsoekere li fihletsoe. Ho qoba hypoglycemia, litekanyetso li eketsoa hanyane ka hanyane nakong ea libeke tse peli. Ka nako ena, litekanyo tse ngata tsa glycemia li hlokahala ho feta kamoo ho tloaelehileng.
- Mokhoa oa kholo ea tekanyetso: hofeta 4 mg, eketsa 1 mg, kamora - 2 mg. Ha tsoekere e se e fihlile ho tloaelehileng, emisa ho eketsa palo ea matlapa.
- Tekanyetso e kholo e lumelletsoeng ke 8 mg, e arotsoe ka litekanyetso tse 'maloa: 2 ho isa ho 4 mg kapa 3; 3 le 2 mg.
Litaelo tse qaqileng tsa tšebeliso
Phello e phahameng ea lithethefatsi e hlaha kamora lihora tse ka bang peli ho tloha ts'ebetsong ea eona. Ka nako ena, glycemia e ka fokotseha hanyane. Ka hona, haeba u noa Glimepiride hang ka letsatsi, tlhoro e joalo e tla ba ngoe, haeba u arola tekanyo ka makhetlo a mabeli, tlhoro eo e tla ba habeli, empa e le bonolo. Ka ho tseba karolo ena ea lithethefatsi, u ka khetha nako ea ho amoheloa. Ho bohlokoa hore tlhōrō ea ts'ebetso e oela ka mor'a nako ea lijo tse felletseng tse nang le lik'habohaedreite tse liehang, 'me ha li tsamaisane le mosebetsi o reriloeng.
Kotsi ea hypoglycemia e eketseha ka lebaka la khaello ea phepo e nepahetseng kapa khaello ea phepo e nepahetseng, ts'ebetso e phahameng e nang le phepo e lekaneng ea lik'habohaedreite, mafu a tebileng, mathata a endocrine le lithethefatsi tse ling.
Ho sebelisana le lithethefatsi ho ea ka litaelo:
| Tataiso ea ketso | Lethathamo la lithethefatsi |
| Matlafatsa phello ea matlapa, eketsa kotsi ea hypoglycemia. | Insulin, lisebelisoa tse sebelisang antidiabetesic. Li-Steroids, testosterone, lithibela-mafu tse ling (chloramphenicol, tetracycline), streptocide, fluoxetine. Li-antitumor, li-antiarrhythmic, li-antihypertgency, li-antifungal agents, li-fibrate, li-anticoagulants. |
| Re khathetse phello e fokotsang tsoekere, keketseho ea nakoana ea tekanyetso ea lithethefatsi Glimepiride ea hlokahala. | Diuretics, glucocorticoids, adrenomimetics, estrogens, triiodothyronine, thyroxine. Methapo e meholo ea vithamini ea B3, kalafo ea nako e telele le laxatives. |
| Nts'a matšoao a hypoglycemia, e etsang hore ho be thata ho e lemoha ka nako. | Clonidine, sympatholytics (reserpine, octadine). |
Lintlha tsa khokahano ea joala tse tsoang ho litaelo tsa glimepiride: lino tse tahang li eketsa kotsi ea litlamorao tsa lithethefatsi, li ama tsoekere e maling ka mokhoa o sa lebelloang. Ho latela maikutlo, tsoekere e tsoha hangata nakong ea mokete, empa bosiu e theoha haholo, ho fihlela ho hypoglycemia e matla. Ho noa khafetsa ho senya matšeliso a lefu la tsoekere, ho sa tsotelehe kalafo e laetsoeng.
Likarolo tsa ho nka bana le basali baimana
Ha e sebelisoa nakong ea kemolo, moriana o bitsoang Glimepiride o kenella maling a lesea le ka pōpelong 'me o ka baka hypoglycemia ho lona. Hape, ntho ena e fetela lebeseng la matsoele, ebe ho tloha moo ho kena leetong la lijo tsa lesea. Nakong ea kemolo le HB, ho nka Glimepiride ho thibetsoe ka thata. FDA (American Medicines Administration) e khetholla Glimepiride e le sehlopha sa C. Sena se bolela hore lithuto tsa liphoofolo li senotse hore ntho ena e na le litlamorao tse mpe ho lesea.
Glimepiride ha e fuoe bana, le haeba ba ka fumanoa ba e-na le lefu la tsoekere la mofuta oa 2. Setlhare ha se felle litlhahlobo tse hlokahalang, phello ea sona seboping se ntseng se hola ha e so ithutoe.
Lethathamo la litla-morao
Phello e mpe e mpe ea Glimepiride ke hypoglycemia. Ho ea ka liteko, kotsi ea eona e tlase haholo ho feta ea PSM e matla ka ho fetisisa - glibenclamide. Ho theoha ha tsoekere, ho lebisitseng ho keneng sepetlele le bakuli ba hlokahalang ba tlotsitsoeng ka tsoekere, ho bakuli ba Glimepiride - likarolo tse 0,86 ka lilemo tse 1000 tsa motho. Ha e bapisoa le glibenclamide, letšoao lena le tlase ka makhetlo a 6.5. Monyetla o sa belaelloang oa lithethefatsi ke kotsi e ka tlase ea hypoglycemia nakong ea boikoetliso bo sebetsang kapa ba nako e telele.
Litlamorao tse ling tsa bohlokoa tsa glimepiride ho tsoa litaelo tse tla sebelisoa:
| Sebaka sa tlolo | Tlhaloso | Khafetsa |
| Sistimi ea 'mele | Litla-morao. E ka etsahala eseng ka glimepiride feela, empa le likarolo tse ling tsa lithethefatsi. Maemong ana, ho khutlisa moriana ka analog ea moetsi e mong ho ka thusa. Mekhatlo e matla e kulang e hlokang ho tlosa kalafo hanghang e fumaneha seoelo. | < 0,1% |
| Phekolo ea ka mpeng | Ho sithabela maikutlo, ho utloa bohloko ka botlalo, bohloko ba ka mpeng. Letšollo, ho nyekeloa le pelo. | < 0,1% |
| Madi | Palo ea lipalo tse fokotsehileng. Ho na le bopaki ba nyeoe e arohaneng ea thrombocytopenia e matla. | < 0,1% |
| Ho fokotsa palo ea lisele tse tšoeu tsa mali, lisele tse khubelu tsa mali. Hyponatremia. | linyeoe ka bomong | |
| Sebete | Ho eketsa li-enzyme tsa hepatic maling, hepatitis. Pathologies e ka ba le ho hloleha ha sebete, ka hona ponahalo ea bona e hloka ho felisoa ha moriana. Kamora ho hlakoloa, litlolo li nyamela butle butle. | linyeoe ka bomong |
| Letlalo | Photosensitivity - keketseho ea kutloisiso ea khanya ea letsatsi. | linyeoe ka bomong |
| Mekhoa ea pono | Qalong ea kalafo kapa ka keketseho ea lethal dose, ho senyeha ha nakoana hoa bonahala hoa khoneha. Li bakoa ke ho fokotseha ho tsoekere ha tsoekere 'me li tla fetela ha mahlo a ikamahanya le maemo a macha. | ha e hlalosoe |
Ho boetse ho na le molaetsa mabapi le monyetla oa ho senyeha ha secretion ea li-hormone tsa antidiuretic. Litla-morao tsena li ntse li lekoa, ka hona ha li so kenyelelitsoe litaelong.
Na ho ka ba le overdose?
Hore na lithethefatsi tsa Glimepiride ke tsa sejoale-joale ebile li bonolo hakae, e ntse e le lihlahisoa tsa sulfonylurea, ho bolelang hore ho fetella hoa eona ho lebisa ho hypoglycemia. Litla-morao tsena li tloaetse mokhoa oa ts'ebetso ea lithethefatsi, li ka qojoa feela ka ho sheba litekanyetso ka hloko.
Molao oa thibelo ea hypoglycemia litaelong tsa ts'ebeliso: haeba letlapa la Glimepiride le ile la hloloa, kapa ha ho na bonnete ba hore moriana o noele, lethal dose ha ea lokela ho eketsoa tekong e latelang, leha tsoekere e maling e tsohile.
Hypoglycemia e ka emisoa ka tsoekere - lero le monate, tee kapa tsoekere. Ha ho hlokahale ho emela matšoao a litšobotsi, data e lekaneng ea glycemic. Kaha moriana o sebetsa hoo e ka bang letsatsi, tsoekere e khutliselitsoeng ho tloaelehileng e ntse e ka fokotseha khafetsa ho lipalo tse kotsi. Nako ena eohle eo u hlokang ho lekola glycemia, u se ke ua tlohela motho ea nang le lefu la tsoekere a le mong.
Tšebeliso e matla ea nako e telele ea ts'ebetso ea nako e telele, ts'ebeliso e telele ea litekanyetso tse phahameng tsa glimepiride e beha bophelo kotsing. Ho mokuli ea nang le lefu la tsoekere, ho lahleheloa ke kelello, mathata a methapo ea kutlo, ho ferekana hoa kelello ho ka khoneha. Maemong a tebileng, marotholi a tsoekere a tsoekere a ka nka matsatsi a 'maloa.
Phekolo ea bongoana - ho lava ho tlisoang ke mpa, ho kenella ka bongata, ho khutlisetsa maemong a tlhaho ka ho kenyelletsa glucose methapong.
Contraindication
Maemong a mang, ho sebelisa lithethefatsi Glimepiride ho ka ba kotsi ho bophelo bo botle:
- HS, lilemo tsa bana;
- ho ima, lefu la tsoekere;
- ka mefuta e matla ea ho hloleha hoa hepatic kapa renal. Ts'ebeliso ea matlapa a glimepiride ho bakuli ba dialysis ha e so ithutoe;
- netefatsa mofuta oa 1 lefu la tsoekere. Haeba ho fumanoe mefuta ea nakoana ea lefu la tsoekere (Modi, latent), ho beoa ha glimepiride ea lithethefatsi hoa khoneha;
- mathata a hlobaetsang a lefu la tsoekere. Hypoglycemia e lokela ho tlosoa pele u nka pilisi e latelang. Bakeng sa mefuta eohle ea lefu la tsoekere le precom, litokisetso leha e le life tsa letlapa li felisitsoe;
- haeba lefu la tsoekere le allergic ho motsoako leha e le ofe oa letlapa, ho se khonehe ho ka ba le tšusumetso ea anaphylactic ka ts'ebeliso e tsoelang pele;
- ka lebaka la hore motsoako oa matlapa a kenyelletsa lactose, li ke ke tsa nkuoa ke bakuli ba nang le lefutso la lefutso la eona.
Taeo e khothaletsa tlhokomelo e khethehileng qalong ea kalafo ka glimepiride, sethaleng sa khetho ea litekanyetso, ha u fetola mokhoa oa ho ja kapa mokhoa oa bophelo. Hyperglycemia e ka lebisa likotsi, mafu a tšoaetsanoang le a ho ruruha, haholoholo a tsamaeang le feberu. Nakong ea ho hlaphoheloa, ho fapana le hoo, hypoglycemia e ka etsahala.
Mafu a amanang le ho ja a ka fetola phello ea litafole haeba ho ts'oaroa ho senyeha. Khaello ea phepelo ea tsoekere ea glucose-6-phosphate dehydrogenase ha o sebelisa moriana o bitsoang Glimepiride o ka mpefala.
Glimepiride analogues
Li-analogues tse fumanehang Russia tse ngolisitsoeng ho ngoliso ea meriana:
| Sehlopha | Lebitso | Moqapi | Naha ea tlhahiso |
| Ka ho phethahetseng analogues, sesebelisoa se sebetsang ke glimepiride feela. | Amaril | Sanofi | Jeremane |
| Glimepiride | Rafarma, Atoll, Pharmproekt, Verteks, Pharmstandard. | Russia | |
| Instolit | Pharmasynthesis | ||
| Glimepiride Canon | Canonpharma | ||
| Diamerid | Akrikhin | ||
| Glime | Sehlopha sa Actavis | Iceland | |
| Glimepiride-teva | Pliva | Kroatia | |
| Glemaz | Kimika Montpellier | Argentina | |
| Glemauno | Wokhard | India | |
| Meglimide | Krka | Slovenia | |
| Glumedex | Shin Pung Pharma | Korea | |
| Likarolo tse sa tšoaneng, litokisetso tse kopaneng tse nang le glimepiride. | Avandaglim (le rosiglitazone) | GlaxoSmithKlein | Russia |
| Amaryl M (ea nang le metformin) | Sanofi | France |
Ho latela maikutlo a batho ba nang le lefu la tsoekere, li-analog tsa boleng bo holimo ba Amaril ke tlhahiso ea lapeng ea Glimepiride-Teva le Glimepiride. Lihlahisoa tse setseng tsa litlama tsa meriana li fumaneha seoelo.
Glimepiride kapa Diabeteson - e leng betere
Ntho e sebetsang ho lefu la tsoekere ke gliclazide, moloko oa PSM 2. Letlapa le na le sebopeho se ikhethileng, se fanang ka ts'ebeliso ea lithethefatsi butle-butle maling. Ka lebaka la sena, Diabeteson MV ha e na monyetla oa ho baka hypoglycemia ho feta gliclazide e tloaelehileng. Ho li-PSM tsohle tse fumanehang, ke glyclazide e fetotsoeng le glimepiride eo li-endocrinologists li e khothalletsang e le eona e sireletsehileng haholo. Li na le phello e ts'oanang ea ho fokotsa tsoekere ho litekanyetso tse bapisoang (1-6 mg bakeng sa glimepiride, 30-120 mg bakeng sa gliclazide). Khafetsa ea hypoglycemia ho lithethefatsi tsena le eona e haufi.
Diabeteson le Glimepiride ba na le liphapang tse fokolang. Bohlokoa ka ho fetisisa ho bona ke:
- Glimepiride e tšoauoa ka karo-karolelano e tlase ea kholo ea insulin / ho fokotseha ha tsoekere - 0,03. Ho Diabeteson, letšoao lena ke 0.07. Ka lebaka la hore ha u nka matlapa a glimepiride, insulin e hlahisoa e le tlase, batho ba nang le lefu la tsoekere ba theola boima ba 'mele, insulin ea theoha,' me lisele tsa beta li sebetsa nako e telele.
- Ho na le datha tse tsoang liphuputsong tse pakang ntlafatso maemong a bakuli ba nang le methapo ea methapo ea methapo ea pelo ka mor'a ho fetoha ho tloha ho lefu la tsoekere ho ea Glimepiride.
- Ho bakuli ba nkang metformin e nang le glimepiride, lefu le fokola hanyane ho feta ho batho ba nang le lefu la tsoekere ba fuoeng kalafo ka "gliclazide + metformin".
Glimepiride kapa Amaryl - e leng betere
Amaril ke lithethefatsi tsa mantlha tse entsoeng ke e mong oa baetapele 'marakeng oa lithethefatsi tsa antidiabetes, ho ameha ka Sanofi. Lithuto tsohle tse boletsoeng ka holimo li entsoe ka ho nka karolo ha moriana ona.
Hape, litokisetso tsa glimepiride li hlahisoa tlasa mabitso a mofuta o le mong ke lik'hamphani tse hlano tsa Russia. Ke li-enjo, kapa li-analogues, li na le sebopeho se tšoanang kapa se tšoanang haholo. Tsena kaofela li theko e tlaase ho feta Amaril. Phapang ea theko e bakoa ke hore lithethefatsi tsena ha lia ka tsa feta liteko tsohle tse hlokahalang ho ngolisa moriana o mocha. Ts'ebetso ea li-generics e nolofalitsoe, ho lekane hore moetsi a netefatse ho lekana ha tlhaho ea matlapa a hae ho Amaril ea mantlha. Tekanyo ea tlhoekiso, li-excipients, foromo ea letlapa e ka fapana.
Leha e le hore litlhahlobo mabapi le Amaril le Russian Glimepirides li batla li tšoana, ho na le batho ba nang le lefu la tsoekere ba ratang litlhare tsa pele feela. Haeba ho na le lipelaelo tsa hore generic e ka sebetsa le ho feta, ho molemo ho reka Amaril, kaha ho tšepa kalafo e boletsoeng ho bohlokoa haholo. Phello ea placebo e ama e mong le e mong oa rona mme e na le phello e tobileng boiketlong ba rona.
Litsenyehelo le polokelo
Theko ea sephutheloana ea Glimepiride, litekanyetso tse 4 mg:
| Khoebo | Moqapi | Theko ea karolelano, rub. |
| Amaril | Sanofi | 1284 (li-ruble tse 3050 ka pakete ea li-pcs tse 90.) |
| Glimepiride | Vertex | 276 |
| Ozone | 187 | |
| Mofumahali | 316 | |
| Khemisi | 184 | |
| Glimepiride Canon | Canonpharma | 250 |
| Diamerid | Akrikhin | 366 |
Li-analogues tse theko e tlaase li hlahisoa ke Samara Ozone le Pharmproject ho tsoa St. Petersburg. Likhamphani tsena ka bobeli li reka thepa ea meriana ho likhamphani tsa meriana tsa India.
Bophelo ba sehatsetsi ba bahlahisi ba fapaneng bo fapana mme ke lilemo tse peli kapa tse tharo. Litlhoko tsa mocheso oa polokelo lia tšoana - ha li holimo ho 25 degrees.
