Niacin (lebitso le leng ke niacin) e bua ka livithamini tsa B tse sa qhibilihang ka har'a metsi; standardization ea lipoprotein maling. Ho fumana phello ea kalafo, ts'ebeliso ea litekanyetso tse eketsehileng ea hlokahala.
Ho hlahisoa mefuta e 'meli ea nicotinic acid - litokisetso tsa tokollo ea hang-hang le ho pepesetsoa nako e telele. Phekolo e qala ka tekanyetso e tlase ea letsatsi le letsatsi, butle-butle e eketsa litekanyetso ho 1500-3000 kapa 4000 mg ka letsatsi. Ho felisa li-cholesterol plaque, ho hlokahala tekanyetso ea 3000 mg.
Boithuto ba kliniki bo bontšitse hore niacin e thusa ho fokotsa LDL ka 20% ho tloha boemong ba pele, e fokotsa khatello ea li-triglycerides ka 25-45%, ha e ntse e eketsa li-lipoprotein tse phahameng haholo ho tloha ho 10 ho isa ho 35%.
Ka lefu la tsoekere, asiti ea nicotinic e ntlafatsa metabolism ea 'mele, e thusa ho theola boima ba' mele, e tsamaisa tsamaiso ea methapo ea pelo le ho ntlafatsa phallo ea mali 'meleng.
Ketso ea pharmacological ea nicotinic acid
Pele re ka latela litaelo tsa tšebeliso ea nicotinic acid, re tla hlahloba hore na ntho ena e sebetsa joang, e amang 'mele oa mokuli. Niacin e sebetsa molemong oa li-anabolic steroids, kaha e thusa ho eketsa boemo ba lihormone tsa kholo. Intravenous tsamaiso ea lithethefatsi e fana ka susumetsa ea adrenal mosebetsi. Ho sebelisa khafetsa ho kenella le mekhoa ea ho ruruha.
Niacin e khothalletsoa lefu la tsoekere le cholesterol e phahameng, kaha e na le phello e ntle tseleng ea maloetse a mabeli. Ts'ebeliso e hlophisehileng e ntlafatsa ho kenngoa ha tsoekere maling, e lebisang ho tloaelo ea glycemia, e fana ka boima ba 'mele, bo bohlokoa ho lefu la tsoekere la mofuta oa 2.
Boithuto ba kliniki bo bontšitse hore niacin e thusa ho fokotsa khatello ea mali. Sena se bakoa ke phello ea vasodilating ea lithethefatsi, keketseho ea matla a methapo ea mali le methapo ea methapo.
Kameho ea nicotinic acid ha e kopana le cholesterol e mpe e ile ea tsebahala ka morao ho 60s. Lithuto tsa kliniki li thathamisitse mekhoa ea ho theola cholesterol tlasa tšusumetso ea niacin:
- Thibelo ea lipolysis tse ikarolang kapa ho lokolloa ha mafura acids a mahala ho tsoa mabenkeleng a subcutaneous ho kena maling;
- Ho hlahisoe ha cholesterol e fokolitsoeng ke lets'ollo la lefu la tsoekere;
- Thepa ea Vasodilating;
- Ho tšela mali, ho netefatsang phallo e tloaelehileng ea mali le khahlanong le bokantle ba likheo tsa methapo ea mali.
Niacin e na le thepa ea ho eketsa ts'ebetso ea enzymatic ea mpeng ea mpa, e potlakisa tšebetso ea tšilo ea lijo, ka hona ts'ebeliso ea eona e ka ba kotsi bakeng sa liso tsa ka mpeng tsa mala kapa mala.
Ketso ea nicotinic acid e rarahane. E fana ka litlamorao tse latelang:
- E ntlafatsa lits'ebetso tsa metabolic.
- Normalizing metabolism.
- E thibela sebopeho sa li-plaque tse mafura.
- E hloekisa methapo ea mali ho tsoa mafura a teng.
- E fana ka boima ba 'mele.
Niacin e fumaneha ka har'a ampoules ea ente le ka foromo ea letlapa. Moriana o lokela ho laeloa ke ngaka feela. Ho ipusa ha hoa lumelloa, esita le ho theola boima ba 'mele. Sena se na le litlamorao tsa bophelo bo botle.
Niacin e tšeloa ka har'a sebete, e pepesetsoa ke liphio. Ha o sebelisa litekanyetso tse phahameng haholo, e qheleloa ka mokhoa o hlakileng.
Litaelo tsa tšebeliso ea lithethefatsi
Joalokaha ho se ho hlokometsoe, ngaka e lokela ho fana ka thuto ea kalafo. Ho ke ke ha khoneha ho etsa kopo ka boithatelo. Matšoao a sebelisoang: hyperlipidemia, atherosclerosis ea methapo ea mali, pelo methapo ea methapo, tšitiso ea phallo ea mali.
Ho bohlokoa ho fana ka lingoloa tsa lefu la tsoekere le polyneuropathy, trophic ulcers, microangiopathy le mathata a mang a lefu la tsoekere. Kamohelo e khothalletsoa khahlanong le semelo sa maqeba a nako e telele a sa foliseng, li-spasms tsa urine, sefahleho le methapo ea sefahleho.
Lifekthering, nicotinic acid e rekisoa ka mabitso a fapakaneng - Nicotinamide, Niacin, Vitamin B3, joalo-joalo. Li-Vitamin complexes, tse kenyeletsang niacin hammoho le likarolo tse ling, li ka amahanngoa le analogues.
Kamano pakeng tsa niacin le cholesterol e amana le lethal dose. Ha tekanyetso ea ntho eo e sebetsa, ho ba bonolo ho ntlafatsa habonolo. Likarolo tsa ts'ebeliso ea nicotinic acid e nang le cholesterol e phahameng:
- Qala ka tekanyetso e fokolang, hlokomela tsela eo 'mele oa motho ea lefu la tsoekere a sebetsang ka eona;
- Li-lipoprotein tse fokolang haholo li qala ho fokotseha ka tekanyetso ea 1,2-1,5 g ka letsatsi;
- Litlamorao tsa lithethefatsi ho cholesterol li fumanoa ka tekanyetso ea 3-4 g ka letsatsi;
- O ka nka litafole ho latela tekanyetso e khothalletsoang kapa oa kenella kahare - 2000 mg ea moriana o fanoang lihora tse ling le tse ling tse 11;
- Ho thibela lefu la pelo, stroke, le li-pathologies tse ling tsa pelo ho mafu a tsoekere, ngaka e ka khothaletsa 4 g ea niacin ka letsatsi;
- Ha e le prophylaxis ea mathata, ho nkuoa 300-1000 mg.
Haeba lefu la tsoekere le fumanoa le na le arterial sclerosis, joale litekanyetso li fapana ho tloha ho 1000 ho isa ho 4200 mg ka letsatsi. Asiti ea Nicotinic e nkuoa e le moemeli a le mong. Haeba setšoantšo sa kliniki se le matla, joale se kopantsoe le lithethefatsi tse ling tse tsoang sehlopheng sa li-statins.
Nicotinamide ka tekanyo ea 25 mg ka kilogram ea boima ba 'mele e thusa ho fokotsa tsoelo-pele ea lefu la tsoekere la mofuta oa 1. Nako ea thupelo ea kalafo e khethoa ka bonngoe, ho latela boemo ba LDL le HDL, lefu la tsoekere, sehlopha sa lilemo, mafu a kopaneng. Niacin e rekisoa ka taelo ea ngaka, e lumelloa ho sebelisa feela litekanyetso tse behiloeng ke litaelo.
Tataiso ea kopo e re acid ea nicotinic e ka sebelisoa ho matlafatsa moriri - e nke ka mokhoa oa litafole, sebelisa tharollo ea metso ea moriri, kapa u e kenyelle lihlahisoa tsa tlhokomelo ea litlolo.
Nakong ea kalafo, ho khothalletsoa ho kenyelletsa lihlahisoa tsa menyu tse nang le li-niacin tse ngata - sebete, li-yolks tsa mahe, li-buckwheat, meroho e tala, nama e halikiloeng, tlhapi, makhapetla.
Litla-morao le litaelo tse khethehileng
Ha se diabetics tsohle tse loketseng phekolo ea nicotinic acid. Haeba nalane ea ts'ebetso ea lefu la sethoathoa e matla, ho tsoa mali, ho otloa, ho se mamellane ho hang keacin, biliary pancreatitis, ha ho mohla meriana e boletsoeng. U ke ke ua sebelisa lipilisi nakong ea sesosa sa mokokotlo. Ha ho na likhanyetsano tse ling hape.
Ka hloko, ho sebelisoa lino tse nang le lefu la tsoekere. Taba ke hore nicotinic acid e na le phello ea vasodilating, e ka lebisang ho fokotseha kapele ha lipalo tsa mali. E laetsoe ka hloko bakeng sa gastritis e nang le acidity e ngata, cirrhosis, hepatitis, nakong ea kemero le ho lactation, ka glaucoma.
Niacin o tla thusa haeba mokuli a sa noe moriana feela, empa a phela le bophelo bo botle. Lijo le lipapali ke maemo a ka sehloohong a thusang cholesterol e tlase ea mali.
Asiti ea Nikotinic ho litekanyetso tse nyane e mamelloa hantle. Empa ho etsa hore maemo a LDL a fetohe, ho hlokahala tekanyetso e kholo, e lebisang ho karabelo e mpe:
- Bofubelu ba letlalo.
- Hypotension.
- Orthostatic hypotension (ka ente).
- Ho eketsa tlhahiso ea lero la gastric.
- Lipontšo tsa dyspeptic.
- Ho tsekela
- Ho fufuleloa ha sefahleho.
- Ho hlohlona le ho chesa letlalo, urticaria.
Litla-morao tse hlalositsoeng li bakoa ke ho lokolloa ha histamine ho arabela ts'ebeliso ea nicotinic acid. Phekolo e hlokofatsang ha e hlakoloe, hobane ha nako e ntse e tsamaea, 'mele oa motho o ikamahanya le liphetoho, matšoao a itlhahela feela.
Tšebeliso ea nako e telele ea lithethefatsi e ka baka mafura a tsoang ho sebete, tlolo ea ts'ebetso ea setho. Khafetsa ho na le ho hlatsa, litulo tse otlolohileng, ho hlonama ka mpeng ka lebaka la ho khopisa mucous membrane ea tšilo ea lijo.
Ho kopantsoe le lijo tse nang le carb e tlaase, acid ea nicotinic e ka fokotsa khatello ea cholesterol e kotsi le li-triglycerides maling a batho ba nang le lefu la tsoekere, e fokotsang tsoelo-pele ea lefu lena le ho fokotsa kotsi ea mathata a bakoang ke lefu la tsoekere.
Tlhahisoleseling ka nicotinic acid e fanoa videong ena.
