Li-antibodies ho lisele tsa pancreatic beta ke liprotheine tse ikhethileng tse etselitsoeng 'mele mme li ama lisele tsa beta tsa li-isanc tsa pancreatic tsa Langerhans.
Ke batho ba fokolang ba tsebang hore mofuta oa lefu la tsoekere la mellitus (DM) ke lefu la autoimmune, mme ho etsahala ha liperesente tse mashome a robong tsa lisele tsa beta li angoa ke antibody. Lisele tsa Beta li fumanehile lihlekehlekeng tsa Langerhans 'me ke tsona tse ikarabellang bakeng sa ho lokolla insulin ea hormone.
Kaha matšoao a pele a kliniki a hlaha ho mokuli kamora lefu le batang la lisebelisoa tse sebelisang ho boloka insulin, ho bohlokoa ho tsebahatsa lefu lena maemong a tlase. Kahoo, ho khethoa ha insulin ho tla etsahala pejana, mme lefu la lefu le tla fokola.
Li-antibodies (AT), tse ikarabellang bakeng sa ts'ebetso ea ts'ebetso ea methapo ea methapo, ha lia aroloa ka mekhatlo e latelang:
- li-antibodies ho islet lisele tsa manyeme;
- li-antibodies tsa tyrosinophosphatase;
- li-antibodies tsa insulin;
- li-antibodies tse ling tse khethehileng.
Lintho tse kaholimo ke karolo ea "mele" ea "immunoglobulin" ea antibody ea subclass G.
Phetoho ea ho tloha sethaleng sa subclinical ho ea sethaleng sa kliniki e tsamaisana le motsoako oa palo e kholo ea li-antibodies. Ka mantsoe a mang, tlhaloso ea li-antibodies ho lisele tsa pancreatic beta e bohlokoa ka mokhoa o sa reroang molemong oa lefu lena.
Li-antibodies ho lisele tsa beta le lisele tsa beta ke eng?
Lisele tsa pancreatic beta ke matšoao a ts'ebetso ea autoimmune e bakang tšenyo ea lisele tse hlahisang insulin. Li-antibodies tsa Seropositive ho lisele tsa islet li fumanoa ho feta liperesente tse mashome a supileng tsa bakuli ba nang le lefu la tsoekere la mofuta oa.
Hoo e ka bang karolo ea 99 lekholong ea linyeoe, mofuta oa lefu la tsoekere o itšetlehileng ka insulin o amahanngoa le ts'ebetso ea ts'oaetso ea "gland" e amanang le 'mele. Tšenyo ea lisele tsa setho e baka tlolo e kholo ea tlholeho ea insulin, 'me ka lebaka leo, bothata bo boholo ba metabolic.
Kaha li-antibodies nako e telele pele matšoao a pele a qala, a ka tsejoa lilemo tse ngata pele ho qaleho ea liketsahalo. Ntle le moo, sehlopha sena sa li-antibodies hangata se fumanoa ho beng ka mali a bakuli. Ho fumanoa ha li-antibodies ho baena ke letšoao la kotsi e kholo ea mafu.
Sesebelisoa sa iscancre sa manyeme (manyeme) se emeloa ke lisele tse fapaneng. Ho khahlisang bongaka ke lerato la lisele tsa iske beta tse nang le li-antibodies. Lisele tsena li etsa insulin. Insulin ke hormone e amang metabolism ea carbohydrate. Ntle le moo, lisele tsa beta li fana ka maemo a insulin ea motheo.
Hape, lisele tsa islet li hlahisa Ceptept, C eo e leng lets'oao le nang le tsebo haholo la lefu la tsoekere la autoimmune.
Bohloko ba lisele tsena, ntle le lefu la tsoekere, bo kenyelletsa hlahala e hlahang ho tsona. Insulinoma e tsamaisana le ho fokotseha ha tsoekere ea serum.
Tlhahlobo ea antipancreatic
Serodiagnosis ea li-antibodies ho lisele tsa beta ke mokhoa o ikhethileng le o tebileng oa ho netefatsa ho fumanoa ha lefu la tsoekere la autoimmune.
Maloetse a Autoimmune ke maloetse a bakoang ke ho phatloha hoa tsamaiso ea 'mele ea ho itšireletsa mafung. Mathateng a ho itšireletsa mafung, liprotheine tse ikhethang li entsoe ka tsela e mabifi e etselitsoeng "lisele tsa 'mele" ka matla. Kamora ts'ebetso ea li-antibodies, ts'ebetso ea ho timetsoa hoa lisele tse li chesang haholo li etsahala.
Ka bongaka ba sejoale-joale, mafu a mangata a fumanoe, a ts'oaroa ke ho phatloha hoa molao oa autoimmune, har'a ona:
- Type 1 lefu la tsoekere.
- Autoimmune thyroiditis.
- Autoimmune hepatitis.
- Maloetse a Rheumatological le a mang a mangata.
Maemo ao tlhahlobo ea antibody e lokelang ho etsoa:
- haeba beng ka motho ba na le lefu la tsoekere;
- ha u bona li-antibodies ho litho tse ling;
- ponahalo ea ho hlohlona 'meleng;
- ponahalo ea monko oa acetone e tsoang molomong;
- lenyora le sa feleng;
- letlalo le omeletseng
- molomo o omileng
- ho theola boima ba 'mele, leha o na le takatso e tloaelehileng ea lijo;
- matšoao a mang a ikhethang.
Lingoliloeng tsa lipatlisiso ke mali a venous. Sampole ea mali e lokela ho etsoa ka mpeng e se nang letho hoseng. Qeto ea antier titer e nka nako. Ho motho ea phetseng hantle, ho ba sieo ka botlalo ha li-antibodies maling ke ntho e tloaelehileng. Ha palo e phahameng ea li-antibodies e le serumeng sa mali, e na le monyetla o moholo oa ho fumana lefu la tsoekere haufinyane.
Qalong ea kalafo, li-AT li oela tlase.
Lefu la tsoekere la autoimmune ke eng?
Autoimmune lefu la tsoekere mellitus (lefu la tsoekere la LADA) ke lefu le laolang taolo ea methapo ea kutlo le sa tsubang o sa le monyane. Lefu la tsoekere la Autoimmune le hlaha ka lebaka la ho hloloa hoa lisele tsa beta ke li-antibodies. Motho e moholo le ngoana ba ka kula, empa boholo ba bona ba qala ho kula ba sa le banyenyane.
Letšoao le ka sehloohong la lefu lena ke keketseho e tsoelang pele ea tsoekere ea mali. Ntle le moo, lefu lena le tšoauoa ka polyuria, lenyora le sa feleng, mathata a takatso ea lijo, ho theola boima ba 'mele, bofokoli le bohloko ba ka mpeng. Ka nako e telele, phefumoloho ea acetone ea hlaha.
Mofuta ona oa lefu la tsoekere o tšoauoa ka ho ba sieo ha insulin ka botlalo, ka lebaka la ts'enyo ea lisele tsa beta.
Har'a mabaka a tlholeho, a bohlokoa ka ho fetisisa ke:
- Khatello ea maikutlo. Haufinyane tjena, bo-rasaense ba pakile hore pancreatic spectrum ea antibodies e entsoe ka mokhoa o arabelang matšoao a itseng a tsoang mohloling o moholo oa methapo nakong ea khatello ea kelello ea mmele.
- Lintho tsa lefutso. Ho latela tlhaiso-leseling ea morao-rao, lefu lena le kentsoe ka har'a liphatsa tsa motho tsa lefutso.
- Lintho tse amanang le tikoloho.
- Khopolo ea bongata Ho latela liphuputso tse 'maloa tsa bongaka, mefuta e meng ea li-enteroviruse, vaerase ea rubella le vaerase ea mumps e ka baka tlhahiso ea li-antibodies tse khethehileng.
- Lik'hemik'hale le meriana le tsona li ka ama hampe boemo ba tsamaiso ea 'mele ea ho itšireletsa mafung.
- Pancreatitis e sa foleng e ka kenyelletsa lihlekehleke tsa Langerhans ts'ebetsong.
Phekolo ea boemo bona ba pathological e lokela ho ba e rarahaneng le ea pathogenetic. Morero oa kalafo ke ho fokotsa palo ea li-autoantibodies, ho felisoa ha matšoao a lefu lena, tekanyo ea metabolic, ho ba sieo ha mathata a tebileng. Mathata a tebileng ka ho fetisisa a kenyelletsa mathata a pelo le mahlaba, marapo a letlalo, komello e fapaneng. Phekolo e etsoa ka ho tsamaisana le phepo ea phepo, ho kenya thuto ea 'mele bophelong ba mokuli.
Katleho ea sephetho e etsahala ha mokuli a ikemetse ka mokhoa o ikemetseng kalafo mme a tseba ho laola maemo a tsoekere ea mali.
Phetoho ea antibody bakeng sa Lisele tsa Beta
Motheo oa phekolo e nkang sebaka ke tsamaiso e tsamaisang insulin. Phekolo ena ke lintho tse rarahaneng tse etsoang ho fihlela metabolism ea carbohydrate.
Hona le litokisetso tse fapaneng tsa insulin. Ba khetholla lithethefatsi ka ho nka nako: ketso ea ultrashort, khato e khuts'oane, bolelele ba nako le ts'ebetso ea nako e telele.
Ho latela maemo a ho itlhoekisa ho litšila, litšebeletso tsa boithatelo bo le bong le tse ling li aroloa ka karolo e le 'ngoe. Ka tlhaho, ba khetholla ponahalo ea liphoofolo (bovine le nama ea kolobe), mofuta oa motho le mofuta o entsoeng ka liphatsa tsa lefutso. Pheko e ka rarahanngoa ke lintho tse kulisoang ke lefu la ho nyekeloa ke methapo le methapo ea methapo ea methapo, empa ho mokuli ho boloka bophelo.
Matšoao a lefu la pancreatic a hlalositsoe videong ena.
