Lithethefatsi tsa ka tlung Glimepiride (INN) tse tsoang k'hamphaning ea pharmacological ka nepo li fokotsa boemo ba glycemia ho bakuli ba nang le lefu la mofuta oa lefu la tsoekere la mofuta oa 2.
Haholo-holo, moemeli oa antidiabetes o thusa ka ho se lekane ha kalafo ea ho ja, ho ikoetlisa le ho theola boima ba 'mele. Joalo ka moriana o mong le o mong, glimepiride e na le litšobotsi tse ling tsa pharmacological tseo ngaka le mokuli ba lokelang ho tseba ka tsona.
Lebitso la Selatine la sesebelisoa sena ke Glimepiride. Karolo e ka sehloohong ea lithethefatsi ke sehlopha sa sulfonylureas. Moetsi o boetse o eketsa karolo e nyane ea lintho tse ling ho sehlahisoa: tsoekere ea lebese (lactose), cellcose ea microcrystalline, sodium lauryl sulfate, stgel ea pregelatinized, magnesium stearate le dyes tse ling.
Pharmstandard e hlahisa moemeli oa antidiabetesic ka sebopeho sa letlapa (1 letlapa le na le 1, 2, 3 kapa 4 mg ea glimepiride).
Setlhare se nooa ka molomo, se hlatsuoa ka metsi a manyane. Kamora ho kena 'meleng oa motho, litaba tse phahameng ka ho fetisisa tsa ntho e sebetsang li fihlella ka lihora tse 2,5. Ho ja ka mokhoa o ikhethileng ha ho ame ho monya ha glimepiride.
Thepa ea mantlha ea karolo e sebetsang e bontšoa ka tsela e latelang:
- Ho khothaletsa tlhahiso ea li-hormone tse fokotsang tsoekere ho tsoa lisele tsa beta tsa lihlekehleke tsa Langerhans.
- Karabelo e molemohali ea lisele tsa beta ho khothaletsa mmele oa tsoekere. Ho lokela ho hopoloa hore palo ea insulin e hlahisitsoeng ha e na thuso ho feta tlasa ts'usumetso ea lithethefatsi tsa setso - lits'oants'o tsa sulfonylurea.
- Ho sitisa secretion ea tsoekere ka sebete le ho fokotsa ho kenngoa ha lihormone tse fokotsang tsoekere ke sebete.
- Ho eketseha habonolo ha lisele tse hlaseloang tsa adipose le mesifa ea mesifa ho litlamorao tsa insulin.
- Glimeperid e eketsa litaba tsa alpha-tocopherol ea endo native, ts'ebetso ea glutathione peroxidase, catalase, le superoxide dismutase. Sena se lebisa ho fokotseha ha kholo ea khatello ea oxidative, e lulang e na le lefu la tsoekere la mofuta oa 2.
- Inhibition e khethiloeng ea cycloo oxygenase, hammoho le ho fokotseha hoa phetoho ea thromboxane A2 ho tloha arachidonic acid. Ts'ebetso ena e na le phello ea antithrombotic.
- Tsamaiso ea maemo a lipid le ho fokotseha hoa phallo ea malondialdehyde ho plasma ea mali. Ts'ebetso tsena tse peli li lebisa ho phello ea anti-atherogenic ea lithethefatsi.
Karolo ea boraro ea metabolites ea glimepiride e epolloa ke mala, 'me likarolo tse peli ho tse tharo li lleloa ke liphio.
Bakeng sa bakuli ba nang le mafu a liphio, ho pepesetsoa ha glimepiride ho eketseha le ho lekanya litekanyetso tsa eona tse akaretsang serumeng ea mali li fokotseha.
Litaelo tsa ho sebelisoa ha matlapa
Tlhahiso ea ngaka e tsoang ho ngaka e fanang ka kalafo ke boemo bo ka sehloohong boo ka bona u ka rekang lithethefatsi Glimepiride. Ha u reka moriana, ke tloaelo ho ela hloko litlhaloso tse boletsoeng ho litaelo tse kentsoeng.
Tekanyetso ea lithethefatsi le nako ea kalafo e khethoa ke endocrinologist, e ipapisitseng le boemo ba glycemia ba mokuli le boemo ba hae ba bophelo bo botle. Ha o nka Glimepiride, litaelo tsa tšebeliso li na le tlhaiso-leseling eo ho hlokahalang hore motho a noe 1 mg hang ka letsatsi. Ho fihlela ts'ebetso e nepahetseng ea pharmacological, tekanyetso ena e ka nkuoa ho boloka maemo a tloaelehileng a tsoekere.
Haeba tekanyetso e tlase ka ho fetisisa (1 mg) e sa sebetse, butle-butle lingaka li beha 2 mg, 3 mg kapa 4 mg ea moriana ka letsatsi. Maemong a sa tloaelehang, litekanyetso li ka eketsoa ho 3 mg habeli ka letsatsi tlasa taolo e tiileng ea ngaka.
Matlapa a tlameha ho nkuoa ka botlalo, a sa tshekeloe le ho hlatsuoa ka metsi. Haeba u tlil'o sebelisa sethethefatsi sena, u ke ke ua eketsa litekanyetso habeli.
Ho kopanya glimepiride le insulin, tekanyetso ea lithethefatsi eo ho buuoang ka eona ha e hloke ho fetoloa. Phekolo ea "insulin" e fanoa ka tekanyo e fokolang, butle-butle e eketsa. Ts'ebeliso e kopaneng ea lithethefatsi tse peli e hloka tlhokomelo e khethehileng ho ngaka.
Ha ba fetola mofuta oa kalafo, ho etsa mohlala, ka lebaka la ho fetoha moemeli e mong oa antidiabetesic ho glimepiride, ba qala ka tekanyetso e tlase (1 mg).
Menyetla ea ho fetisoa ho tloha ho phekolo ea insulin ho ea ho Glimepiride ea khonahala, ha mokuli a boloka tšebetso ea lekunutu ea lisele tsa pancreatic tsa mofuta oa 2 lefu la tsoekere. Tlas'a tlhokomelo ea ngaka, bakuli ba nka 1 mg ea moriana hang ka letsatsi.
Ha o reka moemeli oa lefu la antidiabetes, o lokela ho ela hloko letsatsi la lona la ho felloa ke nako. Bakeng sa glimepiride, ke lilemo tse 2.
Contraindication le liphetoho tse fapaneng
Joalo ka lithethefatsi tse ling, lithethefatsi Glimepiride contraindication le litlamorao tse mpe e ka ba lebaka leo ts'ebeliso ea lona e thibetsoeng bakeng sa lihlopha tse ling tsa bakuli.
Kaha sebopeho sa litafole se kenyelletsa lintho tse bakang ho kulisoa ke lintho tse ngata, e 'ngoe ea lintlha tse ka sehloohong tse khahlanong le lithethefatsi tsena ke hypersensitivity ho likarolo tse joalo.
Ho feta moo, kamohelo ea chelete e thibetsoe ha:
- lefu la tsoekere la ketoacidosis;
- lefu la tsoekere le itšetlehileng ka insulin;
- lefu la tsoekere, precoma;
- ho se sebetse ha liphio kapa sebete;
- ho jara ngoana;
- sefuba.
Bahlahisi ba sethethefatsi sena ba entse lithuto tse ngata tsa kliniki le tsa ho bapatsa. Ka lebaka leo, ba khonne ho etsa lethathamo la litla-morao, tse kenyeletsang:
- Karabelo ea letlalo (ho hlohlona, lekhopho, urticaria).
- Mathata a ka mpeng: (lets'ollo, ho hlatsa, ho nyekeloa le pelo, bohloko ba ka mpeng).
- Ts'ebetso ea sebete e sa sebetseng (hepatitis, li-enzyme tse eketsehileng tsa sebete, jaundice, ho hloleha ha sebete le cholestasis).
- Phokotso e potlakileng ea tekanyo ea tsoekere (hypoglycemia).
- Hypersensitivity reaction (khatello e tlase ea mali, ho hema ka thata, ho tsitsipana).
- Ho fokotsa khatello ea sodium maling.
- Acuity ea pono e theohileng (hangata e etsahala libekeng tsa pele tsa kalafo).
- Ho senya tsamaiso ea hematopoietic (nts'etsopele ea agranulocytosis, leukopenia, hemolytic anemia ho lefu la tsoekere mellitus, thrombocytopenia, pancytopenia).
Haeba ho na le overdose, hypoglycemia e etsahala, e nka lihora tse 12 ho isa ho tse 72. Ka lebaka la ho nka tekanyetso e kholo, mokuli o na le matšoao a latelang:
- bohloko ka lehlakoreng le letona;
- ho khothatsoa ke ho nyekeloa le pelo le ho hlatsa;
- nyakallo;
- ho ithaopa ha mesifa (ho thothomela);
- ho otsela ho eketsehileng;
- ho tsitsipana le ho se sebetsane;
- nts'etsopele ea coma.
Matšoao a ka holimo maemong a mangata a bakoa ke ho monya moriana ka mpeng. E le kalafo ho hlokahala hore ho hlatsoehe mpa kapa ho hlatsa. Ho etsa sena, nka khabone kapa li-adsorbents tse ling tse sebelisoang, hammoho le likhaba. Ho ka ba le maemo a ho kulisoa ha mokuli le tsoekere e kenang ka mpeng.
Ho sebelisana le lithethefatsi tse ling
Bakeng sa batho ba bangata ba lefu la tsoekere, ho hlaha potso ea hore na Glimepiride e ka nooa le meriana e meng ntle le ente ea insulin. Ha ho bonolo ho fana ka karabo. Ho na le lethathamo la lithethefatsi tse ka bang le litlamorao tse fapaneng ts'ebetsong ea glimepiride. Kahoo, ba bang ba eketsa phello ea eona ea hypoglycemic, ha ba bang, ho fapana le hoo, ba e fokotsa.
Ntlheng ena, lingaka li khothaletsa ka matla hore bakuli ba bona ba tlalehe liphetoho tsohle maemong a bona a bophelo, hammoho le mafu afe kapa afe a amanang le lefu la tsoekere.
Tafole e bonts'a lithethefatsi tse ka sehloohong le lintho tse amang glimepiride. Ts'ebeliso ea bona ka nako e ts'oanang ha e ratehe haholo, empa maemong a mang e ka laeloa tlasa taolo e tiileng ea setsebi se phekolang.
Lithethefatsi tse ka ntlafatsang phello ea hypoglycemic ke:
- liente tsa insulin;
- Fenfluramine;
- Fibrate;
- lihlahisoa tsa coumarin;
- Disopyramids;
- Allopurinol;
- Chloramphenicol;
- Cyclophosphamide;
- Feniramidol;
- Fluoxetine;
- Guanethidine;
- MAO inhibitors, PASK;
- Phenylbutazone;
- Sulfonamides;
- Li-inhibitors tsa ACE;
- anabolics;
- Mohlomong;
- Isophosphamides;
- Miconazole;
- Pentoxifylline;
- Azapropazone;
- Tetracycline;
- quinolones.
Meriana e fokotsang tsoekere e fokotsang tsoekere ha e tsamaisoa hammoho le glimepiride:
- Acetazolamide.
- Corticosteroids.
- Diazoxide.
- Diuretics.
- Sympathomimetics.
- Laxatives
- Li-progestogens.
- Phenytoin.
- Lihomone tsa qoqotho.
- Mahlaba.
- Phenothiazine.
- Glucagon.
- Rifampicin.
- Li-barati
- Nicotinic acid
- Adrenaline.
- Tse tsoang ho Coumarin.
Hoa hlokahala hape ho ba hlokolosi ka lintho tse joalo ka joala le histamine H2 receptor blockers (Clonidine le Reserpine).
Lintho tse tsoang ho Coumarin li ka eketsa le ho fokotseha glycemia ho bakuli.
Litšenyehelo, litekolo le litekanyetso tsa moriana
O ka reka moriana ona khemising e tloaelehileng le webosaeteng ea molao ea moetsi, ka mor'a ho bona foto ea pokello e ikhethang pele ho nako.
Hoa khoneha ho fumana glimepiride ka maemo a khethang.
Bakeng sa Glimepiride, theko e fapana ho latela mofuta oa litekanyetso le palo ea matlapa a sethaleng.
Ka tlase ho na le leseli mabapi le litšenyehelo tsa lithethefatsi (Pharmstandard, Russia):
- Glimepiride 1 mg - ho tloha ho li-ruble tse 100 ho isa ho tse 145;
- Glimepiride 2 mg - ho tloha ho li-ruble tse 115 ho isa ho 240;
- Glimepiride 3 mg - ho tloha ho li-ruble tse 160 ho isa ho tse 275;
- Glimepepiride 4 mg - ho tloha li-ruble tse 210 ho isa ho tse 330.
Joalokaha u bona, theko e amoheleha haholo bakeng sa mokuli ka mong, ho sa tsotelehe moputso oa bona. Marang-rang u ka fumana litlhahlobo tse fapaneng mabapi le moriana. E le molao, batho ba nang le lefu la tsoekere ba khotsofetse ke ketso ea sethethefatsi sena, 'me ntle le moo, o hloka ho se noa hang ka letsatsi.
Ka lebaka la litla-morao kapa li-contraindication, ngaka e ka fana ka litlatsetso tse 'maloa. Har'a tsona, lithethefatsi tse tšoanang (tse nang le ntho e le 'ngoe e sebetsang) le lithethefatsi tsa analog (tse nang le likarolo tse fapaneng, empa li na le phello e tšoanang ea kalafo) lia khetholloa.
Lihlahisoa tse tsebahalang haholo tse nang le motsoako o tšoanang o sebetsang ke:
- Lipilisi tsa Glimepiride Teva - sethethefatsi se sebetsang se fokotsang tsoekere ea mali. Baetsi ba mantlha ke Iseraele le Hungary. Ho Glimepiride Teva, thupelo e na le litaelo tse batlang li tšoana le ts'ebeliso ea eona. Leha ho le joalo, litekanyetso li fapana le sethethefatsi sa lapeng. Theko e tloaelehileng ea 1 pack ea Glimepiride Teva 3 mg No. 30 ke li-ruble tse 250.
- Glimepiride Canon ke lithethefatsi tse ling tse tšepahalang ntoeng khahlanong le glycemia le matšoao a lefu la tsoekere. Tlhahiso ea Glimepiride Canon e ntse e etsahala le Russia ke k'hamphani ea meriana ea Canonfarm Production. ho se tšoane khethehileng glimepiride Canon ha se na litaelo fuoeng contraindications tšoanang le kotsi hlahelang. Litsenyehelo tse tloaelehileng tsa Glimepiride Canon (4 mg No. 30) ke li-ruble tse 260. Sethethefatsi Glimepirid Canon se na le palo e kholo ea li-analogues 'me se ka ba molemo ha moriana o sa tšoanele mokuli.
- Altar ke setlhare se tsebahalang har'a bakuli. Glimepiride, eo e leng karolo ea Altar ea lithethefatsi, e susumetsa tokollo ea insulin ka lisele tsa beta. Altar e na le likarolo tsa ts'ebeliso tse tšoanang. Moetsi oa sehlahisoa sa Altar ke Berlin-Chemie. Theko ea pakete e le 'ngoe ea Altar ke likheo tse lekanang le 250.
Ho na le lithethefatsi tse ngata tse nang le phello e tšoanang ea kalafo, mohlala:
- Metformin ke moemeli ea tsebahalang oa hypoglycemic. Karolo e ka sehloohong ea lebitso le le leng (metformin), ka bonolo e fokotsa litekanyetso tsa tsoekere 'me hoo e ka bang ha ho mohla e lebisang ho hypoglycemia. Leha ho le joalo, Metformin e na le lethathamo le lelelele la li-contraindication le litlamorao. Litšenyehelo karolelano ea Metformin lithethefatsi (500 mg, №60) - 130 li-ruble. Kaha motsoako ona ke karolo ea lithethefatsi tse ngata, o ka fumana mefuta e fapaneng - Metformin Richter, Canon, Teva, BMS.
- Lithethefatsi tse ling tsa hypoglycemic - Siofor 1000, Vertex, Diabeteson MV, Amaril, jj.
E le, haeba ka lebaka le itseng ha ho loketse glimepiride, analogues e ka nkeloa sebaka. Leha ho le joalo, sesebelisoa sena se sebetsa hantle ntlafatsong ea hyperglycemia.
Tlhahisoleseling ka lithethefatsi tse sebetsang hantle tse fokotsang tsoekere e fanoa videong ena.
