Lisele tsa mafura li na le lisele tsa mmele tse ka fokotsang kholo ea methapo, lefu la tsoekere le mafu a mang. Empa etelletsa lintho tsa pele pele
Potoloho e mpe
Joalokaha u tseba, lefu la tsoekere la mofuta oa 2 hangata le tsamaea le boima ba 'mele haholo. Mona ke mofuta oa selikalikoe se khopo. Ka lebaka la hore lisele li khaotsa ho tloaela ho arabela insulin le ho monya tsoekere, metabolism e lahlehile, e kenyang ponahalo ea li-kilogram tse ling.
Bathong ba nonneng haholo, lisele tsa mafura li lula li senngoa, 'me li nkeloa sebaka ke tse ncha, ka bongata bo boholo. Ka lebaka leo, DNA ea mahala ea lisele tse shoeleng e hlaha maling le tsoekere e nyoloha. Ho tsoa maling, DNA ea mahala e kenella ka har'a lisele tsa 'mele tse sirelletsang, li-macrophages tse hlahlathelang lithane tsa adipose. Bo-rasaense ba tsoang Univesithing ea Tokushima le Univesithi ea Tokyo ba fumane hore ho arabela sesole sa 'mele, ts'oaetso ea ts'oaetso e qaptjoa, eo hangata e sebetsang e le sebetsa khahlanong le ts'oaetso le libaktheria tse ngata,' me ka tekanyo e kholo e baka mathata a metabolic mme e ka baka lefu la tsoekere.
Litaba tse mpe
Bafuputsi ba tsoang Univesithing ea California, San Diego ba fumane hore li-macrophages secrete tse seng li boletsoe - li-microscopic vesicles tse sebetsang ho fapanyetsanya tlhahisoleseling lipakeng tsa lisele. Exosomes e na le microRNA - limolek'hule tse amang amang synthetiki. Ho ipapisitse le hore na microRNA e tla amohela "molaetsa" ke eng seleng, lits'ebetso tsa taolo li tla fetoha ho latela tlhahisoleseling e fumaneng. Tse ling tsa li-exosomes - ho ruruha - li ama metabolism ka tsela e etsang hore lisele li fetohe insulin.
Nakong ea teko, mantle a tsoang ho litoeba tsa monyaolo o kentsoe liphoofolong tse phetseng hantle, 'me matla a tsona a kutloisiso ea "insulin" a ne a senyehile. Ka lehlakoreng le leng, melemo ea "bophelo bo botle" e fuoang liphoofolo tse kulang e khutlisitse ts'enyeletso ea insulin.
Mollo o hlotsoeng
Haeba ho ka etsahala ho tseba hore na ke li-microRNA life tse tsoang li-exosomes tse bakang lefu la tsoekere, lingaka li tla fumana "liphofu" bakeng sa nts'etsopele ea lithethefatsi tse ncha. Ho latela tlhahlobo ea mali, eo ho leng bonolo ho eona ho khetholla li-miRNA, ho tla ba bonolo ho hlakisa kotsi ea ho ba le lefu la tsoekere ho mokuli ea itseng, hammoho le ho mo khetha moriana o mo loketseng. Tlhahlobo e joalo e ka nka sebaka sa "biopsy" e bohloko e sebelisoang ho bona boemo ba lithane.
Bo-rasaense ba lumela hore ho etsa lipatlisiso tse ling tsa miRNA ho ke ke ha thusa feela kalafong ea lefu la tsoekere, empa hape le ho imolleng mathata a mang a botenya.
