Setlhare sa antidiabetesic Humulin NPH se na le insulin-isophan, e nang le nako e telele ea ketso. E etselitsoe tšebeliso e tsoelang pele ho boloka maemo a tsoekere ea mali ka har'a meeli e tloaelehileng. E fumaneha e le ho emisoa bakeng sa tsamaiso e poteletseng ho linoko United States, Eli Lilly & Company. Mme khamphani ea Mafora "Lilly France" e hlahisa insulin Humulin NPH ka mokhoa oa li-cartridge ka pente ea syringe. Setlhare se na le ponahalo ea ho emisoa ha 'mala o koahetsoeng ke maru kapa o boreleli.
Litaba tsa sengoloa
- 1 Seketso sa ts'ebetso ea insulin ke Humulin NPH
- 2 Melemo ea pharmacological
- 3 Matšoao, contraindication le litla-morao
- 3.1 Contraindication:
- Litla-morao tse fapaneng li kenyelletsa:
- 4 Melao ea kakaretso ea tšebeliso
- 5 Algorithm bakeng sa tsamaiso ea insulin ke Humulin NPH
- 6 Lintlha tsa ts'ebeliso ea pene ea syringe ea sesebelisoa
- 7 Litšebelisano tse ka bang teng le lithethefatsi tse ling
- 7.1 Lithethefatsi tse thibelang ketsahalo ea insulin Humulin NPH:
- 8 Analogs of Humulin
- 9 Litaelo tse ikhethileng tsa tšebeliso
Mochine oa ketso oa insulin Humulin NPH
Phello ea pharmacological ke ho fokotseha ha tsoekere ea mali ka lebaka la keketseho ea ho ts'oaroa ha eona ke lisele le lisele tse sebelisang Humulin NPH. Ho tsoekere ea lefu la tsoekere, tlhahiso ea "pancreatic insulin hormone" e fokotsehile, e hlokang phekolo ea phetisetso ea hormone. Lithethefatsi li eketsa tšebeliso ea tsoekere ke lisele tse hlokang phepo e nepahetseng. Insulin e buisana le li-receptor tse ikhethang holim 'a lisele, tse tsosang mekhoa e mengata ea biochemical, e kenyelletsang, haholo, sebopeho sa hexokinase, pyruvate kinase, glycogen synthetase. Ho tsamaisoa ha tsoekere ho linama ho tsoa maling ho eketseha, moo ho fokolang.
Melemo ea pharmacological
- Tšusumetso ea kalafo e qala hora kamora ho ente.
- Ho fokotsa tsoekere ho nka lihora tse 18.
- Tšusumetso e kholo ke kamora ho qeta lihora tse peli ho isa ho lihora tse 8 ho tloha nakong ea tsamaiso.
Phapang ena nakong ea ts'ebetso ea lithethefatsi e ipapisitse le sebaka sa taolo ea ho emisoa le ts'ebetso ea makoloi. Lits'ebeletso tsena li lokela ho tsotelloa ha li abela mofuta oa litekanyetso le boholo ba tsamaiso. Kaha o na le tšimoloho e telele ea phello, Humulin NPH e laetsoe hammoho le insulin e khuts'oane le ea ultrashort.
Ho tsamaisoa le ho pepesoa ke 'mele:
- Insulin Humulin NPH ha e kenelle ka har'a mokoallo oa hematoplacental ebile ha e pepesehe litšoelesa tse anyesang ka lebese.
- Ha e kenngoe ka har'a sebete le liphio ka har'a insulinase ea enzyme.
- Ho felisoa ha moriana haholo-holo ka liphio.
Matšoao, contraindication le litla-morao
Humulin NPH e etselitsoe ho laola tsoekere ea mali ho bakuli ba nang le lefu la tsoekere le itšetlehileng ka lefu la tsoekere, hammoho le ketsahalo ea pele ea hyperglycemia ho basali nakong ea kemero.
Contraindication:
- hypersensitivity ho lithethefatsi le likarolo tsa eona;
- ho fokotseha ha tsoekere e ka tlase ho 3.3 - 5.5 mmol / l maling.
Litla-morao tse sa rateheng li kenyelletsa:
- hypoglycemia ke motsoako o kotsi o nang le dosing e lekaneng. E iponahatsa e le tahlehelo ea kelello, e ka ferekanngoang le moropa oa hyperglycemic;
- liponahatso tsa allergic sebakeng sa ente (redness, ho hlohlona, ho ruruha);
- ho tsitsa;
- ho hema hanyane
- hypotension;
- urticaria;
- tachycardia;
- lipodystrophy - atrophy ea lehae ea mafura a subcutaneous.
Melao e akaretsang ea tšebeliso
- Setlhare sena se lokela ho fanoa ka tlasa letlalo la mahetla, letheka, mabenyane kapa lebota la mpa ea mpa, 'me ka linako tse ling le ente ea methapo ea methapo le eona e ka khonahala.
- Kamora ho ente, ha oa lokela ho tobetsa ka matla le ho silila sebaka se hlaselang.
- Ho thibetsoe ho sebelisa lithethefatsi hampe.
- Tekanyetso e khethoa ka bonngoe ke endocrinologist mme e ipapisitse le liphetho tsa tlhahlobo ea mali bakeng sa tsoekere.
Algorithm bakeng sa tsamaiso ea insulin Humulin NPH
Litokisetso:
- Humulin ka lipilara e tlameha ho tsoakoa pele e sebelisoa ka ho pikitla vial pakeng tsa liatla ho fihlela 'mala oa lebese o hlaha. Se ke oa sisinyeha, foam, kapa sebelisa insulin e nang le masala a boreleli marakong a vial.
- Humulin NPH ka li-cartridge ha e tsamaise feela lipakeng tsa liatla, e pheta motsamao oa makhetlo a 10, empa hape e kopane, ka bonolo e fetole mokotla. Netefatsa hore insulin e loketse puso bakeng sa ho lekola maemo le mmala. Ho lokela hore ho be le se lumellanang ka har'a 'mala oa lebese. Hape u se ke ua theola sethethefatsi kapa sa foam. Se ke ua sebelisa tharollo ka likhoele kapa thapo. Li-insulin tse ling ha li na ho kenngoa ka har'a cartridge 'me li ke ke tsa tlatsoa.
- Pene ea syringe e na le 3 ml ea insulin-isophan ka tekanyo ea 100 IU / ml. Bakeng sa ente e le 'ngoe, kenya tse fetang 60 IU. Sesebelisoa se lumella metering ka ho nepahala ho fihla ho 1 IU. Etsa bonnete ba hore nale e kenelletse sesebelisoa ka thata.
- Hlatsoa matsoho u sebelisa sesepa, ebe u li tšoara ka motsoako oa litlolo.
- Etsa qeto mabapi le sebaka sa ente mme o phekole letlalo ka tharollo ea antiseptic.
- Lirapa tse ling tsa ente e le hore sebaka se tšoanang se se ke sa hlola se sebelisoa hang ka khoeli.
Likarolo tsa ts'ebeliso ea pene ea syringe ea sesebelisoa
- Tlosa capri ka ho e hula ntle le ho e potoloha.
- Lekola insulin, bophelo ba sehatsetsing, khalase le 'mala.
- Lokisetsa nale ea syringe joalokaha e hlalositsoe ka holimo.
- Khoele nale ena ho fihlela e tiile.
- Tlosa likhaba tse peli ka nale. Kantle - o se ke oa lahla.
- Lekola tšebeliso ea insulin.
- Ho kuta letlalo le ho kenya nale ka tlasa letlalo ka likhato tse 45.
- Kenyelletsa insulin ka ho tšoara konopo ka thipa ea hao ho fihlela e emisa, ho bala butle kelellong ho isa ho 5.
- Kamora ho tlosa nale, beha bolo ea joala sebakeng sa ente ntle le ho itlotsa kapa ho silafatsa letlalo. Ka tloaelo, lerotholi la insulin le ka sala ntlheng ea nale, empa ha le tsoe ho eona, ho bolelang hore lethalinyana le sa phethahalang.
- Koala nale ka sekoaelo sa kantle ebe u e lahla.
Tšebelisano e ka bang teng le lithethefatsi tse ling
Lithethefatsi tse eketsang phello ea Humulin:
- tafole ea li-hypoglycemic;
- li-antidepressants - li-inhibitors tsa monoamine oxidase;
- lithethefatsi tsa hypotonic tse tsoang sehlopheng sa li-inhibitors tsa ACE le beta-blockers;
- li-inhibitors tsa carbonic anhydrase;
- imidazoles;
- lithibela-mafu tsa tetracycline;
- Litokisetso tsa lithium;
- Li-vithamine tsa B;
- theophylline;
- lithethefatsi tse nang le joala.
Lithethefatsi tse thibelang ketso ea "insulin" ea insulin:
- lipilisi tsa thibelo ea bokhachane;
- glucocorticosteroids;
- lihormone tsa qoqotho;
- diuretics;
- li-antidepressants tsa tricyclic;
- mahlahana a buisang ts'ebetso ea methapo ea kutloelo-bohloko;
- calcium blockers;
- analcics ea narcotic.
Li-analog tsa Humulin
| Lebitso la khoebo | Moqapi |
| Insuman Bazal | Sanofi-Aventis Deutschland GmbH, (Duitsland) |
| Protafan | Novo Nordisk A / S, (Denmark) |
| Berlinsulin N Basal U-40 le Berlisulin N pen | Berlin-Chemie AG, (Jeremane) |
| Actrafan HM | Novo Nordisk A / O, (Denmark) |
| Br-Insulmidi ChSP | Bryntsalov-A, (Russia) |
| Humodar B | Indar Insulin Production CJSC, (Ukraine) |
| Mokete oa Lefatše oa Isofan Insulin | AI CN Galenika, (Yugoslavia) |
| Homofan | Pliva, (Kroatia) |
| Biogulin NPH | Bioroba SA, (Brazil) |
Tlhahlobo ea lithethefatsi tsa insulin-isophan antidiabetic:
Ke ne ke batla ho etsa khalemelo - ho thibetsoe ho fana ka insulin ka nako e telele!
Litaelo tse khethehileng bakeng sa tšebeliso
Moriana o lokela ho laeloa ke ngaka feela. Tloha litlolong tsa litlhare ka taelo ea ngaka. Nakong ea phekolo le Humulin NPH, ho hlahlojoa khafetsa ha boemo ba tsoekere hoa hlokahala. Boteng ba maloetse a kopaneng - buisana le ngaka bakeng sa tokiso ea litekanyetso.
