Meriana e fapaneng e sebelisoa ho latela mofuta oa lefu la tsoekere.
Bakeng sa mofuta oa 1, li-insulin li laetsoe, 'me bakeng sa mofuta oa 2, haholo-holo litokisetso tsa letlapa.
Lithethefatsi tse theolelang tsoekere li kenyelletsa Glucovans.
Tlhahisoleseling ka kakaretso mabapi le lithethefatsi
Foromo ea Metformin
Glucovans (glucovance) - sethethefatsi se rarahaneng se nang le phello ea hypoglycemic. Ho ikhetholla ha eona ke ho kopanya likarolo tse peli tse sebetsang tsa lihlopha tse fapaneng tsa meriana ea metformin le glibenclamide. Motsoako ona o matlafatsa phello.
Glibenclamide ke moemeli oa moloko oa 2 oa lihlahisoa tsa sulfonylurea. E tsejoa e le sethethefatsi se sebetsang ka ho fetisisa sehlopheng sena.
Metformin e nkoa e le sethethefatsi sa mola oa pele, se sebelisoang ho sa na le phello ea kalafo ea ho ja. Ntho, ha e bapisoa le glibenclamide, e na le kotsi e tlase ea hypoglycemia. Ho kopana ha likarolo tsena tse peli ho u lumella ho fihlela sephetho se hlakileng le ho eketsa katleho ea kalafo.
Ketso ea moriana e bakoa ke likarolo tse peli tse sebetsang - glibenclamide / metformin. E le tlatsetso, ho sebelisoa magnesium stearate, povidone K30, MCC, sodium ea croscarmellose.
E fumaneha ka foromo ea letlapa ka litekanyetso tse peli: 2,5 mg (glibenclamide) +500 mg (metformin) le 5 mg (glibenclamide) +500 mg (metformin).
Ketso ea pharmacological
Foromo ea Glibenclamide
Glibenclamide - e thibela literata tsa potasiamo mme e tsosa lisele tsa pancreatic. Ka lebaka leo, secretion ea li-hormone e eketseha, e kenella maling le mokelikeli oa methapo.
Katleho ea ho hlohlelletsa secretion ea li-hormone ho latela litekanyetso li nkuoeng. Fokotsa tsoekere ho bakuli ba nang le lefu la tsoekere le batho ba phetseng hantle.
Metformin - e thibela ho thehoa ha tsoekere ka har'a sebete, e phahamisa kutloisiso ea lisele tsa mmele ho ea ho hormone, e thibela ho kenngoa ha glucose maling.
Ho fapana le glibenclamide, ha e khothalletse synthesis insulin. Ntle le moo, e na le phello e ntle ho profid ea lipid - k'holeseterole e felletseng, LDL, triglycerides. Ha e fokotse boemo ba tsoekere ba pele ho batho ba phetseng hantle.
Mofumahali
Glibenclamide e kenella ka mafolofolo ho sa tsotelehe takatso ea lijo. Kamora lihora tse 2,5, karolo ea eona e phahameng maling e fihlella, kamora lihora tse 8 e ea fokotseha butle butle. Bophelo bo halofo ke lihora tse 10, 'me ho felisoa ka botlalo ke matsatsi a 2-3. Hoo e batlang e le metabolism ka botlalo Ntho ena e pepesitsoe ka har'a moroto le bile. Ho kopanya liprotheine tsa plasma ha ho fetele ho 98%.
Kamora ho tsamaisoa ka molomo, metformin e batla e ananeloa ka botlalo. Ho ja ho ama ho amoheloa ha metformin. Kamora lihora tse 2,5, karolo ea tlhoko ea ntho ena e fihlella; e tlase maling ho fapana le plasma ea mali. Ha e tšeloe 'mele' me ha e fetohe. Ho felisoa ha halofo ea bophelo ke lihora tse 6.2. E ntsoa haholo ka moroto. Ho buisana le liprotheine ha ho na thuso.
The bioavailability ea lithethefatsi e tšoana le ka karohano e arohaneng ea motsoako o mong le o mong o sebetsang.
Matšoao le contraindication
Har'a matšoao a ho nka matlapa a Glucovans:
- Mofuta oa 2 oa lefu la tsoekere ha ho na katleho ea kalafo ea ho ja, ho ikoetlisa;
- Mofuta oa 2 oa lefu la tsoekere ha o na phello nakong ea monotherapy ka bobeli ba Metformin le Glibenclamide;
- ha u nkela kalafo ho bakuli ba nang le boemo bo laoloang ba glycemia.
Contraindication e sebelisitsoeng ke:
- Mofuta oa 1 lefu la tsoekere;
- hypersensitivity ho sulfonylureas, metformin;
- hypersensitivity ho likarolo tse ling tsa lithethefatsi;
- ho se sebetse ha liphio;
- ho ima / ho nyekeloa ke mpa;
- lefu la tsoekere la ketoacidosis;
- ts'ebetso ea ho buoa;
- lactic acidosis;
- botaoa ba joala;
- lijo tsa hypocaloric;
- lilemo tsa bana;
- ho nyekeloa ke pelo;
- ho hloleha ho phefumoloha;
- mafu a tšoaetsanoang a matla;
- lefu la pelo;
- porphyria;
- mosebetsi o sa sebetseng oa renal.
Litaelo tsa ho sebelisoa
Pilisi e beoa ke ngaka, e nahanela boemo ba glycemia le litšobotsi tsa 'mele. Ka karolelano, mofuta o tloaelehileng oa kalafo o ka tsamaisana le se boletsoeng. Qalo ea kalafo e le 'ngoe ka letsatsi. Ho thibela hypoglycemia, ha ea lokela ho feta tekanyetso e neng e thehiloe ea metformin le glibenclamide ka thoko. Keketseho, haeba ho hlokahala, e etsoa libeke tse ling le tse ling tse peli kapa ho feta.
Maemong a phetisetso ea meriana ho tloha ho lithethefatsi ho ea Glucovans, kalafo e laetsoe ho nahanoa ka litekanyetso tse fetileng tsa karolo e ngoe le e ngoe e sebetsang. Palo e thehiloeng letsatsi le letsatsi ke likarolo tse 4 tsa 5 + 500 mg kapa 6 likarolo tsa 2,5 + 500 mg.
Matlapa a sebelisoa hammoho le lijo. Ho qoba tsoekere e ngata maling, etsa hore lijo li be le limatlafatsi tse ngata nako le nako ha u sebelisa moriana.
Video e tsoang ho Dr. Malysheva:
Bakuli ba khethehileng
Setlhare ha se laeloe nakong ea ho rera le nakong ea kemolo. Maemong a joalo, mokuli o fetisetsoa ho insulin. Ha u rera ho ima, u lokela ho tsebisa ngaka ea hau. Ka lebaka la tlhaiso ea tlhaiso-leseling, ka lactation, Glucovans ha e sebelisoe.
Bakuli ba baholo (> ba lilemo li 60) ha ba fuoe meriana e laetsoeng. Batho ba sebetsang ka thata 'meleng le bona ha ba khothaletsoe ho sebelisa meriana. Sena se amahanngoa le likotsi tse phahameng tsa lactic acidosis. Ka khaello ea methapo ea methapo ea methapo ea methapo, ho lokela ho hopoloa hore lithethefatsi li liehisa ho amoheloa ha B 12.
Litaelo tse ikhethang
Sebelisa ka hloko ka mafu a tšoelesa ea qoqotho. Ha ho na moriana o laetsoeng bana. Glucovans ha e lumelloe ho kopantsoe le joala.
Phekolo e lokela ho tsamaea le mokhoa oa ho lekanya tsoekere pele / ka mor'a lijo. Ho khothalletsoa hape ho lekola mahloriso a creatinine. Tabeng ea ho senyeha ha mosebetsi oa renal ho batho ba tsofetseng, ho lekola ho etsoa makhetlo a 3-4 ka selemo. Ka ts'ebetso e tloaelehileng ea litho, ho lekane ho etsa tlhahlobo hang ka selemo.
Lihora tse 48 pele / ka mor'a ho buuoa, moriana o hlakotsoe. Lihora tse 48 pele / kamora tlhahlobo ea X-ray e nang le ntho ea radiopaque, Glucovans ha e sebelisoe.
Batho ba nang le ho nyekeloa ke pelo ba na le menyetla e eketsehileng ea ho ba le ho hloleha ha liphio le hypoxia. Ho khothalletsoa ho lekola matla a tšebetso ea pelo le a liphio.
Litla-morao le overdose
Har'a litla-morao nakong ea ho jeoa hoa bonoa:
- e atileng haholo ke hypoglycemia;
- lactic acidosis, ketoacidosis;
- tlolo ea tatso;
- thrombocytopenia, leukopenia;
- ho eketseha ha creatinine le urea maling;
- ho haelloa ke takatso ea lijo le mafu a mang a phepelo ea ka mpeng;
- urticaria le ho hlohlona ha letlalo;
- ho senyeha ha tšebetso ea sebete;
- hepatitis;
- hyponatremia;
- vasculitis, erythema, dermatitis;
- ho ferekana hoa pono hoa tlhaho ea nakoana.
Haeba ho na le overdose ea Glucovans, hypoglycemia e ka hlaha ka lebaka la boteng ba glibenclamide. Ho nka 20 g ya tsoekere e thusa ho emisa mats'oafo a boima bo lekaneng. Ho ea pele, phetoho ea litekanyetso ea phepo e ea phetoa, phepo e ea hlahlojoa. Hypoglycemia e matla e hloka tlhokomelo ea tšohanyetso le ho kena sepetlele. Ho ba le overdose ea bohlokoa ho ka lebisa ho ketoacidosis ka lebaka la ho ba teng ha metformin. Boemo bo tšoanang bo phekoloa sepetlele. Mokhoa o sebetsang ka ho fetisisa ke hemodialysis.
Ho sebelisana le meriana e meng
Se ke oa kopanya sethethefatsi le phenylbutazone kapa danazole. Haeba ho hlokahala, mokuli o beha tšebetso ea hae ka matla. Li-inhibitors tsa ACE li fokotsa tsoekere. Keketseho - corticosteroids, chlorpromazine.
Glibenclamide ha e khothalletsoe ho kopantsoe le miconazole - ts'ebelisano e joalo e eketsa likotsi tsa hypoglycemia. Ho matlafatsa ts'ebetso ea ntho ho ka etsahala ha o ntse o nka Fluconazole, anabolic steroids, clofibrate, antidepressants, sulfalamides, lihormone tsa banna, li-coumarin derivatives, cytostatics. Lihormone tsa basali, lihormone tsa qoqotho, glucagon, barbiturates, diuretics, sympathomimetics, corticosteroids li fokotsa phello ea glibenclamide.
Ka tsamaiso e tšoanang ea metformin e nang le diuretics, monyetla oa ho nts'etsapele lactic acidosis e eketseha. Lintho tsa Radiopaque ha li kopane li ka qholotsa ho hloleha ha meno. Qoba feela tšebeliso ea joala, empa hape le lithethefatsi tse nang le litaba tsa eona.
Tlhahisoleseling e eketsehileng, li-analogues
Theko ea lithethefatsi Glukovans ke li-ruble tse 270. Ha e hloke maemo a itseng a polokelo. E fanoe ke lengolo la ngaka. Bophelo ba Shelf ke lilemo tse 3.
Tlhahiso - Merck Sante, Fora.
Analogue e felletseng (likarolo tse sebetsang) ke Glybomet, Glybofor, Duotrol, Glunored.
Ho na le mefuta e meng ea likarolo tse sebetsang (metformin le glycoslide) - Dianorm-M, metformin le glipizide - Dibizid-M, metformin le glimeperide - Amaryl-M, Douglimax.
Phetoho e ka ba lithethefatsi tse nang le ntho e le 'ngoe e sebetsang. Glucofage, Bagomet, Glycomet, Insufort, Meglifort (metformin). Glibomet, Maninil (glibenclamide).
Maikutlo a lefu la tsoekere
Tlhahlobo ea mokuli e bontša katleho ea li-Glucovans le ka theko e amohelehang. Hape hoa tsebahala hore tekanyo ea tsoekere ha u ntse u sebelisa moriana e lokela ho hlaha hangata.
Qalong o ile a nka Glucophage, kamora hore a ngoletsoe Glucovans. Ngaka e nkile qeto ea hore e tla sebetsa haholoanyane. Setlhare sena se fokotsa tsoekere haholoanyane. Feela joale re tlameha ho nka mehato khafetsa ho thibela hypoglycemia. Ngaka e ile ea ntsebisa ka sena. Phapang lipakeng tsa Glucovans le Glucophage: meriana ea pele e na le glibenclamide le metformin, 'me ea bobeli e na le metformin feela.
Salamatina Svetlana, ea lilemo li 49, Novosibirsk
Ke qetile lilemo tse 7 ke tšoeroe ke lefu la tsoekere. Haufinyane ke ile ka fuoa sehlahisoa se kopaneng sa Glucovans. Hang-hang ho melemo: ts'ebetso, boiketlo ba tšebeliso, polokeho. Theko le eona ha e lome - bakeng sa sephutheloana ke fana feela 265 r, e lekaneng halofo ea khoeli. Har'a mefokolo: ho na le likhohlano, empa ha ke karolo ea sehlopha sena.
Lidia Borisovna, ea lilemo li 56, Yekaterinburg
Lithethefatsi li laetsoe 'm'e oa ka ke lefu la tsoekere. O nka Glucovans hoo e ka bang lilemo tse peli, o ikutloa hantle, ke mo bona a le mafolofolo a bile a thabile. Qalong, mme oa ka o ne a tšoeroe ke mala - ho nyekeloa le pelo le takatso ea lijo, kamora khoeli khoeli tsohle li ile. Ke phethile ka hore moriana o oa sebetsa ebile o thusa hantle.
Sergeeva Tamara, ea lilemo li 33, Ulyanovsk
Ke ile ka nka Maninil pele, tsoekere e bolokiloe e ka ba 7.2. O fetohetse Glucovans, ka beke tsoekere e theohetse ho 5,3. Ke kopanya kalafo le boikoetliso ba 'mele le lijo tse khethiloeng ka ho khethehileng. Ke lekanya tsoekere hangata mme ha ke lumelle maemo a feteletseng. Hoa hlokahala ho fetohela ho moriana feela ka mor'a ho kopana le ngaka, hlokomela litekanyetso tse hlalositsoeng hantle.
Alexander Savelyev, ea lilemo li 38, St. Petersburg
