Lantus ke e 'ngoe ea liphatlalatso tsa pele tse se nang thuso tsa insulin ea motho. E fumaneha ka ho nkela sebaka sa amino acid tlhapi le glycine maemong a 21 a ketane ea A mme o kenyelletsa li-acid tse peli tsa arginine amino acid ka ketane ea B ho terminal amino acid. Setlhare sena se hlahisoa ke mokhatlo o moholo oa meriana oa Mafora - Sanofi-Aventis. Nakong ea lithuto tse ngata, ho ile ha paka hore insulin Lantus ha e fokotse feela kotsi ea hypoglycemia ha e bapisoa le lithethefatsi tsa NPH, empa hape e ntlafatsa metabolism ea carbohydrate. Ka tlase ho na le litaelo tse khutšoane tsa tšebeliso le litlhahlobo tsa lefu la tsoekere.
Litaba tsa sengoloa
- 1 Ts'ebetso ea mahlale
- 2 Moetso
- 3 mokhoa oa ho lokolla
- Matšoao a 4
- 5 Ho sebelisana le lithethefatsi tse ling
- 6 Khahlano le lipuisano
- 7 Phetoho ho Lantus e tsoang insulin e 'ngoe
- 8 Li-Analog
- 9 Insulin Lantus nakong ea kemolo
- 10 Mokhoa oa ho boloka
- 11 Moo u ka rekang teng, theko
- Litlhahlobo tse 12
Ketso ea pharmacological
Ntho e sebetsang ea Lantus ke insulin glargine. E fumanoa ka ho ikatisa ka liphatsa tsa lefutso, ho sebelisoa mofuta oa k-12 oa bacterium Escherichia coli. Sebakeng se sa jeleng paate, se qhibiliha hanyane, ka har'a asiti e qhibiliha ka sebopeho sa microprecipitate, e hlahisang insulin khafetsa le hanyane ka hanyane. Ka lebaka lena, Lantus e na le profil ea liketso e nkehang e nka lihora tse 24.
Melemo ea mantlha ea meriana
- Slow adsorption le profil ea ketso e se nang thuso nakong ea lihora tse 24.
- Khatello ea liprotheine le lipolysis ho li-adipocytes.
- Karolo e sebetsang e tlama ho li-insulin receptors ka makhetlo a 5-8 le ho feta.
- Taolo ea tsoekere ea glucose, thibelo ea sebopeho sa tsoekere bokong.
Sebopeho
Ho 1 ml ea Lantus Solostar e na le:
- 3.6378 mg ea insulin glargine (e thehiloeng ho 100 IU ea insulin ea motho);
- 85% glycerol;
- metsi bakeng sa ente;
- asiti ea hydrochloric e kenelletseng;
- m-cresol le sodium hydroxide.
Fomu ea tokollo
Lantus - tharollo e hlakileng ea ente ea sc, e fumaneha ka mokhoa oa:
- li-cartridge tsa sistimi ea OptiClick (5pcs ka pakete);
- Lipentšele tse 5 tsa syringe Lantus Solostar;
- OptiSet peni ea syringe ka paketeng e le 'ngoe 5 likhomphutha. (likhato tsa 2);
- Li-viel tse 10 (likoto tse 1000 ka botlolo).
Matšoao a ho sebelisoa
- Batho ba baholo le bana ba lilemo tse 2 ba nang le lefu la tsoekere la mofuta oa 1.
- Type 2 lefu la tsoekere mellitus (tabeng ea ho se sebetse hantle ha litokisetso tsa letlapa).
Bophelong ba botenya, kalafo e kopaneng ea sebetsa - Lantus Solostar le Metformin.
Ho sebelisana le lithethefatsi tse ling
Ho na le lithethefatsi tse amang metabolism ea carbohydrate, ha li ntse li eketsa kapa li fokotsa tlhoko ea insulin.
Fokotsa tsoekere: li-antidiabetesic tsa molomo, sulfonamides, li-inhibitors tsa ACE, salicylates, angioprotectors, monoamine oxidase inhibitors, li-dysopyramides tsa antiarrhythmic, li-analcics tsa narcotic.
Eketsa tsoekere: lihormone tsa qoqotho, li-diuretics, li-audiathomimetics, lithibela-pelehi tsa molomo, litlamorao tsa phenothiazine, li-inhibitors tsa protheine.
Lintho tse ling li na le phello ea hypoglycemic le phello ea hyperglycemic. Tsena li kenyeletsa:
- li-beta blockers le lithaelese tsa lithium;
- joala
- clonidine (setlhare sa antihypertensive).
Contraindication
- Ha hoa lumelloa ho sebelisoa ho bakuli ba sa mamelleng ho kenya insulin glargine kapa likarolo tse thusang.
- Hypoglycemia
- Phekolo ea lefu la tsoekere la ketoacidosis.
- Bana ba ka tlase ho lilemo tse peli.
Liphetoho tse ka ba teng tse nyarosang ha li hlahe hangata, litaelo li re ho ka ba le:
- lipoatrophy kapa lipohypertrophy;
- litla-morao (motsamao oa Quincke oa Quincke, tšohanyetso) le bronchospasm);
- bohloko ba mesifa le ho lieha 'meleng oa li-ion tsa sodium;
- dysgeusia le ho senyeha hoa pono.
Phetoho ho Lantus e tsoang insulin e 'ngoe
Haeba lefu la tsoekere le sebelisitse insulin tsa nako e telele, joale ha le fetoha Lantus, litekanyetso le mofuta oa lithethefatsi li oa fetoloa. Phetoho ea insulin e lokela ho etsoa sepetlele feela.
Haeba li-insulin tsa NPH (Protafan NM, Humulin, joalo-joalo) li ne li tsamaisoa makhetlo a 2 ka letsatsi, hangata Lantus Solostar e sebelisoa hangata 1. Ka nako e ts'oanang, bakeng sa ho fokotsa kotsi ea hypoglycemia, tekanyo ea pele ea insulin glargine e lokela ho ba tlase ka 30% ho feta NPH.
Nakong e tlang, ngaka e sheba tsoekere, tsela eo mokuli a phelang ka eona, boima ba eona le ho ntlafatsa palo ea likarolo tse tsamaisitsoeng. Kamora likhoeli tse tharo, katleho ea kalafo e boletsoeng e ka hlahlojoa ka tlhahlobo ea hemoglobin ea glycated.
Taeo ea video:
Li-analog
| Lebitso la khoebo | Ntho e sebetsang | Moqapi |
| Tujeo | insulin glargine | Jeremane, Sanofi Aventis |
| Levemir | insulin | Denmark, Novo Nordisk A / S |
| Islar | insulin glargine | India, Biocon Limited PAT "Farmak" |
Naheng ea Rashea, bohle ba nang le lefu la tsoekere ba itšetlehileng ka insulin ba ile ba tlosoa Lantus ba isoa Tujeo ka likhoka. Ho latela liphuputso, sethethefatsi sena se secha se na le kotsi e tlase ea ho ba le hypoglycemia, empa ts'ebetsong, batho ba bangata ba tletleba hore kamora ho fetohela Tujeo tsoekere ea bona e tlole haholo, kahoo ba tlameha ho ithekela insulin ea Lantus Solostar ka bo bona.
Levemir ke lithethefatsi tse ntle, empa e na le ntho e fapaneng e sebetsang, leha nako ea ts'ebetso e boetse e le lihora tse 24.
Aylar ha a ka a kopana le insulin, litaelo li re ena ke eona Lantus e tšoanang, empa moetsi le eena o theko e tlase.
Insulin Lantus nakong ea kemolo
Lithuto tsa semmuso tsa Lantus le basali baimana ha li e-so tšoaroe. Ho latela mehloli e seng ea semolao, lithethefatsi ha li ame hampe mokhachane le ngoana ka boeena.
Liteko li ile tsa etsoa ho liphoofolo, nakong eo ho ileng ha netefatsoa hore insulin glargine ha e na phello e kotsi mosebetsing oa ho ikatisa.
Mokhachane Lantus Solostar a ka khethoa haeba a hloka insulin NPH. Bo-'mè ba nakong e tlang ba lokela ho lekola tsoekere ea bona, hobane ka trimester ea pele, tlhoko ea insulin e ka fokotseha, mme ho trimester ea bobeli le ea boraro.
Se ke oa tšaba ho anyesa lesea, litaelo ha li na tlhahisoleseling eo Lantus e ka e fetisang lebeseng la matsoele.
Mokhoa oa ho boloka
Letsatsi la ho felloa ke nako la Lantus ke lilemo tse 3. U hloka ho boloka sebakeng se lefifi se sirelelitsoeng ke khanya ea letsatsi ka mocheso oa likhato tse 2 ho isa ho tse 8. Ka tloaelo sebaka se loketseng hantle ke sehatsetsi. Maemong ana, etsa bonnete ba hore u shebile puso ea mocheso, hobane ho kenella ka mokhoa o sa tsitsang oa insulin Lantus ho thibetsoe!
Ho tloha ts'ebeliso ea pele, moriana o ka bolokoa khoeli sebakeng se lefifi ka mocheso o sa feteng 25 degrees (eseng sehatsetsing). Se ke oa sebelisa insulin e felletseng.
Moo u ka rekang teng, theko
Lantus Solostar e laetsoe ntle ho tefo ka taelo ea ngaka ke endocrinologist. Empa ho boetse ho etsahala hore motho ea nang le lefu la tsoekere a tlameha ho reka sehlahisoa sena a le mong khemising. Theko e tloaelehileng ea insulin ke li-ruble tse 3300. Ukraine, Lantus e ka rekoa ka 1200 UAH.
Litlhahlobo
Litsebi tsa lefu la tsoekere le re ke insulin e ntle haholo, hore tsoekere ea bona e bolokoa ka har'a meeli e tloaelehileng. Mona ke seo batho ba se buang ka Lantus:
Boholo bo siile feela litlhahlobo tse ntle. Batho ba 'maloa ba boletse hore Levemir kapa Tresiba o ba loketseng hantle.
