Ho sebetsa ha Tritace Plus ho ipapisitse le litlamorao tsa ramipril le hydrochlorothiazide. Likarolo tsena ka bobeli li thibela phetoho ea angiotensin I hore e be mofuta oa angiotensin II, ka tsela eo, e ka fihlela katleho. Maemong ana, lithethefatsi ha li hlalosoe hangata litloaelong tsa bongaka e le monotherapy. Bakuli ba fumana moemeli ea hapang maikutlo e le karolo ea kalafo e rarahaneng ea khatello ea mali ea methapo ho fihlella maemo a tsitsitseng a khatello ea mali.
Lebitso la Machaba le sa Tšoanelehang
Hydrochlorothiazide + Ramipril.
ATX
C09BA05.
Ho sebetsa ha Tritace Plus ho ipapisitse le litlamorao tsa ramipril le hydrochlorothiazide.
Lokolla liforomo le sebopeho
Setlhare se fumaneha ka foromo ea lipilisi. Letlapa le le leng la 1 le kopanya likhomphutha tse peli tse sebetsang - ramipril le hydrochlorothiazide.
| Lintho tse sebetsang | Motsoako o ka khonehang, mg | |||
| Ramipril | 12,5 | 12,5 | 25 | 25 |
| Hydrochlorothiazide | 5 | 10 | 5 | 10 |
| Lipilisi tsa mmala | pinki | lamunu | tšoeu | pinki |
Ho ntlafatsa likarolo tsa pharmacokinetic, ho sebelisoa metsoako e meng:
- sodium stearyl fumarate;
- iron oxide, e fanang ka litafole 'mala oa motho ka mong ho latela bongata ba likarolo tse sebetsang;
- sterek ea lijo-thollo tsa gelatinized;
- cellcose ea microcrystalline;
- hypromellose.
Matlapa a Oblong, a nang le mola o arolang mahlakore ka bobeli.
Ha ho na lithethefatsi tse fanoang ka tloaelo molemong oa bongaka.
Ketso ea pharmacological
Tritace e kopanya angiotensin e fetolang enzyme (ACE) inhibitor - ramipril, le thiazide diuretic hydrochlorothiazide. Motsoako oa likarolo tse sebetsang o na le phello e matla ea antihypertensive. The ACE blocker e thibela ho etsoa ha angiotensin II, e hlokahalang ho fokotsa mesifa e boreleli ea vasotine endothelium.
Ramipril e thibela ho hlaha ha phello ea vasoconstrictor mme e thibela ho phatloha ha bradykinin, ntho ea keketseho ea tlhaho ea methapo ea mali. Hydrochlorothiazide e ntlafatsa vasodilation, ka lebaka la eona likepe li atoloha haholoanyane. Ho bohlokoa ho boloka molumo o tloaelehileng oa ho potoloha mali e le ho qoba nts'etsopele ea bradycardia le arterial hypotension.
Phello e phahameng ea kalafo e bonoa lihora tse 3-6 ka mor'a kopo mme e phehella letsatsi. Phello ea diuretic ea thiazide diuretic e nka lihora tse 6-12.
Mofumahali
Ramipril le hydrochlorothiazide li kenella ka potlako ho projimalum ea jejunum, ho tloha moo li kenellang tsamaisong ea kemiso. The bioavailability ea hydrochlorothiazide ke 70%. Meleng, metsoako ka bobeli ea lik'hemik'hale e fihla sehlohlolong ka nako ea lihora tse 2 ho isa ho tse peli. Ramipril o na le tekanyo e phahameng ea ho tlama liprotheine tsa plasma - 73%, ha 40% feela ea hydrochlorothiazide e theha rarahaneng e nang le albin.
Bophelo ba halofo ea likarolo tsena ka bobeli bo fihlella lihora tse 5-6. Ramipril e qotsitsoe ka 60% ka kopanelo le moroto. Hydrochlorothiazide e siea 'mele ka sebopeho sa eona sa pele ka 95% ho isa liponong nakong ea lihora tse 24.
Matšoao a ho sebelisoa
Setlhare sea hlokahala ho theola khatello e phahameng ea mali.
Setlhare sea hlokahala ho theola khatello e phahameng ea mali.
Contraindication
Lithethefatsi li kopantsoe ho batho ba nang le:
- hypersensitivity ho hydrochlorothiazide, ramipril le lintho tse ling tsa sebopeho sa Tritace;
- maikemisetso a nts'etsopele ea Quincke edema;
- ho se sebetse hantle ha renal;
- liphetoho tsa li-electrolyte tsa plasma: potasiamo, magnesium, calcium;
- lefu le matla la sebete;
- khatello e matla ea methapo ea kutlo.
Ka tlhokomelo
Hoa hlokahala ho laola boiketlo ka kakaretso nakong ea phekolo ea lithethefatsi boteng ba li-pathologies tse latelang:
- lefu la pelo le matla;
- ho senyeha ka har'a ventricle e ka letsohong le letšehali, ho khetholloang ka liphetoho tsa hypertrophic;
- stenosis ea methapo e ka sehloohong ea mokokotlo, mokokotlo kapa methapo ea kutlo;
- khathatso ea metabolism ea-electrolyte;
- ka tumello ea creatinine ea 30-60 ml / min;
- nako ea ho hlaphoheloa kamora ho fetisoa ha meno;
- lefu la sebete
- ho senya lithane tse sebetsanang - scleroderma, lupus erythematosus;
- khatello ea ho potoloha ha lisele.
Bakuli ba neng ba nkile diuretics pele ba tlameha ho laola boemo ba letsoai la metsi.
Mokhoa oa ho nka Tritace Plus
Moriana ha o fuoe kalafo ea kalafo ea kalafo ea kalafo. Matlapa a etselitsoe ho sebelisoa ka molomo. Ho khothalletsoa ho noesa meriana hoseng. Litekanyetso li beoa ke setsebi sa bongaka ho latela matšoao a khatello ea mali (BP) le ho teba ha khatello ea mali.
Tekanyetso e tloaelehileng qalong ea kalafo ea lithethefatsi ke 2,5 mg ea ramipril hammoho le 12,5 mg ea hydrochlorothiazide. Ka mamello e ntle, ho eketsa phello e matlafatsang, litekanyetso li ka eketsoa kamora libeke tse 2-3.
Le lefu la tsoekere
Lithethefatsi li ka lebisa ho hypoglycemia ka tšebeliso e tšoanang ea lithethefatsi tsa hypoglycemic kapa insulin, ka hona, nakong ea kalafo ka moriana oa antihypertgency, ho hlokahala hore o fetole litekanyetso tsa lithethefatsi tsa antidiabetesic. Bakuli ba nang le lefu la tsoekere ba lokela ho lula ba lekola likhahla tsa tsoekere ea mali.
Litla-morao tsa Tritace Plus
Maemong a mangata, ho tšeloa ha Tritace ka tsela e sa lokang ho lebisa ho mokhathala o sa feleng le feberu.
Phekolo ea ka mpeng
Mathata a amanang le tšilo ea lijo a bontšoa ke nts'etsopele ea ho ruruha ha lisele tsa mucous, ponahalo ea gingivitis, reflexes ea ho hlatsa le ho sokela. Mohlomong nts'etsopele ea gastritis, ho hlonama ka mpeng.
Ka mafu a ka mpeng, gastritis e ka hlaha e le litla-morao.
Hematopoietic litho tsa ka hare
Ka ho fokotseha ha hematopoiesis ea masapo, palo ea lisele tse bopehileng joaloka mali ea fokotseha.
Tsamaiso ea methapo e bohareng
Ka tahlehelo ea taolo ea maikutlo le kelello, mokuli o na le khatello ea maikutlo, ho tšoenyeha le bothata ba ho robala. Khahlano le semelo sa khatello ea maikutlo, ho lahleheloa ke kelello sebakeng, hlooho, hlooho e tukang, tahlehelo kapa tatso e halefileng.
Ho tsoa ts'ebetsong ea moroto
Mohlomong keketseho ea bongata ba moroto o ntšoa le nts'etsopele ea ho hloleha ha liphio ka matla.
Ho tsoa tsamaisong ea phefumoloho
Maemong a mangata, ka lebaka la keketseho ea boemo ba bradykinin, ho khohlela ho omileng ho ka hlaha, ho bakuli ba bang - ho tsitsipana ha nko le ho ruruha ha litlolo.
Karolong ea letlalo
Ho na le kotsi ea ho ba le angioedema, e ka lebisang ho asphyxia maemong a mang. Matšoao a kang a Psoriasis, mofufutso o eketsehang, makhopho, ho hlohlona le erythema ea etiology tse fapaneng li a khonahala.
Ka lebaka la ho sebelisa lithethefatsi, erythema ea etiology tse fapaneng e ka hlaha.
Ho tsoa ts'ebetsong ea genitourinary
Bakeng sa banna, ho fokotseha ha erection le keketseho ea litšoelesa tsa mammary lia khonahala.
Ho tsoa ho tsamaiso ea methapo ea pelo
Mohlomong ho theoha ho matla ha khatello ea mali, thrombosis ka lebaka la ho fokola hoa metsi, stenosis ea methapo e meholo, thibelo ea phallo ea mali, ho ruruha ha methapo ea methapo le lefu la Raynaud.
Sistimi ea Endocrine
Ho ka etsahala hore ebe ho eketsa tlhahiso ea li-hormone tsa antidiuretic.
Karolong ea sebete le tsamaiso ea biliary
Maemong a ikhethang, ho ruruha ha cytolytic ea sebete ho hlaha ka phello e ka bolaeang. Ho na le keketseho ea boemo ba bilirubin maling le ho hlaha ha cholecystitis e baloang.
Allergie
Mathata a ho kula a bonahala ka ponahalo ea ho fetoha ha letlalo.
Mathata a ho kula a bonahala ka ponahalo ea ho fetoha ha letlalo.
Ho tsoa ho tsamaiso ea musculoskeletal le lisele tse sebetsanang
Motho a ka utloa bohloko le bofokoli mesifa.
Ho tloha ka lehlakoreng la metabolism
Maemong a ikhethang, ho na le phokotseho ea mamello ea lithane ho tsoekere, ka lebaka leo tsoekere ea mali e eketsang. Khahlano le metabolism e akaretsang, litaba tsa urea tse tsoang plasma ea mali li eketseha, 'me ea mpefala le ho hlohlontša. Maemong a sa tloaelehang, ho ba le hypokalemia le metabolic acidosis.
Ho tsoa ho sesole sa 'mele
Mohlomong nts'etsopele ea karabelo ea anaphylactic mabapi le keketseho ea karolo ea lithibela-mafu tse thibelang likokoana-hloko. Tritace ea kamohelo ea motho e ka tsosa Angioedema ea sefahleho, mala a manyane, maoto le leleme.
Tšusumetso ho bokhoni ba taolo ea methapo
Ka lebaka la ho fokotseha ho hoholo ha pono ea mahlo le ho lahleheloa ke kelello, mokuli o tlameha ho ba hlokolosi ha a khanna lisebelisoa tse thata kapa likoloi tsa makoloi tse hlokang lebelo le leholo la karabelo ea psychomotor le khatello e eketsehileng.
Ka lebaka la ho fokotseha ho hoholo ha pono le ho lahleheloa ke kelello, mokuli o lokela ho ba hlokolosi ha a khanna lisebelisoa tse thata kapa likoloi.
Litaelo tse khethehileng
Pele ho ts'ebetso e reriloeng ea ts'ebetso ea bongaka e hlokahalang, ho bohlokoa ho lemosa ngaka e buoang le ngaka e robatsang ka thipa mabapi le kalafo e nang le ACE inhibitor. Sena se hlokahala ho thibela ho theoha ha khatello ea mali nakong ea ts'ebetso.
Sebelisa nakong ea bokhachane le pelehi
Ka lebaka la litlamorao tse ka ba teng tsa teratogenic le fetotoxic, moriana ha o fuoe basali ba baimana. Ho na le kotsi ea ho senyeha ha litho tsa ka hare ho mpa.
Nakong ea kalafo, o lokela ho emisa ho anyesa.
Khetho ea Tritace Plus ea bana
Ka lebaka la khaello ea tlhaiso-leseling ka phello ea Tritace 'meleng oa motho nakong ea kholo, moriana o kopantsoe le bana ba ka tlase ho lilemo tse 18.
Sebelisa botsofaling
Batho ba baholo ha ba hloke ho etsa liphetoho ho mofuta oa kalafo.
Batho ba baholo ha ba hloke ho etsa liphetoho ho mofuta oa kalafo.
Kopo ea ts'ebetso ea renal e senyehileng
Bakuli ba nang le lefu la liphio tse bonolo le tse itekanetseng ba lokela ho hlokomela tšebetso e sebetsang ea litho nakong ea kalafo.
Sebelisa bakeng sa ts'ebetso ea sebete e sa sebetseng
Moriana o thibetsoe hore o sebelisoe ke batho ba nang le bothata ba sebete.
Tekanyetso e feteletseng ea Tritace Plus
Setšoantšo sa tliliniki ea motho ea feteletseng o iponahatsa ts'ebelisong ea moemeli ea matla ebile o bontšoa ke ponahatso ea matšoao a latelang:
- polyuria, eo ho eona bakuli ba nang le benign Prostatic adenoma kapa mofuta o mong o sa sebetseng oa moroto o qholotsang nts'etsopele ea ho ruruha ho ntša uration ka ho senya lesapo la mokokotlo;
- bradycardia, arrhythmia;
- vasodilation ea peripheral;
- tlolo ea metabolism ea metsi-electrolyte;
- pherekano le ho lahleheloa ke kelello le nts'etsopele e latelang ea komello;
- mesifa ea mesifa;
- ho se sebetse hantle ha mala.
Haeba ho se ho fetile metsotso e 30-90 ho tloha ha pilisi e nkiloe, ho bohlokoa hore motho ea hlasetsoeng a hlatsoe le ho hlatsoa mpa. Kamora ts'ebetso, mokuli o lokela ho nka adsorbent ho liehisa ho kenngoa ha lintho tse sebetsang. Ka bradycardia e matla, ho hlokahala ho hlahisa kahare ea methapo ea 1-2 mg ea adrenaline kapa ho theha pacemaker ea nakoana. Haeba ho na le bongoana bo bongata, ho hlokahala hore u laole boemo ba seruminine le khatello ea mali nakong ea kalafo e nang le matšoao.
Ka moriana o feteletseng oa lithethefatsi, makhopho a 'mele a ka hlaha.
Ho sebelisana le lithethefatsi tse ling
Ka tsamaiso e tšoanang ea Tritace e nang le thiazides, khatello ea cholesterol e ngata serum ea mali e ka eketseha.
Motsoako o kopantsoeng
Ho se lumellane ha meriana ho bonoa ka tšebeliso e ts'oanang ea aliskiren le angiotensin II receptor antagonists. Maemong a ho qetela, tsamaiso e hanyetsanoa ho bakuli ba nang le lefu la tsoekere la polyneuropathy. Aliskiren ha e fuoe tokisetso e lekanyelitsoeng ea ho ba le phofshoana e matla ea renal.
Ha e khothalletsoe motsoako
Moemeli ea kopaneng oa antihypertgency le lipilisi tsa ho robala, salate ea lithium, tacrolimus e nang le sulfamethoxazole ha ea lokela ho beoa.
Mekhaako e hlokang ho ba hlokolosi
Hoa hlokahala ho latela mehato ea polokeho ka nako e ts'oanang:
- li-antidepressants tsa tricyclic;
- lithethefatsi tse ling tsa antihypertensive;
- li-barbituric acid tse tsoang ho tsona;
- chelete bakeng sa anesthesia e akaretsang;
- tharollo ea sodium chloride;
- lithethefatsi tsa diuretic;
- vasopressor sympathomimetics;
- allopurinol, li-agents tsa immunomodulatory, glucocorticosteroids, cytostatics;
- estramustine, heparin, vildagliptin;
- hypoglycemic agents.
Nakong ea kalafo, litokisetso tse nang le ethanol le lihlahisoa tsa joala ha lia lokela ho sebelisoa.
Hoa hlokahala ho emisa ho nka ethanol.
Tekanyo ea joala
Nakong ea kalafo, litokisetso tse nang le ethanol le lihlahisoa tsa joala ha lia lokela ho sebelisoa. Ha u nka Tritace ka ethanol ka ho tšoana, ho na le monyetla oa ho oela.
Li-analog
Phetoho ea moriana o mong oa antihypertgency e etsoa tlasa taolo ea ngaka, e ka fanang ka e 'ngoe ea lithethefatsi tse latelang e le pheko e ncha:
- Hartil-D;
- Amprilan NL;
- Amprilan ND;
- Wazolong H;
- Ramazid H.
Li-Analogs li fumaneha haholoanyane mokokotlong oa litheko - li-ruble tse 210 - 358.
Lipehelo tsa khefu ea khemisi
E rekisitsoe ka mabaka a bongaka.
A na nka reka ntle le lengolo la ngaka?
Moriana o ka baka hypotension ea orthostatic haeba e sebelisoa hampe. Bakeng sa polokeho ea bakuli litsing tsa meriana, meriana e ka rekoa feela ka lengolo la ngaka.
Theko ho Tritac Plus
Theko e tloaelehileng ea matlapa a 5 mg ke li-ruble tse 954-1212, ka litekanyetso tsa li-ruble tse 10 mg - 1537.
Maemo a polokelo ea moriana
Matlapa a lumelloa ho bolokoa ka mocheso oa + 8 ... + 30 ° C sebakeng se arohaneng le ketso ea letsatsi.
Letsatsi la ho felloa ke nako
Lilemo tse 3
Moqapi
Sanofi Aventis, Italy.
Litlhahlobo tsa Tritac Plus
Tlhahlobo e ntle mabapi le lithethefatsi e bonts'a hore lithethefatsi li ikhethile 'marakeng oa meriana.
Lingaka
Svetlana Gorbacheva, setsebi sa pelo, Ryazan
Ke moemeli ea sebetsang oa hydrochlorothiazide. Khemik'hale e ntlafatsa phello ea antihypertensive. Ke fana ka moriana ona ho bakuli ba ka feela ka khatello ea mali ea methapo bakeng sa lethal e le 'ngoe ka letsatsi. Nako ea kalafo ke motho ka mong ho mokuli e mong le e mong. Ha ho litla-morao tse ileng tsa bonoa. Batho ba nang le ts'oaetso e matla ea a renal ha ba lumelloe ho nka moriana.
Bakuli
Alexey Lebedev, ea lilemo li 30, Yaroslavl
Mme o ile a qala ho bonts'a khatello ea mali le botsofali. Ka lebaka la khatello e phahameng ea mali, lithethefatsi tse antihypertensive li lokela ho nooa letsatsi le letsatsi. Matsatsing a 'maloa a fetileng, Tritace e bile thuso ea nako e telele. Matlapa a tloaela khatello ea mali hantle 'me ha a bake litla-morao. Ka tšebeliso ea nako e telele, o hloka ho phomola kapa ho eketsa tekanyetso, hobane mmele o khaotsa ho bona phello ea matlapa. Tharollo feela ke tatso e bohloko.
Elena Shashkina, ea lilemo li 42, Vladivostok
Tritace o ile a isoa ho 'm'ae kamora ho otloa ke lefu la khatello e phahameng ea mali. Setlhare se thusitse - mme o ikutloa a le betere, ho fetoha ho matla ha khatello ho emisitse. Mme o nka ka tekanyo e nyane e le hore moriana o nka nako e telele. Ho latela likhothaletso tsa ngaka, kamora khoeli ea ho amoheloa khafetsa, o emisa ho e sebelisa bakeng sa libeke tse 1-2. Sena sea hlokahala e le hore ho se be le litlamorao le ho lemalla.
