Noliprel Bee ke moriana o kopanyang likarolo tse peli tse sebetsang - perindopril arginine le indapamide. Ka lebaka la ketso e kopaneng, hoa khoneha ho tsitsisa khatello ea mali khahlanong le semelo sa phello e bonolo ea diuretic. Setlhare sena ha se reretsoe ho sebelisoa ho bana le basali baimana.
Lebitso la Machaba le sa Tšoanelehang
Perindopril + Indapamide.
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Noliprel Bee ke moriana o kopanyang likarolo tse peli tse sebetsang - perindopril arginine le indapamide.
ATX
C09BA04.
Lokolla liforomo le sebopeho
Moriana o fumaneha ka mokhoa oa matlapa a biconvex a masoeu a koahelang moea. Yuniti ea meriana e na le arginine kapa tert-butylamine letsoai, 10 mg ea perindopril le 2,5 mg ea indapamide. Sehlopha sa likarolo tse ling se kenyeletsa:
- silika colloidal;
- tsoekere ea lebese;
- sodium carboxymethyl starch;
- maltodextrin;
- magnesium stearate.
Filimi e kantle ea letlapa e na le macrogol 6000, titanium dioxide, glycerol, magnesium stearate le hypromellose.
Ketso ea pharmacological
Moriana o na le phello e matlafatsang le e hlotsang 'mele. Setlama se kopaneng se thusa ho hatella eniotensin-converting enzyme (ACE). Melemo ea pharmacological ea lithethefatsi e fihlella ka lebaka la tšusumetso ea motho ka mong ea ntho e 'ngoe le e' ngoe e sebetsang. Ho kopana ha indapamide le perindopril ho eketsa phello ea antihypertensive.
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Ka lebaka la phello ea diuretic ea lithethefatsi, khatello ea mali ea mokuli ea fokotseha.
Letsoai la Perindopril tertbutylamine le thibela phetoho ea angiotensin I ho ea mofuta oa angiotensin ka lebaka la thibelo ea kinase II (ACE). Qetellong ke peptidase ea ka ntle, e amehang ho phatloheng ha vasodilating bradykinin ho heptapeptide, metabolite e sa sebetseng. ACE e thibela phetoho ea mofuta oa li-khemikhale tsa angitensin e le mofuta oa vasoconstrictor.
Indapamide ke ea sehlopha sa sulfonamides. Thepa ea pharmacological e tšoana le mochine oa ts'ebetso oa thiazide diuretics. Ka lebaka la ho thibela ho khutlisetsoa ha limolek'hule tsa sodium ho glomerulus ea monoana, tlhahiso ea chloride le sodium ion ea eketseha, 'me tlhahiso ea magnesium le potasiamo ea fokotseha. Ho na le keketseho ea diuresis. Ka lebaka la diuretic, khatello ea mali ea fokotseha.
Mofumahali
Ha ho nkuoa ka molomo, letlapa le robeha ka litheko tsa mala. Perindopril le indapamide e ntšoa kahare le ka mpeng e nyane, moo lintho li monkoang ka villi e ikhethang. Ha ba kena betheng ea methapo, metsoako ka bobeli e sebetsang e fihlella maemo a phahameng a plasma ka nako ea hora.
Ha perindopril e kena ka sekepeng sa mali, e robeha ho perindoprilat ka 27%, e nang le phello ea antihypertensive mme e thibela ho etsoa ha angiotensin II. Ho bohlokoa ho hopola hore ho ja ho liehisa phetoho ea perindopril. Sehlahisoa sa metabolic se fihla moqoqong o moholo oa plasma nakong ea lihora tse 3-4. Bophelo ba halofo ea perindopril ke metsotso e 60. Seketsoana sa lik'hemik'hale se sibolloa ka mokhoa oa urine.
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Sehlahisoa sa metabolic se fihla sehlohlolong sa plasma e kholo ka nako ea lihora tse 3-4, 'me halofo ea bophelo ke metsotso e 60.
Indapamide e hokahana le albin ka 79% mme ka lebaka la sebopeho sa ts'ebetso ena e ajoa kahare ho lithishu tsohle. Ho felisoa ha halofo ea bophelo ka kakaretso ho nka lihora tse 14 ho isa ho tse 24. Ka taolo e pheta-phetoang, ho kopanya ntho e sebetsang ha ho shebjoe. 70% ea indapamide ka sebopeho sa lihlahisoa tsa metabolic e tlohela 'mele ho ea liphio, 22% - e nang le mantle.
Matšoao a ho sebelisoa
Moriana o etselitsoe ho fokotsa khatello ea mali moo ho nang le bohlokoa ba khatello ea mali ho bakuli ba hlokang kalafo ea lithethefatsi ka indapamide ka tekanyo ea 2,5 mg le 10 mg perindopril.
Contraindication
Moriana ha o fanoe maemong a latelang:
- taolo e tšoanang ea lithethefatsi e eketsang nako ea QT, le lithethefatsi tse nang le lithium le potasiamo ion, khahlano le semelo sa hyperkalemia;
- hypersensitivity ho dintho tse etsang sehlahiswa;
- mofuta oa lefutso la ho se mamelle lactose, galactosemia, khaello ea lactase, malabsorption ea monosaccharides;
- tumello ea creatinine (Cl e ka tlase ho 60 ml / min) - ho hloleha ho matla ha renal;
- lefu la pelo le sa foleng mokhatlong oa ho bola;
- ka tlase ho lilemo tse 18.
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Ho hlokahala hore ho sebelisoe tlhokomeliso ha u nka Noliprel moo ho nang le ts'ebetso ea methapo methapong ea khokahano (lupus erythematosus, sclerodermaem), khatello ea hematopoiesis, lefu la pelo le coronary.
Mokhoa oa ho nka Noliprel Bi
Matlapa a lokela ho nkuoa ka molomo, sengoathoana se le seng hang ka letsatsi. Ho kgothaletswa ho nwa moriana hoseng pele ho lijo tsa hoseng, hobane ho ja ho fokotsa ho monya le ho fokotsa ho ikatisa hoa likarolo tse sebetsang.
Mokhoa oa ho phekola lefu la tsoekere la mofuta oa 2
Moriana ona ha o ame secretion ea lihormone tsa lisele tsa pancreatic mme ha o fetole ho ts'oaroa ha tsoekere maling a mali, ka hona, bakuli ba nang le lefu la tsoekere le sa ts'epheng la insulin ha ba hloke phetoho ea tekanyetso.
Litla-morao tsa noliprel bi
Litla-morao li hlaha khahlano le semelo sa regimen e sa nepahalang kapa ho na le ts'oaetso ea lisele tse ling tsa likarolo tsa sebopeho.
Phekolo ea ka mpeng
Boitšoaro bo fosahetseng tseleng ea tšilo ea lijo bo tšoailoe ke:
- molomo o omileng
- ho hloka tatso;
- bohloko ba epigastric;
- takatso e fokotsehileng;
- ho hlatsa, lets'ollo, dyspepia le ho ruruha hoa methapo.
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Maemong a sa tloaelehang, ponahalo ea pancreatitis, cholestatic jaundice khahlanong le semelo sa hyperbilirubinemia, angioedema ea mala.
Hematopoietic litho tsa ka hare
'Meleng le lymph, ho fokotseha ha palo le thibelo ea ho etsoa hoa liplatelese, li-neutrophils le leukocytes li ka bonoa. Ka lebaka la khaello ea lisele tse khubelu tsa mali, anemia ea mofuta oa aplastic le hemolytic e hlaha. Ponahalo ea agrenulocytosis e ka etsahala. Maemong a ikhethang: bakuli ba hemodialysis, nako ea ho hlaphoheloa kamora ho fetisoa ha menoana - li-inhibitors tsa ACE li qholotsa nts'etsopele ea anemia.
Tsamaiso ea methapo e bohareng
Ka tlolo ea tsamaiso ea methapo e kholo, ho hlaha hoa:
- vertigo;
- hlooho e opang;
- paresthesia;
- Ho tsekela
- likhathatso tsa boroko le tahlehelo ea taolo ea maikutlo.
Maemong a ikhethang, mokuli a le mong ho bakuli ba 10,000 a ka ba le pherekano le ho akheha.
Litla-morao tsa leihlo la leihlo li tšoauoa ka ho fokotseha hoa maikutlong a pono, ha ho utloahala ha kutlo ho bonahatsoa ka mokhoa oa ho lla litsebeng.
Ho tsoa ts'ebetsong ea moroto
Maemong a sa tloaelehang, ho hloleha ha menoo le ho se sebetse hantle ha erectile hoa ntlafala.
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Ho tsoa tsamaisong ea phefumoloho
Khahlano le semelo sa kalafo ea lithethefatsi, li-inhibitors tsa ACE li ka nts'etsapele ho khohlela, ho hema, bronchospasm, ho nyekeloa ke pelo le pneumonia ea eosinophilic.
Allergie
Ho na le monyetla oa hore ho be le lekhopho, rythema le ho hlohlona letlalong. Maemong a mang, angioedema ea sefahleho le maemo a phahameng e hlaha, edema ea Quincke, urticaria, vasculitis. Haholo-holo boteng ba ntho e reriloeng esale pele mabapi le karabelo ea anaphylactoid. Boteng ba systemic lupus erythematosus, setšoantšo sa kliniki ea lefu se mpefala. Ts'ebetsong ea bongaka, linyeoe tsa photosensitivity le epidermal necrolysis ea mafura a subcutaneous a tlalehiloe.
Tšusumetso ho bokhoni ba taolo ea methapo
Setlhare ha se ame bokhoni ba ho tsepamisa mohopolo ebile ha se fokotse lebelo la karabelo, empa ka lebaka la kotsi ea litla-morao tsamaisong ea methapo e meholo, tlhokomelo e lokela ho nkuoa ha ho sebetsoa lisebelisoa tse thata, lipapali tse feteletseng, ho khanna.
Litaelo tse khethehileng
Ho nka moriana o kopaneng ha ho thibele tsoelo-pele ea hypokalemia, ho kenyelletsa le bakuli ba nang le bothata ba ho hlaphoheloa kelellong le lefu la tsoekere. Boemong bona, ho hlokahala hore ho be le tlhaiso-leseling ea potasiamo ea potasiamo plasma.
Nakong ea phekolo, ho fokotseha ha lintho tse nang le sodium 'meleng hoa khoneha ka lebaka la nts'etsopele ea hypotension. Kotsi ea hyponatremia e eketseha ka stenosis ea methapo ea methapo, ka hona maemong ana ho hlokahala ho tsebisa ngaka ka ho omella, ho hlatsa le lets'ollo. Ho fokotseha ha nakoana ha khatello ea mali ha ho thibele tsamaiso e tsoelang pele ea Noliprel.
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Sebelisa botsofaling
Bakuli ba fetang lilemo tse 65 ba nang le ts'ebetso e tloaelehileng ea meno ha ba hloke phetoho e eketsehileng ea lethal dose. Maemong a fapaneng, litekanyetso le nako ea phekolo li fetoloa ho latela lilemo, boima ba 'mele le bong ba mokuli.
Ho rera bana ba hlaprel bi
Ka lebaka la khaello ea ya data ka phello ea lintho tse sebetsang mabapi le kholo le kholo ea bongoaneng le bohlankana, lithethefatsi li thibetsoe ho sebelisoa ke bana ba ka tlase ho lilemo tse 18.
Sebelisa nakong ea bokhachane le pelehi
Ho nka moriana o le teng ka har'a mofuta oa II le oa boraro oa lefu la "embryonic" ho ka baka tsitsipano e sa nepahalang ea menoana le masapo a lehata, oligohydramnios, mme hona ho eketsa menyetla ea ho ba le mathata a methapo ea kutlo le ho hloka kutloelo-bohloko ha lesea. Ka hona, tšebeliso ea Noliprel ho basali baimana e thibetsoe.
Nakong ea kalafo, emisa ho lactation.
Kopo ea ts'ebetso ea renal e senyehileng
Ka tumello ea creatinine e kaholimo ho 60 ml / min, ho hlokahala hore ho be le ho lekola boemo ba ioninine le potasiamo ka plasma.
Sebelisa bakeng sa ts'ebetso ea sebete e sa sebetseng
Moriana o thibetsoe hore o sebelisoe ho bakuli ba nang le bothata bo matla ba sebete.
Bongata bo feteletseng ba Noliprel Bi
Ka tekanyetso e le 'ngoe ea lethal dose le phahameng la lithethefatsi, setšoantšo sa kliniki ea overdose se bontšoa:
- ho theoha haholo ha khatello ea mali, ho tsamaeang le ho hlatsa le ho nyekeloa ke pelo;
- mesifa ea mesifa;
- Ho tsekela
- oliguria le nts'etsopele ea anuria;
- tlolo ea tekanyo ea letsoai le metsi;
- pherekano, bofokoli.
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Motho ea hlokofalitsoeng o hloka tlhokomelo ea bongaka e potlakileng ho thibela ho kenngoa ha moriana hape. Sepetlele, mokuli o hlatsoa ka lesapo la mokokotlo, e leng k'habone e behiloeng. Ka ho theoha ho matla ha khatello ea mali, mokuli o isoa sebakeng se tsitsitseng mme maoto a tsosoa. Ka nts'etsopele ea hypovolemia, tharollo ea 0,9% ea sodium chloride e fanoa kahare.
Ho sebelisana le lithethefatsi tse ling
Ka tsamaiso e tšoanang ea lithethefatsi tsa antipsychotic le antidepressants, ho ka etsahala ho eketsa phello ea antihypertensive, e eketsang monyetla oa hypotension ea methapo e kopanyang. Glucocorticosteroids le tetracosactides li baka ho bolokoa ha metsi le sodium, li fokolisa phello ea diuretic. Ka lebaka leo, keketseho ea khatello ea mali ea hlaha. Mekhoa ea ho ruruha ka kakaretso e eketsa ho fokotseha ha khatello ea mali methapong ea methapo.
Ka tlhokomelo
Ho hlokomelisoa tlhokomeliso ha ho fanoa ka li-agents tse latelang ka mokhoa o ts'oanang:
- Lithethefatsi tse seng khahlanong le ho ruruha, acetylsalicylic acid e nang le litekanyetso tsa letsatsi le letsatsi tse fetang 3000 mg. Ho na le ho fokotseha hoa phello ea antihypertensive, e khahlano le ho hloleha ha pheko le serum hyperkalemia.
- Cyclosporin. Kotsi ea ho eketseha ha maemo a creatinine ntle le ho fetola khatello ea cyclosporine e nang le metsi a tloaelehileng e eketseha.
- Baclofen e ka ntlafatsa phello ea kalafo ea moriana, kahoo ha e laetsoe, hoa hlokahala ho lekola khatello ea mali le boemo ba liphio. Haeba ho hlokahala, mofuta oa moriana oa litlhare ka bobeli oa fetoha.
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Motsoako ha oa khothalletsoa
Ha u nka lihlahisoa tse nang le lithium hammoho le Noliprel Bi-Forte, ho se lumellane ha litlhare hoa hlokomeleha. Ka kalafo e tšoanang ea lithethefatsi, khatello ea plasma ea lithium e eketseha ka nakoana le menyetla ea ho ba le chefo e eketseha.
Tekanyo ea joala
Ho thibetsoe ka thata ho sebelisa joala nakong ea phekolo ea lithethefatsi. Joala ba ethyl bo ntlafatsa boemo ba sebete le ho fokolisa phello ea kalafo ea moriana, bo matlafatsa phello e thibelang methapo ea methapo le ea hepatobiliary.
Li-analog
Baithaopi ba nang le mohato o tšoanang oa ts'ebetso ba kenyelletsa:
- Ko-perineva;
- Noliprel A;
- Noliprel A-Forte;
- ka nako e ts'oanang o nka Perindopril le Indapamide, tse rekisoang ka theko e tlase haholo ho feta li-generator.
O ka fetohela moriana o mong kamora ho buisana le ngaka.
Lipehelo tsa khefu ea khemisi
E rekisoa ka lengolo la ngaka.
A na nka reka ntle le lengolo la ngaka?
Ho rekisoa mahala ho na le meeli ka lebaka la kotsi ea tahi le litlamorao tse ngata ha li nkuoa ntle le taelo e tobileng ea bongaka.
Theko ea noliprel bi
Litsenyehelo tse tloaelehileng tsa lithethefatsi ke li-ruble tse 540., Ukraine - 221 UAH.
Maemo a polokelo ea moriana
Ho khothalletsoa ho boloka ka mocheso + 15 ... + 25 ° C.
Letsatsi la ho felloa ke nako
Likhoeli tse 36.
Moqapi
Indasteri ea Labs Service, Fora.
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Litlhahlobo mabapi le Noliprel Bi
Liforomong tsa inthanete ho na le litlhahlobo tse ntle tsa litsebi tsa meriana le bakuli mabapi le lithethefatsi.
Litsebi tsa kelello
Olga Dzhikhareva, ngaka ea methapo ea maikutlo, Moscow
Ke nka sethethefatsi se kopaneng sa antihypertensive e le pheko e sebetsang. Mori ka tlhaho o fokotsa khatello ea mali ka lebaka la indapamide e nang le phello ea diuretic. Moriana o fuoa bakuli nako e le 'ngoe hoseng. Tsela ea kalafo e thehiloe ka bonngoe.
Svetlana Kartashova, setsebi sa pelo, Ryazan
Setlhare se setle sa kalafo ea kalafo ea antihypertensive ka tokafatso e latelang ea mofuta oa kalafo. Moriana o thusa ho fokotsa khatello ea methapo ea methapo ea methapo 'me o ntlafatsa ho phutholoha ha mesifa ea pelo le marako a methapo. Ena ke setlhare sa mantlha bakeng sa kalafo ea khatello ea mali.
Bakuli
Anastasia Yashkina, ea lilemo li 37, Lipetsk
Moriana o ne o laetsoe khatello ea mali. Khatello ha ea ka ea phahamisoa hanyane, kahoo qalong ke ne ke sa ea ngakeng. Ha ho hlaha khatello ea khatello ea mali e phahameng, khatello e ile ea phahama ho isa ho 230/150. Kenya sepetlele. Matlapa a hlalositsoeng a Noliprel Bi-Fort. Kamora matsatsi a 14 a ho ja kamehla, khatello e ile ea khutlela ho tloaelehileng. Ho ne ho se na lintho tse kulang, lipilisi li ne li fihla 'meleng. Khatello e tsitsitse lilemo tse 3.
Sergey Barankin, ea lilemo li 26, Irkutsk
Selemong se fetileng, khatello e ile ea nyolohela ho 170/130. O batlile thuso ea bongaka - ngaka e laetse 10 mg ea Noliprel mme a re a nke pilisi e le 'ngoe hoseng ka mpeng e se nang letho. Qalong, ke ne ke ikutloa ke sa phutholoha 'me ke ikana haholo. Ke nkile qeto ea ho nka letlapa. Boemo le khatello li khutlela ho tloaelehileng. Lipalo li fihlile ho 130/80.