Sesosa se tloaelehileng sa lefu la pelo le methapo e matla ea mali, e bonahatsoang ke khatello e phahameng ea mali e telele. Sena se fokotsa boleng ba bophelo ba motho. Litsebi li khothaletsa ho sebelisa litlhare tse fapaneng tsa antihypertensive tse thibelang lihormone tsa oligopeptide (angiotensins) tse bakang vasoconstriction. Lithethefatsi tsena li kenyelletsa Lorista kapa Losartan.
Lithethefatsi tse li sebetsa joang?
Khatello ea mali e phahameng e ka baka liphetoho tsa methapo ea methapo ea methapo ea mali methapong eohle. Sena se kotsi haholo bakeng sa pelo, boko, retina le liphio. Karolo e sebetsang ea lithethefatsi tsena tse peli (losartan potasiamo) e thibela li-angiotensin, e etsa hore vasoconstriction le khatello e eketsehang, e hlahise ho lokolloa ha lihormone tse ling (aldosterones) ho tsoa gland ea adrenal.
Lorista kapa Losartan ke lithethefatsi tse antihypertensive tse thibelang lihomone tsa oligopeptide (angiotensins) tse bakang vasoconstriction.
Tlas'a tšusumetso ea aldosterone:
- reabsorption (ho amoheloa) ha sodium e ntlafatsoa ka ho lieha ha eona 'meleng (Na e phahamisa hydration, e kenella ho kenyeng lihlahisoa tsa metabolic ea meno, e fana ka pokello ea alkaline ea plasma ea mali;
- N-ions le ammoneum tse fetelletseng lia felisoa;
- 'meleng, chloride e tsamaisoa kahare ho lisele mme e thusa ho qoba ho omella;
- molumo oa phallo ea mali o eketseha;
- tekanyetso ea acid-base e tloaelehile.
Lorista
Setlhare sa antihypertensive se etsoa ka mokhoa oa matlapa a koahetsoeng ka enteric, ho kenyelletsa le potasiamo losartan, hammoho le lisebelisoa tse ling.
- cellactose;
- silicon dioxide (sorbent);
- magnesium stearate (binder);
- setlolo sa poone se nang le micronized;
- hydrochlorothiazide (diuretic e kenyellelitsoeng ho sireletsa ts'ebetso ea menoana e fumanoang ho li-analogues tsa Lorista, joalo ka Lorista H le ND).
E le karolo ea khetla e kantle:
- protheine ea ntho e sirelletsang hypromellose (sebopeho se bonolo);
- propylene glycol plasticizer;
- dyes - quinoline (mosehla oa E104) le titanium dioxide (tšoeu E171);
- talcum phofo.
Ke mekhabiso efe ea likuku e ka sebelisoang bakeng sa lefu la tsoekere?
Cardioactive Taurine: matšoao le li-contraindication ho moriana.
Bala ka lisosa tse ka sehloohong tsa lefu la tsoekere lengolong lena.
Ntho e sebetsang, e thibelang angiotensin, e etsa hore contraction ea methapo e se ke ea khoneha. Sena se thusa ho leka-lekanya khatello ea maikutlo. Losartan e abetsoe:
- ka matšoao a pele a khatello ea methapo ea kutlo ho monotherapy;
- le khatello ea methapo e phahameng maemong a phekolo e kopaneng;
- lefu la tsoekere.
Lorista e hlahisoa ho 12,5, 25, 50 le 100 mg ea ntho ea mantlha ka har'a letlapa le le leng. E pakiloe ka li-pcs tse 30, 60 le 90. mekotla ea likarete. Mehatong ea pele ea khatello ea mali, ho behiloe 12,5 kapa 25 mg ka letsatsi. Ka keketseho ea tekanyo ea khatello ea mali, molumo oa tšebeliso le eona oa eketseha. Nako ea thupelo le litekanyetso li lokela ho lumellanoa le ngaka e eang.
Ntho e sebetsang ea Lorista inhibiting angiotensin e etsa hore contraction ea methapo e se ke ea khoneha. Sena se thusa ho leka-lekanya khatello ea maikutlo.
Losartan
Mefuta eo e nkuoa ka molomo 'me e na le 25, 50 kapa 100 mg ea motsoako oa mantlha le lintho tse ling letlapeng le le leng:
- lactose (polysaccharide);
- selulose (fiber);
- silicon dioxide (emulsifier le tlatsetso ea lijo E551);
- magnesium stearate (emulsifier E572);
- crodarmellose sodium (sethala sa lijo);
- povidone (enterosorbent);
- hydrochlorothiazide (litokisetsong tsa Lozartan N Richter le Lozortan Teva).
Ho kopanya lifilimi ho kenyelletsa:
- emollient hypromellose;
- dyes (white titanium dioxide, oxide oxide ea tšepe);
- macrogol 4000 (e eketsa palo ea metsi 'meleng);
- talcum phofo.
Losartan, e hatellang angiotensin, e thusa ho khutlisa ts'ebetso e tloaelehileng ea setho sohle:
- ha e ame liketso tsa limela;
- ha e bake vasoconstriction (vasoconstriction);
- e fokotsa ho hanyetsa ha bona;
- e laola khatello ea methapo ea mali le mokokotlong oa phallo ea mali e tlase;
- e fokotsa hypertrophy ea myocardial;
- imolla molumo likepeng;
- e sebetsa joalo ka diuretic;
- e fapana nakong ea ketso (ho feta letsatsi).
Setlhare se kenoa habonolo ho tsoa mokokotlong oa lijo, se entsoeng ka metsoako liseleng, 'me se fumanehang ka bongata maling se hlaha kamora hora, mme se kopana le liprotheine tsa plasma 95% ea metabolite e sebetsang. Losartan e tsoa e sa fetohe ka moroto (35%) le bile (60%). Pilisi e lumelloang e fihla ho 200 mg ka letsatsi (e arotsoe ka litekanyetso tse peli).
Losartan, e hatellang angiotensin, e thusa ho khutlisa tšebetso e tloaelehileng ea setho sohle.
Papiso ea Lorista le Losartan
Ketso ea litlhare ka bobeli e reretsoe ho fokotsa khatello. Hangata bakuli ba nang le khatello ea maikutlo ba laetsoe, hobane ho fumanoe phello e sebetsang ho thibela mafu a pelo le methapo le kalafo e ka sehloohong bakeng sa maemo a sa foleng. Meriana ha e bake litlamorao, e na le matšoao a mangata le phapang e nyane.
E tšoanang
Ho sebetsa ha lithethefatsi ho netefalitsoe bakeng sa bakuli ba nang le khatello e phahameng ea mali, e tsamaeang le lintlha tse kotsi tse kang:
- botsofali;
- bradycardia;
- liphetoho tsa pathological ka lehlakoreng le letšehali la myocardium e bakoang ke tachycardia;
- ho nyekeloa ke pelo;
- nako kamora ho hlaseloa ke pelo.
Meriana e thehiloeng ho potasiamo ea losartan e bonolo ka hore:
- etsa kopo 1 nako ka letsatsi (kapa khafetsa, empa joalo ka ha ho laetsoe ke setsebi);
- kamohelo ha ea itšetleha ka lijo;
- ntho e sebetsang e na le phello e matla;
- lithuto tse nepahetseng ke ho tloha beke ho isa ho khoeli.
Lithethefatsi li na le li-contraindication tse tšoanang:
- allergy ho likarolo;
- hypotension;
- boimana (bo ka baka lefu la fetal);
- nako ea ho anyesa;
- lilemo ho isa ho lilemo tse 18 (ka lebaka la hore phello ho bana ha e utloisisoe ka botlalo);
- hepatic dysfunction.
Bakeng sa bakuli ba nang le mathata a a liphio, moriana ha o kopantsoe 'me o ka khethoa haeba ho na le hydrochlorothiazide sebopeho, e leng:
- e potlakisa phallo ea mali a renal;
- e baka phello ea nephroprotective;
- ntlafatsa ntlafatso ea urea;
- E thusa ho lieha ho qala ha lefu la sethoathoa.
Phapang ke efe?
Phapang e teng lipakeng tsa lisebelisoa tsena e ikemiselitsoe haholo ke theko le moetsi. Lorista ke sehlahisoa sa k'hamphani ea Slovenia KRKA (Lorista N le Lorista ND li hlahisoa ke Slovenia hammoho le Russia). Ka lebaka la lipatlisiso tsa litsebi, khamphani e kholo ea meriana e nang le lebitso 'marakeng oa machabeng e tiisa boleng ba moriana.
Losartan e hlahisoa Ukraine ke Vertex (Losartan Richter - Hungary, Losartan Teva - Israel). Ena ke analogue e theko e tlaase ea Lorista, e sa boleleng litšobotsi tse mpe kapa ho se sebetse hanyane. Litsebi tse fanang ka sena kapa sethethefatsi seo, li hlokometse liphapang tse ling, tse nang le litlamorao.
Ha o sebelisa Lorista:
- ho 1% ea linyeoe, arrhythmia e bakoa;
- lipontšo li bonoa, li hlohlelletsoa ke diuretic hydrochlorothiazide (tahlehelo ea letsoai la potasiamo le sodium, anuria, gout, proteinuria).
Ho lumeloa hore ho bonolo ho tsamaisa losartan, empa ha ho lebise ho:
- ho 2% ea bakuli - ho nts'etsopele ea letšollo (karolo ea macrogol ke provocateur);
- 1% - ho myopathy (bohloko bo ka morao le mesifa ka nts'etsopele ea mesifa ea mesifa).
Maemong a sa tloaelehang, losartan e ka ama kholo ea lets'ollo.
Ke eng e theko e tlase?
Litsenyehelo li susumetsoa ke lintlha tse kang sebaka sa naha, lipapatso le litheolelo, palo le bophahamo ba mofuta oa tlhahiso.
Theko ea Lorista:
- Li-pcs tse 30 12,5 mg ka 'ngoe - li-ruble tse 113-152. (Lorista N - li-ruble tse 220.);
- Li-pcs tse 30 25 mg e ngoe le e ngoe - li-ruble tse 158-211. (Lorista N - li-ruble tse 302, Lorista ND - li-ruble tse 372);
- Likhomphutha tse 60. 25 mg e ngoe le e ngoe - li-ruble tse 160- 245. (Lorista ND - li-ruble tse 570);
- Li-pcs tse 30 50 mg ka 'ngoe - li-ruble tse 161-280. (Lorista N - li-ruble tse 330);
- Likhomphutha tse 60. 50 mg ka 'ngoe - li-ruble tse 284-353;
- Li-pcs tse 90 50 mg ka ngoe - li-ruble tse 386-491;
- Li-pcs tse 30 100 mg ka 'ngoe - li-ruble tse 270-330;
- 60 tab. 100 mg - li-ruble tse 450-540;
- Li-pcs tse 90 100 mg ka 'ngoe - li-ruble tse 593-667.
Litšenyehelo tsa losartan:
- Li-pcs tse 30 25 mg e ngoe le e ngoe - li-ruble tse 74-80. (Losartan N Richter) - li-ruble tse 310 .;
- Li-pcs tse 30 50 mg ka 'ngoe - li-ruble tse 87-102;
- Likhomphutha tse 60. 50 mg ka 'ngoe - li-ruble tse 110-157;
- Li-pcs tse 30 100 mg - li-ruble tse 120 -138;
- Li-pcs tse 90 100 mg ka 'ngoe - ho fihlela ho li-ruble tse 400.
Ho tsoa lethathamong le ka holimo ho hlakile hore ho na le chelete e ngata ho reka losartan kapa sethethefatsi leha e le sefe, empa ka palo e kholo ea matlapa a le paketeng e le 'ngoe.
Ke eng e molemohali ea lorista kapa losartan?
Ke moriana ofe o leng betere, ho ka se khonehe ho bua ka ho hlaka, hobane li thehiloe nthong e le 'ngoe e sebetsang. Sena se lokela ho susumetsoa ke ngaka e eang, ho latela litšobotsi tsa mokuli. Empa ha e sebelisoa, phello ea metsoako e meng e kenyelletsoeng litokisetsong e tlameha ho tsotelloa.
Ka lebaka la hore Lorista e etsahala ka tekanyetso e tlase (12.5 mg), e laetsoe thibelo ea khatello ea mali, ho ba teng ha likotsi tsa pelo tse sa khaotseng, maemong a liphetoho tsa spasmodic maemong a khatello. Ho joalo, ka ho se laolehe ho feta tekano hypotension e ka ba teng, e leng kotsi hape ho mokuli, hobane matšoao a eona ha a hlahe hanghang. Hypertension e tsebahalang ka ho phahama khafetsa le phokotseho e matla ea khatello ea mali e ka laoloa ke tekanyetso e nyane ea moriana e nooang habeli.
Tlhahlobo ea Mamello
Olga, ea lilemo li 56, Podolsk
Ha ke khone ho nka meriana ena e laetsoeng ke setsebi sa bongaka. Pele, ke ile ka noa tekanyetso ea letsatsi le letsatsi ea 50 mg ea losartan. Khoeli hamorao, ho ile ha hlaha madi matsohong a (a fokotsehile 'me a phatloha matsohong). Askorutin o ile a emisa ho e nka mme a qala ho nwa, jwalokaha maemo a sekepe a se a sentse. Empa khatello e ntse e le teng. O falletse ho Lorista e theko e boima haholo. Kamora nakoana, ntho e ngoe le e ngoe e ile ea phetoa. Ke balile ka litaelo - ho na le litla-morao tse joalo. Hlokomela!
Margarita, ea lilemo li 65, ke toropo ea Tambov
E ngotsoe ho Lorista, empa ka boithatelo a fetohela Losartan. Hobaneng u lefella sethethefatsi se nang le ntho e le 'ngoe e sebetsang?
Nina, ea lilemo li 40, Murmansk
Hypertension ke lefu la lekholo lena la lilemo. Matšoenyeho mosebetsing le lapeng ka lilemo leha e le life li eketsa khatello. Ba laetse Lorista joalo ka mokhoa o bolokehileng, empa ho litlatsetso ho moriana ho na le litlolo tse ngata. Kamora ho bala litaelo, ke nkile qeto ea ho ea ngakeng hape.
Bokhachane ke tlolo ea litlhare ka bobeli.
Tlhahlobo ea litsebi tsa lefu la pelo mabapi le Lorista le Losartan
M.S. Kolganov, ngaka ea lefu la pelo, Moscow
Lichelete tsena li na le mathata a tlhaho a sehlopha sohle sa li-angiotensin blockers. Li na le taba ea hore phello e etsahala butle, ka hona ha ho na mokhoa oa ho phekola khatello ea mali ea methapo kapele.
S.K. Sapunov, ngaka ea pelo, Kimry
Ka sebopeho sa li-blocker tse fumanehang tsa angiotensin tsa mofuta oa bobeli, ke Losartan feela e kopanang le matšoao a 4 a semmuso bakeng sa ts'ebeliso: khatello ea methapo ea methapo; khatello e phahameng ea mali ka lebaka la hypertrophy ea 'mele e ka letsohong le letšehali; mofuta oa 2 lefu la tsoekere le hlasimolloang; pelo e sa foleng.
T.V. Mironova, ngaka ea methapo ea pelo, Irkutsk
Lipilisi tsena tsa khatello li laola boemo hantle haeba li nooa khafetsa. Ka kalafo e reriloeng, menyetla ea mathata e fokotseha haholo. Empa maemong a hlobaetsang ha ba na thuso. E rekisoa ka lengolo la ngaka.
