Lorista ke setlhare se tsoang ho sehlopha sa lingaka tsa li-angiotensin-2 receptor antagonists (bahlolisani). E qetellang e bua ka lihormone. E kenya letsoho ho vasoconstriction, tlhahiso ea aldosterone (hormone ea adrenal) le keketseho ea khatello ea mali. Angiotensin ke karolo ea tsamaiso ea renin-angiotensin.
Ath
Code Lorista anatomical le phekolo ea lik'hemik'hale tsa C09CA01.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta.jpeg)
Lorista ke lithethefatsi tse tsoang sehlopheng sa bahanyetsi ba khothalletsang vasoconstriction, tlhahiso ea li-adrenal gland le keketseho ea khatello ea mali.
Lokolla liforomo le sebopeho
Setlhare se rekisoa ka mokhoa oa matlapa a koahetsoeng ka filimi. Potasiamo losartan ke ntho e sebetsang ea sethethefatsi sena. Likahare tsa eona ke letlapeng la 1 ke 12,5 mg, 25 mg, 50 mg kapa 100 mg.
Sebopeho sa moriana o boetse o kenyelletsa cellactose, starch, hypromellose ea filimi le likarolo tse ling.
Matlapa a tšikinyetse ka mahlakoreng ka bobeli, a 'mala o mosehla kapa o mosoeu ka' mala (ka tekanyo ea 50 le 100 mg) mme oa potoloha.
Mokhoa oa ketso
Setlhare sea khetha. E ama li-receptor tsa AT1 lipelong, mesifa e boreleli, pelo, methapo ea mali, sebete le adrenal, e lebisang ho fokotseheng hoa phello ea khatello ea mali ea angiotensin-2.
Lithethefatsi li na le litlamorao tse latelang tsa pharmacology:
- E eketsa mosebetsi oa ho nchafatsa.
- Fokotsa khatello ea methapo ea aldosterone.
- E thibela vasoconstriction (vasoconstriction).
- Ha e ame sebopeho sa bradykinin.
- Fokotsa ho hanyetsa ha methapo ea mali.
- Matlafatsang diuresis (keketso ea mokelikeli o mongata ka har'a moroto ka ho sefa plasma ea mali).
- E fokotsa khatello ea mali (haholo mokokotlong oa pulmonary). E fokotsa khatello e phahameng ea mali le e tlase. Ho fokotseha ho phahameng ha khatello ho bonoa lihora tse 5-6 ka mor'a ho nka matlapa. Monyetla oa bohlokoa oa lithethefatsi ke ho ba sieo ha syndrome ea ho ntša maikutlo.
- E fokotsa khatello ea maikutlo pelong.
- E thibela hypertrophy ea mesifa ea pelo.
- E eketsa ho hanyetsa ha motho mesebetsing ea 'mele. Sena ke sa bohlokoa ho bakuli ba nang le ho nyekeloa ke pelo.
- Ha e fetole sekhahla sa pelo.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta.png)
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-2.jpeg)
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-3.jpeg)
Mofumahali
Ho latela lithuto tsa pharmacokinetic, ho kenngoa ha Lorista ka mpeng le mala a manyane ho hlaha kapele.
Ho ja ha ho ame ho sithabela ha metabolite e sebetsang. The bioavailability ea lithethefatsi e ka ba 33%. Hang ha e le maling, losartan e kopana le albin mme e ajoa ho pholletsa le litho tsohle. Ha karolo ea sethethefatsi e fihla ka har'a sebete, metabolism ea eona e etsahala.
Bophelo ba halofo ea Lorista ke lihora tse 2. Boholo ba meriana bo qhekelloa ka bile. Karolo ea losartan e pepesoa ke liphio ka moroto. Karolo ea Lorista ke hore sethethefatsi ha se kene ka bokong.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta.jpg)
Ho ja ha ho ame ho hlaseloa ha ntho e sebetsang ea lithethefatsi.
Ho thusang
Moriana o bontšoa bakeng sa:
- phallo ea mali ea methapo e fapaneng;
- hypertrophy ea ventricular ea letsoho le letšehali (ventricle e ka letsohong le letšehali);
- CHF;
- proteinuria e nang le lefu la tsoekere la mofuta oa 2 (moriana o fokotsa menyetla ea ho ba le nephropathy le ho se sebetse hantle ha renal).
Ho khatello ea maikutlo
Ho nka moriana ho na le lebaka le nang le khatello ea mali ea 140/90 mm Hg. le holimo. Motsoako ona hangata o laetsoe haeba ho sa sebetse hantle kapa ho se khone ho sebelisa li-inhibitors tsa ACE.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-2.jpg)
Ho nka moriana oa Lorista ho nepahetse ka khatello ea mali ea 140/90 mm Hg. le holimo.
Contraindication
Loreist ha ea lokela ho abeloa le:
- khatello e tlase ea mali;
- potasiamo e ngata maling;
- ho se mamellane ha motho ka mong likarolo tsa moriana;
- ho ba le ngoana le ho nyeka;
- ho felloa ke metsi 'meleng;
- malabsorption ea galactose kapa tsoekere;
- mamello ho lebese tsoekere.
Lithuto tse felletseng tsa kliniki mabapi le litlamorao tsa moriana 'meleng oa bana ha li e-so tšoaroe, ka hona, moriana o fuoa feela batho ba baholo. Tabeng ea tlolo ea tekanyo ea motlakase-electrolyte, renal, ho se sebetse ha sebete le ho fokotseha ha methapo ea methapo ea kutlo, ho hlokahala tlhokomeliso nakong ea kalafo.
U ka e nka joang
Moriana o nooa ka molomo nako e le 'ngoe ka letsatsi pele ho lijo kapa ka mor'a lijo. Ka khatello e phahameng, litekanyetso li 50 mg / letsatsi. Tekanyetso e ka eketsoa ho 100 mg.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-6.jpeg)
Moriana o nooa ka molomo nako e le 'ngoe ka letsatsi pele ho lijo kapa ka mor'a lijo.
Ho feta moo, khafetsa ea tsamaiso ke makhetlo a 1-2 ka letsatsi. Kaha moriana o na le phello ea diuretic, ha o alafa ka diuretics, Lorista e laetsoe litekanyetso tsa 25 mg, butle-butle e eketsa litekanyetso.
Batho ba baholo, bakuli ba sebelisang lisebelisoa tsa hemodialysis le batho ba nang le pheko ea methapo ea methapo.
Ka CHF, tekanyetso ea pele ea letsatsi le letsatsi ke 12,5 mg. Ebe e eketseha ho fihlela ho 50 mg / ka letsatsi. Beke e 'ngoe le e' ngoe bakeng sa khoeli, tekanyetso ea pele e eketseha ka 12,5 mg. Hangata, Lorista e kopantsoe le li-agents tse ling tse amang methapo ea pelo (diuretics, glycosides). Bakuli ba nang le kotsi e eketsehang ea koluoa e mpe ea cerebrovascular Lorista ba hloka ho nka 50 mg / ka letsatsi.
Ho nka moriana oa lefu la tsoekere
Bakeng sa thibelo ea tšenyo ea liphio ho bakuli ba nang le lefu la tsoekere la mofuta oa 2, litekanyetso li ka 50-100 mg / ka letsatsi.
Litlamorao
Karolong ea sistimi ea endocrine le litho tsa sefuba, karabelo e bohloko ha e bonoe.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-7.jpeg)
Ha u nka Lorista, bohloko ba ka mpeng bo ka hlaha.
Phekolo ea ka mpeng
Ha u nka Lorista, ho ka ba le litlamorao tse latelang tse sa rateheng.
- bohloko ba ka mpeng
- tlolo ea setofo ka mokhoa oa lets'ollo;
- ho nyekeloa
- leino le opang
- molomo o omileng
- bloating;
- ho hlatsa
- ho sokela
- ho theola boima ba 'mele ho fihlela ho anorexia;
- keketseho ea khoholeho ea li-enzyme tsa sebete maling (ka seoelo);
- eketsehile bilirubin maling.
Maemong a tebileng, nakong ea phekolo, gastritis le hepatitis li ka hlaha.
Hematopoietic litho tsa ka hare
Nako le nako, ho hlaha hoa tšoelesa ea methapo le ea methapo.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-3.jpg)
Ho nwa moriana ho ka baka phokolo ya madi.
Tsamaiso ea methapo e bohareng
Ka lehlakoreng la ts'ebetso ea methapo, asthenia (ho fokotseha ho sebetsa, bofokoli), ho hloka boroko, ho opeloa ke hlooho, ho imeloa kelellong, ho tsekela, kutloelo-bohloko ka mokhoa oa paresthesia (tingling, goosebumps) kapa hypesthesia, migraine, ho tšoenyeha, ho akheha le khatello ea maikutlo. Ka linako tse ling ho ruruha neuropathy le ataxia ea nts'etsapele.
Allergie
Ha u nka Lorista, mefuta e latelang ea karabelo e ka khoneha:
- ho hlohlona
- makhopho
- urticaria;
- Edema ea Quincke.
Maemong a tebileng, mokhoa o ka holimo oa phefumoloho o ruruha le ho hema ho thata.
Tšusumetso ho bokhoni ba taolo ea methapo
Ha ho na tlhahisoleseling mabapi le phello ea Lorista ho bokhoni ba motho ba ho khanna koloi le ho sebetsa lisebelisoa.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-4.jpg)
Ha ho na tlhahisoleseling ka phello ea Lorista ho bokhoni ba motho ba ho khanna koloi.
Litaelo tse khethehileng
Ha o phekola Lorista, o tlameha ho latela litaelo tse latelang:
- boemong ba ho fokotseha ha molumo oa mali o potoloha, ho hlokahala ka mokhoa oa pele ho e khutlisa kapa ho qala kalafo ka tekanyetso e tlase ea moriana;
- hlokomela litekanyetso tsa "metabolinine" ea mali;
- hlokomela boemo ba potasiamo maling.
Bakuli ba nang le ts'ebetso ea sebete e sa sebetseng
Ka cirrhosis e itekanetseng, keketseho ea palo ea losartan maling e ka khona, ka hona, batho ba nang le lefu la sebete ba hloka ho fokotsa litekanyetso tsa moriana.
Bakuli ba nang le ts'oaetso ea renal
Ka ts'ebetso e sa lekaneng, Lorista e nkoa ka hloko. Bakuli ba eletsoa hore ba fane ka mali bakeng sa tlhahlobo ho bona hore na metsoako ea naetrojene e kae.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-8.jpeg)
Ha o sebelisa Lorista, o hloka ho emisa ho anyesa.
Nakong ea bokhachane le pelehi
Tšebeliso ea lithethefatsi nakong ea ho beleha ngoana e eketsa kotsi ea ho senyeha ha "fetus" ka lebaka la ts'usumetso ea Lorista ho sisteme ea renin-angiotensin. Ha o sebelisa Lorista, o hloka ho emisa ho anyesa.
Kopano ea bana ba Lorist
Setlhare sena se kopantsoe ho bana le lilemong tsa bocha.
Tekanyetso botsofaling
Bakeng sa batho ba botsofe, tekanyetso ea pele e tsamaisana le mofuta o tloaelehileng oa kalafo. Matlapa a nooa hoseng, thapama kapa mantsiboea.
Tekanyo ea joala
Ha o sebelisa Lorista, ho khothalletsoa ho tlohela tšebeliso ea joala.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-9.jpeg)
Ha o sebelisa Lorista, ho khothalletsoa ho tlohela tšebeliso ea joala.
Bongata
Matšoao a bosholu ke:
- pelo lippitations;
- khatello ea khatello ea mali le mathata a potoloho ea mali;
- pallor ea letlalo.
Ka linako tse ling bradycardia ea hlaha. Bathong ba joalo, sekhahla sa pelo se ka tlase ho 60 beats / min. Thuso e na le diuresis e qobelloang le tšebeliso ea lithethefatsi tse nang le matšoao. Ho hloekisoa ha mali ka hemodialysis ha ho na katleho.
Ho sebelisana le lithethefatsi tse ling
Ho se tšoane hantle ha Litaba tsa Lorista le:
- lithethefatsi tse thehiloeng ho fluconazole;
- Rifampicin;
- Spironolactone;
- Li-NSAID;
- Triamteren;
- Amiloridine.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-10.jpeg)
Ho se tšoane hantle ha Lorista le lithethefatsi tse thehiloeng ho fluconazole hoa tsebahala.
Karolo ea Lorista ke hore e ntlafatsa phello ea hypotensive ea beta-blockers, diuretics le sympatholytics.
Li-analog
Litaba tsa Lorista tse nang le losartan ke meriana e kang Presartan, Lozarel, Kardomin-Sanovel, Blocktran, Lozap, Vazotens, Lozartan-Richter, Kozaar le Lozartan-Teva.
Li-badala tsa Lorista e ka ba lithethefatsi tse thata. Tsena li kenyelletsa Lortenza, GT Blocktran, Losartan-N Canon, Lazarel Plus, Gizaar le Gizaar Forte.
Ha ho na lithethefatsi Lorista Plus. Litokisetso tse rarahaneng, Lozap AM, e nang le losartan le amlodipine le tsona lia rekisoa.
Moqapi
Baetsi ba Lorista le lipapatso tsa bona ke Russia, Jeremane, Slovenia, Iceland (Vazotens), USA, Netherlands, Korea le United Kingdom.
![](http://img.diabetesentity.com/img/sayd-2020/1761/kak-pravilno-ispolzovat-lorista-ot-diabeta-11.jpeg)
E 'ngoe ea baetsi ba Lorista le liemeli tsa eona ke Russia.
Lipehelo tsa khefu ea khemisi
Setlhare se rekisoa feela ka taelo ea ngaka.
Theko ea Lorista
Litšenyehelo tsa Lorista li tsoa ho li-ruble tse 130. Litheko tsa analog li fapana ho li-ruble tse 80. (Losartan) ho fihlela ho li-ruble tse 300. le holimo.
Maemo a polokelo ea lithethefatsi Lorista
Setlhare se bolokiloe ka mocheso oa kamore (ho fihlela 30ºC). Sebaka sa polokelo se tlameha ho sireletsoa mochesong le hole le bana.
Letsatsi la ho felloa ke nako
Lilemo tse 5 ho tloha ka letsatsi la tlhahiso.
Tlhahlobo
Litsebi tsa kelello
Dmitry, ea lilemo li 55, Moscow: "Ke fana ka lengolo la ho ngola la Lorista kapa liphihlelo tsa lona ho bakuli ba ka ba nang le khatello ea mali."
Bakuli
Alexandra, ea lilemo li 49, Samara: "Ke noella Lorista ka tekanyetso ea 50 mg ho tsoa khatello e phahameng. Lithethefatsi li theola khatello ea mali hantle."