Aries ke lithethefatsi tse laetsoeng e le sethethefatsi se kulang bakeng sa ho fumanoa ha hypercholesterolemia le lefu la pelo ho mokuli. Sesebelisoa se ka sehloohong sa lithethefatsi ke simvastatin. K'homphieutha ena e phatlalalitse thepa e fokotsang lipid.
Moriana o ka har'a matlapa. Moetsi oa sehlahisoa sena ke k'hamphani ea meriana ea Russia e leng OZON LLC. Sebopeho sa matlapa ke potoloho ea setso. Ho hlophisoa ha matlapa e le motsoako o ka sehloohong oa kenyelletso ho kenyelletsa simvastatin ka boholo ba 10 kapa 20 mg.
Ntle le sehlahisoa sa mantlha sebopeho sa matlapa, ho na le mefuta e fapaneng ea likhomphutha tse ling:
- asiti ea ascorbic;
- asiti ea citric;
- setene sa gelatinized;
- lactose;
- tekanyetso ea titanium;
- magnesium stearate;
- talc;
- propylene glycol;
- oli ea castor;
- starch ea poone.
Setlhare sena se rekisoa ka litlolong ka mokhoa oa litafole tse pakiloeng ka mekotleng e 'ngoe,' me e 'ngoe le e' ngoe e na le likotoana tse 10, 20 kapa tse 50. Phutheloana ea pampiri e kenngoe ka har'a liphutheloana tse entsoeng ka karete.
Ts'ebetso ea ts'ebetso ea lithethefatsi e etsoa hafeela ho na le mokhoa oa ngaka o eang.
Bophelo ba Shelf ea lithethefatsi ke lilemo tse 3. Ho bolokoa ha moriana ho lokela ho etsoa sebakeng se sirelelitsoeng ke letsatsi. Mocheso oa polokelo ha oa lokela ho ba holimo ho likhato tse 25 tsa Celsius. Sebaka sa polokelo se tlameha ho sireletsoa mochesong le hole le bana.
Kamora letsatsi la ho felloa ke matla, moriana o lahloa.
Pharmacodynamics le pharmacokinetics ea lithethefatsi
Ovenkor ea meriana e bua ka lithethefatsi tse fokotsang lipid tse entsoeng ka maiketsetso. Ho hlophisoa ha moriana ho etsoa ka ho belisoa ha sehlahisoa se fumanoang ho fungus ea Aspergillusterreus saprophyte pathogenic.
Lactone e sa sebetseng e tšelisoa, e lateloe ke motsoako oa hydroxy acid e tsoang teng.
Metabolite e sebetsang ea simvastatin inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase.
Enzyme e boletsoeng e thusa karabelo ea pele ea HMG-CoA mevalonate.
Ho fetoloa ha HMG-CoA ho mevalonate ho emela mohato oa pele oa motsoako oa cholesterol. Ts'ebeliso ea simvastatin ha e qholotsa kholo ea 'mele ea ts'ebetso ea ho bokella li-sterols tse ka bang chefo. HMG-CoA e fetoloa habonolo ho acetyl-CoA. K'hemik'hale ena e kenella 'meleng ka palo e kholo ea lits'ebetso tsa metabolic.
Bakeng sa simvastatin, thepa ea mantlha e latelang ke tšobotsi:
- Ho theola maemo a plasma a triglycerides, LDL le VLDL, hammoho le cholesterol e felletseng.
- Keketseho ea mahloriso a HDL le ho fokotseha ha karolelano ea lipoprotein tse tlaase le lipoprotein tse phahameng.
- Fokotsa karolelano lipakeng tsa cholesterol e felletseng le HDL.
Kameho ea ts'ebeliso ea lithethefatsi e bonoa e se e le matsatsi a 14 kamora ho qala ts'ebeliso ea ts'ebetso ea Ovenkor.
Ho fihlella phello e matla ea kalafo, ho hlokahala hore motho a fumane kalafo, eo nako ea eona e tlohang ho libeke tse 4 ho isa ho tse 6.
Haeba ho hlokahala, ngaka e eang e lelefatsa nako ea kalafo, e thusang ho boloka phello ea moriana. Tšebeliso ea nako e telele ea lithethefatsi e lebisa ho maemo a tloaelehileng a cholesterol 'meleng oa mokuli.
Simvastatin e na le monko o phahameng haholo. Khokahano e phahameng ea lithethefatsi e fumanoa 'meleng ka mor'a lihora tse 1,3-2,5. Kamora lihora tse 12 kamora tšebeliso ea lithethefatsi, ho fokotseha hoa khatello ea mali maling a mokuli ka 90% ho bonoa.
Ntho e sebetsang ea Ovenkor e khona ho tlama liprotheine tsa plasma .. Tekanyo ea liprotheine e tlamang e ho fihlela ho 95%.
Bophelo ba halofo ea motsoako o sebetsang oa lithethefatsi ke lihora tse 1,9.
Excretion ea metabolites e etsoa ke mala hore e be karolo ea makhopho. Mofuta o sa sebetseng oa metabolites o epolloa ke liphio ka har'a moroto.
Hoo e ka bang 60% ea setofo e epollotsoe 'meleng,' me ke hoo e ka bang karolo ea 10-15% ea moriana o tsoang kahara moroto.
Litaelo tsa tšebeliso ea lithethefatsi
Pele o etsa kopo ea Ovenkor, ho hlokahala hore o ithute litaelo tsa ho li sebelisa ka botlalo, ntle le sena, o lokela ho tloaelana le theko ea meriana le litlhahlobo tsa bakuli le lingaka, hape o lokela ho ithuta li-analogues tsa moriana haeba ho hlokahala.
Pele a nka moriana, mokuli o fuoa lijo tse tloaelehileng tsa hypocholesterol.
Ha u fana ka litlhare, tekanyetso ea letsatsi le letsatsi e ka fapana ho tloha ho 1- ho isa ho 80 mg.
Motsoako oa ho qala o khothalelitsoeng ke 10 mg; Phetoho ea litekanyetso li etsoa ka nako ea libeke tse 4. Hangata, lethal dose e nepahetseng ke 20 mg ka letsatsi.
Litekanyetso tse sebetsang tsa Ovenkor moo ho nang le lefu la pelo kapa ho na le monyetla o moholo oa ho ba le ts'oaetso e joalo ho tloha ho 20 ho isa ho 40 mg ka letsatsi. Boemong ba pele ba kalafo, moriana o noang ka tekanyetso ea 20 mg o sebelisoa mme kamora libeke tse 4 litekanyetso li fetoloa ho 40 mg.
Haeba tekanyetso ea cholesterol e ka tlase ho 140 mg / dl e fumanoe 'meleng, litekanyetso tsa lithethefatsi li fokotsehile.
Tekanyetso e nyane e sebelisoa maemong ao ho eona mokuli a nang le bothata ba ho fokola ba a renal kapa ha a etsa liphekolo tsa motsoako hammoho le Cyclosporine, Danazole, Gemfibrozil kapa li-fibrate tse ling.
Matšoao a ho sebelisoa ho latela litaelo a
- ho ba teng ha hypercholesterolemia;
- boteng ba 'mele oa IHD kapa li-prerequisites bakeng sa nts'etsopele ea tlolo ena.
Lintho tse amanang le tšebeliso ea lithethefatsi ke tsena:
- Lefu la sebete le sebopeho se sebetsang.
- Porphyria.
- Myopathy
- Lilemo tsa mokuli li ho fihlela lilemo tse 18.
- Bokhachane le pelehi.
- Boteng ba mamello ea motho ka mong.
Tlhokomeliso ha u sebelisa moriana o lokela ho bontšoa ka tšebeliso e mpe ea joala, boteng ba khatello ea methapo ea mali ho mokuli, nakong ea kalafo ea immunosuppression. Ntle le moo, ho hlokahala tlhokomeliso haeba mokuli a e-na le lefu la ho akheha le lefu la sethoathoa ka molumo oa mesifa ea marapo a genesis e sa tsejoeng.
Ha o sebelisa lithethefatsi, ponahalo ea litla-morao tsa moriana e bonahala ka mokhoa o latelang:
- bohloko bo ka mpeng;
- ho ruruha, ho ruruha, ho nyekeloa, ho hlaba ka matla ka mpeng, lefu la sethoathoa, takatso ea ho hlatsa;
- hlooho e bohloko
- peripheral neuropathy;
- Ho tsekela
- ho hloka boroko
- feberu
- ho hlohlona
- urticaria;
- ho phahama ha pelo, phokolo ea mali, phokotso ea potency.
Haeba matšoao a pele a litlamorao a fumanoa, Ovenor e lokela ho emisoa.
Litsenyehelo tsa moriana, analogues le litlhahlobo mabapi le lithethefatsi
Ho latela tlhahlobo e fumanehang ea bakuli le ho phekola lingaka, Ovencor ke mokhoa o sebetsang haholo oa ho loants'oa cholesterol e ngata 'meleng. E 'ngoe ea maemo a ho fihlella liphetoho tse ntle boits'oarong ba kalafo e hloka ho khomarela lijo ka tieo. Phoso ea meriana ke tsoelo-pele e ka etsahalang ho mokuli ea litlamorao tse fapaneng tse ka lebisang ho feliseng kalafo.
Theko ea Ovenkor hajoale lijong tsa litlama ho la Russian Federation e tloha ho li-ruble tse 300 ho isa ho tse 600 ka sephutheloana, ho latela sebaka.
Lithethefatsi tse latelang ke papiso ea lingaka:
- Simvastatin.
- Vero-simvastatin.
- Zokor.
- Atherostat.
- Zovatin.
- Avestitin.
- Simvastol.
- Simvakard.
- Simlo.
- Holvasim.
- Zorstat.
Litsenyehelo tsa li-analogues tsa moriana o ka sehloohong li ka feto-fetoha maemong a bohlokoa. Kahoo, ka mohlala, Simvastatin e na le litšenyehelo tsa li-ruble tse 41 ka matlapa a 30, e 'ngoe le e' ngoe e na le 10 mg ea motsoako o sebetsang, 'me Vasilip e na le theko ea li-ruble tse 124 bakeng sa sephutheloana se nang le matlapa a 14, e' ngoe le e 'ngoe e na le 10 mg ea motsoako o sebetsang.
Pele u khetha analogue e nepahetseng bakeng sa ho fetola moriana o ka sehloohong, o lokela ho bona ngaka ea hau.
Na ho na le molemo hore o nke li-statins tseo litsebi li tla li bua videong ena.
