Lefu la tsoekere ke lefu le tloaelehileng le hlokang kalafo. Ka hona, mofuteng oa pele oa lefu le maemong a hatetseng pele ka mofuta oa bobeli oa lefu la tsoekere, bakuli ba hloka taolo ea insulin e sa fetoheng, e thusang ho fokotsa tsoekere, ka potlako ba e fetole matla.
Hangata ka lefu la tsoekere, insulin Aspart e sebelisoa. Ena ke setlhare sa ultrashort.
Sesebelisoa ke analogue ea "insulin" ea motho, e fumanoang ke theknoloji ea DNA e sebetsang hape e sebelisang mofuta oa Saccharomyces cerevisiae, moo proline e maemong a B28 (amino acid) e nkeloang sebaka sa "aspartic acid". Boima ba molek'hule ke 5825.8.
Sebopeho, foromo ea tokollo le phello ea pharmacological
Biphasic insulin e kopanya aspart e qhibilihang le protulin ea insulin ea kristale ka tekanyo ea 30 ho isa ho 70%.
Sena ke ho emisoa bakeng sa tsamaiso ea sc, ho ba le 'mala o mosoeu. Millilita e le 'ngoe e na le li-unit tse 100,' me e le 'ngoe ea ED e tsamaellanang le 35 μg ea insulin Aspart.
Analogue ea insulin ea motho e theha motsoako oa "insulin receptor" le "cell" ea "membrane" ea "cell" membrane. Ho qetela ho sebetsa ho hlophisoa ha glycogen synthetase, pyruvate kinase le hexokinase enzymes.
Ho fokotseha ha tsoekere ho etsahala ka keketseho ea lipakeng tsa intracellular le ho fumana tsoekere e ntlafalitsoeng ea tsoekere. Hape, hypoglycemia e fumanoa ka ho fokotsa nako ea secretion ea tsoekere ke sebete, glycogenogeneis le ts'ebetso ea lipogenesis.
Biphasic insulin aspart e fumanoa ka ho fetoloa ha biotechnological ha molek'hule ea "proline ea" hormone e nkeloa sebaka ke acid ea "aspartic". Li-insulin tse joalo li na le phello e tšoanang ho hemoglobin ea glycosylated, joalo ka insulin ea motho.
Ka bobeli lithethefatsi li sebetsa ka tsela e tšoanang ho molar e lekanang. Leha ho le joalo, Aspart insulin e sebetsa ka potlako ho feta hormone ea motho e qhibilihang. Mme protstalline Aspart protamine e na le phello ea nako e mahareng.
Ketso kamora ho tsamaisoa ha moriana oa sc e fumaneha kamora metsotso e 15. Phekolo e phahameng ka ho fetisisa ea moriana e etsahala lihora tse 1-4 kamora ho kenngoa. Nako ea phello e fihla ho lihora tse 24.
Ho serum, Cmax ea insulin e 50% ho feta ha o sebelisa insulin ea motho ea biphasic. Ho feta moo, nako ea karolelano ea ho fihla Cmax e ka tlase ho halofo.
T1 / 2 - ho fihlela lihora tse 9, e bonts'a sekhahla sa ho kenngoa ha karoloana e tlameletsoeng protamine. Maemo a "insulin" a motheo a bonoa lihora tse 15-18 kamora hore a tsamaiso.
Empa ka lefu la tsoekere la mofuta oa 2, katleho ea Cmax e ka ba metsotso e 95. E boloka e le maemong a ka tlase ho 14 le kaholimo ho 0 kamora ho tsamaisoa ha sc. Hore na sebaka sa tsamaiso se ama sebaka sa ho amoheloa ha se na ho ithutoa.
Tekanyetso le tsamaiso
Hangata insulin Degludek, Aspart-insulin e tsamaisoa ka mokhoa o sa tsamaeeng. Ente e etsoa likarolong tse ling tsa 'mele:
- buttock;
- Belly
- serope
- lehetla.
U hloka ho enta insulin pele ho lijo (mokhoa oa prandial) kapa kamora ho ja (mokhoa oa postprandial).
Algorithm le litekanyetso tsa tsamaiso li khethoa ke ngaka e eang. Empa khafetsa palo ea lithethefatsi ea letsatsi le letsatsi ke 0.5-1 UNITS ka kilo e le 'ngoe.
Maemong a boima, insulin Aspart biphasic e tsamaisoa iv. Ts'ebetso e etsoa ho sebelisoa lits'ebetso tsa infusion maemong a mantsiboea kapa a inpatient.
Likarabo tse fapaneng, Contraindication le overdose e ngata
Ts'ebeliso ea insulin Asparta e ka ama mosebetsi oa Seboka sa Naha, kaha maemo a tsoekere a potlakileng a litekanyetso tsa tsoekere ka linako tse ling a baka bohloko ba methapo ea kutlo. Leha ho le joalo, boemo bona bo feta ha nako e ntse e tsamaea.
Hape, insulin ea biphasic e lebisa ponahalong ea lipodystrophy sebakeng sa ente. Karolong ea litho tsa kutlo, ho senyeha hoa pono le ho se sebetse hantle ka har'a refraction ho hlokomeloe.
Contraindication ke ho se mamellane ka seqo ho likarolo tsa lithethefatsi le hypoglycemia.
Ntle le moo, tšebeliso ea Insulin Aspart ha e eletse ho fihlela lilemo tsa 18. Kaha ha ho na tlhaiso-leseling ea bongaka e netefatsang ts'ebetso le polokeho ea moriana bakeng sa setho se hlahang.
Haeba ho na le overdose, matšoao a latelang a hlaha:
- cramps
- ho fokotseha ho matla ha tsoekere;
- hypoglycemic coma ho lefu la tsoekere.
Ka tekanyetso e nyane haholo, ho etsa hore khatello ea tsoekere e tloaelehe, ho lekane ho nka lik'habohaedreine tse potlakileng kapa ho noa seno se tsoekere. U ka kenya glucagon ka mokhoa o ikhethileng kapa ka mokhoa oa intramuscularly kapa tharollo ea dextrose (iv).
Maemong a coma ea hypoglycemic, ho tloha ho 20 ho isa ho 100 ml ea dextrose (40%) e kenngoa ka tsela e kenang ka mpeng ho fihlela boemo ba mokuli bo lekane. Ho thibela nts'etsopele ea linyeoe tse joalo, tšebeliso ea nama ea nama ea nama ea kolobe e khothalletsoang hape.
Ho sebelisana le lithethefatsi tse ling le litaelo tse ikhethang
Phello ea hypoglycemic e ka matlafatsoa haeba ho tsamaisoa ha insulin ea biphasic ho kopantsoe le tsamaiso ea molomo ea litlhare tse latelang:
- lithethefatsi tse nang le joala le hypoglycemic;
- MAO / carbonic anhydrase / ACE inhibitors;
- Fenfluramine;
- Bromocriptine;
- Cyclophosphamide;
- somatostatin analogues;
- Theophylline;
- Sulfonamides;
- Pyridoxine;
- Li-steroid tsa anabolic.
Ts'ebeliso ea li-tetracyclines, Mebendazole, Dizopyramide, Ketonazole, Fluoxetine le Fibrate le eona e lebisa phokotsong e kholo ea tsoekere. Mme li-antidepressants tsa tricyclic, lithibela-pelehi tsa molomo, nicotine, sympathomimetics, glucocorticosteroids, thiazide diuretics, lihormone tsa qoqotho le lithethefatsi tse ling li kenya letsoho ho fokolleng ha phello ea hypoglycemic.
Lithethefatsi tse ling li ka eketsa le ho fokotsa litekanyo tsa tsoekere. Tsena li kenyelletsa litokisetso tsa lithium, beta-blockers, salicylates, clonidine le reserpine.
Ho bohlokoa ho hlokomela hore Flekspen e sebelisitsoeng e lokela ho bolokwa ka mocheso oa kamore, le pene e ncha ea syringe sehatsetsing. Pele ho tsamaiso, lintho tse kahare tsa vial li bohlokoa ho kopanya hantle.
Ka ts'ebetso e eketsehileng ea 'mele, mafu a tšoaetsanoang kapa a tšoaetsanoang, keketseho ea tekanyetso ea insulin e hlokahala. 'Me qalong ea phekolo, ha ho khothalletsoe ho laola mekhoa le likoloi tse rarahaneng. Video e sehloohong sena e tla bua ka ho eketsehileng ka hormone.
