Lefu la tsoekere le bitsoa "seoa" sa lekholo la XXI. Ka hona, ho nka meriana ke e 'ngoe ea lintlha tsa bohlokoa ho phekoleng lefu lena. Litokisetso tsa litaelo tsa Pioglitazone li na le tlhaloso e qaqileng ea ts'ebeliso ea bona.
Lithethefatsi tse ka sehloohong tsa lefu la tsoekere tse nang le ntho ena ke Aktos, Pioglar, Diab-tloaelehileng, Diaglitazone. Pioglitazone ka boeona ke phofo e tšoeu ea kristale, e seng monko.
Ha e qhibilihe ka metsing, empa e ts'oaroa haholo ka dimethylformamide. Ha e le ananthrous ethanol, acetone le acetonitrile, ntho e ho tsona e qhibilihile hanyane.
Pioglitazone ke karolo ea sehlopha sa thiazolidinediones (glitazones); ts'ebeliso ea eona e bonts'oa ho fokotsa tsoekere ea mali. Kaha mofuta oa bobeli oa lefu la tsoekere o tšoauoa ka tlolo ea methapo ea lisele tsa mmele ho kenella ho insulin, li-glitazones li kenya tšebetsong li-receptors tse teng ka har'a li-nuclei tsa tsona. Ka lebaka leo, lisele tsa paripheral li qala ho arabela ho insulin ea hormone.
Bakuli ba bangata ba botsa potso, na ho ka khoneha ho sebelisa moriana o nang le pioglitazone mofuteng oa pele oa lefu? Glitazones ke lithethefatsi feela mofuta oa bobeli oa lefu la tsoekere. Li sebelisoa e le moriana o ka sehloohong, 'me li eketsoa ka metformin, sulfonamide kapa insulin. Bakuli ba qala ho nka moriana haeba ho ikoetlisa le ho ja hantle ho se na phello e lakatsehang - tsoekere e tloaelehileng ea mali.
Li-glitazones ha li bapisoa le lithethefatsi tse ling tse theolelang tsoekere ka mokhoa o atlehileng li tlosa ho hanyetsa insulin. Ba fokotsa palo ea mafura a mangata maling a batho le ho li fetisetsa linama tsa mmele tsa "adipose" ho tloha mpeng ea mpa ho ea sebakeng se tlase. Ntle le moo, lintho li theoha triglycerides.
Litaelo tsa tšebeliso ea lithethefatsi
Ho nka moriana ho bontšoa feela kamora ho buisana le ngaka e eang, ea fanang ka taelo e nepahetseng, a nahanela litšobotsi tsa mokuli. Tabeng ea ho itšebeliso ea ntho ea pioglitazone, litaelo tsa sehlahisoa li tlameha ho ithutoa ka hloko ho qoba mathata.
Setlhare se bontšoa hore se ka sebelisoa haeba litekanyetso tsa pele li tsoa 15 ho isa ho 30 mg, mme boholo (ka letsatsi) ke 45 mg. Haeba u kopanya ntho ena le meriana e meng, lethal dose ha ea lokela ho feta 30 mg. Pioglitazone e bontšoa hore e sebelisoe hang ka letsatsi.
Nakong ea kalafo, o tlameha ho tsoela pele ho latela lijo le ho ikoetlisa. Ho bohlokoa haholo ho hlahloba boemo ba hemoglobin maling.
Pioglitazone e bontšoa ka tlhokomelo e khethehileng ho bakuli ba nang le ho ruruha, 'me sebete se na le li-enzyme tse eketsehileng. Ka nts'etsopele ea hypoglycemia nakong ea phekolo e kopaneng e hloka hore ho fokotsoe litekanyetso tsa insulin kapa sulfonamides. Haeba mokuli a na le jaundice, ho ka ba le tšusumetso e mpe 'meleng, ka hona, kalafo e lokela ho emisoa. Bakuli ba nang le potoloho ea anovulatory nakong ea kemiso ea bokhachane ba kotsing ea ho ima, ka hona thibelo ea bokhachane e lokela ho sebelisoa.
Contraindication le litla-morao
Pele u sebelisa meriana e thehiloeng ho Pioglitazone, o hloka ho buisana le ngaka ea hau. Ntho ena e na le li-contraindication tse ngata: ho se mamellane ho motho ka mong ho ea ho pioglitazone, mofuta oa 1 lefu la tsoekere, lefu la tsoekere la methapo (metabolite ea carbohydrate) ka lebaka la khaello ea insulin), methapo ea methapo ea methapo sethaleng.
Tekanyetso ea ALT (alanine aminotransferase) e phahame ka makhetlo a 2,5 ho feta e tloaelehileng, e ka bonts'ang nts'etsopele ea maloetse a mangata a tebileng, lilemo tse fihla ho 18 (katleho ea ntho ho bakuli ba sehlopha sena sa lilemo ha e e-so tsebisoe) nako ea ho emara le ho anyesa.
Haeba Pioglitazone e sebelisoa hampe kapa ka lebaka le leng, mokuli a ka ba le karabelo e latelang e bohloko:
- hypoglycemia - ho fokotseha kapele ha tsoekere ea mali;
- ho ruruha, le ho kopana le insulin ho eketsa menyetla ea ho ruruha ho fihlela ho 15,3%;
- anemia - hemoglobin e tlase maling a motho;
- ho fokotseha ha boemo ba bilirubin;
- ho fokotseha ha alanine aminotransferase (ALT) - enzyme ea hypogenic;
- ho fokotsa li-amartotransferase ea li-aspartate - A enzyme e ikarabellang bakeng sa motsoako oa li-amino acid;
- ho fokotseha ha alkaline phosphatase (ALP) - enzyme e theohang phosphates ho tsoa liprotheine, alkaloids, jj.
- fokotseha ea gamma glutamyl e fetotsoe.
Ho feta moo, litokisetso tsa ho kopanya tse nang le sulfonamide derivatives, metformin, insulin, e lebisa ho hypoglycemia.
Hape, ha e sebelisoa, phello ea ho fokotsa katleho ea lithibela-pelehi tsa molomo e ka hlahisoa.
Litlhahlobo, melemo le likotsi
Tlhahlobo ea bakuli ba bangata ba sebelisitseng Aktos, Pioglar le lithethefatsi tse ling, tse ntle haholo. Har'a melemo, ho ka khoneha ho totobatsa katleho ea ho fokotsa khatello ea insulin har'a lithethefatsi tsohle tse fokotsang tsoekere tse nooang ka molomo.
Empa ho na le mathata a itseng a glitazones, a bonahatsoang ka ho latelang: a tlase ho lithethefatsi tse nang le metformin le sulfonylurea, hemoglobin e fokotseha ka 0.5-1,5%, ha o sebelisa, phaello e akaretsang ea boima ba ligrame tse 1-3 e bonoa ka lebaka la ho bokelloa ha mafura le ho bolokoa hoa mokelikeli 'meleng.
Ka hona, pele u nka glitazones, o hloka ho bona ngaka le ho bala litlhahlobo tsa bakuli ba seng ba li qetile.
Mokuli ea nkang Pioglitazone ntho eo theko ea eona e itšetlehileng ka moriana o tlameha ho tseba hore na o tla sebelisa pheko efe. Litšenyehelo tse tloaelehileng tsa matlapa a pioglar (likotoana tse 30 tsa 30 mg ka ngoe) ke li-ruble tse 1083, Actos (likotoana tse 28 tsa 30 mg ka ngoe) ke li-ruble tse 3000. Ha e le hantle, motho ea maemong a mahareng o khona ho reka lithethefatsi tsena. Litsenyehelo tsa bona tse phahameng li bakoa ke taba ea hore tsena ke lithethefatsi tse tsoang kantle ho naha, Pioglar e hlahisoa India, Actos - ho la Ireland.
Lits'enyehelo tse tlase ha li theko e phahameng li etsoa Russia. Tsena li kenyeletsa:
- Litekanyetso tsa Diab;
- Astrozone;
- Diaglitazone.
Ha e sebelisoa, phello ea hypoglycemic e tla fanoa. Diaglitazone, e jang li-ruble tse 295, e ka ba sebaka se setle ho lithethefatsi tse theko e boima haholo. Astrozone le Diab-tloaelehileng li na le li-contraindication le litlamorao tse tšoanang.
Diagnitazone e ka fokotsa katleho ea ho sebelisa bokhachane ba molomo, bo lokelang ho tsotelloa.
Litlhaku tsa pioglitazone
Ka lebaka la ho se mamellane le litlamorao ka bomong, ts'ebeliso ea pioglitazone e kanna ea thibeloa. Ka hona, ngaka e fana ka litlhare tse ling tse nang le rosiglitazone.
Ntho ena e kenyelelitsoe le sehlopha sa thiazolidinediones (glitazones). Ha u e sebelisa, phello e ts'oanang e tla hlahisoa joalo ka pioglitazone, ka mantsoe a mang, ke ho tsosa lisele le li-receptor tsa lisele ho tlosa khanyetso ea insulin.
Lithethefatsi tse ka sehloohong tse nang le rosiglitazone ke:
- Avandia
- Qhekella.
Pele u li sebelisa, u hloka ho buisana le ngaka le ho bala litaelo tsa tšebeliso.
Litokisetso tsa Biguanide li fokotsa ho hanyetsa insulin. Metformin, e leng karolo ea sehlahisoa, e fokotsa tlhahiso ea tsoekere ke sebete. Sebelisa lithethefatsi tsena ka hloko, hobane li-biguanides li ama ts'ebetso ea pelo ho batho ba tsofetseng, phello e mpe mosebetsing oa liphio le nts'etsopele ka lebaka la lactic acidosis le eona e ka hlahisoa. Litokisetso tse nang le metformin e sebetsang ea lintho li kenyelletsa Bagomet, Glucofage, Metformin-BMS, NovoFormin, Siofor le ba bang.
Hape, e fokotsa tsoekere e maling. Mochine oa ketso ea ona o etselitsoe ho thibela li-enzyme tse thusang ho kopanya lik'habohaedreite kahara lijo tse silang lijo. Hypoglycemia e khoneha ka ts'ebeliso e eketsehileng ea lithethefatsi tse ling le insulin. Ho thibela ho hlaha ha litla-morao tse amanang le ts'oaetso ea mala, ho molemo ho qala ho nka ka litekanyetso tse nyane.
Phekolo ea lefu la tsoekere la mofuta oa 2, lithethefatsi tse nang le pioglitazone kapa li-analogues tsa eona, ekaba Diaglitazone kapa Metformin, li ka sebelisoa. Kaha lithethefatsi tsena li na le li-contraindication le litlamorao tse ngata, ho khothaletsoa haholo ho li sebelisa ka mor'a ho buisana le lefu la tsoekere. le ngaka. Video e sehloohong sena e akaretsa puisano ka
