Diabetes ke sethethefatsi se sebetsang ho mofuta oa 2 lefu la tsoekere. Karolo ea eona e sebetsang ke gliclazide. Phekolo ena e tšoauoa ka tokollo e potlakileng ka potlako le ka theko e phahameng, kahoo bakuli ba bangata ba batla li-analogues tse fumanehang habonolo tsa Diabeteson. Ho itšireletsa ha lithethefatsi ha hoa lumelloa: ho hlokahala boeletsi bo ikhethang.
Tlhaloso ea Sehlahisoa
Diabeteson ke moemeli oa hypoglycemic ebile e tsoa ho β-sulfonylurea, e nkuoa ka molomo. Phapang ea eona ho li-synonyms ke ho ba teng ha reng e nang le heterocyclic ea N e nang le tlamo ea endocyclic. Moriana ona o khothaletsa tlhahiso ea "insulin" ke li-cells-cell tsa lihlekehleke tsa Langerhans le ho fokotsa litaba tsa glucose tse maling.
Kamora kalafo ea lilemo tse peli, keketseho ea bongata ba C-peptide le postprandial insulin. Karolo e sebetsang e bonts'a litla-morao tsa hemovascular mme e ama metabolism ea carbohydrate. Mofuteng oa 2 oa lefu la tsoekere, e eketsa mohato oa bobeli oa ho lokolloa ha insulin le ho khutlisetsa tlhoro ea eona ea secretion ho keneleng tsoekere. Ts'ebetso tsena li shebiloe haholo-holo ka kenyelletso ea eona le karabelo ea phello, e bakoang ke takatso ea lijo.
Moriana o fokotsa kotsi ea "thrombosis" e nyane ea mali le nts'etsopele ea mathata a hlahisoang ke lefu la tsoekere. Kamora letsatsi la tšebeliso e le 'ngoe ea lithethefatsi, phello ea metabolites e sebetsang le pioglitazone e serum ea mali e lula e le boemong bo phahameng haholo.
Litaelo tsa ho sebelisoa
Sengoloa se bontša meeli ea ho nka meriana. Li-contraindication tsa tsona tse ka sehloohong ke maemo a latelang:
lefu la tsoekere le letšollo;- nako ea ho beleha le ho ba le ngoana;
- ho hlohlona ho matla ha hepatic le renal;
- dikahare tse phahameng tsa 'mele oa ketone le glucose ea mali;
- mamello ho lactose, sulfanilamide, gliclazide.
lefu la tsoekere le letšollo;Setlhare sena se fuoa feela bakuli ba baholo. Letlapa le tlameha ho nooa hang ka letsatsi nakong ea lijo. Tekanyetso e kholo ea letsatsi le letsatsi ke 120 mg. Setlhare se ke ke sa qhekelloa le ho hlafuna, se tlameha ho hlatsuoa ka metsi a hlakileng. Haeba u tlil'o nooa moriana, ho nooa meriana e 'meli.
Boemong ba pele ba kalafo, lethal dose ke 30 mg. Haeba ho hlokahala, e eketsoa ke setsebi pele ho matsatsi a 40 kamora ho khethoa ha e fetileng. Bakuli ba kaholimo ho lilemo tse 65 ha ba hloke phetoho ea litekanyetso. Nakong ea kalafo, nako ea ho felisoa ha meriana e fetileng e lokela ho nahaneloa. Ha u sebelisa sethethefatsi sena, ho ka hlaha mathata a fapaneng. Tsena li kenyeletsa:
ho felloa ke letsoalo;- ho otsela ho eketsehileng kapa ho hloka boroko;
- thabo ea letsoalo;
- ho se utloane ho sa hlokahaleng;
- ho fokola le bofokoli bo akaretsang;
- Pherekano e sa bonahaleng, ho tsekela.
ho felloa ke letsoalo;Li-analoggs le tse nkang sebaka sa lithethefatsi
Lithethefatsi li na le litšenyehelo tse phahameng haholo. Li-analog le tsa lefu la tsoekere li emeloa ke litlhare tse latelang:
- Diabetesalong;
- Gliclazide;
- Glidiab;
- Diabefarm MV;
- Predian;
- Glucostabil;
- Piroglar.
Diabetesalong - Analogue e theko e tlaase ea lefu la tsoekere, e kopanyang tlhahiso ea insulin, kutloisiso ea lisele tsa tharollo le ho fokotsa bongata ba tsoekere maling. Ha e lemalle esita le ka mor'a lilemo tse 3 tsa ts'ebeliso. Setlhare se fokotsa hyperglycemia ea postprandial, e khutlisa tlhoro ea pele ea tlhahiso ea insulin, e fokotsa nako ea nako pakeng tsa ho ja le ho boloka insulin. Sebeteng, sethethefatsi se fokotsa sebopeho sa tsoekere 'me se etsa hore se sebetse hantle.
Ntho e sebetsang e ntlafatsa metabolism ea mmele le carbohydrate, e fokotsa kotsi ea thrombosis mme e khutlisetse ts'ebetso ea activator ea tisy plasminogen.
Gliclazide - Ona ke mofuta oa lithethefatsi tse fanoang kahare. E kenyelletsa selikalikoe sa heterocyclic ka tlamo ea endocyclic. Setlhare sena se matlafatsa tlhahiso ea insulin hape se fokotsa bongata ba tsoekere. Kamora kalafo ea lilemo tse tharo, keketseho ea khatello ea C-peptide le postprandial insulin e ntse e le teng. Sesebelisoa se sebetsang se bonts'a tšebetso ea methapo ea methapo 'me se ama metabolism ea carbohydrate. Ho sebelisa moriana ho fokotsa kotsi ea mathata a lefu la tsoekere.
Glidiab ke lithethefatsi tsa tsoekere tsa moloko oa 2-sulfonylurea le hypoglycemic. E ntlafatsa ts'ebetso ea ts'ebetso ea "glucose insulin-secretory", sensitivity ea peripheral ea methapo mme e na le phello e ntle ho secretion ea insulin, e tsosa mohato oa methapo ea methapo ea methapo ea methapo le ho fokotsa tlhoro ea hyperglycemia kamora ho ja. Ts'ebeliso ea moriana e lokela ho qalisoa khahlanong le nalane ea lijo tse nang le khalori e tlase e nang le lik'habohaedreite.
Ho khothalletsoa ho lula u lekola boemo ba tsoekere maling maling ka mor'a ho ja le ka mpeng e se nang letho. Tekanyetso e lokisoa bakeng sa khatello ea maikutlo kapa ea 'mele.
Diabefarm MV - Ena ke analogue ea lefu la tsoekere la 60, e leng lithethefatsi tse amanang le hypoglycemic ebile le amana le moloko oa bobeli oa litlamorao tsa sulfonylurea. E kenya letsoho tlhahiso ea insulin ke lisele tsa manyeme le ketso ea li-enzyme tse ka hare. Moriana o sebetsa haholo mofuteng oa 2 oa "mellitus" o amanang le lefu la tsoekere ka lipontšo tsa lefu la tsoekere le lefu la tsoekere le prophylactic ea mathata a microcirculation.
Predian - meriana ea tlhaho e entsoeng ka maiketsetso. E ka rekoa ka mokhoa oa matlapa a nang le litekanyetso tsa 0,08 g, e pakiloeng ka lebokoseng la karete. Motsoako o sebetsang o theola mali le ho fokotsa tsoekere. Moriana o tlameha ho qala ka halofo ea pilisi. Moriana o ke ke oa kopantsoe le acetylsalicylic acid, butadione, amidopyrine ka lebaka la ts'okelo ea hypoglycemia.
Glucostabil e ntlafatsa ts'ebetso ea methapo ea methapo ea methapo, e fokotsa nts'etsopele ea "parietal thrombus" e kopantsoeng le liplatelete. Lithethefatsi li eketsa microcirculation, palo ea HDL-C, e fokotsa cholesterol e felletseng, kutloisiso ea methapo ea mali ho adrenaline mme e thibela nts'etsopele ea atherosulinosis le microthrombosis. Ho fokotseha ha nako e telele ha proteinuria ho hlokomeloa ho latela tšebeliso ea nako e telele ea gliclazide ho lefu la tsoekere.
Peoglar - moriana oa molomo oa hypoglycemic le agonist e matla ea khetho ea "ma " Karolo e sebetsang e bonts'a phetoho liphatseng tsa lefutso tse amehang ho phatloheng ha lipid le taolo ea tsoekere. Sebeteng le linthong tse poteletseng, e fokotsa khatello ea insulin. Le mofuta oa lefu la tsoekere la mofuta oa 2 mellitus lowers glycated hemoglobin le insulin ho plasma.
O ka tseba hore na lefu la tsoekere le ka nkela ngaka ea hau sebaka joang. Ha ho kgothaletswe ho sebelisa moriana u le mong, kaha sena se ka lebisa litlamorao tse kotsi.
