Ha ho bonolo kamehla ho laola mofuta oa tsoekere ea mofuta oa 2 feela ka thuso ea phepo e tlase ea carb le mojaro o boima oa mesifa. 'Me hoa hlokahala ho loants'a hyperglycemia, hobane kalafo e sa rutehang e baka mathata a maholo.
A mang a a kotsi haholo ke mathata a pelo le pelo. Diabetesalong (Latin Diabetalong), setlhare sa hypoglycemic se nang le nako e telele kapa se lokisitsoeng se tla thusa ho fokotsa kotsi ea ho ba le CVD.
Monyetla oa pharmacological
Melemo ea antidiabetesic ea lithethefatsi e bakoa ke karolo e sebetsang ea gliclazide. Matlapa a na le 30 kapa 60 mg ea motsoako oa mantlha le litlamorao: calcium stearate, hypromellose, talc, lactose monohydrate, colloidal silicon dioxide.
Diabetesalong ke setlhare sa sehlopha sa bobeli sa sulfonylurea. Ha e kenella maling, gliclazide e phahamisa tlhahiso ea li-hormone tsa endo native ka cells-lisele tsa manyeme, e potlakisa ts'ebeliso ea tsoekere (e potlakisa mosebetsi oa mesifa ea glycogen synthase). Matsatsing a 'maloa ho tloha ha ho qala thupelo, boemo ba glycemic bo tloaelehile. Nako ea nako ho tloha ho kenyelletsa lijo ka har'a tšilo ea lijo ho ea ho tlhahiso ea "insulin" ea mali e fokotsehile, 'me matšoao a glycemic a khopisitsoeng ke lijo a fokotsehile.
Hoa makatsa hore lilemo tse 2 kamora ho sebelisa moriana, khatello ea "insprandial insulin" le C-peptide e lula e le teng. Matla a amang 'mele a Diabetalong a rarahane:
- E laola metabolism ea carbohydrate;
- E na le systemic antioxidant phello;
- E susumetsa secretion ea insulin;
- E na le phello ea hemovascular (suppress platelet aggregation).
Ha tsoekere e kena maling, gliclazide e potlakisa tlhahiso ea insulin. Ka kalafo e sa feleng, setlhare se lemosa:
Mathata a Microvascular - retinopathy (ts'ebetso ea ho ruruha ho retina) le nephropathy (dnessfunction ea renal);- Liphetho tsa Macrovascular - stroke, ho otloa ke pelo.
Mathata a Microvascular - retinopathy (ts'ebetso ea ho ruruha ho retina) le nephropathy (dnessfunction ea renal);Litšobotsi tsa Pharmacokinetic
Ho tloha ka mpeng, sethethefatsi se kenngoa ka botlalo. Likahare tse phahameng maling a fihla ka mor'a lihora tse 2-6, le bakeng sa litafole tse nang le MV - lihora tse 6-12.
Phello ea kalafo e nka lihora tse 24, liprotheine tsa mali glycazide e tlama ho 85-99%. Sebeteng, sehlahisoa sa bioloji se fetoloa metabolites, e 'ngoe ea tsona e na le phello e ntle ho microcirculation. Bophelo ba halofo ke lihora tse 8-12, bakeng sa matlapa a nang le MB - 12-16 lihora. Setlhare sena se tlotsoa ka 65% ka moroto, ka 12% ka mantle.
Ke mang ea bontšitsoeng moriana?
Lebaka la ho khethoa ha lefu la tsoekere ke mofuta oa 2 lefu la tsoekere, ka bobeli e le monotherapy hape le motsoako oa "insulin" kapa "antidiabetesic agents".
Contraindra le mefokolo
- Mofuta oa 1 lefu la tsoekere;
- Hypersensitivity;
- Pathology ea sebete;
- Ho se sebetse hantle ha renal reysction;
- Ketoacidosis;
- Hypo- le hyperthyroidism;
- Lefu la tsoekere kapa hyperosmolar coma;
- Boimana le ho anyesa
- Likotsi tse mpe le ho cha.
Diabetesalong e kopantsoe le basali ba bakhachane, haeba e ke ke ea hlakoloa nakong ea kanyeso, ngoana o fetisetsoa phepelong ea phepo e nepahetseng.
Tšebeliso ea glycoside ha e lumelloe ha e nkuoa ka nako e tšoanang le miconazole.
Litlamorao
Liphetho tse sa rateheng bakeng sa pampitšana ea ka mpeng li ka baka mathata a methapo ho ea ka litlhaselo tsa ho nyekeloa ke pelo, ho hlatsa, bohloko ba ka mpeng. Ho tloha lehlakoreng la metabolism, hypoglycemia e ka etsahala, bakeng sa tsamaiso ea potoloho - eosinophilia, cytopenia, anemia. Ka lehlakoreng la letlalo, allergy le photosensitization lia khoneha. Ho tsoa lithong tsa kutlo ho na le likhathatso tsa tatso, hlooho e bohloko, tahlehelo ea tšebelisano, ho felloa ke matla.
Ho sebelisana le lithethefatsi
Ts'ebetso ea glycoside e ntlafatsoa ke ts'ebeliso e kopaneng ea anabolic steroid, ACE inhibitors, β-blockers, cimetidine, fluoxetine, salicylates, MAO inhibitors, Flucanazole, Pentoxifylline, Miconazole, Theophylline, Tetracycline.
Monyetla oa glycoside oa fokola ha o sebelisoa ka mokhoa o tšoanang le barbiturates, glucocorticoids, sympathomimetics, saluretics, rifampicin, lipilisi tsa thibelo ea bokhachane, li-estrogens.
U ka etsa kopo joang
Glycloside e lokela ho nkuoa ka tlhahiso ea lijo. Letlapa le metsoa kaofela, le hlatsuoa ka metsi ka mocheso oa kamore. The endocrinologist e khetha litlhare le mefuta ea kalafo ka bonngoe, ho latela sethala sa lefu lena le karabelo ea lefu la tsoekere ho moriana. Bakeng sa moriana Diabetesalong, litaelo tsa tšebeliso li khothaletsa tloaelo ea ho qala ea 30 mg le khalemelo e eketsehileng ntlheng ea keketseho (haeba ho hlokahala).
Ho fihlella phello e matla ea kalafo, ho bohlokoa ho latela melao e bonolo.
- Tekanyetso eohle ea letsatsi le letsatsi e nkuoa hang, ho fetisisa ho tsohle - hoseng;
- Palo ea lithethefatsi e ka fetoloa nakong ea 30 -120 mg / ka letsatsi;
- Haeba nako ea ho amoheloa e lahlehile, moetlo ha oa lokela ho phetoa ka nako e latelang;
- Ha a bala tekanyetso, ngaka e nahana ka ho bala ha mitha le HbAlc.
Ka ts'ebetso e sa lekaneng, ho tloaelehile ho eketseha (kamora tumellano le ngaka), empa eseng pele ho feta khoeli kamora hore ho nkuoe lethal la pele la glycoside. Libeke tse ling le tse ling tse 2, ka phello e sa foleng ea glycemia, o ka eketsa lethal dose.
Ho bohlokoa ho ela hloko hore Letlapa le le leng la Diabetesalong PV le na le 60 mg ea glyclazide, sena se tsamaisana le matlapa a 2 a Diabetalong MV 30 mg ka ngoe.
Ha ho fetisoa ha lefu la tsoekere ho gliclazide ho tsoa ho lithethefatsi tse ling tsa hypoglycemic, likhahla ha li hlokahale, ntle le melemo ea sulfonylurea. Tekanyetso ea pele ntlheng ena e tloaelehile - 30 mg, haeba endocrinologist ha e laetse morero oa hae.
Ka kalafo e rarahaneng, Diabetalong e sebelisoa hammoho le mefuta e fapaneng ea insulin, biagudins, α-glucosidase inhibitors. Ka hloko, moriana o fuoa lingaka tsa lefu la tsoekere ho tsoa sehlopheng sa kotsi sa hypoglycemic (tšebeliso e mpe ea joala, mosebetsi o boima oa 'mele kapa lipapali, tlala, semelo se phahameng sa khatello ea maikutlo). Mesebetsi ea Hematopoietic e sitisoa ke nts'etsopele ea anemia, thrombocytopenia, leukopenia, granulocytopenia.
Litlhokahalo tsa polokeho
Bakeng sa ho qoba hypoglycemia, ho bohlokoa ho fana ka nako ea ts'ebeliso ea moriana bakeng sa ho ja, ho thibela likhefu tse kholo tsa lijo, ho felisa ka botlalo ts'ebeliso ea lino tse tahang. Tsamaiso e tšoanang ea li-β-blockers e ka sotha matšoao a hypoglycemia.
Boemo ba hypoglycemic bo ka lemohuoa ke hlooho e opang, mathata a ho hokahanya, litlhaselo tse sa laoleheng tsa tlala, khatello ea maikutlo, ho akheha, pono e fifalitsoeng, mathata a dyspeptic. Boitšoaro ba adrenergic bo boetse bo bonahatsoa: ho tšoenyeha, ho fufuleloa, marotholi a khatello ea mali, lefu la pelo la mokokotlo, pherekano ea morethetho oa pelo. Mathata a dyspeptic, ho tsitsipana ho morethetho oa ho qhekella, le ho fetoha hoa letlalo (lekhopho, ho se khotsofale, erythema, urticaria, edincke's edema) ke tšobotsi.
Pheko e atlehang ha e khonehe ntle le lijo tse nang le carb e tlase. Ka lebaka la kotsi ea litlamorao, bakhanni ba lokela ho nka meriana ka hloko. Litlhahiso tse tšoanang li sebetsa ho baemeli ba maprofesa ba amanang le litheko tse phahameng le khatello ea maikutlo.
Pathologies ea sebete le li-ducts tsa bile li baka lefu la hepatitis, keketseho ea tšebetso ea enzyme.
Haeba motho ea hlokofalitsoeng a hlokometse, o hloka ho ja pompong, ho noa khalase ea tee kapa ho hong ho nang le lik'habohaedreite tse ngata. Kamora hore boemo bo ntlafale, setsebi sa endocrinologist se hloka ho botsoa ho lokisa lethal dose kapa ho fetola moriana.
Menahano ea lithethefatsi
Ho latela karolo e sebetsang ea Diabetalong, analogue e tla ba lithethefatsi tsa Glidiab tse ka bang li-ruble tse ka bang 140. Lingaka li fa lithethefatsi tsa Diabeteson le Diabeteson MV litheko tse phahameng ho litheko ho tloha ho 286 ho isa ho 318 li-ruble. Bakeng sa litokisetso tse tšoanang, Glyclada le eona e ka khothaletsoa.
Litokisetso tse nang le phello e ts'oanang ea hypoglycemic joalo ka Amaril, Glimepiride, Glemaz, Glyurenorm li tla ba hantle ka sebopeho. Li etselitsoe hypersensitivity kapa li-contraindication tse ling bakeng sa glycoside.
Fomu ea tokollo, maemo a polokelo
Matlapa a Diabetesalong a hlahisoang ke Synthesis OJSC le MS-Vita LLC a hlahisoa ka lipakete tsa blister. Makhopho a beoa ka lebokoseng la karete.
Moriana o ka bolokoa lilemo tse 3 mochesong oa kamore, ntle le khanya ea letsatsi le bana. Lifekthering, Diabetesalong e fumaneha bakeng sa lengolo la ngaka ka theko ea li-ruble tse 98-127. bakeng sa matlapa a 60 a 30 mg.
Litlhahlobo tsa Diabetesalong
Litsebi tsa lefu la tsoekere tse boneng litlamorao tsa lefu la tsoekere, ho litekolo li hlokomela melemo ea lona:
- Ntlafatso ea butle-butle ea matšoao a glucometer;
- Ho tsamaisana hantle le meriana e meng;
- Litsenyehelo tse theko e tlaase tsa meriana;
- Bokhoni ba ho theola boima ba 'mele nakong ea kalafo.
Ha se motho e mong le e mong ea khotsofalitsoeng ke tlhoko ea taolo ea glycemic (ho fihlela makhetlo a 5 ka letsatsi, empa ha nako e ntse e tsamaea, matšoao a eona aa tsitsa mme tlhokeho ea boitšoaro e ntlafalitsoeng ea fokotseha.
Ka kakaretso, Diabetesalong ke lithethefatsi tse ka tšeptjoang tsa lefu la ho fokola lefu le hlasimollang boemo ba bophelo ba glycemic hantle. Ha e sebelisoa hantle, e khona ho thibela liketsahalo tsa pelo le mathata a mang a tebileng a lefu la tsoekere la 2.
