Gluconorm ke e 'ngoe ea lithethefatsi tse noang ho phekola lefu la tsoekere la mofuta oa 2. Lithethefatsi li na le phello ea hypoglycemic.
Gluconorm e fumaneha ka sebopeho sa letlapa 'me e etselitsoe tsamaiso ea molomo.
Tlhahisoleseling ka kakaretso, sebopeho le mefuta ea tokollo
Gluconorm ke sethethefatsi sa hypoglycemic se entsoeng India. Ntle le phello ea hypoglycemic, lithethefatsi li thusa ho fokotsa khatello ea cholesterol maling a mokuli.
E lumelloa ho fana ka chelete ho latela taelo ea setsebi se tlang. Setlhare sena se sebelisoa lilemo tse 3 ho tloha ka letsatsi leo se hlahisoang ka sona.
Hoa hlokahala ho boloka maemo a polokelo ea meriana ena. E bolokiloe sebakeng se lefifi se sa fumanehe ke bana. Mocheso o nepahetseng oa polokelo ke oa 20-230C.
Ntle le moo, Gluconorm e nang le li-blueberries ka tsela ea tee ea limela e hlahisoa, e seng lithethefatsi, empa e nkuoa e le seno se theolang tsoekere.
Lintho tse ka sehloohong tsa lithethefatsi ke Metformin Hydrochloride le Glibenclamide. Likahare tsa ntho ea pele ho 1 letlapeng ke 400 mg, ea bobeli - 2,5 mg. Cellulose e li-microcrystals le colloidal silicon dioxide e teng e le lintho tse ling tlhahisong ea tlhophiso. Ho fumanoe le mesaletsa ea croscarmellose, diethyl phthalate le glycerol.
Har'a likarolo tse ling tsa lithethefatsi, sodium carboxymethyl starch, magnesium stearate le cellacephate li hlokomelehile. Maemong a itseng, talc e nang le starch ea poone le gelatin e teng ka har'a moriana.
Pakete e le 'ngoe e na le lilakane. Ka har'a blister ho ka ba le matlapa a 10, 20, 30 a moriana. Matlapa a lithethefatsi a soeufetse ebile a na le sebopeho sa biconvex. Nakong ea khefu, matlapa a ka ba le lerootho le bosesane.
Tai ea Gluconorm Blueberry ha e na likarolo tse teng matlapeng. E entsoe ka litlama tsa tlhaho ebe e rekisoa ka mekotla ea tee. Nako ea kamohelo e etselitsoe libeke tse 3.
Pharmacology le pharmacokinetics
Gluconorm e na le likarolo tse peli tsa sehlooho: Glibenclamide le Metformin. Lintho tsena ka bobeli li sebetsa ka mokhoa o kopaneng, li eketsa katleho ea moriana.
Glibenclamide ke moloko oa 2nd sulfonylurea o tsoang ho. Ka lebaka la ts'ebetso ea eona, secretion ea insulin e ts'oaroa, hape, insulin e eketseha haholo liseleng tsa sepheo.
Glibenclamide e ntshetsa pele ho nts'oa insulin ka mafolofolo le ho ntlafatsa phello ea eona ho monya ha tsoekere ke sebete, hammoho le mesifa. Tlas'a ketso ea ntho, ts'ebetso ea ho petsoha mafura liseleng tsa adipose e ea fokotseha.
Metformin ke ntho e bitsoang Biguanide. Ka lebaka la ketso ea eona, phallo ea tsoekere maling maling a motho ea kulang e fokotsehile, ho na le khokahano e eketsehileng ea tsoekere ke lisele tsa thipa.
Ntho ena e rata ho fokotseha hoa khatello ea cholesterol ea mali. Ka lebaka la ts'ebetso ea Metformin, ho kenngoa ha lik'habohaedreite ka mpeng le mala a fokotseha. Mokelikeli o thibela ho thehoa ha tsoekere kahare ho sebete.
Glibenclamide le Metformin, tseo e leng karolo ea lithethefatsi, li na le li-pharmacokinetics tse fapaneng.
Ho kenngoa ha glibenclamide kamora ho kenella ho tsoa ka mpeng le mala ho fihla ho 84%. Khokahanyo e phahameng ea ntho e ka fihlella ka hora kapa tse peli. Ntho ena e tsamaisana hantle le liprotheine tsa mali. Sekhahla ke 95%. Bonyane halofo ea bophelo ke lihora tse 3, boholo ke lihora tse 16. Ntho ena e hlakoloa ke liphio, karolo e 'ngoe ke mala.
Tekanyo e phahameng ea bioavailability ea Metformin ha e fetang 60%. Ho ja haholo ho fokotsa ho kenngoa ha metformin. Ntho e nkiloeng ka mpeng e se nang letho e ananeloa hantle ho tloha mpeng le mala.
Ho fapana le Glibenclamide, e na le liprotheine tse fokolang tsa mali. E hloekisoa ke liphio. 30% ea ntho ena e ka ba teng ka har'a maro a mokuli. Ho felisoa ha halofo ea bophelo ho fihla lihora tse 12.
Matšoao le contraindication
Letšoao le ka sehloohong la ho sebelisa sethethefatsi sena ke boteng ba lefu la tsoekere la mofuta oa II ho mokuli. Hape, lithethefatsi li laetsoe ho sa natsoe phello e nepahetseng ea kalafo ka lijo, boikoetliso le kalafo e thehiloeng ho nka Metformin le Glibenclamide.
Moriana ona o bontšoa le ho bakuli ba nang le tsoekere e tloaelehileng le e tsitsitseng ea mali, empa ba nang le tlhoko ea ho khutlisetsa kalafo ka Glibenclamide le Metformin.
Palo e kholo ea litlolo ke tšobotsi ea moriana:
- ho hloleha ha sebete;
- ho fokotseha ha khatello ea tsoekere ea mali (hypoglycemia);
- kutloisiso e phahameng ea likarolo tsa moriana;
- mofuta oa lefu la tsoekere;
- joala bo sa feleng;
- boimana
- mosebetsi o sa sebetseng oa renal ka lebaka la tšoaetso, ho thothomela;
- ketoacidosis;
- tšebeliso ea miconazole;
- boteng ba ho chesa 'meleng;
- ho nyekeloa ke pelo;
- ho anyesa;
- tšoaetso e fapaneng;
- lefu la tsoekere;
- ho hloleha ha rems;
- myocardial infarction;
- etsa ts'ebetso ea ho buoa;
- lactic acidosis;
- chefo ea joala;
- ho hloleha ho phefumoloha;
- lefu la tsoekere;
- lefu la porphyrin.
Litaelo tsa ho sebelisoa
Moriana o nooa le lijo. Bakeng sa mokuli ka mong, ho thehiloe litekanyetso tsa Gluconorm ka bomong.
Phekolo le sethethefatsi e etsahala ka mekhahlelo e mengata. Boemong ba pele, Letlhare le le leng la lithethefatsi le nooa letsatsi le leng le le leng. Phekolo ho ea ka morero ona e nka matsatsi a 14. Nakong e tlang, tekanyetso e tlil'o fetoha le maemo ho latela boemo ba mokuli le matšoao a tsoekere maling a hae.
Ha u khutlisetsa kalafo, mokuli o nka matlapa a 1-2 a moriana. Tekanyetso e phahameng ka ho fetisisa nakong ea letsatsi lena ke matlapa a 5.
Bakuli le Litataiso tse Khethehileng
Moriana ona o thibetsoe basali ba bakhachane. Hape ha ho amohelehe ho nka moriana nakong ea kemiso ea bokhachane.
Gluconorm ha ea lokela ho nkuoa ke basali ba anyang, hobane Metformin e kenella ka matla lebeseng mme e ka ama hampe bophelo bo botle ba lesea. Maemong ana, ho khothalletsoa ho khutlisetsa lithethefatsi ka kalafo ea "insulin".
Setlhare sena ha se khothaletsoe bakuli ba tsofetseng ba lilemo tse fetang 60. Hammoho le mojaro o boima, Gluconorm e ka baka lactic acidosis sehlopheng sena sa batho.
Moriana o hloka ho tsamaisoa ka hloko ke bakuli ba nang le:
- ho hloleha ha adrenal;
- feberu;
- mafu a qoqotho.
Bakeng sa moriana, ho fanoa ka litaelo tse 'maloa tse ikhethang:
- nakong ea kalafo, ho hlahlojoa khafetsa ha tsoekere ea mali hoa hlokahala ka mpeng e se nang letho le ka mor'a lijo;
- meriana e kopaneng le joala li thibetsoe;
- hoa hlokahala ho khutlisetsa meriana ka kalafo ea insulin haeba mokuli a lemetse, a tšoaelitsoe, feberu, a chesa, ts'ebetso e fetileng;
- Matsatsi a 2 pele ho kenngoa sehlahisoa sa radiopaque se nang le iodine 'meleng oa mokuli, hoa hlokahala ho khaotsa ho sebelisa lithethefatsi (kamora matsatsi a 2, lethal dose le qalile hape);
- tsamaiso e kopaneng ea Gluconorm le ethanol e khopisa hypoglycemia, e etsahala hape nakong ea ho itima lijo le ho nka lithethefatsi tse khahlanong le ho ruruha tsa mofuta o seng oa steroid;
- lithethefatsi li ama bokhoni ba mokuli ba ho khanna koloi (o tlameha ho hana ho tsamaea ka koloi nakong ea kalafo le lithethefatsi).
Litla-morao le ho sebelisa overdose haholo
Nakong ea kalafo ka moriana, mokuli a ka ba le litlamorao:
- tsoekere e maling e fokotsehileng (hypoglycemia);
- takatso e fokotsehileng;
- leukopenia;
- ho tsekela
; - ho hlohlona letlalong;
- lactic acidosis;
- ho nyekeloa ke pelo le ho hlatsa;
- thrombocytopenia;
- mokhathala
- urticaria;
- ho hloleha ho phefumoloha hammoho le feberu sefahlehong le tachycardia, e le karabelo ho noeng e le 'ngoe ka nako e tšoanang;
- bohloko ba ka mpeng
- phokolo ea mali
- hlooho e opang;
- feberu;
- ho fokotseha hoa kutlo;
- ponahalo ea mesaletsa ea protheine moriring;
- jaundice
- hepatitis maemong a sa tloaelehang.
;Bongata ba lithethefatsi bo ka hlahisoa e le:
- lactic acidosis;
- hypoglycemia
Lactic acidosis e halefisa mesifa, ho hlatsa le bohloko ba ka mpeng. Matšoao a lefu lena a hloka ho khaola meriana le ho beoa ha mokuli sepetlele. Khetho e sebetsang ka ho fetisisa ea phekolo ke tlhoekiso ea mali e fetelletseng (hemodialysis).
Glibenclamide e ka baka hypoglycemia ho mokuli. Ha ho etsahala ho otsela, hlooho e bohloko. Hape ho hlokometsoe: tumellano ea pallor, ho sitisoa, ho fufuleloa, ho lahleheloa ke kelello.
Hypoglycemia ka mokhoa o bonolo le o leka-lekaneng o felisoa ka ho nka tharollo ea tsoekere ho bakuli. Maemong a tebileng, o kenngoa ka tharollo ea glucose ea 40%. Kenyelletso e etsoa kahare le kahare.
Tšebelisano ea lithethefatsi le li-Analog
Litšobotsi tse latelang tsa ho sebelisana le lithethefatsi tse ling ke tšobotsi ea lithethefatsi:
- ethanol le gluconorm hammoho li baka lactic acidosis;
- lithethefatsi tsa cationic (Vancomycin, Morphine, Quinine, Amiloride) li eketsa khatello ea Metformin ka 60%;
- barbiturates, joalo ka clonidine, furosemide,
Danazole, Morphine, salate ea lithium, estrogens, Baclafen, Glucagon, lihormone tsa qoqotho, Phenytoin, Epinephrine, Chlortalidone, nicotinic acid, Triamteren, Acetazolamide e fokotsa haholo ts'ebetso ea meriana; - Cimetidine, li-hypoglycemic agents, Tetracycline, Ethionamide, Guanethidine, fibrate, antifungals, enalapril, Theophylline, Cyclophosphamide, salicitates, Pentoxifylline, Pyridoxine, Reserpine, anabolic steroids e ntlafatsa lithethefatsi tsa antidiabetic;
- calcium chloride hammoho le ammonium chloride, hammoho le acid e eketsehileng ea ascorbic, e ntlafatsa katleho ea moriana;
- Furosemide e ama mahloriso a metformin ka lehlakoreng la keketseho ea eona ka 22%.
Danazole, Morphine, salate ea lithium, estrogens, Baclafen, Glucagon, lihormone tsa qoqotho, Phenytoin, Epinephrine, Chlortalidone, nicotinic acid, Triamteren, Acetazolamide e fokotsa haholo ts'ebetso ea meriana;Har'a tse ling tsa sehlooho tsa lithethefatsi ke:
- Lebotho la Metglib;
- Glibomet;
- Glucophage;
- Glucovans;
- Metglib;
- Bagomet Plus.
Lintho tsa video tse mabapi le ho theola tsoekere ea mali ka mofuta oa 2 lefu la tsoekere:
Maikutlo a mamello
Litlhahlobo tse ngata tsa lefu la tsoekere tse mabapi le lithethefatsi Gluconorm li na le karabelo e ntle ea ho nka moriana, leha ho le joalo, litla-morao li boleloa, tseo ho tsona ho nyekeloa ke pelo le hlooho li atisang ho khaoloa.
Setlhare se lokile, se theola tsoekere hantle. Ho makatsang ke hore ha kea ka ka fumana litla-morao tseo ho buuoang ka tsona hangata. Ke theko e tlase haholo. Ke odara Gluconorm nako le nako.
Svetlana, ea lilemo li 60
Ke qetile lilemo tse ngata ke e-na le lefu la tsoekere la mofuta oa 2. Ngaka e eang teng e laetse Gluconorm. Qalong, ho ne ho e-na le litlamorao: hangata ho kula, ho ne ho na le likotsi. Empa nakong e tlang re ile ra fetola lethal dose, 'me tsohle tsa feta. Sesebelisoa sea sebetsa haeba u kopanya tšebeliso ea sona le lijo.
Tatyana ea lilemo li 51
Gluconorm e tšepahala ka botlalo. Molemong oa ka, ke thusitse ho ntlafatsa boima. Setlhare se fokotsa takatso ea lijo. Ho li-minuses, ke tla totobatsa litla-morao. Ho na le tse ngata tsa tsona. Ka nako e 'ngoe, hlooho ea ka e ne e kula ebile e kula.
Eva, ea lilemo tse 43
Ha se khale haholo, setsebi sa endocrinologist se ile sa etsa tlhahlobo e sa thabiseng ea lefu la tsoekere la mofuta oa 2. Gluconorm e ne e laetsoe ho lokisa tsoekere ea mali. Ke thabo ka kalafo ka botlalo. Ka tsoekere e phahameng, sethethefatsi se ka fokotsa boemo ba sona ho isa ho 6 mmol / L. Ho na le litla-morao, empa li felisitsoe. Lijo lia hlokahala.
Anatoly, ea lilemo li 55
Litsenyehelo tsa gluconorm libakeng tse fapaneng tsa naha li na le phapang. Theko e tloaelehileng ka hare ho naha ke li-ruble tse 212. Karolo ea theko ea lithethefatsi ke li-ruble tse 130-294.
