Glimecomb e bua ka lithethefatsi tse sebelisoang ho lefu la tsoekere la mofuta oa 2.
Sesebelisoa se na le thepa e kopaneng ea hypoglycemic.
Kamora ho sebelisa moriana, ho tloaela boemo ba tsoekere maling maling a mokuli hoa hlokomeleha.
Tlhahisoleseling ka kakaretso, sebopeho le mofuta oa tokollo
Setlhare se boletsoeng se bolela li-agents tsa hypoglycemic tse nkuoeng ka molomo. Sesebelisoa se na le phello e kopaneng. Ntle le phello e fokotsang tsoekere, Glimecomb e na le pancreatic effect. Maemong a mang, moriana o na le phello ea extrapancreatic.
Sebopeho sa moriana se na le Metformin hydrochloride ka bongata ba 500 mg le Gliclazide - 40 mg, hammoho le li-sorbitol le sodium ea lipalesa. Ka tekanyo e nyane, magnesium stearate le povidone li teng kalafong.
Setlhare se fumaneha ka mokhoa oa matlapa a cylindrical ka bosoeu, tranelate kapa 'mala o mosehla. Bakeng sa litafole, ho sesa hoa amoheleha. Lipilisi li na le kotsi le bevel.
Glimecomb e rekisoa ka matlapa a 10 ka har'a mekotla ea blister. Pakete e le 'ngoe e na le liphutheloana tse 6.
Pharmacology le pharmacokinetics
Glimecomb ke lithethefatsi tse kopanyang tse kopanyang li-hypoglycemic agents tsa sehlopha sa Biguanide le lihlahisoa tsa sulfonylurea.
Moemeli o bontšoa ke litlamorao tsa pancreatic le extrapancreatic.
Gliclazide ke e 'ngoe ea likarolo tsa mantlha tsa moriana. Ke tšibollo ea sulfonylurea.
Ntho e kenya letsoho ho:
- tlhahiso ea insulin e sebetsang;
- ho fokotseha ha khatello ea tsoekere ea mali;
- fokotsa ho khabeloa ha liplatelete, tse thibelang ho etsoa ha methapo ea mali ka har'a lijana;
- normalization ea vascular permeability.
Gliclazide e thibela ho hlaha ha microthrombosis. Nakong ea tšebeliso ea nako e telele ea lithethefatsi ho bakuli ba nang le lefu la tsoekere, ho fokotseha ha protheine (boteng ba protheine ho moroto).
Gliclazide e ama boima ba mokuli ea sebelisang moriana. Ka phepo e nepahetseng ho bakuli ba lefu la tsoekere ba nkang Glimecomb, ho fokotsa boima ba 'mele hoa tsebahala.
Metformin, e leng karolo ea lithethefatsi, e bua ka sehlopha sa Biguanide. Ntho ena e fokotsa bongata ba tsoekere maling, e thusa ho fokolisa tšebetso ea ho monya tsoekere maling le mala. Metformin e thusa ho potlakisa ts'ebetso ea ho sebelisa tsoekere ho linama tsa 'mele.
Ntho ena e theola cholesterol, litheko tse tlase tsa methapo. Tabeng ena, Metformin ha e ame boemo ba lipoprotein ba methapo e fapaneng. Joalo ka Glyclazide, e fokotsa boima ba mokuli. Ha e na phello ho ba teng ha insulin maling. Ha e kenye letsoho ponahalong ea karabelo ea hypoglycemic. Gliclazide le metformin ka mokhoa o fapaneng li ananeloa ka mokhoa o fapaneng le ho tsoa ho mokuli. Gliclazide e tšoauoa ka monko o phahameng ho feta oa Metformin.
Khatello e phahameng ea Gliclazide maling e fihlella ka mor'a lihora tse 3 ho tloha nakong ea ho kenella ha moriana. Ntho ena e hloekisoa ka liphio (70%) le mala (12%). Ho felisoa ha halofo ea bophelo ho fihla lihora tse 20.
Bioavailability ea Metformin ke 60%. Ntho ena e bokellana ka matla liseleng tse khubelu tsa mali. Bophelo ba halofo ke lihora tse 6. Ho ikarola 'meleng ho etsahala ka liphio, hammoho le mala (30%).
Matšoao le contraindication
Moriana ona o khothaletsoa ho batho ba nang le lefu la tsoekere ba nang le lefu la tsoekere la mofuta oa 2 haeba:
- kalafo ea nakong e fetileng ka lijo le ho ikoetlisa e ne e se na katleho e nepahetseng;
- Ho na le tlhokahalo ea ho khutlisetsa kalafo e kopaneng e neng e entsoe pele ka Gliclazide le Metformin ho bakuli ba nang le maemo a tsitsitseng a glucose.
Moriana o tšoauoa ka lenane le pharaletseng la li-contraindication, tseo ho tsona:
- boteng ba lefu la tsoekere la mofuta oa 1;
- ho hloka mamello ho likarolo tsa moriana;
- ts'ebetso ea menoana e sa sebetseng;
- boimana
- ho hloleha ha sebete;
- lactic acidosis;
- ho nyekeloa ke pelo;
- lefu la tsoekere;
- lebone
- tšoaetso e fapaneng;
- myocardial infarction;
- lefu la porphyrin;
- lefu la tsoekere;
- mehato ea pele ea ho buuoa;
- nako ea mokuli ea fumanang lithuto tsa X-ray le litlhahlobo a sebelisa radioisotope ka ho hlahisoa ha li-iodine-anos agents (ho thibetsoe ho nka matsatsi a 2 pele le kamora lithuto tsena);
- likotsi tse mpe;
- maemo a makatsang a amanang le mafu a pelo le a liphio;
- ho hloleha ho phefumoloha;
- botaoa ba joala;
- tsoekere e fokolang ea mali (hypoglycemia);
- tšoaetso e matla ea liphio;
- joala bo sa feleng;
- ho chesa haholo 'meleng;
- khomarela bakuli ba nang le phepo ea hypocaloric;
- ho nka miconazole;
- lefu la tsoekere la ketoacidosis.
Litaelo tsa tšebeliso le litaelo tse ikhethang
Litekanyetso tsa lithethefatsi ke motho ka mong ho mokuli e mong le e mong. Ho khothalletsoa ho nka matlapa a 1-3 ka letsatsi. Matsatsing a latelang a kalafo, keketseho ea tekanyetso ea khonahala, e ipapisitse le matšoao a tsoekere maling a mokuli le tekanyo ea pontšo ea lefu la hae. Bakeng sa Glimecomb, litekanyetso tse phahameng ke matlapa a 5 ka letsatsi.
Sethethefatsi se khothalletsoa ho nooa hoseng le mantsiboea. Moriana o nooa nakong ea lijo kapa ka mor'a tsona.
Sesebelisoa ha se khothalletsoe ho bakuli ba lilemo tse fetang 60, ba sebetsang maemong a thata a 'mele. Ka ho sebetsa ka thata le ho nka Glimecomb ho batho ba tsofetseng, lactic acidosis e ka hlaha.
Bokhachane ke e 'ngoe ea lintho tse hanyetsanang le tšebeliso ea litlhare tsena. Ha ho ima ho etsahala, le pele ho moralo oa eona, hoa hlokahala ho khutlisetsa litlhare ka kalafo ea "insulin".
Ho anyesa le eona ke ntho e hanyetsanang ka lebaka la ho monya lintho tse ngata tsa motsoako ka lebeseng la matsoele. Hoa hlokahala ho hlakola phepelo ea nako ea ho nka Glimecomb ke mme kapa ho emisa ho sebelisa moriana ka booona nakong ea ho beleha.
Ka hloko, ho hlokahala hore u ise moriana ona ho bakuli ba nang le:
- feberu;
- mathata a qoqotho;
- ho hloleha ha adrenal.
Setlhare sena ha sea lumelloa ho bakuli ba nang le mafu a sebete, hammoho le ts'ebetso ea ho hlaphoheloa ha renal, e tsamaeang le ho tsitsipana, ho felloa ke metsi le lintho tse ling tse mpe.
Setlhare sena se nkuoa feela ho latela lijo tse nang le khalori e tlase tse nang le phepo e tlase ea nama ea nama ea kolobe. Matsatsing a pele a kalafo, ho laoloa tsoekere ea mali hoa hlokahala. Pheko le sethethefatsi e etsoa feela ho bakuli ba fumanang phepo e tloaelehileng.
Sulfonylureas, e leng karolo ea lithethefatsi, e ka tsosa hypoglycemia. E etsahala ka phepo e tlase ea khalori le ho ikoetlisa. Hoa hlokahala ho lula u fetola tekanyo ea lithethefatsi, haholoholo ho bakuli ba tsofetseng.
Hypoglycemia e ka hlaha ho bakuli ha u nka:
- ethyl joala;
- lithethefatsi tse seng khahlanong le ho tsoa mali.
Ho itima lijo ho boetse ho eketsa menyetla ea hypoglycemia ho bakuli, le lithethefatsi tse kang reserpine e nang le clonidine e ea e koenya.
Maemong a ts'ebetso ea ts'ebetso ea bakuli ho bakuli, haeba ba chesa, likotsi, tšoaetso ea feberu, hammoho le myalgia, lactic acidosis, ho felisoa ha lithethefatsi hoa hlokahala hanghang.
Moriana o ka ama ho khanna. Tlhokomelo e tlameha ho nkuoa.
Ho hlokahala ho emisa ho nka Glimecomb matsatsi a 2 pele le kamora ho kena 'meleng oa mokuli moemeli oa radiopaque le iodine.
Litla-morao le ho sebelisa overdose haholo
Har'a litla-morao tse hlahang ka lebaka la ts'ebeliso ea lithethefatsi lia khoneha:
- hypoglycemia le mofufutso o matla, bofokoli, ho tsekela, tlala le ho akheha;
- lactic acidosis e nang le ho otsela, khatello e tlase ea mali, bofokoli, bohloko ba ka mpeng, myalgia;
- ho nyekeloa
- phokolo ea mali
- mathata a pono;
- urticaria;
- allergic vasculitis;
- lets'ollo
- ho hlohlona
- anemia ea hemolytic;
- ho hlohlona
- erythropenia;
- maemong a sa tloaelehang, hepatitis;
- ho hloleha ha sebete.
Matšoao a atileng haholo a overdose ke hypoglycemia le lactic acidosis. Matšoao ana ka bobeli a hloka kalafo hanghang sepetlele. Maemong ana ka bobeli, sethethefatsi se emisitsoe. Boemong ba pele, mokuli o fumana tlhokomelo ea bongaka, hemodialysis e etsoa.
Ka hypoglycemia e bonolo le e leka-lekaneng, ho lekane hore bakuli ba nke tharollo ea tsoekere ka hare. Ka mokhoa o matla, tsoekere e fanoa ka methapo ho mokuli (40%). Mefuta e meng e ka ba glucagon, e tsamaisoang ka bobeli ka methapo le ka mokhoa o ikhethileng. Kalafo e eketsehileng e etsahala le mokuli ho ja lijo tse nang le lik'habohaedreite tse ngata.
Tšebelisano ea lithethefatsi le li-Analog
Lithethefatsi li sebelisana le meriana e meng ka tsela e latelang:
- phello ea hypoglycemic e matlafatsoa ha e etsoa hammoho le enalapril, cimetidine, miconazole, clofibrate, ethionamide, anabolic steroids, cyclophosphamide, tetracycline, reserpine le li-agents tse ling tse nang le phello ea hypoglycemic;
- phello ea hypoglycemic ha e nkuoa hammoho le Clonidine, Phenytoin, Acetazolamide, Furosemide, Danazole, Morphine, Glucagon, Rifampicin, acid ea nicotinic ka tekanyo e kholo, estrogen, letsoai la lithium, lithibela-pelehi tsa molomo;
- tšebeliso e kopanetsoeng le nifedipine e liehisa ho tlosoa ha metformin;
- tšebelisano-'moho le lithethefatsi tsa cationic e eketsa khatello e phahameng ea metformin maling ka 60%;
- e eketsa khatello ea ts'ebelisano-'moto ea metformin ea lithethefatsi ka furosemide.
Glimecomb e na le li-analogues le maele:
- Glidiab;
- Glyformin;
- Glidiab MB;
- Khemo ea Gliformin;
- Metglib;
- Foromo;
- MB ea Glyclazide;
- Diabetesalong;
- Gliclazide-Akos.
Pilisi ea video e bonts'a matšoao le kalafo ea lefu la tsoekere:
Maikutlo a litsebi le bakuli
Ho tsoa ho litlhahlobo tsa bakuli, ho ka fihlela qeto ea hore Glimecomb e fokotsa tsoekere ea mali hantle mme e mamelloa hantle, leha ho le joalo, lingaka li tsitlella tlhokomeliso ea eona ka lebaka la litla-morao tse 'maloa.
Glimecomb ke kalafo e sebetsang hantle bakeng sa lefu la tsoekere la mofuta oa 2. Empa ha ho fanoa ka litlatsetso tse ngata ho eona, ho khothalletsoa hore e fuoe bakuli ka hloko. Haholo-holo ba tsofetseng.
Anna Zheleznova, ea lilemo li 45, endocrinologist
Sesebelisoa se setle sa ho laola tsoekere ea mali. Ke e nkile ka khoeli, ho ne ho se na litla-morao, leha ho na le tse ngata tsa tsona ka litaelo. E khahliloe ke theko.
Lerato, ea lilemo li 57
Ke qetile nako e telele ke e-na le lefu la tsoekere la mofuta oa 2. Ke amohela Glimecomb. Moriana o motle ebile ha o theko e boima. E fokotsa tsoekere hantle. Ntho ea bohlokoa ke ho ja hantle le ho ja hantle.
Alexandra, ea lilemo li 51
Setlhare se boletsoeng se fanoa ka taelo ea ngaka. Litsenyehelo tsa eona li tsoa ho li-ruble tse 440-580. Theko ea bo-mphato ba bang ba lapeng e tsoa ho li-ruble tse 82 ho isa ho tse 423.
