Mikardis Plus e bua ka lithethefatsi tse thibelang pelehi ka molomo. Lithethefatsi li na le phello e kopaneng ea likhomphutha tse peli tse sebetsang - telmisartan le diuretic. Ka lebaka la motsoako ona oa lik'hemik'hale, phello e telele ea hypotensive e fihlella, e tšoarella lihora tse 6-12. Ho kopana ha hydrochlorothiazide le telmisartan ho u lumella ho etsa hore khatello e phahameng ea mali e lekane.
ATX
C09DA07.
Mikardis Plus e bua ka lithethefatsi tse thibelang pelehi ka molomo.
Lokolla liforomo le sebopeho
Setlhare se entsoe ka mokhoa oa matlapa, a nang le metsoako e 'meli e sebetsang - telmisartan le hydrochlorothiazide.
| Khokahano e sebetsang | Motsoako o ka bang teng oa litekanyetso, mg | ||
| Telmisartan | 80 | 80 | 40 |
| Diuretic | 12,5 | 25 | 12,5 |
| Lipilisi tsa mmala | Khubelu e kenelletseng bopinki | E putsoa ka inclusions tsa mosehla | Pinki |
E le likarolo tse ling tse ntlafatsang lebelo le botlalo ba ho monya, ke:
- starch ea poone;
- tsoekere ea lebese;
- cellcose ea microcrystalline;
- sodium hydroxide;
- Dyes ea oxide ea tšepe;
- povidone;
- sorbitol;
- meglumine.
Matlapa a entsoe a oval ka biconvex holim '. Moemeli oa antihypertgency ha a hlahisoe ka mokhoa oa thipa, gel, kapa tharollo ea botsoali.
Setlhare se entsoe ka mokhoa oa matlapa, a nang le metsoako e 'meli e sebetsang - telmisartan le hydrochlorothiazide.
Ketso ea pharmacological
Telmisartan e na le phello ea antihypertensive ka lebaka la tlamo ea li-receptors tsa angiotensin II. Ka ho theha mofuta o joalo, karolo e sebetsang e kena-kenana le ts'ebetso ea enzyme ea vasoconstrictor mme e fokotsa khatello ea aldosterone maling. Angiotensin II e ka baka ho senyeha ha bradykinin, hobane e thibetsoe ke telmisartan. Ka hona, motsoako oa bradykinin o ntse o tsoela pele - vasodilator e eketsa lumen maling.
Matla a vasodilating a ntlafatsa hydrochlorothiazide ka lebaka la phello ea diuretic. A thiazide diuretic e thusa ho fokotsa khatello e phahameng ea mali ka khatello e matla ea mali. Ka tšebeliso ea nako e telele, hydrochlorothiazide e fokotsa kotsi ea ho ba le methapo ea pelo le lefu la mafu ana.
Phekolo e phahameng ka ho fetisisa ea phekolo e fihlella ka nako ea lihora tse 3.5-4.
Matšoao a khatello ea mali a lula a tsitsitse bakeng sa lihora tse 6-12.
Mofumahali
Kamora ho sebelisoa, letlapa le robehile ka enzymes tsa mala.
Ha e lokolloa, likarolo tse sebetsang tsa lithethefatsi Mikardis Plus li kenella ka potlako leboteng la mala a manyane.
Ha e lokolloa, likarolo tse sebetsang li kenella ka potlako leboteng la mala a manyane ebe li kena maling. Tsamaisong ea potoloho, telmisartan le hydrochlorothiazide li fihla sehlohlolong ka metsotso e 30-90. Bioavailability ea mofuta oa bobeli oa angiotensin receptor antagonist e fihla ho 50%, hydrochlorothiazide ka hare ho 60%. Lintho tse sebetsang li fetoloa ho hepatocytes.
Bophelo ba halofo ke hoo e ka bang lihora tse 6. Telmisartan e siea 'mele ka sebopeho sa lihlahisoa tse sa sebetseng tsa ho bola ka hara urinary system ka 60-70%. Hydrochlorothiazide e hlahisoa e sa fetohe moroto ka 95%.
Matšoao a ho sebelisoa
Setlhare se hlokahala ho fokotsa khatello e phahameng ea mali le ho se sebetse hantle ha kalafo ea telmirsartan e le monotherapy.
Contraindication
Setlhare sena ha se reretsoe kalafo ea bakuli ba nang le mamello ea motho ka mong ho likarolo tse sebetsang le tse ling tsa Mikardis Plus. Lits'ebetso tse latelang tsa pathological li sebetsa hape e le mokhoa oa ho hatella tšebeliso:
- bile duct obstruction le concomitant cholestasis;
- ts'ebetso ea sebete sa ho sebetsa;
- letšoao le fokotsehileng la tšebetso ea a liphio;
- lefu la tsoekere le matla haholo;
- ho eketseha ha khalsiamo le maemo a tlase a potasiamo 'meleng;
- mofuta oa lefutso la lefutso oa galactose, fructose, lactose.
Moriana o thibetsoe hore o sebelisoe ho bakuli ba nang le bothata ba liphio le lefu la tsoekere ka ts'ebeliso e ts'oanang ea Aliskiren.
U ka e nka joang
Ka tekanyo e bonolo le e itekanetseng ea pathology, Mikardis e nkuoa nako e le 'ngoe ka letsatsi, ntle le ho hlafuna. Ho ja ka nako e tšoanang ha ho ame pharmacokinetics ea Mikardis.
Ka tekanyo e bonolo le e itekanetseng ea pathology, Mikardis e nkuoa nako e le 'ngoe ka letsatsi, ntle le ho hlafuna.
Bakeng sa batho ba baholo
Tekanyetso e tloaelehileng ea letsatsi le letsatsi e fana ka tekanyetso e le 'ngoe ea letlapa le nang le 80 mg ea telmisartan le 12,5 mg ea hydrochlorothiazide. Haeba phello ea hypotensive e sa lekana, empa ka mamello e ntle, ho hlokahala hore u noe matlapa a nang le 80 mg ea telmisartan le 25 mg ea hydrochlorothiazide.
Phello e phahameng ea hypotensive e bonoa ka mor'a likhoeli tse 1-2 kamora ho qala kalafo e matlafatsang.
Bakuli ba nang le khatello e matla ea mali ba lokela ho nka matlapa a mabeli ka letsatsi. Maemong ana, litekanyetso tsa hydrochlorothiazide li fanoa ke ngaka e eang ho latela tlhaiso-leseling ea mokuli.
Khetho ea Mikardis Plus bakeng sa bana
Setlhare sena se kopantsoe hore se sebelisoe ho fihlela lilemo tsa 18 ka lebaka la tlhaiso-leseling mabapi le phello ea lintho tse sebetsang ho nts'etsopele ea motho sekolong sa pele le bohlankana.
Lithethefatsi Mikardis Plus li kopantsoe hore li sebelisoe ho fihlela lilemo tse 18.
Ho nka moriana oa lefu la tsoekere
Bakuli ba nang le lefu la tsoekere ba hloka ho hlahloba litekanyetso tsa tsoekere ea serum kamehla. Nakong ea phekolo le Mikardis, ho na le kotsi ea hypoglycemia ka lebaka la phello ea diuretic ea hydrochlorothiazide.
Litlamorao
Litlamorao tse mpe li bonahatsoa ka lebaka la litekanyetso tse sa khethiloeng hantle mme li bonahala maemong a mangata ke likhathatso tse akaretsang.
Phekolo ea ka mpeng
Ho na le kotsi ea ho ba le liso tsa ho ruruha tsa ka mpeng. Bakuli ba bang ba na le bohloko ba ho hlohlona kapa ho nyekeloa ke pelo.
Hematopoietic litho tsa ka hare
Boemo ba lintho tse bōpiloeng ka plasma ea mali boa fokotseha.
Tsamaiso ea methapo e bohareng
Ka khatello ea maikutlo ea tsamaiso ea methapo e bohareng le kholo ea kholo ea mafu a kelello ho motho, mohlala oa boitšoaro o fetoha - boemo bo sithabetsang, ho bonahala maikutlo a ho tšoenyeha.
Ho ts'oaroa ke hlooho, ho opeloa ke hlooho, paresthesia, bofokoli bo akaretsang, likotsi tsa boroko li ka hlaha.
Ho tsoa ts'ebetsong ea moroto
Ho bakuli ba nang le bothata ba ho ntša metsi ka ntle ho mokokotlo (ba nang le benign Prostatic hyperplasia, prostatitis), ho boloka urination, ho arohana ha lesapo la senya ho ka etsahala. Maemong a sa tloaelehang, ho na le keketseho ea mahloriso a plasma ea uric acid.
Ho tsoa tsamaisong ea phefumoloho
Khahlano le semelo sa angioedema, ponahalo ea tšitiso ea moea, ho hlaha ha bronchospasm hoa khoneha.
Ho tsoa tsamaisong ea musculoskeletal
Boitšoaro bo bobe tsamaisong ea musculoskeletal bo tšoauoa ka ponahalo ea makhopho mesifa ea namane, bohloko manonyeletsong le mesifa, haholoholo ka morao.
Allergie
Ts'ebetsong ea morao-rao ea ho bapatsa, linyeoe tsa ho bonahala ha systemic lupus erythematosus, angioedema, le liphetoho tsa letlalo li tlalehiloe.
Litaelo tse khethehileng
Setlhare se na le phetoho e tsoelang pele ea vasodilating. Ka palo e tlase ea mali a potoloha (BCC), khatello e maling e tla fokotseha, kaha mokelikeli le phallo ea mali e ke ke ea lekana bakeng sa ho potoloha ho tloaelehileng. Ka lebaka la monyetla oa ho ba le hypotension ea matšoao, bakuli ba jang lijo tse nang le letsoai le fokolang, ba nang le lets'ollo le ho hlatsa nako le nako, ha ba nka diuretics pele ba nka Mikardis Plus, ho bohlokoa ho khutlisetsa BCC.
Maemong a mang, lithethefatsi li baka karabelo ea letlalo.
Ho nka moemeli ea nang le khatello ea kelello ho ka lebisa nts'etsopele ea kotsi ea methapo ea methapo kapa lefu la pelo ho bakuli ba nang le pelo ischemia ea pelo.
Hydrochlorothiazide e khona ho tsosa mofuta o matla oa myopathy kapa ponahalo ea glaucoma ea angle-shutter. Letšoao la pele la methapo ea methapo ea kutlo ke bohloko bo bohale mahlong, bo sa tloheng nako e telele. Haeba u utloa bohloko ebile o fokotseha ka matla a bonono, o lokela ho emisa hang hang ho nka Mikardis Plus.
Tekanyo ea joala
Nakong ea kalafo ea antihypertensive, ha ho khothalletsoe ho noa lino tse tahang.
Tai ea Ethyl e ka fokolisa phello ea antihypertensive, ea ntlafatsa phello ea diuretic ea hydrochlorothiazide mme ea baka spasm ea vasotine endothelium likepeng tse potileng.
Tšusumetso ho bokhoni ba taolo ea methapo
Setlhare ha se ame ts'ebetso ea ts'ebetso ea methapo le bokhoni bo botle ba koloi. Maemong ana, o tlameha ho hlokomela mehato ea polokeho ha o sebetsa ka mekhoa e rarahaneng le ha o khanna, hobane ho a khonahala ho lahleheloa ke kelello, ponahalo ea litlamorao (ho otsela, ho tsekela). Litlamorao tse mpe li ka baka ho fokotseha ha tlhokomelo ea batho le lebelo la maikutlo a hlokehang bakeng sa ho khanna.
Sebelisa nakong ea bokhachane le pelehi
Basali nakong ea kemolo ba thibetsoe ho nka Mikardis ka lebaka la menyetla e ka bang teng ea bokhachane.
Ts'ebetsong ea nts'etsopele ea embryonic, ho beoa ha methapo ea pelo le urinary ho ka senyeha.
Ha u sebelisa kalafo ea lithethefatsi, ho hlokahala ho emisa ho anyesa.
Ha a fuoa meriana, Mikardis Plus e tlameha ho emisa ho anyesa.
Bongata
Ka tekanyetso e le 'ngoe ea litekanyetso tse phahameng tse fetang tekanyetso e khothalletsoang, menyetla ea ho ba le matšoao a overdose e eketseha. Matšoao a kenyeletsa:
- ho fokotsa khatello ea mali;
- ho phahama kapa ho fokotseha ha sekhahla sa pelo;
- ho nyekeloa
- pherekano ea letsoalo;
- ho otsela
Maemong a mang, ho ba le phello e matla ea diuretic. Ka lebaka la tahlehelo ea mokelikeli o moholo, 'mele oa felloa ke metsi' meleng, 'me boemo ba li-electrolyte bo fokotseha. Ponahalo ea hypoglycemia e baka mesifa ea mesifa kapa e ntlafatsa arrhythmia.
Haeba ho na le lithethefatsi tse ngata, mokuli o hloka ho kena sepetlele. Maemong a ho ema, kalafo e shebane le ho tlosa mats'oao a mabe le ho etsa hore tekano ea motlakase oa metsi e be e lekanang.
Ho sebelisana le lithethefatsi tse ling
Ka tšebeliso e ts'oanang ea Mikardis e nang le li-lithium tse nang le li-lithium, keketseho e khutlisetsang ea mahlakore a serum a lithium a khonahala.
Ntlheng ena, tumello ea ho reculment ea lithium e fokotseha 'me ho nts'etsopele ke ka hona ho sa khothalletsoang ho fana ka kalafo e ts'oanang le lithium le moriana o matlafatsang. Boemo bo tšoanang bo bonoa ka litokisetso tsa potasiamo.
Moriana e fokotsang litaba tsa potasiamo ka plasma ea mali e kenya letsoho kholisong ea hypokalemia. Ka tsamaiso ea bona e ts'oanang le Mikardis, hoa hlokahala ho laola boemo ba potasiamo 'meleng.
Lithethefatsi tse seng khahlanong le ho ruruha (NSAIDs) li ka baka nts'etsopele ea ho omella, ke ka lebaka leo batho ba fetang lilemo tse 50 ba nang le kotsi e kholo ea ho hloleha ha liphio. Li-NSAID li fokotsa phello ea kalafo ea li-diuretics le li-antihypertensive lithethefatsi.
Lithethefatsi tsa anticholinergic hammoho le Mikardis Plus li fokotsa khatello ea mesifa e boreleli ea sepetlele sa ka mpeng.
Liphetoho tsa barbituric acid le antipsychotic li baka nts'etsopele ea hypotension ea orthostatic ka ho lahleheloa ke kelello ka mor'a moo.
Metformin e eketsa kotsi ea lactic acidosis ha e sebelisana le hydrochlorothiazide.
Lithethefatsi tse ling tsa antihypertensive hammoho le Mikardis li-synergistic - phello ea hypotensive e ntlafatsoa ka makhetlo a mangata ho latela litšobotsi tsa motho ka mong.
Cholesterol e thusa ho fokotsa sekhahla sa ho monya ha hydrochlorothiazide. Lithethefatsi tsa anticholinergic li eketsa bioavailability ea thiazide diuretics, ka lebaka leo ho nang le ho fokotseha ha peristalsis ea mesifa e boreleli ea seterata sa ka mpeng.
Moqapi
Beringer Ingelheim Ellas A.E., Koropi, Greece.
Mikardis Plus Analogs
Ntle le tšusumetso ea hypotensive, Mikardis e ka nkeloa sebaka ke e 'ngoe ea li-analogues:
- Tsena;
- Mohloekisi;
- Lozap Plus;
- Telmisartan;
- Telmisartan Richter;
- Telmista.
Lipehelo tsa khefu ea khemisi
Moriana o ka rekoa feela ka taelo ea ngaka.
Theko
Litsenyehelo tse tloaelehileng tsa matlapa a fapana ho tloha ho li-ruble tse 1074 ho isa ho 1100.
Maemo a polokelo ea Mikardis Plus
Ho khothalletsoa ho boloka moemeli oa antihypertensive sebakeng se arohaneng le mahlaseli a kotsi a mocheso oa + 8 ... + 25 ° C.
Letsatsi la ho felloa ke nako
Lilemo tse 3
Litlhahlobo mabapi le Mikardis Plus
Ho latela litsebi tsa lefu la pelo le bakuli, Mikardis ke sesebelisoa se sebetsang ntoeng ea ho loants'a khatello ea mali.
Litsebi tsa kelello
Elena Bolshakova, ngaka ea methapo ea maikutlo, Moscow
Ke entse thuto e le karolo ea lingoloa mabapi le litlamorao tsa lithethefatsi, kahoo ke khona ho bua ka kholiseho ka katleho ea Mikardis. Moriana o thusa ho tsitsisa khatello ea methapo ea pelo le ho fokotsa lebelo la maqhubu a pelo, a qholotsang nts'etsopele ea mafu a pelo le pelo. Moriana ona o sebetsa hantle ho bacha le ho batho ba tsofetseng. Litla-morao tse ka hlokang ho phekoloa ka mokhoa o mong, ha li ikoetlise ha li a kopana. Moriana ha o ame khatello ea maikutlo.
Sergey Mukhin, ngaka ea pelo, Tomsk
Ke nahana hore setlhare ke sesebelisoa se sebetsang sa ho fokotsa khatello e phahameng ea mali. Ha e nkoa hanngoe ka letsatsi, phello ea kalafo e tsoela pele letsatsi. Theko e phahame. Lenane le leholo la li-contraindication. Empa moriana o sebetsa bakeng sa lefu la tsoekere la mofuta oa 2, lefu la pelo le tsitsitseng. Ho thibetsoe ho sebelisa ho bakuli ba nang le ho nyekeloa ke pelo ho sa feleng. Boitšoaro bo kulang bo sa atiseng ho bonoa hangata litloaelong tsa ka tsa bongaka.
Mikardis Plus e ka nkeloa sebaka ke Pritor, e bolokiloeng sebakeng se arohaneng le mahlaseli a kotsi a mocheso oa + 8 ... + 25 ° C.
Bakuli
Dmitry Gavriilov, ea lilemo li 27, Vladivostok
Hlooho ea methapo ea kutlo e ile ea qala, ka lebaka leo mantsiboea ho neng ho e-na le bophelo bo botle, ho hloka moea khafetsa, le ho tsofala ho tsoetseng pele. Lingaka li ngotse matlapa a Mikardis. Setlhare se ile sa qala ho sebetsa ka letsatsi la pele. Lihora tse 3 kamora ho nka litafole, khatello e ile ea tsitsa lihora tse 20 tse tlang. Ho bohlokoa ho sebelisa meriana e meng e tla u thusa ho boloka phello. Ke khothaletsa ho buisana le ngaka ea hau ka kalafo e tšoanang ea lijo le li-vithamine complexes.
Alexandra Matveeva, ea lilemo li 45, St. Petersburg
O tobana le khatello ea maikutlo ka mor'a ho buuoa ho tšoelesa ea qoqotho. Setsebi sa pelo se hlalositse matlapa a MikardisPlus a ketso ea nako e telele. Ke ratile sethethefatsi, se theola khatello ea mali ka bonolo. Tšusumetso ea lithethefatsi ha e ame 'mele ebile ha e bake maikutlo a mabe le a maikutlo. Khatello e fihlile ho 130/80 mme e lula e le boemong bona. Ke u eletsa hore u nke phomolo ea libeke tse 2 ha u sebelisa moriana.
