Ka lefu la tsoekere, ho bohlokoa eseng feela ho lekanya tsoekere ea mali, empa le ho etsa liteko tsa cholesterol khafetsa. Haeba letšoao lena le fetisitsoe, ngaka e beha tlhahiso ea phekolo e khethehileng le kalafo ea lithethefatsi.
Setlhare se tsebahalang haholo bakeng sa hypercholesterolemia ke Simvagexal, e bua ka lithethefatsi tse fokotsang lipid tse nang le ntho e sebetsang ea simvastatin.
Matlapa a loketse kalafo ea bakuli ba fetang lilemo tse 18. U ka li reka k'hemisteng efe kapa efe ha u hlahisa lengolo la ngaka. Litekanyetso li beoa ke ngaka ka bonngoe, e shebane le nalane ea bongaka, boteng ba li-contraindication le mafu a manyane.
Moriana o sebetsa joang?
Litokisetso tse fumanoeng li entsoe ka sehlahisoa sa enzymatic Aspergillus terreus se theola litaba tsa plasma tsa triglycerides, lipoprotein tse tlase haholo le tse tlase, hape e eketsa litaba tsa lipoprotein tse phahameng.
Liphetho tse ntle tsa pele li ka bonoa matsatsi a 14 kamora ho qala kalafo. Phello e phahameng ea kalafo e fumanoa butle-butle, kamora khoeli le halofo.
Ho bohlokoa ho phethela mokhoa o behiloeng oa kalafo ho boloka litefiso tse tloaelehileng bakeng sa nako e telele.
Ngaka e u fa moriana haeba mokuli a na le:
- Hypercholesterolemia;
- Hypertriglyceridemia;
- Hypercholesterolemia e kopaneng.
Motsoako oa sebelisoa haeba lijo tse khethehileng li sa ka tsa thusa. Hape, ts'ebeliso ea matlapa a lumelloa bakeng sa merero ea thibelo haeba ho na le kotsi ea infyo ea myocardial ka index ea cholesterol e fetang 5,5 mmol / litha.
Ntle le ntho e sebetsang ea simvastatin, matlapa a oval a 'mala o mosoeu, o mosehla kapa o pinki o na le ascorbic acid, iron oxide, lactose monohydrate, starch ea poone, stearate ea magnesium, hypromellose, titanium dioxide.
Litaelo tsa tšebeliso ea lithethefatsi
Ho ea ka bukana e kentsoeng, o hloka ho nka Simvagexal ka shoalane hang ka letsatsi, ho nooa metsi a mangata. Nako ea kalafo e khethoa ke ngaka e eang, ho fetola litekanyetso ka mokhoa o ikemetseng mme kalafo ha e lumelloe.
Haeba tekanyetso ea hona joale e lahlehile, moriana o nooa neng kapa neng ha litekanyetso li ntse li tšoana. Kamora ho hlahloba mokuli, ho ithuta nalane ea bongaka le tlhahlobo, ngaka e etsa qeto ea hore na ho hlokahala matlapa a makae qalong ea kalafo.
Tekanyetso ea mantlha e thehiloe, e shebane le boemo ba plasma ea cholesterol, e fumanoeng kamora libeke tse 'ne.
- Ka litekanyetso tse tloaelehileng, mokuli o nka 40 mg ka letsatsi. Bophahamo ba modumo ona bo ka eketseha ho isa ho 80 mg ka letsatsi moo ho nang le kotsi ea pelo le kalafo ha kalafo e sa sebetse.
- Bakuli ba nang le lefu la pelo ba nka 20 mg ka letsatsi. Kamora khoeli, tekanyetso haeba ho hlokahala e eketseha ho 40 mg. Tabeng ea ho fokotseha ha cholesterol e felletseng ho isa ho 3,6 mmol / litha mme ka tlase, palo ea matlapa e fokotsehile.
- Haeba motho a phekoloa ka ho eketsehileng ka cyclosporine, Nicotinamide kapa fibrate, lethal dose la letsatsi le letsatsi le leholo le phahameng le fokotsoa ho 5-10 mg. Mehato e ts'oanang e nkuoa haeba ho e-na le ho se sebetse hantle ha renal.
Ka kalafo ea immunosuppression, litekanyetso tse phahameng ha li eketsoe ka holimo ho 5 mg ka letsatsi.
Ke mang ea kopantsoeng le kalafo ea lithethefatsi?
Ho bohlokoa ho ela hloko hore matlapa a na le li-contraindication tse ngata, ka lebaka leo, boikoetliso ha boa lokela ho etsoa. Pele o nka Simvagexal, o hloka ho bala litaelo tsa ho li sebelisa.
Theko ea lithethefatsi tse nang le litlhahlobo tse ntle ke li-ruble tse 140-600, ho latela sephutheloana. Ka k'hemisteng o ka fumana lipakete tsa 5, 10, 20, 30, 40 mg. Ho feta thupelong e tloaelehileng ea bongaka, ho kgothaletsoa ho reka matlapa a Hexal Simvagexal 20mg ka bongata ba li-pcs tse 30.
Setlhare sena se kopantsoe ha mokuli a le:
- ho hloleha ha sebete;
- hypersensitivity ho likarolo tsa moriana;
- sensitivity to statins;
- myopathy
- tlolo ea sebopeho sa lisele tse khubelu tsa mali (porphyria).
U ke ke ua etsa kalafo haeba motho a sebelisa Itraconazole, Ketoconazole, lithethefatsi bakeng sa kalafo ea ts'oaetso ea HIV. Hape, matlapa a tlotsitsoe ho basali baimana le ba anyang.
Ho lokela hore ho sebelisoe tlhokomeliso ha mokuli a sebelisa lino tse tahang hampe, a phekoloa ka li-immunosuppressants, a e-na le tonus e eketsehileng kapa e fokotsehileng ea masapo a marapo, a na le lefu la ho akheha, ho kula ho sa foleng, ho ruruha ha methapo ea methapo, endocrine e matla le mathata a metabolic. Phekolo e etsoa har'a bakuli ba kaholimo ho lilemo tse 18.
Nakong ea kemolo, ho molemo ho hana sethethefatsi sena, hobane maemong a tloaelo ea bongaka ho hlahisoa lits'oants'o tse bobebe ho ngoana kamora ho ja litafole tse tloaelehileng.
Nakong ea phekolo, ho bohlokoa hore u qobe ho ima e le hore u se ke oa ntša mpa.
Litlamorao
Ha u fana ka kalafo ka lipilisi, ngaka e lokela ho etsa bonnete ba hore mokuli ha a noe litlhare tse ling. Mokuli le eena o lokela ho tsebisa ngaka hore na o se a ntse a e-noa lipilisi life. Sena sea hlokahala e le ho qoba tšebelisano e sa batleheng le lithethefatsi tse ling.
Haholo-holo, ka tšebeliso ea li-fibrate, cytostatics, litekanyetso tse phahameng tsa nicotinic acid, Erythromycin, liproteine inhibitors, li-antifungal agents, li-immunosuppressants, Clarithromycin, rhabdomyolysis li ka nts'etsapele.
Ka lebaka la litlamorao tse eketsehileng tsa li-anticoagulants tsa molomo, ho tsoa mali ho ka hlaha, ka hona o hloka ho lekola boemo ba mali nakong ea kalafo. Simvagexal e boetse e eketsa litaba tsa plasma tsa digoxin. Haeba mokuli a kile a sebelisa cholestyramine le colestipol, matlapa a lumelloa ho nooa feela kamora lihora tse 'ne.
- Litla-morao li bonahala ka tsela ea ho fokola ha mesifa, asthenic syndrome, ho tsekela, pono e fifalitsoeng, paresthesia, ho senyeha ha hlooho, hlooho e opang, ho hloka boroko, neuropathy ea pherekano.
- Ho na le maemo a ho senyeha ha tsamaiso ea tšilo ea lijo, ho ruruha, ho nyekeloa ke pelo, dyspepsia, ho hlatsa, bohloko ka mpeng, bolulo, pancreatitis, lets'ollo, hepatitis.
- Maemong a sa tloaelehang, karabelo ea allergic e bonoa ka mokhoa oa ho hlohlona ha letlalo le lekhopho, polymyalgia rheumatism, thrombocytopenia, feberu, palo e matla ea erythrocyte sedimentation, urticaria, ho hema, eosinophilia, angioedema, hyperemia ea letlalo, vasculitis, arusus, eustheusosus.
- Motho a ka ba le myalgia, myopathy, bofokoli bo akaretsang, rhabdomyolysis. Ka lebaka leo, potency e fokotseha, palpitations e potlaka, anemia ea eketseha, le ho se sebetse hantle ha sebete.
Tabeng ea overdose, joalo ka molao, matšoao a itseng ha a hlahe, empa ho bohlokoa ho tlosa ntho e sebetsang e ngata 'meleng. Ho etsa sena, mokuli oa hlatsoa, a fane ka mashala a entsoeng ka mollo. Nakong ea phekolo, ho hlokahala hore ho hlahlojoe boemo ba serum ba creatine phosphokinase, renal le hepatic.
Haeba u nka li-statin nako e telele, ka nako e sa tloaelehang ho hlaha lefu la masapo la matšoafong, le tsamaeang le ho khohlela ho omileng, ho mpefala ha maemo ka kakaretso, mokhathala o eketsehileng, ho theola boima ba 'mele le ho tsitsa.
Ha matšoao ana a hlaha, kalafo e nang le matlapa e lokela ho emisoa.
Litlhahiso tsa lingaka
Haeba motho nakong ea ts'ebetso ea kalafo a eketsa ts'ebetso ea moeine phosphokinase le mesifa ea mesifa e hlaha, ho hlokahala hore o tlohele ho ikoetlisa ka matla.
Ho hlokahala hape ho felisa lisosa tsa ts'ebetso ea enzyme e eketsehileng, e kenyelletsang boteng ba feberu, ho longoa, likotsi, hypothyroidism, ts'oaetso, chefo ea khase ea carbon diapo, polymyositis, dermatomyositis, joala le lithethefatsi tsa lithethefatsi. Haeba kamora sena ts'ebetso ea enzyme e ntse e eketseha, matlapa a Simvagexal a lokela ho tloheloa ka botlalo. Sebakeng seo, o ka sebelisa li-analogues tse tsoang ho bahlahisi ba bang.
Pele a qala kalafo, ngaka e lokela ho etsa tlhahlobo ea mali bakeng sa ts'ebetso ea KFK. Ts'ebetso ena e lokela ho phetoa kamora likhoeli tse tharo. Ho beha leihlo li-phosphokinase ho batho ba tsofetseng le bakuli ba nang le ts'oaetso ea lefu la tsoekere le itšetlehileng ka lefu la tsoekere, hypothyroidism, dysfunction ea renal e etsoa selemong.
Bakeng sa mofuta leha e le ofe oa lefu la tsoekere, ho hlokahala hore kamehla a etse tlhahlobo ea tsoekere ea mali, kaha setlhare se thusa ho eketsa tsoekere e ngata maling ka har'a plasma.
Bakuli ba bang ba ba le hyperglycemia, e hlokang meriana e khethehileng.
Empa lingaka ha li khothaletse ho emisa kalafo ka li-statin, hobane cholesterol e phahameng e ka baka mathata a tebileng ho ba lefu la tsoekere ha ho se na kalafo e nepahetseng.
Matlapa a lokela ho nkuoa ka hloko haeba mokuli a sebelisa joala hampe. Haeba ts'ebetso ea qoqotho e fokotseha, lefu la liphio, lefu le ka sehloohong le phekoloa pele, ka mor'a moo o ka qala ho theola khatello ea cholesterol maling.
Lithethefatsi tse tšoanang li kenyelletsa Zokor, Avestatin, Sinkard, Simgal, Vasilip, Aterostat, Zorstat, Ovenkor, Holvasim, Simplakor, Actalipid, Zovatin le ba bang.
Boloka moriana ka mocheso o sa feteng 30 degrees, hole le khanya ea letsatsi le bana.
Lijo ho theola k'holeseterole e ngata
Ntle le ho nka meriana, mokuli o tlameha ho latela lijo tsa hypocholesterol, tse amanang le ho ja lijo tse mafura a liphoofolo. Phepo e nepahetseng e ka ntlafatsa boemo ba methapo ea mali le ho tlosa li-plaque atherosranceotic.
Lijo tse thibetsoeng li kenyelletsa mafura a liphoofolo le a khathollang, botoro ea tlhaho, margarine, nama e mafura, lisoseji le lisoseji. Mokuli o lokela ho hana li-yolks tsa mahe, litapole tse halikiloeng, li-pancake, li-pastries le sec confery ea tranelate.
Hape, ho sa kenyele lisoso, lebese lohle, lebese le tlotsitsoeng, tranelate, tranelate e bolila, chisi e mafura e ea hlokahala lijong.
Ho khothalletsoa hore mokuli a hlatsoe lijana tse nang le soya, canola, mohloaare, sesame le oli e meng ea meroho, e nang le li-acid tse omega tse tharo.
U hloka ho ja salmon, trout, mackerel le mefuta e meng ea litlhapi tse mafura, nama e halikiloeng, khoho le mohatla. Lijo tse joalo ke mohloli o motle oa protheine.
Lijo li na le lijo-thollo tse phehiloeng metsing, bohobe bohle ba lijo-thollo, makhapetla a lijo-thollo tse ngata, meroho le litholoana tse ncha.
Ka lefu la tsoekere la mofuta ofe kapa ofe, o ke ke oa sebelisa li-sweets, lipie, li-biscuits.
Lijo tsa kalafo tse nang le cholesterol e phahameng li na le melao e 'maloa ea motheo e lokelang ho lateloa. Lino tse tahang, kofi, tee e matla e kopantsoe ka ho felletseng, lijo tse monate le tse tsoekere li sebelisoa ka bongata.
Lijo li kenyelletsa meroho, litholoana, lihlahisoa tsa lebese tse mafura a fokolang. Lijo tse halikiloeng li nkeloa sebaka ke lijo tse phehiloeng le tse halloang. Li-broth tsa nama tse phehiloeng li jeoa li halikiloe ntle le mafura. Khoho e entsoeng ka boi e lokiselitsoeng e sebeletsoa tafoleng ntle le letlalo, mafura ha a sebelisoe ha a pheha. Mahe a likhoho a jeoa ntle le li-yolks.
Lijo tse nang le phepo e nepahetseng li tla imolla cholesterol e ngata, li sireletse methapo ea mali le sebete. Matsatsing a pele a supileng, mokuli o ikutloa a le betere, kaha mokhoa oa ho silila o sa pepesele khatello ea maikutlo. Lijo tse joalo ha li na li-contraindication, kaha li leka-lekane, ka hona li ntle ho batho ba nang le lefu la tsoekere.
Mokhoa oa ho fetisa metabolism ea lipid o hlalositsoe videong ena.
