Ho fihlela puseletso ea nako e telele bakeng sa lefu la tsoekere, ho sebelisoa mefuta e mengata e fapaneng ea insulin. Insulin Lizpro ke lithethefatsi tsa sejoale-joale tse bolokehileng ho feta tsa tlhaho tse khutšoane tse laolang tsoekere ea tsoekere.
Sesebelisoa sena se ka bontšoa hore se sebelisoe ke batho ba tsoekere ba lihlopha tsa lilemo tse fapaneng. Insulin Lizpro e ka fuoa bana ba nang le lefu la tsoekere.
Ha e bapisoa le li-insulin tse etsang lintho tse khutšoanyane, Insulin Lizpro e sebetsa ka potlako, ka lebaka la ho kenoa ka bongata.
Ketso ea mahlale le lipontšo
Lizpro biphasic insulin e entsoe ka ho sebelisa theknoloji ea DNA e kopanyang. Ho na le tšebelisano le li-receptor tsa membrane ea cytoplasmic ea lisele, ho thehoa "insulin-receptor" e hlohlelletsang lits'ebetso kahare ho lisele, ho kenyelletsa motsoako oa li-enzyme tsa bohlokoa.
Ho fokotseha ha khatello ea tsoekere ea mali ho hlalosoa ke keketseho ea tšebetso ea eona e makatsang, hammoho le ho monya le ho amoheloa ke lisele ka bongata. Tsoekere e ka fokotseha ka lebaka la ho fokotseha ha sekhahla sa tlhahiso ea eona ke sebete kapa ka ho susumetsoa ke glycogenogeneis le lipogenesis.
Lyspro insulin ke mofuta o mong oa lipalo tsa DNA o fapaneng ka tatellano e setseng ea masale a lysine le proline amino acid maemong a 28 le a 29 mokokotlong oa insulin B. Setlhare se na le ho emisoa ha protamine ea 75% le 25% insulin lispro.
Lithethefatsi li na le litlamorao tsa anabolic le regulation ea glucose metabolism. Ho li-tishu (ntle le lisele tsa boko), phetoho ea tsoekere le amino acid ka seleng e potlakisitsoe, e leng se etsang hore ho be le glycogen e tsoang tsoekere maling.
Moriana ona o fapana le li-insuline tse tloaelehileng tloaelong e potlakileng ea ts'ebetso 'meleng le bonyane litla-morao.
Setlhare se qala ho sebetsa kamora metsotso e 15, se hlalosoang ke ho monya haholo. Ka hona, e ka tšeloa metsotso e 10-15 pele ho lijo. Insulin ea kamehla e fanoa ka nako e ka tlase ho halofo ea hora.
Sekhahla sa ho koaloa se angoa ke sebaka sa ente le lintho tse ling. Ketso ea tlhoro e bonoa ka bongata ba lihora tse 0.5 - 2,5. Insulin Lizpro e sebetsa lihora tse 'ne.
Lizpro insulin e hlahisoa bakeng sa batho ba nang le mofuta oa 1 lefu la tsoekere, haholoholo haeba ho e-na le mamello ho insulin e 'ngoe. Ntle le moo, e sebelisoa maemong a joalo:
- postprandial hyperglycemia,
- subcutaneous insulin hana ka tsela e hlobaetsang.
Setlhare se boetse se sebelisetsoa mofuta oa lefu la tsoekere la mofuta oa 2 o hananang le lithethefatsi tsa molomo tsa hypoglycemic.
Lizpro insulin e ka hlahisoa bakeng sa li-pathologies tsa kahare.
Litaelo tsa tšebeliso ea lithethefatsi
Litaelo tsa ts'ebeliso ea lithethefatsi li bonts'a hore tekanyetso e lokela ho baloa ho ipapisitsoe le boemo ba glycemia. Haeba ho hlokahala, moriana o fanoa hammoho le li-insulin tsa nako e telele, kapa ka litlhare tsa sulfonylurea tsa molomo.
Ente e etsoa ka mokhoa o ikhethileng libakeng tse joalo tsa mmele oa mokuli:
- letheka
- mpa
- li-buttocks
- mahetla.
Libaka tsa ente li lokela ho fetoloa hore li se sebelisoe nako e fetang e le 'ngoe ka khoeli. Se ke oa fana ka ente libakeng tseo ho tsona ho nang le methapo ea mali e haufi haholo.
Batho ba nang le ho haelloa ke hepatic le renal ba kanna ea ba le insulin e ngata e potolohang le tlhoko e fokotsoeng ea eona. Sena se hloka ho hlahlojoa khafetsa glycemia le khalemelo e nepahetseng ea litekanyetso tsa moriana.
Sengolo sa humalog syringe (Humapen) se se se fumaneha; ho bonolo haholo ho se sebelisa. Hona le likhetho tse 'maloa bakeng sa yuniti ena, tekanyo e nyane haholo e fumaneha li-unit tsa 0.5.
Mekhoa e joalo ea rekisoa:
- "Humapen Luxura". Sehlahisoa se na le skrine ea elektroniki e bonts'ang nako ea ente ea ho qetela le boholo ba tekanyetso e boletsoeng.
- Humapen Ergo. Pene ka boleng bo holimo ka ho fetisisa ba chelete.
Insulin Lizpro, le pente ea syringe ea Humapen li rekisoa ka theko e loketseng 'me li na le litlhahlobo tse ntle.
Litla-morao le li-contraindication
Insulin Lizpro e na le li-contraindication tse latelang:
- motho ka mong,
- hypoglycemia,
- insulinoma.
Ho se mamelle ho bontšoa ka lintho tse joalo tse sa hlokeng ho arabela:
- urticaria
- angioedema ka feberu,
- ho hema hanyane
- ho theola khatello ea mali.
Ponahalo ea hypoglycemia e fana ka maikutlo a hore litekanyetso tsa moriana li khethiloe ka nepo kapa phoso ke khetho e fosahetseng ea sebaka kapa mokhoa oa ente. Mofuta ona oa insulin ha oa lokela ho tsamaisoa ka matla, empa ka mokhoa o ikhethileng.
Maemong a sa tloaelehang haholo, ho kula ho ka mpefatsa kelello ho ka hlaha.
Lipodystrophy e thehoa haeba ente ea subcutaneous e entsoe ka phoso.
Matšoao a latelang a lithethefatsi tse ngata tsa lithethefatsi a khethiloeng:
- lethargy
- mofufutso
- pelo e matla
- tlala
- ho tšoenyeha
- paresthesia molomong,
- pallor ea letlalo,
- hlooho e bohloko
- ho thothomela
- ho hlatsa
- bothata ba ho robala
- ho hloka boroko
- Ho sithabela maikutlo
- ho se khonehe
- boits'oaro bo sa lokang
- mathata a pono le a puo,
- glycemic coma
- cramps.
Haeba motho a hlokomela, joale ho bontšoa dextrose ka hare. Glucagon e ka tsamaisoa ka matla, ka mokhoa o ikhethileng le ka mokhoa o kopaneng. Ha ho etsoa komisi ea hypoglycemic, ho fihla ho 40 ml ea tharollo ea dextrose 40% e tsamaisoang kahare. Phekolo e ntse e tsoela pele ho fihlela mokuli a tsoa komellong.
Hangata, batho ba mamella Insulin Lizpro ntle le litlamorao tse mpe.
Maemong a mang, kamohelo e ka fapana ts'ebetsong e fokotsehileng.
Likarolo tsa ho sebelisana le lithethefatsi tse ling
Lizpro insulin ha ea lokela ho sebelisoa ka tharollo ea lingaka. Phello ea hypoglycemic ea lithethefatsi e ntlafatsoa:
- MAO inhibitors
- androgens
- ACE
- mebendazole,
- sulfonamides,
- khalase ea k'habone
- theophylline
- li-anabolic steroids
- Litokisetso tsa lithium
- NSAIDs
- chloroquinine,
- bromocriptine
- marangrang
- ketoconazole,
- clofibrate
- fenfluramine,
- quinine
- cyclophosphamide
- ethanol
- pyridoxine
- quinidine.
Phello ea hypoglycemic e fokolisoa ke:
- estrogens
- glucagon,
- heparin
- zangoloteas
- danazol
- GKS,
- lithibela-pelehi tsa molomo
- diuretics
- lihormone tsa qoqotho
- calcium antagonists
- kutloelo-bohloko
- morphine
- clonidine
- santantantanthuri
- diazoxide
- matekoane
- nikotine
- phenytoin
- BMKK.
Ketso ena e ka fokolisa le ho ntlafatsa:
- Octreotide
- beta blockers,
- reserpine
- pentamidine.
Tlhahisoleseling e Khethehileng
Hoa hlokahala ho boloka ka hloko mekhoa ea ts'ebetso ea lithethefatsi e thehiloeng ke ngaka.
Ha u fetisetsa bakuli ho Insulin Lizpro ka insulin e sebetsang ka potlako, ho ka hlokahala phetoho ea tekanyetso. Ha tekanyetso ea letsatsi le letsatsi ea motho e feta li-unit tse 100, phetisetso ho tsoa ho mofuta o mong oa insulin o etsoa ho ea tlasa maemo a station.
Tlhokahalo ea tekanyetso e eketsehileng ea insulin e ka ts'oaroa ka lebaka la:
- mafu a tšoaetsanoang
- khatello ea maikutlo
- eketsa palo ea lik'habohaedreite lijong,
- ha u sebelisa meriana e nang le ts'ebetso ea hyperglycemic: lihormone tsa qoqotho, diuretics le lithethefatsi tse ling.
Ho fokotsa tlhoko ea insulin ho ka ba le ho fokola ha sebete kapa a liphio, ho eketsa mesebetsi ea mmele, kapa ha u ntse u sebelisa meriana ka ts'ebetso ea hypoglycemic. Chelete e joalo e kenyeletsa:
- beta-blockers
- MAO inhibitors
- sulfonamides.
Kotsi ea hypoglycemia e fokotsa bokhoni ba motho ba ho khanna makoloi le ho boloka mekhoa e fapaneng.
Batho ba nang le lefu la tsoekere ba ka fokotsa hypoglycemia e bonolo ka ho ja tsoekere kapa lijo tse nang le lik'habohaedreite tse ngata.
Ngaka e eang teng e tlameha ho tsebisoa ka 'nete ea hypoglycemia, kaha litekanyetso li tlameha ho fetoloa.
Litšenyehelo le litšoantšiso tsa moriana
Hajoale, Insulin Lizpro e rekisoa ka theko ea li-ruble tse 1800 ho isa ho tse 2000.
Likhakanyo tsa lithethefatsi Insulin Lizpro ke:
- Insulin Humalog Remix 25.
- Insulin Humalog Remix 50.
Mofuta o mong o fapaneng oa "insulin" ea insulin ke karolo ea likarolo tse peli tsa insulin.
Ho bohlokoa ho hopola hore o ke ke oa sebelisa Insulin Lizpro motheong oa qeto e ikemetseng. Moriana o lokela ho nooa feela kamora ho khethoa ke ngaka e eang. Melemo le eona ke boikarabello ba ngaka.
Tlhaloso le melao ea ho sebelisa insulin ea Lizpro e fanoe ka har'a video ena sengoliloeng sena.
