Phekolo ea lefu la tsoekere la mofuta oa 2 e kenyelletsa ho tsamaisoa ha lithethefatsi tsa hypoglycemic tsa lihlopha tse fapaneng.
Tsena li kenyelletsa tse tsoang ho sulfonylurea.
E mong oa baemeli ba sehlopha sena ke chlorpopamide.
Tlhahisoleseling ka kakaretso mabapi le lithethefatsi
Chlorpropamide ke ntho e sebetsang eo e leng karolo ea motsoako oa pele oa sulfonylurea. Sehlopha sa eona sa lithethefatsi ke mahlahana a maiketsetso a maiketsetso. Chlorpropamide ha e qephe ka metsing, empa, ho fapana le moo, e qhibilihang ka joala.
Ho fapana le meloko e meng ea lihlahisoa tse tsoang sulfonylurea, chlorpropamide e sebetsa hanyane ka hanyane. Ho fihlela boemo bo nepahetseng ba glycemia, e sebelisoa ho litekanyetso tse kholo.
Litlamorao tse tlisoang ke ho sebelisa moriana o phatlalalitsoe haholoanyane ha li bapisoa le Glibenclamide le baemeli ba bang ba moloko oa bobeli. E sebetsa hantle ka tlhahiso e sa lekanang ea lihormone (insulin) le ho fokotseha ha sesole sa ts'ebetso ea eona. Phekolo ka chlorpropamide e na le phello ho bakuli ba nang le lefu la tsoekere la nakoana le / kapa lefu la tsoekere la mofuta oa 2.
Chlorpropamide ke lebitso la mofuta o tloaelehileng la sehlahisoa. E theha motheo oa moriana (ke karolo e sebetsang). E fumaneha matlapeng.
Ketso ea pharmacological
Moriana o na le phello ea hypoglycemic. Ntho ena e tlama ho liteishene tsa potasiamo, e tsosa secretion ea insulin. Liseleng le litho tse kenngoeng ke insulin, palo ea li-receptor tsa li-hormone ea eketseha.
Boteng ba insulin ea endo native, maemo a tsoekere a fokotsehile. E na le ts'ebetso ea antidiuretic. Ka lebaka la secretion ea insulin, ho nona hoa boima.
Ho tlosa glycemia ho itšetlehile hanyane ka tsoekere ea mali. Chlorpropamide, joalo ka sulfonylureas tse ling, e na le likotsi tsa hypoglycemia, empa ka tekanyo e fokolang.
Ha e kopantsoe le baemeli ba bang ba hypoglycemic (biguanides, thiazolidatediones, bona o sebelisana le lithethefatsi tse ling), litekanyetso tsa morao li fokotsoa hanyane.
Mokhoa oa ts'ebetso oa tšebetso ea sulfonylurea
Mofumahali
Kamora ho kenella ka har'a tšilo ea lijo, chlorpropamide e kenella hantle. Kamora hora, ntho ena e maling, khokahanyo ea eona e phahameng - kamora lihora tse 2,4. Plasma protein e tlamang> 90%.
Setlhare sena se sebetsa ho pholletsa le letsatsi ha ho sebelisoa joalo. Ho felisoa ha halofo ea bophelo ke lihora tse ka bang 36. E tšeloa ka bongata moroto (ho fihlela ho 90%).
Matšoao le contraindication
Matšoao a sebelisoang ke lefu la tsoekere le sa itšetleheng ka insulin, hammoho le insipidus ea lefu la tsoekere. Chlorpropamide e ne e laetsoe maemong ao kalafo ea ho ja, boikoetliso ba 'mele bo sa tliseng sephetho se nepahetseng ho tokiso ea matšoao.
Har'a lintho tse khahlanong le tšebeliso ea meriana ena, li kenyeletsa:
- hypersensitivity ho chlorpropamide;
- Mofuta oa 1 lefu la tsoekere;
- hypersensitivity ho sulfonylureas tse ling;
- metabolism e nang le khethollo ho acidosis;
- Psychology
- ketoacidosis;
- ho se sebetse ha sebete le liphio;
- mafu a tšoaetsanoang a hlobaetsang;
- ho ima / ho nyekeloa ke mpa;
- ntate-moholo le komisi;
- lilemo tsa bana;
- ho hloleha khafetsa ha kalafo ea chlorpropamide;
- maemo kamora ho pancreatic resection.
Tekanyetso le tsamaiso
Motsoako o beoa ke ngaka ho ipapisitse le lefu la tsoekere le phallo ea glycemia. Ha o fumana puseletso e tsitsitseng ho mokuli, e ka fokotsoa. E le molao, le lefu la tsoekere la mofuta oa 2, tloaelo ea letsatsi le letsatsi ke 250-500 mg. Ka lefu la tsoekere la lefu la tsoekere - 125 mg ka letsatsi. Ha e fetisetsoa ho lithethefatsi tse ling, phetoho ea litekanyetso ea hlokahala.
Litaelo tsa tšebeliso ea chlorpropamide li bonts'a tšebeliso ea moriana halofo ea hora pele ho lijo. Ho bohlokoa ho e sebelisa ka nako e le 'ngoe. Haeba litekanyetso li fana ka lipilisi tse ka tlase ho tse 2, kamohelo e etsahala hoseng.
Video e tsoang ho setsebi mabapi le lefu la tsoekere le hore na u ka e phekola joang:
Litla-morao le ho sebelisa overdose haholo
Litlamorao tse latelang li ka hlaha nakong ea tsamaiso ea chlorpropamide:
- ho nyekeloa ke pelo, ho hlatsa, ho opeloa ke mpa, ho lula setulong;
- hypoglycemia;
- hyponatremia;
- tatso ea tšepe ka hanong, ho hloka takatso ea lijo;
- ho senyeha ha pono;
- makhopho a letlalo a mofuta o fapaneng;
- anemia ea hemolytic;
- ho eketseha ha matšoao a sebete;
- thrombo-, leuko-, erythro-, granulocytopenia;
- ho opeloa ke hlooho le ho tsitsipana;
- khatello ea khatello;
- bofokoli, ho hloka thahasello, ho otsela, ho tšoenyeha;
- cholestatic jaundice;
- ho bolokoa hoa mokelikeli 'meleng;
- anaphylactic makala.
Ka tekanyo e bonolo / e leka-lekaneng ea hypoglycemia, mokuli o nka ligrose tse 20-30 tsa tsoekere. Nakong e tlang, litekanyetso li ntlafatsoa 'me phepo e ea phetoa.
Maemong a matla, a tsamaeang le ho akheha le letsoalo, tsoekere e tsamaisoa ka matla. Ntle le moo, glucagon e ka tsamaisoa kahare kapa ka intra. Kamora ho emisa hypoglycemia nakong ea matsatsi a mabeli, matšoao a hlahlojoa a sebelisa glucometer.
Likarolo tsa ts'ebeliso
Pele o rera ho ima, o tlameha ho lahla chlorpropamide. Taolo ea lefu la tsoekere la mofuta oa 2 le "insulin" e nkoa e le pheko e nepahetseng. Nakong ea kotlo, ba latela melao-motheo e tšoanang.
Phetisetso ea lithethefatsi e etsoa ho tloha halofo ea letlhare ka letsatsi, ebe e beheloa mohala oa pele. Bakuli ba nang le mathata a ho ba le mathata a renal / hepatic ba tla hloka phetoho ea tekanyetso. Ha ho fanoa ka litekanyetso tsa lithethefatsi ho batho ba baholo, lilemo tsa bona li nahaneloa.
Ha ho lefella lefu lena, ho hlokahala hore ho fokotsoe litekanyetso. Khalemelo e boetse e etsoa ka liphetoho tsa boima ba 'mele, mojaro, ho ea sebakeng se seng sa nako.
Ka lebaka la khaello ea tlhaiso-leseling ka polokeho ea tšebeliso, moriana ona ha o ngoletsoe bana. Ka likotsi, pele ho ts'ebetso, le nakong ea mafu a tšoaetsanoang, mokuli o fetisetsoa ho insulin nakoana.
Se ke oa sebelisa le Bozetan. Ho na le bopaki ba hore e ama hampe bakuli ba fumanang chlorpropamide. Ba hlokometse keketseho ea li-indices tsa hepatic (enzymes). Ho latela maemo a lipilisi tsena ka bobeli, mochini oa li-acid acid tse tsoang liseleng oa fokotseha. Sena se kenyelletsa ho bokella ha bona, e leng se lebisang ho phello e chefo.
Ho sebelisana le meriana e meng
Biguanide Metformin
Ka tšebeliso e tšoanang ea chlorpropamide le meriana e meng, phello ea eona e ka fokola kapa ea eketseha. Kopano ea bohlokoa pele u nka meriana e meng.
Eketseha bohato lithethefatsi ho etsahala ha coadministered le a ntse insulin, lithethefatsi tse ling tse hypoglycemic, biguanides, coumarin derivatives, phenylbutazone, lithethefatsi tetracycline, Mao inhibitors, fibrates, salicylates, miconazole, streroidami, e motona hormone, cytostatics, sulfonamides, derivatives quinolone, clofibrate, sulfinpyrazone.
Lithethefatsi tse latelang li nyenyefatsa phello ea chlorpropamide: barbiturates, diuretics, adrenostimulants, estrogens, lithibela-pelehi tse behiloeng ka bongata, litekanyetso tse kholo tsa nicotinic acid, diazoxide, lihomone tsa qoqotho, phenytoin, glucocorticosteroids, sympathomimetics, phenothiazine.
Chlorpropamide ke moemeli oa hypoglycemic o buang ka melemo ea 1st sulfonylurea. Ha e bapisoa le balateli ba eona, e na le matla a ho fokotsa tsoekere le litlamorao tse ngata tse boletsoeng. Hajoale, sethethefatsi ha se sebelisoe.
